The document discusses personalized nutrition and the role of gut bacteria. It summarizes that individual responses to foods can vary widely due to differences in gut microbiomes. A breakthrough study found that a person's gut bacteria composition was a better predictor of their glycemic response to bread than the bread's fiber or glycemic index. The document advocates increasing fiber intake through whole grains and plants to feed and diversify gut bacteria for better health outcomes. Precision nutrition approaches that consider an individual's genes, microbiome, lifestyle and environment are presented as the future of nutrition.
BACCHUS FP7 presentation - MoniQA International Conference, Budapest 2013BACCHUS_FP7
BACCHUS is a four-year FP7-KBBE-funded Collaborative (Research) Project, targeted at a special group, with 28 beneficiaries including 16 SMEs from 11 countries, led by the Institute of Food Research (IFR, UK).
The main objective of the BACCHUS project is to develop tools and resources that will facilitate the generation of robust and exploitable scientific evidence that, which can be used to support claims of a cause and effect relationship between consumption of bioactive peptides and polyphenols, and beneficial physiological effects related to cardiovascular health in humans.
Text in small letters in footer:
BACCHUS is a collaborative projectCollaborative Project under the 7th Framework Program of the European Commission, funded by Specific Programme 'Cooperation' - Research Theme: 'Food, agriculture and fisheries, and biotechnology', funded within the FP7-KBBE-2012-6-single-stage, under Grant Agreement no 312090.
2019 10-14 2nd Int Congress on Precision Medicine, Munich, Alain van GoolAlain van Gool
Opening lecture at the 2nd International Congress on Precision Medicine in Munich, outlining progress in omics-based biomarkers for rare diseases, biomarker innovation gaps and multi-partner initiatives to bridge those gaps to applications. Also reviewed the highlights of our recently published Handbook of Biomarkers and Precision Medicine.
Bill Faloon 2019 RAADfest keynote presentationmaximuspeto
Bill Faloon presents updates on human age-reversal research, including his announcement of two human trials testing potential age-reversal interventions in humans.
2018 11-26 KNAW-AcTI symposium Personalized Health, Amsterdam, Alain van GoolAlain van Gool
Lecture at a citizen discussion evening, reviewing the promises and (ethical) considerations of technology developments to support personalized health, organised by the Royal Academy of Sciences and the Netherlands Academy of Technology and Innovation.
BACCHUS FP7 presentation - MoniQA International Conference, Budapest 2013BACCHUS_FP7
BACCHUS is a four-year FP7-KBBE-funded Collaborative (Research) Project, targeted at a special group, with 28 beneficiaries including 16 SMEs from 11 countries, led by the Institute of Food Research (IFR, UK).
The main objective of the BACCHUS project is to develop tools and resources that will facilitate the generation of robust and exploitable scientific evidence that, which can be used to support claims of a cause and effect relationship between consumption of bioactive peptides and polyphenols, and beneficial physiological effects related to cardiovascular health in humans.
Text in small letters in footer:
BACCHUS is a collaborative projectCollaborative Project under the 7th Framework Program of the European Commission, funded by Specific Programme 'Cooperation' - Research Theme: 'Food, agriculture and fisheries, and biotechnology', funded within the FP7-KBBE-2012-6-single-stage, under Grant Agreement no 312090.
2019 10-14 2nd Int Congress on Precision Medicine, Munich, Alain van GoolAlain van Gool
Opening lecture at the 2nd International Congress on Precision Medicine in Munich, outlining progress in omics-based biomarkers for rare diseases, biomarker innovation gaps and multi-partner initiatives to bridge those gaps to applications. Also reviewed the highlights of our recently published Handbook of Biomarkers and Precision Medicine.
Bill Faloon 2019 RAADfest keynote presentationmaximuspeto
Bill Faloon presents updates on human age-reversal research, including his announcement of two human trials testing potential age-reversal interventions in humans.
2018 11-26 KNAW-AcTI symposium Personalized Health, Amsterdam, Alain van GoolAlain van Gool
Lecture at a citizen discussion evening, reviewing the promises and (ethical) considerations of technology developments to support personalized health, organised by the Royal Academy of Sciences and the Netherlands Academy of Technology and Innovation.
