This editorial criticizes the private finance initiative (PFI) model for funding infrastructure projects in the UK. It argues that PFI schemes are more expensive than traditional public funding, as the private capital used is always more costly than public capital. The extra costs of PFI are leading NHS trusts to reduce the capacity and staffing of new hospitals. This undermines the goal of equitable access to healthcare. Alternatives like a public health development bank should be pursued instead of persisting with the flawed PFI approach.
The presentation was from the Business as Mutual conference held at Anglia Ruskin University on 12th September 2012. To find out more visit www.businessasmutual.co.uk
The presentation was from the Business as Mutual conference held at Anglia Ruskin University on 12th September 2012. To find out more visit www.businessasmutual.co.uk
A publication for government on pandemic flu and faith communities. Prepared as a sister document to Key Communities, Key Resources, a report for government on faith communities and pandemic preparedness
A description of PFI and PF2 with a short Case Study on leading PFI company Inishfree and it's involvement with Bart's Hospital and Norwich & Norfolk Foundation Trust. Feel free to download and use for your own purposes. You can view the video version on YouTube: www.youtube.com/watch?v=YSzejDVdCzw&t=8s
How can we afford to meet the future needs of people with dementia and their ...Adelina Comas-Herrera
There is a lot of uncertainty about the future but what we do know is that we will need to spend more on the care of people with dementia than we do today.
A publication for government on pandemic flu and faith communities. Prepared as a sister document to Key Communities, Key Resources, a report for government on faith communities and pandemic preparedness
A description of PFI and PF2 with a short Case Study on leading PFI company Inishfree and it's involvement with Bart's Hospital and Norwich & Norfolk Foundation Trust. Feel free to download and use for your own purposes. You can view the video version on YouTube: www.youtube.com/watch?v=YSzejDVdCzw&t=8s
How can we afford to meet the future needs of people with dementia and their ...Adelina Comas-Herrera
There is a lot of uncertainty about the future but what we do know is that we will need to spend more on the care of people with dementia than we do today.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Evaluation of antidepressant activity of clitoris ternatea in animals
Pfi richard smith.full copia
1. Editorials
The reference in the guidelines to patient prescribe adrenaline and intravenous fluids with more
self-administration devices is of particular importance confidence. We are sure that the guidelines will soon be
to general practitioners who may find that using the seen adorning the walls of emergency departments,
patient’s own syringes is more efficient than trying to general practitioners’ surgeries, and outpatient clinics,
open their bags and prepare an adrenaline injection. just as cardiac resuscitation guidelines now do.
The Epipen device, for example, has been shown to
Geoff Hughes Clinical director
give more consistent and rapid adrenaline absorption
Emergency Services, Wellington Hospital, Wellington, New Zealand
than that obtained with subcutaneous adrenaline.3
(wemgh@mash.wnhealth.co.nz )
Finally, the guidelines give due recognition to the
importance of prevention through reducing exposure Penny Fitzharris Clinical immunologist and allergist
to suspected allergens. Preventive measures include, Department of Medicine, Wellington School of Medicine, Wellington,
New Zealand (pfitzharris@wnmeds.ac.nz)
for example, the removal of peanuts from in flight
refreshment menus; rapid identification of sufferers
from anaphylaxis, who should wear appropriate infor-
1 Project Team of the Resuscitation Council (UK). The emergency medical
mation bracelets; and their assessment at a specialist treatment of anaphylactic reactions. J Accid Emerg Med 1999;16:243-7.
allergy clinic. 2 Advanced paediatric life support course manual. 2nd ed. London: BMJ Books,
1997:92-4.
These guidelines are welcome. They offer sound 3 Simons FE, Robert JR, Gu X, Simons KJ. Epinephrine absorption in chil-
and pragmatic advice that will enable doctors to dren with a history of anaphylaxis. J Allergy Clin Immunol 1998;101:33-7.
