This document discusses mechanical ventilation and the weaning process. It outlines the 7 stages of weaning and indicators for readiness to wean, including parameters like respiratory rate, tidal volume, rapid shallow breathing index, and maximum inspiratory pressure. It describes methods for spontaneous breathing trials and criteria for weaning failure. Difficult weaning can be caused by respiratory, cardiac, psychological, ventilator or nutritional factors. Daily assessment is important to evaluate readiness and avoid complications from prolonged mechanical ventilation.
1. Mechanical ventilation can be associated with significant morbidity and mortality if prolonged. Weaning patients from mechanical ventilation in a timely manner is important.
2. There are seven stages of weaning which include assessing patient readiness, conducting spontaneous breathing trials, and using various ventilator modes like pressure support to gradually reduce support.
3. Spontaneous breathing trials for 30 minutes to 2 hours are generally preferred for weaning but gradual reduction over days may be better in some cases. Daily assessment of readiness and trials are recommended with prompt reintubation if trials fail.
1. Mechanical ventilation troubleshooting involves identifying the cause of a patient's sudden respiratory distress by analyzing monitor alarms, physical signs, and ventilator graphs.
2. Common causes include ventilator issues like leaks, circuit blocks, or setting errors as well as patient issues such as pneumonia or pneumothorax.
3. The document outlines steps for troubleshooting including disconnecting the patient to manually bag and assess response, then treating the most likely problem by procedures like suctioning, adjusting settings, or emergency thoracostomy.
1. Mechanical ventilation settings like PEEP aim to reduce ventilator-induced lung injuries from atelectrauma and overdistension while improving oxygenation.
2. The optimal PEEP level can be determined through methods like the ARDSnet table, transpulmonary pressure measurements, lung compliance curves, and stress indexes. Higher PEEP recruits more alveoli but may affect hemodynamics.
3. Pressure-volume curves can help identify the lower inflection point and lower deflection point to guide PEEP setting, along with recruitment maneuvers. Slow-flow curves more accurately detect inflection points.
PC mode uses pressure control ventilation where the ventilator controls the inspiratory pressure and the patient controls the respiratory rate and inspiratory time. The tidal volume depends on the inspiratory pressure set, lung compliance, and airway resistance. Key settings include inspiratory pressure, respiratory rate, inspiratory time, and PEEP. Plateau pressure and driving pressure should be monitored to avoid overinflation and volutrauma. PEEP is used to prevent alveolar collapse and improve oxygenation but can impact hemodynamics at higher levels by decreasing venous return and cardiac output.
This document discusses various cardiopulmonary exercise testing metrics including:
1. Maximal oxygen consumption (VO2max) reflects the highest attainable oxygen level during exercise and is defined by the Fick equation. The oxygen pulse reflects stroke volume.
2. End tidal carbon dioxide (PetCO2) normally increases slightly during exercise and then declines at maximal effort due to increased minute ventilation.
3. The ventilatory efficiency ratio (VE/VCO2) measured at the anaerobic threshold can indicate obstructive, restrictive, or vascular lung diseases.
4. Achieving age-predicted maximal heart rate indicates maximal effort and likely achievement of VO2max, while little heart rate reserve at
This document appears to contain statistical data from 2014-2015 on various health and socioeconomic indicators in different regions of Mongolia. It includes data on population numbers, mortality rates from different diseases, healthcare access indicators, and economic data. The statistics are broken down by individual aimags (provinces) and compare data between 2014 and 2015.
This document discusses different types of mechanical ventilation and ventilation modes. It begins by outlining four types of respiratory failure that may require mechanical ventilation. It then discusses goals of mechanical ventilation related to oxygenation and ventilation. The document goes on to explain various ventilation modes including volume control, pressure control, pressure support, and APRV. It provides details on settings for tidal volume, minute ventilation, and initial mechanical ventilation settings. Overall, the document provides an overview of mechanical ventilation types, goals, modes, and initial settings.
1) The digital ESC Congress 2020 attracted over 116,000 healthcare professionals from 211 countries, focusing on new knowledge in arrhythmias and device therapy.