Predictive and Preventive Care: Metabolic Diseasesasclepiuspdfs
South Asians have a very high incidence of ischemic heart disease and stroke. In addition, they also have a very high incidence of metabolic diseases such as prehypertension, hypertension, visceral obesity, metabolic syndrome, prediabetes, type-2 diabetes, and its clinical complications. Currently, there are over 75 million diabetic subjects in India and an equal number of prediabetics. Republic of China has taken over India as the diabetes capital of the world, with over 115 million diabetics. Modern medicine is disease focused and has failed to address the prevention of these chronic diseases. According to the reports from the United Nations (Millennium Development Goals [MDGs], the World Health Organization, Global Health Initiatives, and the non-communicable disease risk task force), obesity has increased by 2-fold and type-2 diabetes by 4-fold worldwide. Experts in this field predict that chances of meeting the MDGs set by the UN members of reducing the incidence of these diseases at 2025 to the level of 2020 are very little. Western medicine has failed to reduce or reverse the trend in the incidence of these diseases. We feel that an integrated approach to health care may be a better option, to reduce the disease burden in developing and resource-poor countries. Having said that, one cannot prevent something that one is not aware of, as such it is the need of the hour for us, to develop a robust predictive and preventive health-care platform. In an earlier article, we presented our views on reducing or reversing cardiometabolic diseases. There is great enthusiasm among the health-care providers and professional bodies that integration of emerging technologies will help develop personalized, precision medicine, as well as reduce the cost of health-care worldwide.
For how long can the world’s agro-alimentary system be sustained? It is estimated that our global population is set to reach nine billion by 2050. Demand for food products will double by then, with an increased need for more animal proteins and processed foods. As a direct result, the food-processing sector is now gearing up to address how we are going to feed a population that is growing at a rate never experienced before by mankind.
You have in front of you a depressed man with a smiling face," Professor Jorgen Randers of BI Norwegian Business School told the 800-plus delegates attending this year's Biomin World Nutrition Conference in Munich, Germany this morning in his keynote address.
Literary Research on Cancer Life Style Disorder and its Managementijtsrd
The primary goal of palliative cancer care is typically to relieve suffering and improve quality of life. Most approaches to diet in this setting have focused only on eating as many calories as possible to avoid cachexia. However, as the concept of palliative care has evolved to include all aspects of cancer survivorship and not just end of life care, there is an increasing need to thoughtfully consider diet and nutrition approaches that can impact not only quality of life but overall health outcomes and perhaps even positively affect cancer recurrence and progression. In this regard, there has been a recent emphasis in the literature on nutrition and cancer as an important factor in both quality of life and in the pathophysiology of cancer. Hence, the primary purpose of this paper is to review the current data on diet and nutrition as it pertains to a wide range of cancer patients in the palliative care setting. Dr. Mahan Choudhary | Dr. Prerna Tiwari | Dr. Kamal Dwivedi "Literary Research on Cancer - Life Style Disorder and its Management" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52018.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/52018/literary-research-on-cancer--life-style-disorder-and-its-management/dr-mahan-choudhary
Stephen_Ezell_Redefining Healthcare_#theindiadialogue Feb 2023.pdfDr. Amit Kapoor
Presentation done by Stephen Ezell, Vice President, Global Innovation Policy, ITI on "Redefining Healthcare" at #TheIndiaDialog on February 24 at Stanford University. The #TheIndiaDialog was organised by Institute for Competitiveness and US Asia Technology Management Center at Stanford University.
Find the tentative program of 3rd International Conference on Chronic Diseases.http://bit.ly/2HMRBOV
Exciting waivers on single and group participation
Interested drop a mail : chronicdiseases@pulsusmeet.com
Chat with us through : https://bit.ly/2IGEvzW
Adult Vaccination in an ageing society: Immune responseILC- UK
Highlights the importance of vaccinating older people in the context of an ageing society. Sets out how levels of uptake vary across Europe. And highlights ideas for policy makers on how to increase uptake of adult vaccination
David Sinclair on the challenges of vaccinating adultsILC- UK
Presented at the IFA Champions Summit in early November, Director of the International Longevity Centre - UK, David Sinclair, considers the challenges and solutions to vaccinating adults.
The Role of Artificial Intelligence and Machine Learning in Clinical Research...ClinosolIndia
Artificial Intelligence (AI) and Machine Learning (ML) have emerged as powerful tools with immense potential to transform various aspects of clinical research and pharmacovigilance. This paper explores the role of AI and ML in these fields, highlighting their applications, benefits, and challenges.
In clinical research, AI and ML offer significant advancements in data analysis, patient stratification, and decision support. These technologies can efficiently process large volumes of clinical data, including electronic health records, genomic data, medical imaging, and clinical trial data, to identify patterns, predict outcomes, and generate actionable insights.
One major application of AI and ML in clinical research is patient stratification and personalized medicine. These technologies can analyze patient data to identify subgroups with specific characteristics or treatment responses. By understanding these subgroups, researchers can design more targeted clinical trials, identify appropriate patient populations for specific interventions, and develop personalized treatment approaches.
