Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
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Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
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ABSTRACT
This paper will introduce the origins and demonstrate how the concept and implementation of Total Exposure Health (TEH) is ushering in a bold solution to capture workplace, environmental, and lifestyle exposures to the individual using advances in science, technology, and informatics.
It will also introduce and describe the power behind Total Exposure Health, which is a mathematical process to quantitatively evaluate individual health risks based on genetics, occupational, lifestyle, and environmental exposures, medical disposition, protective factors, etc., forming the Individual Exposure Health Risk Profile (IEHRP).
KEYWORDS
Genomics; informatics; noise; precision health; risk assessment; sensors
Hartman, R.T. and Oxley. M., Total Exposure Health, MultiConference on Computer Science and Information Systems (MCCSIS), Porto, Portugal, 18 July 2019.
HIV, AIDS AND STD's
HIV
HIV stands for human immunity deficiency virus. HIV weakens the body immune system by entering into white blood cell (lymphocytes) and binds itself to chromosome and integrates into the genetic material. The virus now multiplies very fast using genetic materials of White Blood Cells. The daughter virus invades White Blood Cells destroy and kill them. As more White Blood Cells are killed the body becomes less and less fight against disease. Patient with aids are prone to opportunistic infection caused by fungi, bacteria and protozoa.
In nutshell people with AIDS die with disease their body cannot resist. These diseases are referred to as opportunistic infection. E.g. tuberculosis, severe diarrhea, skin cancer and pneumonia.
AIDS
AIDS stand for; Acquire Immune Deficiency Syndrome. For someone with AIDS T-helper fall below.
the T-helper count for health person range between 450 and 1200
CAUSES
AIDS is viral infection caused by a strain of a virus called HIV. HIV means Human Immunodeficiency Virus. HIV mainly found in body fluids such as blood, semen and vaginal secretion. Also traces of HIV found on saliva, tear and sweat
Primary stage (window stage) : It does not show any symptoms except for slight flu HIV test result is negative
A-symptomatic stage : Has no symptoms but the HIV test is positive
Full blown aids : Where by one gets various opportunistic infections and diseases
SEXUALLY TRANSMITTED INFECTION
These are infection, which are transmitted through sexually contact during sexually intercourse. Sexually transmitted disease are also referred to as venereal disease
RELATIONSHIP BETWEEN HIV, AIDS AND STD’s
HIV is sexually transmitted. Having STD's can increase risk of acquiring and transmitting HIV.
Some STI’s such as chlamydia cause open sores in the skin and become exit point into and from the brood stream of HIV.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. Exposure
OCCUPATIONAL EXPOSURE that may
place a worker at risk of HIV infection is a
percutaneous injury ,contact of mucous
membrane or contact of skin (especially when
the skin is chapped, abraded or affected with
dermatitis or the contact is prolonged or
involves an extensive area ) with blood tissue or
other body fluids to which universal precautions
apply.
Institute of Infectious Diseases
5. Why this helpline ?
The needle stick injury can not only lead to some life
threatening blood borne infections as well as have
severe emotional impact on health care personnel.
It is an medical emergency and can happen anywhere
anytime
FOGSI initiative is first of its kind in world
Institute of Infectious Diseases
6. What is the extent of the problem ?
Survey of 428 HCW in India
- 343 (80%) had 1 PI in past 1
year (IJMR, April,2010)
In USA there are 57 documented
cases of health care workers
contracting
HIV
from
exposures; 137 other possible
cases
(NEJM 2003;348:826)
Institute of Infectious Diseases
7.
8. Rationale of PEP
Information about primary HIV infection
indicate that systemic infection does not occur
immediately leaving a brief period within ‘window
of opportunity’ during which post exposure antiretroviral intervention may modify viral replicaiton
Institute of Infectious Diseases
9. Principle behind administering PEP
Surface ligands of
dendritic cells of skin
or mucous membrane
CD4 CELL
Institute of Infectious Diseases
10. WHAT TO DO ON EXPOSURE
It is a medical emergency
Do not panic
Institute of Infectious Diseases
11. WHAT NEXT
REPORT PROMPTLY
PEP MUST START AT THE EARLIEST
PREFERABLY WITHIN TWO HOURS
MAY BE UPTO 72 HOURS
Institute of Infectious Diseases
12. How to assess risk ?
The exposure report
(Each exposure is unique)
•
Date and time of exposure
Accurate report: Minute to minute details are ideal
Procedure details…what, where, how, with what
device
Exposure details...route, body substance involved,
volume/duration of contact
Information about source person and exposed
person
Exposure management details
Institute of Infectious Diseases
16. How helpline works
A call is received from an exposed health care
worker by Dr Alok Vashishtha, Specialist in
HIV/AIDS on his cell. He then follows
following procedure:
Details of exposure are taken
A protocol is decided
ARV drugs are made available (if required)
Follow up is done as decided
Have a team of resource persons for complex
scenarios
17. How drugs are made available
Have a memorandum of understanding with all
companies making and marketing HIV drugs.
Dr Alok Vashishtha have the mobile numbers of
National Sales manager of all companies in field
of HIV therapy.
Their pan India sales network of about 2500
executives is used to locate the pharmacy
catering these drugs.
Address is given to the exposed health care
provider
18.
19. Type of calls
Call from around all states of India
Call from Asia, Africa, Europe and USA.
Problem phone calls (General query about
HIV/AIDS)
Special kind of exposures
Missed calls
Stigma calls
For locating a OBGYN
20. Conclusions
Health care workers put themselves at risk in their work
Prevention of exposures is critical
PEP can be useful intervention
Management of occupational exposure is complex
Expert consultation should be sought
Finally
Awareness of Universal precautions and PEP options:
- allay fears of caring for HIV infected persons
- reduced stigma and discrimination
- better care of PLHIV
Institute of Infectious Diseases
21. HELP LINE TEAM
Dr. Narendra Malhotra
Dr. C.N. Purandare
Dr. Laxmi Shrikhande
Dr .Alok Vashistha
ACKNOWLEDGEMENTS
All FOGSI Members
www.fogsi.org
23. Thank You for your kind attention
Institute of Infectious Diseases
Nirmal Medical Foundation, Hardwar
Institute of Infectious Diseases
Editor's Notes
{"12":"It is important to collect and record information about the exposure on an exposure report, and to maintain the confidentiality of both the worker and the source patient. An exposure report should include the date and time that the exposure occurred, as well as details of what procedure was being performed, where, how, and what device (if any) was involved. If a device was involved, OSHA requires that the brand and manufacturer of the device be recorded. Details such as the route of exposure, body substance involved, and volume or duration of contact also should be included. Additionally, information about the source person and exposed person, if known, is critical, along with exposure management details, which will be discussed later.\n"}