2) New guidelines and studies provided updates on atrial fibrillation screening and management, showing benefits of early rhythm control and new anticoagulants.
3) Studies explored new pacing approaches like His bundle and left bundle pacing to improve effectiveness and reduce fluoroscopy time.
1. Mechanical ventilation can be associated with significant morbidity and mortality if prolonged. Weaning patients from mechanical ventilation in a timely manner is important.
2. There are seven stages of weaning which include assessing patient readiness, conducting spontaneous breathing trials, and using various ventilator modes like pressure support to gradually reduce support.
3. Spontaneous breathing trials for 30 minutes to 2 hours are generally preferred for weaning but gradual reduction over days may be better in some cases. Daily assessment of readiness and trials are recommended with prompt reintubation if trials fail.
1. Mechanical ventilation troubleshooting involves identifying the cause of a patient's sudden respiratory distress by analyzing monitor alarms, physical signs, and ventilator graphs.
2. Common causes include ventilator issues like leaks, circuit blocks, or setting errors as well as patient issues such as pneumonia or pneumothorax.
3. The document outlines steps for troubleshooting including disconnecting the patient to manually bag and assess response, then treating the most likely problem by procedures like suctioning, adjusting settings, or emergency thoracostomy.
1. Mechanical ventilation settings like PEEP aim to reduce ventilator-induced lung injuries from atelectrauma and overdistension while improving oxygenation.
2. The optimal PEEP level can be determined through methods like the ARDSnet table, transpulmonary pressure measurements, lung compliance curves, and stress indexes. Higher PEEP recruits more alveoli but may affect hemodynamics.
3. Pressure-volume curves can help identify the lower inflection point and lower deflection point to guide PEEP setting, along with recruitment maneuvers. Slow-flow curves more accurately detect inflection points.
PC mode uses pressure control ventilation where the ventilator controls the inspiratory pressure and the patient controls the respiratory rate and inspiratory time. The tidal volume depends on the inspiratory pressure set, lung compliance, and airway resistance. Key settings include inspiratory pressure, respiratory rate, inspiratory time, and PEEP. Plateau pressure and driving pressure should be monitored to avoid overinflation and volutrauma. PEEP is used to prevent alveolar collapse and improve oxygenation but can impact hemodynamics at higher levels by decreasing venous return and cardiac output.
This document discusses various cardiopulmonary exercise testing metrics including:
1. Maximal oxygen consumption (VO2max) reflects the highest attainable oxygen level during exercise and is defined by the Fick equation. The oxygen pulse reflects stroke volume.
2. End tidal carbon dioxide (PetCO2) normally increases slightly during exercise and then declines at maximal effort due to increased minute ventilation.
3. The ventilatory efficiency ratio (VE/VCO2) measured at the anaerobic threshold can indicate obstructive, restrictive, or vascular lung diseases.
4. Achieving age-predicted maximal heart rate indicates maximal effort and likely achievement of VO2max, while little heart rate reserve at
This document appears to contain statistical data from 2014-2015 on various health and socioeconomic indicators in different regions of Mongolia. It includes data on population numbers, mortality rates from different diseases, healthcare access indicators, and economic data. The statistics are broken down by individual aimags (provinces) and compare data between 2014 and 2015.
This document discusses different types of mechanical ventilation and ventilation modes. It begins by outlining four types of respiratory failure that may require mechanical ventilation. It then discusses goals of mechanical ventilation related to oxygenation and ventilation. The document goes on to explain various ventilation modes including volume control, pressure control, pressure support, and APRV. It provides details on settings for tidal volume, minute ventilation, and initial mechanical ventilation settings. Overall, the document provides an overview of mechanical ventilation types, goals, modes, and initial settings.
1) The digital ESC Congress 2020 attracted over 116,000 healthcare professionals from 211 countries, focusing on new knowledge in arrhythmias and device therapy.
2) New guidelines and studies provided updates on atrial fibrillation screening and management, showing benefits of early rhythm control and new anticoagulants.
3) Studies explored new pacing approaches like His bundle and left bundle pacing to improve effectiveness and reduce fluoroscopy time.