Additionally, AI and ML can aid in the identification of potential therapeutic targets, prediction of treatment responses, and optimization of clinical trial designs. These technologies can analyze complex datasets, uncover hidden correlations, and generate hypotheses that can guide researchers in their investigations. Furthermore, AI and ML can assist in adverse event prediction and monitoring, aiding in early detection and intervention.
In the field of pharmacovigilance, AI and ML have the potential to revolutionize adverse event detection, signal generation, and signal validation. These technologies can process large volumes of real-world data, including electronic health records, social media, and spontaneous reporting systems, to identify potential safety concerns associated with medications. AI and ML algorithms can detect patterns, associations, and unexpected relationships between drugs and adverse events, enabling proactive pharmacovigilance activities.
The integration of AI and ML in pharmacovigilance also facilitates signal validation and risk assessment. These technologies can analyze diverse data sources, identify potential signals, and prioritize them based on their significance and impact. By automating certain aspects of signal validation, AI and ML can streamline the pharmacovigilance process, allowing for more efficient and timely identification and management of drug safety concerns.
At an event hosted by the Royal College of Nursing on the 19th November, ILC-UK launched a new report on adult immunisation. We also presented findings of major new research on adult immunisation across Europe which was published by the SAATI coalition in November 2013. The debate considered the findings of the research and explored how policymakers should respond to the challenges highlighted in the new reports.
The report on adult immunisation, 'Immune Response', has been funded through an unrestricted educational grant from Pfizer International Operations.
Download 'Immune Response' here:
http://www.ilcuk.org.uk/index.php/publications/publication_details/immune_response._adult_immunisation_in_the_uk
Food Nutrition Health RI presented at IAAE VancouverKrijn Poppe
Presentation of the Food Nutrition and Health Research Infrastructure, as developed in European projects EuroDISH and Richfields, for the IAAE Conference 2018 in Vancouver
Antibiotic Guardian Leeds Workshop 20164 All of Us
Antibiotic resistance is one of the biggest threats facing us today.
Why it is relevant to you: without effective antibiotics many routine treatments will become increasingly dangerous. Setting broken bones, basic operations, even chemotherapy and animal health all rely on access to antibiotics that work.
What we want you to do: To slow resistance we need to cut the unnecessary use of antibiotics. We invite the public, students and educators, farmers, the veterinary and medical communities and professional organisations, to become Antibiotic Guardians.
Call to action: Choose one simple pledge about how you’ll make better use of antibiotics and help save these vital medicines from becoming obsolete.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Similar to Personalised nutrition, Michael Gusko, ICC Conference, Vienna, 24-APR-2019
Predictive and Preventive Care: Metabolic Diseasesasclepiuspdfs
South Asians have a very high incidence of ischemic heart disease and stroke. In addition, they also have a very high incidence of metabolic diseases such as prehypertension, hypertension, visceral obesity, metabolic syndrome, prediabetes, type-2 diabetes, and its clinical complications. Currently, there are over 75 million diabetic subjects in India and an equal number of prediabetics. Republic of China has taken over India as the diabetes capital of the world, with over 115 million diabetics. Modern medicine is disease focused and has failed to address the prevention of these chronic diseases. According to the reports from the United Nations (Millennium Development Goals [MDGs], the World Health Organization, Global Health Initiatives, and the non-communicable disease risk task force), obesity has increased by 2-fold and type-2 diabetes by 4-fold worldwide. Experts in this field predict that chances of meeting the MDGs set by the UN members of reducing the incidence of these diseases at 2025 to the level of 2020 are very little. Western medicine has failed to reduce or reverse the trend in the incidence of these diseases. We feel that an integrated approach to health care may be a better option, to reduce the disease burden in developing and resource-poor countries. Having said that, one cannot prevent something that one is not aware of, as such it is the need of the hour for us, to develop a robust predictive and preventive health-care platform. In an earlier article, we presented our views on reducing or reversing cardiometabolic diseases. There is great enthusiasm among the health-care providers and professional bodies that integration of emerging technologies will help develop personalized, precision medicine, as well as reduce the cost of health-care worldwide.
For how long can the world’s agro-alimentary system be sustained? It is estimated that our global population is set to reach nine billion by 2050. Demand for food products will double by then, with an increased need for more animal proteins and processed foods. As a direct result, the food-processing sector is now gearing up to address how we are going to feed a population that is growing at a rate never experienced before by mankind.
You have in front of you a depressed man with a smiling face," Professor Jorgen Randers of BI Norwegian Business School told the 800-plus delegates attending this year's Biomin World Nutrition Conference in Munich, Germany this morning in his keynote address.