PFI: perfidious financial idiocy
A “free lunch” that could destroy the NHS
“I see the private finance initiative in very simple and the intensity and urgency it deserves. This week we Education and debate
personal terms. At the moment I own a beautiful but p 48
begin a series on the private finance initiative that we
outdated home in a prime position in Edinburgh, hope will contribute to changing policy (p 48).1–4
one of the world’s loveliest cities. Now I’m going to
‘give it away’ at below market value in exchange for a
The private finance initiative has its roots in
smaller, unglamorous modern house on the edge of governments everywhere wanting to reduce public
the city that doesn’t have enough bedrooms and is expenditure and in the desperate need in many places,
hard to reach by public transport. Worse, I’ll have to certainly in the NHS, to replace outdated infrastruc-
pay for it for 30 years—without any option of moving ture. Electorates are unwilling to elect governments
elsewhere. Worse still, we will have to reduce how
which are explicit about increasing taxation, and there
much we do around the home in order to pay for the
new building. Worst of all, my children will find them- are legitimate economic arguments that public
selves years from now in an outdated building in an expenditure creates less value than equivalent expendi-
awful position. They won’t be able to afford either a ture in the private sector. Hence the mantra is to
new home or the services of the home. They’ll have to reduce public expenditure, even though governments
buy them privately.” as market oriented as that of Margaret Thatcher
T
usually fail to do so. The private finance initiative is
his is the view of one doctor in the Royal Infir-
presented as using private money to pay for the infra-
mary of Edinburgh of what the private finance
structure developments that are needed for public
initiative (PFI) means to him, his colleagues,
services, but it is still paid for through the public
and his successors. His view may simplify some of the
purse—so it is not new money. Unfortunately the
complexities of the initiative, but it’s more true than
untrue. The private finance initiative is a “smoke and schemes produce more problems than solutions, partly
mirrors” policy that may destroy the NHS.1–8 The com- for the simple reason that private capital is always more
plexity of it all has left many electors bemused, and the expensive than public capital.2 5
English media (unlike their Scottish equivalents9) have Much evidence is accumulating to show that
not managed to put this issue before the public in a private finance initiative schemes are costing much
way that grabs their attention. But we must wake up to more than traditional public funding of capital
the profound implications of the private finance initia- developments.1 2 7 10 The £2.7bn ($4.3bn) Scottish
tive before it’s too late. And this is not just some local private finance initiative programme, for example, will
dispute: public-private partnerships, of which the cost some £2bn ($3.2bn) more than it would have done
private finance initiative is one form, are being used if the Treasury had acquired the assets directly.2 Trusts
worldwide and in sectors other than health care—such embarking on private finance initiative projects thus
as education and criminal justice. Poor people in the have a considerable gap to fill. The first way they try to
developing world may suffer much more than the do so is by reducing the proposed capacity of the new
people of Edinburgh. hospitals—possibly, even probably, to a point where
The BMJ has already published extensively on the they won’t be able to do the job. Hereford’s plans, for
private finance initiative,1–8 and the BMA has example, began with a requirement for 351 beds.1 This
campaigned against it.10 In Scotland the whole policy proved unaffordable. The latest scheme envisages
is falling into disrepute,11 12 but in the rest of the United around 250. Funds also have to come from reducing
Kingdom the debate about private finance has not had service delivery, meaning fewer staff. Because no BMJ 1999;319:2–3
2 BMJ VOLUME 319 3 JULY 1999 www.bmj.com
2. Editorials
scheme funded through the private finance initiative is All these arguments against the private finance ini-
yet fully up and running we must wait to see how much tiative are becoming familiar. Why, then, does the gov-
staffing will be reduced to meet the extra costs. What’s ernment persist? Partly, as always, it’s the problem of
more, the NHS as a whole is having to underwrite saving face, but more important may be the lack of suf-
these extra costs, meaning that resources shift from ficient imagination (and commitment) to think of an
providers who remain in public ownership to those alternative. Direct public support for capital projects
privately owned,1 undermining still further the goal of would be much better than the private finance
greater equity in the NHS. initiative, but there are other alternatives—like a health
One way that trusts can fill the affordability gap is development bank, proposed by the King’s Fund.13 The
through increasing “income generation,” which mainly great minds of the Treasury should abandon the
means increasing the number of private beds. In areas private finance initiative and come up with an alterna-
with private finance initiative schemes both the tive that will allow the modernisation of the NHS, not
number of private beds and the proportion of all beds oblige it to shrink to a rump service. The electorate
that they represent is increasing.3 Private finance initia- wants modernisation not destruction.
tives may inevitably lead to an increase in the private
sector and user charges, providing one way for the Richard Smith Editor, BMJ
NHS to shrink to a rump service for the poor. This is
almost certainly not the intention of the government,
but it may be starting a process that will lead inevitably
to that end. 1 Gaffney D, Pollock AM, Price D, Shaoul J. NHS capital expenditure and
The extra cost in a cash limited system is the biggest the private finance initiative. BMJ 1999;319:48-51.