This document discusses point-of-care testing (POCT) and provides examples of its use and limitations. It describes rapid influenza diagnostic tests which can quickly (within 15 minutes) detect influenza A and B viruses at the site of patient care. While providing rapid results, these tests have limitations including lower sensitivity (50-70%) leading to false negatives, and an inability to distinguish influenza types (e.g. H1N1 versus H3N2) in some cases. Other examples discussed include rapid tests for COVID-19 antibodies.
The document summarizes guidelines for the management of upper gastrointestinal bleeding. It was developed by a consensus panel of experts in 2004. The summary provides recommendations for resuscitation of patients with upper GI bleeding and use of antisecretory and endoscopic therapies to treat and diagnose the source of bleeding. The panel reviewed available evidence to develop consensus-based guidelines to standardize the management of upper GI bleeding and ensure best practices. The document is intended to help clinicians appropriately treat and care for patients experiencing upper GI bleeding within 1-2 days to reduce morbidity and mortality.
1. Initial management of hemorrhagic stroke focuses on stabilizing the patient, performing a CT scan of the brain, and determining if hemorrhage is present.
2. Subarachnoid hemorrhage requires prompt diagnosis using CT scan to rule out aneurysm.
3. Patients under 45 years old or with unusual bleeding patterns require further evaluation with contrast CT scan to identify underlying causes like tumors or abnormal vessels.
Mechanical ventilation can be used to support or replace spontaneous breathing in patients unable to maintain adequate ventilation on their own. It aims to facilitate carbon dioxide release and maximize oxygen delivery. Modes include controlled mandatory ventilation where the ventilator controls both tidal volume and rate, and assist-control where the ventilator provides a minimum rate with additional breaths triggered by the patient. Synchronized intermittent mandatory ventilation delivers mandatory breaths at set intervals while allowing spontaneous breathing in between to reduce asynchrony.
Optimizing Critical Care Ventilation: What can we learn from Ventilator Wavef...Dr.Mahmoud Abbas
This document provides an overview of optimizing critical care ventilation based on ventilator waveforms. It discusses:
1. The basic physiology of ventilation and the equation of motion of the respiratory system.
2. Different modes of mechanical ventilation including volume-controlled, pressure-controlled, bi-level, and pressure support ventilation.
3. How changes in ventilator settings and patient physiology affect breath delivery and waveforms.
4. Specific situations like ARDS and weaning where understanding waveforms can help guide ventilation.
This document provides instructions for using the Microlife BP 3AP1-3E blood pressure monitor. It begins with important facts about blood pressure self-measurement and how to evaluate readings. It then explains how to set up and take a measurement with the monitor. The document also describes what the arrhythmia indicator means and how to set options like date, time, language, and volume. It concludes with safety information, specifications, and guidance on interpreting error messages.
This document provides information about a nutritional cleansing product line. It discusses how nutritional cleansing can help the body remove impurities and provide nourishment. It explains that everyone can benefit from cleansing as it helps renew energy, lose weight, and improve overall health and well-being. The document also introduces the founders and formulators of the product line and describes their expertise in nutritional science.
This document provides information about an intermediate life support workshop. The workshop aims to develop rapid assessment skills and airway, breathing, circulation and defibrillation skills through hands-on training. No written exam will be given, and the goal is to make the course as relevant as possible for participants. The document then outlines various life support techniques and considerations for adults and pediatrics, including airway management, ventilation, oxygen supplementation, monitoring, and sample cases to discuss.
This seminar discusses various physiologic tests used to assess pelvic floor and anorectal disorders, including manometry, defecography, anal ultrasound, MRI, and EMG. Manometry measures anorectal pressures and reflexes and can diagnose sphincter defects, constipation, and pain syndromes. Defecography evaluates anorectal anatomy and function during defecation. Anal ultrasound and MRI identify anatomical abnormalities of the anal sphincters. EMG assesses the integrity of the anal sphincter muscle and its nerve supply. These tests provide objective data to diagnose disorders and monitor treatments like biofeedback or surgery.