Literary Research on Cancer Life Style Disorder and its Managementijtsrd
The primary goal of palliative cancer care is typically to relieve suffering and improve quality of life. Most approaches to diet in this setting have focused only on eating as many calories as possible to avoid cachexia. However, as the concept of palliative care has evolved to include all aspects of cancer survivorship and not just end of life care, there is an increasing need to thoughtfully consider diet and nutrition approaches that can impact not only quality of life but overall health outcomes and perhaps even positively affect cancer recurrence and progression. In this regard, there has been a recent emphasis in the literature on nutrition and cancer as an important factor in both quality of life and in the pathophysiology of cancer. Hence, the primary purpose of this paper is to review the current data on diet and nutrition as it pertains to a wide range of cancer patients in the palliative care setting. Dr. Mahan Choudhary | Dr. Prerna Tiwari | Dr. Kamal Dwivedi "Literary Research on Cancer - Life Style Disorder and its Management" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52018.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/52018/literary-research-on-cancer--life-style-disorder-and-its-management/dr-mahan-choudhary
Stephen_Ezell_Redefining Healthcare_#theindiadialogue Feb 2023.pdfDr. Amit Kapoor
Presentation done by Stephen Ezell, Vice President, Global Innovation Policy, ITI on "Redefining Healthcare" at #TheIndiaDialog on February 24 at Stanford University. The #TheIndiaDialog was organised by Institute for Competitiveness and US Asia Technology Management Center at Stanford University.
Find the tentative program of 3rd International Conference on Chronic Diseases.http://bit.ly/2HMRBOV
Exciting waivers on single and group participation
Interested drop a mail : chronicdiseases@pulsusmeet.com
Chat with us through : https://bit.ly/2IGEvzW
Adult Vaccination in an ageing society: Immune responseILC- UK
Highlights the importance of vaccinating older people in the context of an ageing society. Sets out how levels of uptake vary across Europe. And highlights ideas for policy makers on how to increase uptake of adult vaccination
David Sinclair on the challenges of vaccinating adultsILC- UK
Presented at the IFA Champions Summit in early November, Director of the International Longevity Centre - UK, David Sinclair, considers the challenges and solutions to vaccinating adults.
The Role of Artificial Intelligence and Machine Learning in Clinical Research...ClinosolIndia
Artificial Intelligence (AI) and Machine Learning (ML) have emerged as powerful tools with immense potential to transform various aspects of clinical research and pharmacovigilance. This paper explores the role of AI and ML in these fields, highlighting their applications, benefits, and challenges.
In clinical research, AI and ML offer significant advancements in data analysis, patient stratification, and decision support. These technologies can efficiently process large volumes of clinical data, including electronic health records, genomic data, medical imaging, and clinical trial data, to identify patterns, predict outcomes, and generate actionable insights.
One major application of AI and ML in clinical research is patient stratification and personalized medicine. These technologies can analyze patient data to identify subgroups with specific characteristics or treatment responses. By understanding these subgroups, researchers can design more targeted clinical trials, identify appropriate patient populations for specific interventions, and develop personalized treatment approaches.
Additionally, AI and ML can aid in the identification of potential therapeutic targets, prediction of treatment responses, and optimization of clinical trial designs. These technologies can analyze complex datasets, uncover hidden correlations, and generate hypotheses that can guide researchers in their investigations. Furthermore, AI and ML can assist in adverse event prediction and monitoring, aiding in early detection and intervention.
In the field of pharmacovigilance, AI and ML have the potential to revolutionize adverse event detection, signal generation, and signal validation. These technologies can process large volumes of real-world data, including electronic health records, social media, and spontaneous reporting systems, to identify potential safety concerns associated with medications. AI and ML algorithms can detect patterns, associations, and unexpected relationships between drugs and adverse events, enabling proactive pharmacovigilance activities.
The integration of AI and ML in pharmacovigilance also facilitates signal validation and risk assessment. These technologies can analyze diverse data sources, identify potential signals, and prioritize them based on their significance and impact. By automating certain aspects of signal validation, AI and ML can streamline the pharmacovigilance process, allowing for more efficient and timely identification and management of drug safety concerns.
At an event hosted by the Royal College of Nursing on the 19th November, ILC-UK launched a new report on adult immunisation. We also presented findings of major new research on adult immunisation across Europe which was published by the SAATI coalition in November 2013. The debate considered the findings of the research and explored how policymakers should respond to the challenges highlighted in the new reports.
The report on adult immunisation, 'Immune Response', has been funded through an unrestricted educational grant from Pfizer International Operations.