2 Gaffney D, Pollock AM, Price D, Shaoul J. PFI in the NHS—is there an
problem with the private finance initiative, but there economic case? BMJ (in press).
are others. One is the closed nature of the planning 3 Gaffney D, Pollock AM, Price D, Shaoul J. Planning the new NHS: down-
process.6 7 An important part of NHS planning is in sizing for the 21st century. BMJ (in press).
4 Gaffney D, Pollock AM, Price D, Shaoul J. The politics of the private
effect being done by private companies without finance initiative and the new NHS. BMJ (in press).
adequate accountability. Bed numbers are reduced to 5 Dawson D, Maynard A. Private finance for the public good? BMJ
1996;313:312.
make plans affordable without any thought of what the 6 Boyle S. The private finance initiative. BMJ 1997;314:1214.
knock on will be for other parts of the NHS. A second 7 Pollock AM, Dunnigan M, Gaffney D, Macfarlane A, Majeed FA on behalf
factor that infuriates many of those working within the of the NHS Consultants’ Association, Radical Statistics Health Group,
and the NHS Support Federation. What happens when the private sector
NHS is the complete absence of evidence for the plans hospital services for the NHS: three case studies under the private
private finance initiative.5 8 In fact all the evidence we finance initiative. BMJ 1997;314:1266-71.
8 Price D. Profiting from closure: the private finance initiative and the NHS.
have suggests that it’s a very bad idea. A third problem BMJ 1997;315:1479-80.
lies with the generous scope for corruption. The ingre- 9 Christie B. Media: Scottish fears over PFI. BMJ 1999;318:1220.
dients are all there: big sums of public money; closed 10 Gaffney D, Pollock AM. Can the NHS afford PFI? London: BMA, 1997.
11 Hardie A. Labour reveals radical changes for future PFIs. Scotsman 1999;
decision making and inadequate accountability; and 25 Jun:10.
“consultants” jumping backwards and forwards from 12 Veitch J. Flagship PFI hospital plans are “in chaos.” Evening News 1999; 24
Jun:5.
the private to the public sector. Sooner or later we will 13 Cresswell J. King’s Fund proposes health development bank. BMJ
have a scandal. 1997;314:1365.
Magnesium sulphate and pre-eclampsia
Trial needed to see whether it’s as valuable in pre-eclampsia as in eclampsia
M
agnesium sulphate has been used for enormous differences in attitude are mirrored by prac-
treating eclampsia in the United States for tice in other countries6 and reflect uncertainty about
much of the 20th century.1 The international the best treatment of “the disease of theories.”7
collaborative eclampsia trial confirmed that this The central issues are:
anticonvulsant is indeed more effective, and safer, than x Even for women with severe pre-eclampsia, the risk
alternative drugs.2 British obstetric practice has of eclampsia is low—around 1%.3
changed rapidly in response to these findings,3 and x The risk of eclampsia is probably reduced by
standard treatment of eclampsia in the United magnesium sulphate, but, even if this reduction is by as
Kingdom now much more closely corresponds to that much as 50%, very large numbers of women will need
of the United States, although some controversies to be treated to prevent a single fit.
remain about optimal dosage. x Therefore, if prophylaxis with magnesium sulphate
Is treatment of pre-eclampsia also better in the is to do more good than harm it must be very safe for
United States? As many as 5% of all pregnant women both the woman and her child and should have few
in some US centres receive magnesium sulphate in the side effects.
belief that this prevents eclampsia and thus improves Pre-eclampsia is a complex, multisystem disorder
the outcome of pregnancy.4 In contrast, some UK and how magnesium sulphate may prevent eclamptic
experts advocate never using anticonvulsants for convulsions is unclear. Magnesium may have localised
pre-eclampsia5; many clinicians would use anticonvul- effects, producing cerebral vasodilatation with subse-
BMJ 1999;319:3–4 sants only in women with severe pre-eclampsia.3 Such quent reduction of cerebral ischaemia,8 or blocking of
BMJ VOLUME 319 3 JULY 1999 www.bmj.com 3