Asthma triggers and preventions are discussed. Common asthma triggers include allergens, dust mites, tobacco smoke, air pollution, changes in weather, exercise and emotions. During an asthma attack, the airways become narrow making it difficult to breathe. Symptoms include wheezing, coughing and shortness of breath. Asthma can be serious and even cause death. Ways to reduce triggers in the home are consulting an air conditioning engineer and maintaining good indoor air quality.
1. The document provides instructions for candidates taking an examination.
2. It specifies that the examination will consist of 50 multiple choice questions and candidates have 1 1/4 hours to complete it.
3. Candidates are instructed to verify that their question booklet is complete and not damaged or duplicated before starting the exam and to notify the invigilator if there are any issues.
The document summarizes various physiologic tests that can be used to assess pelvic floor and anorectal disorders. It describes tests such as manometry, defecography, anal ultrasound, and tests of transit time. For each test, it provides details on the technique, indications for use, preparation, interpretation of results, and how the tests can help diagnose conditions like incontinence, constipation, and pain. The tests provide objective measures that can confirm diagnoses and evaluate treatments. When used together, the tests provide complementary information to fully assess pelvic floor and bowel function.
This document provides health advice for various common ailments and recommends foods to help treat each one. It suggests eating foods like fish, ginger and yogurt for headaches, tea for stroke prevention, honey for insomnia, and various fruits and vegetables to help with conditions like asthma, arthritis, cancer, high blood pressure, and more. The foods are said to contain beneficial nutrients and chemicals that can ease symptoms and promote healing.
- Upper GI bleeding is common and affects 10-15% of people, usually caused by ulcers. Early resuscitation, antisecretory drugs, and endoscopy are used to manage bleeding.
- This document summarizes clinical practice guidelines from 2004 for managing upper GI bleeding. It aims to standardize treatment based on evidence and expert consensus.
- The guidelines recommend initial treatment for 1-2 days with antisecretory drugs, followed by endoscopy for diagnosis and possible intervention. Early management and resuscitation are emphasized to prevent complications.
The incremental shuttle walk test (ISWT) is a field walking test that simulates a cardiopulmonary exercise test. The test requires patients to walk around two cones set 9 meters apart that get progressively closer together each minute as the test increases in difficulty. Patients walk until they are too breathless to continue or can no longer keep pace, and the number of shuttles completed is recorded. Standardization is important for meaningful results, including performing the test twice, using only instructions from the audio recording, and maintaining consistent testing conditions. The ISWT can be used to evaluate exercise training programs and track changes in exercise capacity over time.
This document discusses parts of speech in the Thai language, including nouns, determiners, pronouns, adjectives, and adverbial quantifiers. It provides classifications and examples for each part of speech. Key points covered include the different types of nouns like plural nouns, compound nouns, and uncountable nouns. It also examines the different types of determiners such as articles, demonstratives, possessives, and numerals. Classifications are given for pronouns, adjectives, and adverbial quantifiers as well.
This document provides an overview of glaucoma, including its definition, types, symptoms, risk factors, diagnostic techniques, and treatment approaches. Primary open-angle glaucoma is the most common type of glaucoma. It is characterized by optic nerve damage and visual field loss associated with elevated intraocular pressure. While increased IOP is a major risk factor, some patients can have glaucoma despite normal IOP levels. Diagnosis involves measuring IOP, examining the optic nerve head and retinal nerve fiber layer, and testing visual fields. Treatment may involve eye drops or surgery to reduce IOP and prevent further optic nerve damage.
Optimal timing of umbilical cord clampingMahmoudRavari
The optimal timing of umbilical cord clamping has been debated for over a century. Before the 1950s, the cord was usually cut after pulsations ceased from 1-5 minutes after birth, but views changed after studies found babies achieved most blood volume within first few breaths. Immediate clamping became routine in the US without research on health impacts. Delayed clamping may reduce infant anemia risk and have long term health benefits for both mother and baby. Guidelines recommend delaying clamping until 1-3 minutes after birth or when pulsations cease.
This document discusses nutrition guidelines for critically ill patients. It recommends starting enteral nutrition within 24-48 hours of admission to provide 25 kcal/kg/day and over 1.2 g/kg/day of protein. Enteral nutrition is preferred over parenteral nutrition when possible. Guidelines suggest not stopping nutrition without a definite medical cause and consulting nutrition support teams.