Download 'Immune Response' here:
http://www.ilcuk.org.uk/index.php/publications/publication_details/immune_response._adult_immunisation_in_the_uk
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Presentation of the Food Nutrition and Health Research Infrastructure, as developed in European projects EuroDISH and Richfields, for the IAAE Conference 2018 in Vancouver
Antibiotic Guardian Leeds Workshop 20164 All of Us
Antibiotic resistance is one of the biggest threats facing us today.
Why it is relevant to you: without effective antibiotics many routine treatments will become increasingly dangerous. Setting broken bones, basic operations, even chemotherapy and animal health all rely on access to antibiotics that work.
What we want you to do: To slow resistance we need to cut the unnecessary use of antibiotics. We invite the public, students and educators, farmers, the veterinary and medical communities and professional organisations, to become Antibiotic Guardians.
Call to action: Choose one simple pledge about how you’ll make better use of antibiotics and help save these vital medicines from becoming obsolete.
Similar to Personalised nutrition, Michael Gusko, ICC Conference, Vienna, 24-APR-2019 (20)
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
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from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
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effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...
Personalised nutrition, Michael Gusko, ICC Conference, Vienna, 24-APR-2019
1. www.goodmillsinnovation.com
SHAPING THE FUTURE OF NUTRITION:
THE CASE OF PERSONALISED NUTRITION
19th ICC Conference 2019, SCIENCE MEETS TECHNOLOGY
Michael Gusko
Vienna, Austria, 24-APR-2019
2. Subject GI
1 42.8
2 61.5
3 59.4
4 143.0
5 42.8
6 50.5
7 40.3
8 84.5
9 39.0
10 37.1
Mean 60.1
In 2004 we launched ‘GLYX Ideal Diet Bread’ - a premix for
a low GI bread (GI 38, GL 6, TDF 10g)
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 2
Randomly selected test results from the series of studies during the product
development phase → high interindividual variations in glycaemic response.
GI of bread
Advertising poster for bakeries. GLYX is the acronym of ‘GLYcemic Index’; it’s phonetically similar to the German word “luck” or “lucky”.
THE DAY MY
INNOCENCE
DIED!
Data sheet of
the medical
university of
31-OCT-2002
3. THE FLAW OF AVERAGES: REAL LIFE IS NEVER AVERAGE!
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 3
The average advice is
fine if you’re average.
4. THE MOST IMPORTANT RESOURCE FOR HEALTH
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 4
19th century:
CLEAN WATER
21st century:
CLEAN KNOWLEDGE
Statement: Günther Jonitz, President of the Berlin Medical Association, 2018
5. 5
We must, however, take an honest look at ourselves as well
Allen Roses, worldwide vice-president
of genetics at GlaxoSmithKline (GSK),
London, 2012
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019
”OUR DRUGS DO NOT WORK ON MOST PATIENTS.”
6. 6
“Fewer than half of the patients prescribed some of the most
expensive drugs actually derived any benefit from them.”
GSK figures on how well different classes of
drugs work in real patients:
• Depression 62%
• Asthma 60%
• Diabetes mellitus 57%
• Migraine, osteoporosis, and arthritis 50%
• Alzheimer‘s disease 30%
• Cancer 25%
Source: Allen Roses, GlaxoSmithKline (GSK), London, 2012
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019
Allen Roses, GSK, London, 2012
7. 7
“Most drugs work in fewer than one in two patients
mainly because the recipients carry genes that interfere
in some way with the medicine.”
Allen Roses, GSK, 2012
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019
8. PRECISION MEDICINE: PHARMA USES “BIG DATA”
APPROACH TO TARGETED PRECISION DRUGS
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 8
Adapted from Eric Topol, Individualized Medicine from Prewomb to Tomb, Cell (2014): 157(1), 241-253
Input
Layer
Hidden
Layer 1
Output
Layer
Hidden
Layer 2
1. Deep
Phenotyping
2. Deep
Learning (AI)
3. Deep
Empathy and Connection
Ability to deeply define each individual
(digitizing the medical essence of a human being)
Deep learning AI is all about inputs and outputs:
Pattern recognition and machine learning is a
new superpower
After decades of degradation of the human side
of medicine → Comeback of deep empathy and
connection between patients and clinicians
The three components of the deep medicine model according to Eric Topol
9. The Fourth Industrial Revolution is here: How can food
and nutrition be a part of this change?
