This document outlines the organizational structure and activities of Personalized Health Basel (PHB), a joint project between the University of Basel and University Hospital Basel focused on personalized health. PHB has an executive board that provides strategic and operational leadership, as well as steering and extended advisory boards. It coordinates several active research clusters in areas like oncology and infectious diseases. PHB is also involved in national personalized health projects through the Swiss Personalized Health Network, focusing on initiatives in areas like sepsis, oncology, frailty, and immunology. It helps manage resources and infrastructure to support this work, such as biobanking, a clinical data warehouse, and legal and ethical issues. PHB collaborates closely with other Swiss institutions and holds