1. The patient is a 75-year-old male admitted to the EICU for septic shock due to pneumonia and colitis. He received TPN for nutrition support from admission until signs of bowel recovery were seen.
2. Enteral nutrition was started with 500 kcal/day of tube feeding once bowel sounds returned, but was reduced due to distension. IV fluids were given initially until TPN was started providing over 1300 kcal per day.
3. Laboratory findings and the patient's clinical status including hemodynamics, mottling, and ventilator settings are discussed to determine the adequacy and progression of nutrition support and management of septic shock. Further suggestions may be considered.
This document discusses point-of-care testing (POCT) and provides examples of its use and limitations. It describes rapid influenza diagnostic tests which can quickly (within 15 minutes) detect influenza A and B viruses at the site of patient care. While providing rapid results, these tests have limitations including lower sensitivity (50-70%) leading to false negatives, and an inability to distinguish influenza types (e.g. H1N1 versus H3N2) in some cases. Other examples discussed include rapid tests for COVID-19 antibodies.
The document summarizes guidelines for the management of upper gastrointestinal bleeding. It was developed by a consensus panel of experts in 2004. The summary provides recommendations for resuscitation of patients with upper GI bleeding and use of antisecretory and endoscopic therapies to treat and diagnose the source of bleeding. The panel reviewed available evidence to develop consensus-based guidelines to standardize the management of upper GI bleeding and ensure best practices. The document is intended to help clinicians appropriately treat and care for patients experiencing upper GI bleeding within 1-2 days to reduce morbidity and mortality.
1. Initial management of hemorrhagic stroke focuses on stabilizing the patient, performing a CT scan of the brain, and determining if hemorrhage is present.
2. Subarachnoid hemorrhage requires prompt diagnosis using CT scan to rule out aneurysm.
3. Patients under 45 years old or with unusual bleeding patterns require further evaluation with contrast CT scan to identify underlying causes like tumors or abnormal vessels.
Mechanical ventilation can be used to support or replace spontaneous breathing in patients unable to maintain adequate ventilation on their own. It aims to facilitate carbon dioxide release and maximize oxygen delivery. Modes include controlled mandatory ventilation where the ventilator controls both tidal volume and rate, and assist-control where the ventilator provides a minimum rate with additional breaths triggered by the patient. Synchronized intermittent mandatory ventilation delivers mandatory breaths at set intervals while allowing spontaneous breathing in between to reduce asynchrony.
Optimizing Critical Care Ventilation: What can we learn from Ventilator Wavef...Dr.Mahmoud Abbas
This document provides an overview of optimizing critical care ventilation based on ventilator waveforms. It discusses:
1. The basic physiology of ventilation and the equation of motion of the respiratory system.
2. Different modes of mechanical ventilation including volume-controlled, pressure-controlled, bi-level, and pressure support ventilation.
3. How changes in ventilator settings and patient physiology affect breath delivery and waveforms.
4. Specific situations like ARDS and weaning where understanding waveforms can help guide ventilation.
This document provides instructions for using the Microlife BP 3AP1-3E blood pressure monitor. It begins with important facts about blood pressure self-measurement and how to evaluate readings. It then explains how to set up and take a measurement with the monitor. The document also describes what the arrhythmia indicator means and how to set options like date, time, language, and volume. It concludes with safety information, specifications, and guidance on interpreting error messages.
This document provides information about a nutritional cleansing product line. It discusses how nutritional cleansing can help the body remove impurities and provide nourishment. It explains that everyone can benefit from cleansing as it helps renew energy, lose weight, and improve overall health and well-being. The document also introduces the founders and formulators of the product line and describes their expertise in nutritional science.
This document provides information about an intermediate life support workshop. The workshop aims to develop rapid assessment skills and airway, breathing, circulation and defibrillation skills through hands-on training. No written exam will be given, and the goal is to make the course as relevant as possible for participants. The document then outlines various life support techniques and considerations for adults and pediatrics, including airway management, ventilation, oxygen supplementation, monitoring, and sample cases to discuss.