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 9
connectivity
1st Industrial Revolution
MECHANICAL, water and steam power
Age of machine aided production
Power generation and mechanical
automation empowers industrial processes
2nd Industrial Revolution
ELECTRICAL: Mass production, assembly line
Age of mass production
Division of work, global connections and
transportation systems
1830 1910 1990 2010
3rd Industrial Revolution
INTERNET: IT automates production
Age of electronic automation
Use of electronic and IT systems that further
automate production, internet technology
Shareholder value Capitalism
Firms should maximize shareholders’ wealth
4th Industrial Revolution
DIGITAL: Cyber-physical systems
Age of smart connectivity
Internet of Things (IoT),Artificial Intelligence
(AI), big data, cloud, empowered customers
Customer driven Capitalism
Firms focus on creating customer value
Managerial Capitalism
Firms require professional management
10. PERSONALIZED FOODS AND DRUGS: WHY NOW?
New technologies and algorithms are making the individualization strategy more viable today
10Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019
Fitness tracker Nutrition AppsMachine learningDNA & Microbiome testing Big data & Data mining
11. MEDICINE: WISDOM OF THE PAST AND ITS
TRANSMISSION INTO THE FUTURE
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 11
“If the pattern of the heart beat becomes as
regular as the tapping of a woodpecker or
the dripping of rain from the roof, the
patient will be dead in four days.”
Chinese physician Shu-He Wang (265–317 AD)
300 AD
After the morning toilet you get a call:
“At 11:40 in the morning, you’ll have a heart attack. Don’t worry.
Please come to the Holistic Health Center after breakfast.
We’ll solve the problem right away.”
2025 AD
FDA clears AliveCor’s Kardia-
band in 2017 as a medical
device for the Apple Watch to
detect atrial fibrillation
AliveCor clinician-facing app
using artificial intelligence
(AI) to pick up signs of atrial
fibrillation earlier
12. New gadget can detect early signs of heart failure by picking
up blood pressure, oxygen levels and heart rate (2019)
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 12
A team from Rochester Institute of Technology has developed a toilet seat
that can measure a host of important cardiovascular parameters while the
patient is using it. The new toilet seat measures diastolic and systolic
blood pressures, stroke volume, blood oxygenation, heart rate, heart rate
variability, QRS duration, and corrected QT interval. The patient is also
weighed, though that would require lifting the feet off the ground.
https://www.medgadget.com/2019/02/toilet-seat-automatically-measures-host-of-cardiac-parameters-to-monitor-heart-health.html
13. Big tech pushes into wellness: Apple Watch can detect early
signs of diabetes + supporting diabetes management
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 13
Apple CEO Tim Cook has been spotted testing a glucose monitor prototype which was connected
to his Apple Watch to understand how his blood sugar is affected by food and exercise.
2017
14. Tufts University, 2018: Tooth-mounted sensors track
your diet and health from inside your mouth
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 14
15. NUTRITION: WISDOM OF THE PAST AND ITS
TRANSMISSION INTO THE FUTURE
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 15
“Let food be thy medicine
and medicine be thy food.”
Hippocrates of Kos (460–370 BC)
300 AD
In 2030, the metabolism of each human being is decoded and we
can quantify to the minute how a food or drink affects our lifetime.
2030 AD
„The drug we all take multiple times a day that needs to
be personalized most is food.“ Lisa Pettigrew, 2017
16. Postprandial blood glucose (PPBG) regulation is
crucial for the development of metabolic diseases
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 16
Credit: Ted Naiman Glycemic index, glycemic load and glycemic response: An International Scientific
Consensus Summit from the International Carbohydrate Quality Consortium
(ICQC), Nutrition Metabolism and Cardiovascular Diseases, May 2015
17. 17
Zeevi et al., Cell, 2015
Breakthrough study, 2015: Personalized Nutrition – proof
of concept study (Eran Segal, Eran Elinav, Weizman Inst.)
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019
A close examination of all the factors that enabled us to predict each person’s individual response showed that one of the most significant of
them was the microbe population. We discovered that each person has a distinctive cocktail of microbes, a kind of characteristic
signature, which affects his responses to food.
18. The body's reaction to food is a very personal matter
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 18
http://dx.doi.org/10.1016/j.cell.2015.11.001
The food constituents weren‘t
the driver for glucose response.
The bacterial species in the gut
microbiome proved to be the
key determinant of each person‘s
glucose response to eating.
KEY FINDING:
“Because our data set was so
large and our analysis so
comprehensive, these results have
an enormous impact – they show
more conclusively than has ever
been shown before that a generic,
universal approach to nutrition
simply cannot work.”
Segal and Elinav, The Personalized Diet, 2017
19. Bread intervention study: Comparing the effect of white
bread and sourdough bread (e.g. postmeal blood sugar)
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 19
Eran Segal and Eran Elinav, The Personalized Diet, 2017
White Bread Sourdough Bread
OR
• „Whole-grain” sourdough bread (“sifted the flour to
remove only the largest bran particles”)
• Ingredients: Stone milled fresh hard red wheat,
water, salt, and a mature sourdough starter
• Diet: 5 ounces (= 142 g) of sourdough bread every
morning (= 50 grams of available carbohydrates)
• Industrially produced white bread (Israel)
• 100% wheat flour
• Yeast-risen
• Diet: 4 ounces (113 g) of white bread every
morning (= 50 grams of available carbohydrates)
20. Glucose response to bread is highly personalized →
no universal dietary rule can possibly apply to all people
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 20
Korem & Zeevi et al., 2017
LEFT GRAPH:
Example of two participants in the
bread intervention study:
• The top participant responds
more highly to sourdough bread
• The lower participant responds
more highly to white bread
• The reactions were essentially
opposite
RIGHT GRAPH:
• Differences between the average
PPGR to white and sourdough bread.
• Some people had quite modest blood
sugar rises after eating bread, while
others had larger spikes.
• In term of blood sugar spikes big
differences between breads.
iAUC: Incremental area under the curve from
fasting to at least 120 minutes after consumption
PPGR: Postprandial Glycemic Response
21. Different people have widely different post-meal
responses to the same standardized meal
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 21
Zeevi et al., Cell 2015 PPGRs = postprandial glycaemic responses
Example of high interpersonal variability
and low intra-personal variability in the
PPGR to bread across four participants
(two replicates per participant consumed
on two different mornings).
22. Glucose response of different foods and drinks
(taken as an individual meal)
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 22
AUC: Area under the curve iMF: intermittent fasting Each dot represents the glucose response (tissue) of a single person
Glucoseresponse(AUCiMF)
C. Sina, 2018, NEWTRITION X. conference
23. Breakthrough in dieting science: Gut bacteria are
behind relapsing obesity (monozygotic twin study)
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 23
Ridaura VK. et al. Science 2013
It has long been
a frustrating mystery
why some people ...
… while others just look at
a potato and put on weight.
eat a lot and
still stay slim, ...
24. Transplantation of the microbiota of two twins into
normal weight mice
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 24
Treatment of obesity and the associated metabolic syndrome:
Modulation of the intestinal microbiome could be a weapon against obesity
Result: Insulin sensitivity was transferred
from the donor to the recipient!
Ridaura VK. Et al. Science 2013
25. The multiple hit hypotheses for how microbiota has
lost diversity over time
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 25
•MAC: microbiota-accessible
carbohydrates
(remark: cellulose is not
fermentable)
•MAP: microbiota-accessible
phytonutrients
Source: Modified after Sonnenburg
and Sonnenburg, Cell, 2014
100-150 g fiber/d
bitter fruits/veg.
15-20 g fiber/d
sweet fruits/veg.
35 g fiber/d
mild fruits/veg.
26. Gut bacteria feeds on fiber. A starving microbiota
eats you (mucus layer) → “leaky gut”
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 26
Fiber-rich diet Fiber-deficient diet
Earle et al., Cell Host
Microbe, 2015
(Green) mucus layer
on a high-fiber diet
pushing away the
(red) microbes from
the (blue) intestinal
cells) → keeps us
safe from infection
(Yellow) plant cell
wall material (fiber
= food for the
microbes)
Microscopic image,
mouse model with a
human microbiota (colon)
(Red) microbes starve
and start eating the
mucus layer (which is
made of carbohy-
drates, back-up food
source for microbes if
they don’t have
anything to eat)
Microbes move closer
to the intestinal cells
→ and start an inflam-
matory response
(Green) mucus layer
thins (starves)
one month later
27. Rewilding the microbiota with High-MAC wholegrain
flour: Bran/germ micronized (<150 µm) + heat treated
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 27
Standard
Refined wheat flour
Type 405
THE „BAD“
White
Fine texture
Low fiber
Standard (Red Wheat)
Wholegrain flour
1st generation
THE „UGLY“
Reddish
Rough texture
High fiber
Micronized White W.**
Wholegrain flour
4th generation
High-MAC
Light brown
Fine texture
High-MAC fiber
White Wheat*
Wholegrain flour
2nd generation
Light brown
Medium texture
High fiber
THE „GOOD“
Modulation of the microbiome:
“The two wheat bran fractions (1690
µm versus 150 µm) differently
affected specific gut bacteria
known to be involved in the
regulation of the gut barrier
function and/or inflammatory
processes.
Moreover, wheat bran with small
particle size was the sole fibre that
reduced hepatic and systemic
inflammatory markers upon high
fructose intake.
The anti-inflammatory effects of
wheat bran may be dependent on
their particle size and could be
related to the changes in caecal
Enterobacteriaceae.”
Suriano et al: Journal of Func-
tional Foods 41 (2018) 155-162
Note: 3rd generation of wholegrain flour is
a fermented wholegrain flour, Carat®
(EU HealthBread project)
* Snow Wheat® ** White Gold®
28. Ancient peach and today‘s modern peach: bigger,
sweeter, juicier
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 28
https://jameskennedymonash.files.wordpress.com/2014/07/artificial-natural-peach2.png
ANCIENT PEACH, 4000 B.C. TODAY‘S PEACH, 2014
29. Our microbiota is an „unsupervised drug factory“
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 29
“We used to think that drugs were
developed by drug companies,
approved by the FDA, and
prescribed by physicians,
but we now think there are
many drugs of equal potency
and specificity being produced
by the human microbiota.”
Michael Fischbach, UCSF
A team led by UCSF microbiome
expert Michael Fischbach
identified more than 3,000
clusters of bacterial genes at
different body sites that contain
the blueprints for cellular
factories that make drug-like
molecules.
Michael Fischbach, UCSF, on identifying & characterizing functional significance of metabolites produced by microbiome
30. Continuous glucose monitoring
Using a subcutaneous sensor (Abbott FreeStyle Libre)
Diary (food, sleep, physical activity
Using smartphone-adjusted App (Food Database)
Standardized meals (50g available carbohydrates)
Per person profiling
…
… Day 14
Three dietary intervention studies with Tartary buckwheat:
Blood sugar response (2017, 2018, 2019)
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 30
Prof. Dr. med. Christian Sina
Universität zu Lübeck, Germany
Test subjects (100, 20, 160 people)
(Glucose response)
Microbiome analysis
(+ Metabolome, ...)
High-MAP quality
(Rutin encapsulated, …)
…
2017: Data-mining for natural ingredients with bioactive properties,
2018: dose-response relationship, 2019: modulation of the microbiome
31. Day 8
60g
glucose
185 mg/dl
STUDY 1: Blood sugar 115 mg/dl, variance 45 – 185 mg/dl
my max. glucose level
(glucose test meal)
185
High-MAC and High-MAP diet: Modulation of the micro-
biome and blood sugar response
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 31
Day 12 → much lower blood sugar
135 mg/dl
60g
glucose
Seven months later:
STUDY 2: Blood sugar 75 mg/dl, variance 40 – 145 mg/dl
60g
glucose
145 mg/dl
my max. glucose level
(glucose test meal)
145
Day 8
Day 14
85 mg/dl
60g
glucose
hereafter: High-MAC
and High-MAP diet
hereafter:
High-MAP diet
32. Day 8
60g
glucose
185 mg/dl
hereafter: High-MAC
and High-MAP diet
STUDY 1: Blood sugar 115 mg/dl, variance 45 – 185 mg/dl
my max. glucose level
(glucose test meal)
185
High-MAC and High-MAP diet: Modulation of the micro-
biome and blood sugar response
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 32
Day 12 → much lower blood sugar
135 mg/dl
60g
glucose
Seven months later:
STUDY 2: Blood sugar 75 mg/dl, variance 40 – 145 mg/dl
60g
glucose
145 mg/dl
my max. glucose level
(glucose test meal)
145
Day 8
Day 14
85 mg/dl
60g
glucose
INSIGHT
With a High-MAC and High-MAP diet I (!) could reduce my (!)
personal blood sugar reaction significantly. Blood sugar
increase after consumption of glucose much lower than before.
hereafter:
High-MAP diet
33. History is being repeated: The established world view
is on shaky ground
Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 33
Church Inquisition Court, Rome, 1633
HEALTHY EATING PYRAMIDS ON TRIAL
1992 2005
RELIGIOUS BELIEF ON TRIAL
• Galileo’s championing of the heliocentric view - overturning the
geocentric model - was opposed by the Catholic church.
• Galileo’s trial is often referred to being the classical fight
science-versus-religious belief.
• 1992: After 350 years, Vatican says Galileo was right and the
“infallible” pope was wrong.
“This indeed is the biggest problem facing nutrition guidelines –
the idea that there is a simple one diet that all human beings should
follow. The idea is both biologically and physiologically implausible,
contradicting our uniqueness, the remarkable heterogeneity and
individuality of our metabolism, microbiome, environment, to name a
few dimensions.” Eric Topol, in: Deep Medicine, 2019
Food Guide Pyramids, U.S. Department of Agriculture (USDA)
34. Shaping the future of nutrition: The case of personalized nutrition | 19th ICC Conference – Science meets technology | Vienna, Austria | 24-APR-2019 34
Nutrition experts need to dive into the world of ‘smart connectivity’
if they want to have a real impact on nutrition in the future.
The rate that tech is evolving to influence nutrition is fascinating and ‘scary’ at the same time:
Algorithms of health apps are calculating a “health score” of the individual’s food & drinks.