This seminar discusses various physiologic tests used to assess pelvic floor and anorectal disorders, including manometry, defecography, anal ultrasound, MRI, and EMG. Manometry measures anorectal pressures and reflexes and can diagnose sphincter defects, constipation, and pain syndromes. Defecography evaluates anorectal anatomy and function during defecation. Anal ultrasound and MRI identify anatomical abnormalities of the anal sphincters. EMG assesses the integrity of the anal sphincter muscle and its nerve supply. These tests provide objective data to diagnose disorders and monitor treatments like biofeedback or surgery.
Asthma triggers and preventions are discussed. Common asthma triggers include allergens, dust mites, tobacco smoke, air pollution, changes in weather, exercise and emotions. During an asthma attack, the airways become narrow making it difficult to breathe. Symptoms include wheezing, coughing and shortness of breath. Asthma can be serious and even cause death. Ways to reduce triggers in the home are consulting an air conditioning engineer and maintaining good indoor air quality.
1. The document provides instructions for candidates taking an examination.
2. It specifies that the examination will consist of 50 multiple choice questions and candidates have 1 1/4 hours to complete it.
3. Candidates are instructed to verify that their question booklet is complete and not damaged or duplicated before starting the exam and to notify the invigilator if there are any issues.
The document summarizes various physiologic tests that can be used to assess pelvic floor and anorectal disorders. It describes tests such as manometry, defecography, anal ultrasound, and tests of transit time. For each test, it provides details on the technique, indications for use, preparation, interpretation of results, and how the tests can help diagnose conditions like incontinence, constipation, and pain. The tests provide objective measures that can confirm diagnoses and evaluate treatments. When used together, the tests provide complementary information to fully assess pelvic floor and bowel function.
This document provides health advice for various common ailments and recommends foods to help treat each one. It suggests eating foods like fish, ginger and yogurt for headaches, tea for stroke prevention, honey for insomnia, and various fruits and vegetables to help with conditions like asthma, arthritis, cancer, high blood pressure, and more. The foods are said to contain beneficial nutrients and chemicals that can ease symptoms and promote healing.
- Upper GI bleeding is common and affects 10-15% of people, usually caused by ulcers. Early resuscitation, antisecretory drugs, and endoscopy are used to manage bleeding.
- This document summarizes clinical practice guidelines from 2004 for managing upper GI bleeding. It aims to standardize treatment based on evidence and expert consensus.
- The guidelines recommend initial treatment for 1-2 days with antisecretory drugs, followed by endoscopy for diagnosis and possible intervention. Early management and resuscitation are emphasized to prevent complications.
The incremental shuttle walk test (ISWT) is a field walking test that simulates a cardiopulmonary exercise test. The test requires patients to walk around two cones set 9 meters apart that get progressively closer together each minute as the test increases in difficulty. Patients walk until they are too breathless to continue or can no longer keep pace, and the number of shuttles completed is recorded. Standardization is important for meaningful results, including performing the test twice, using only instructions from the audio recording, and maintaining consistent testing conditions. The ISWT can be used to evaluate exercise training programs and track changes in exercise capacity over time.
This document discusses parts of speech in the Thai language, including nouns, determiners, pronouns, adjectives, and adverbial quantifiers. It provides classifications and examples for each part of speech. Key points covered include the different types of nouns like plural nouns, compound nouns, and uncountable nouns. It also examines the different types of determiners such as articles, demonstratives, possessives, and numerals. Classifications are given for pronouns, adjectives, and adverbial quantifiers as well.
This document provides an overview of glaucoma, including its definition, types, symptoms, risk factors, diagnostic techniques, and treatment approaches. Primary open-angle glaucoma is the most common type of glaucoma. It is characterized by optic nerve damage and visual field loss associated with elevated intraocular pressure. While increased IOP is a major risk factor, some patients can have glaucoma despite normal IOP levels. Diagnosis involves measuring IOP, examining the optic nerve head and retinal nerve fiber layer, and testing visual fields. Treatment may involve eye drops or surgery to reduce IOP and prevent further optic nerve damage.
Optimal timing of umbilical cord clampingMahmoudRavari
The optimal timing of umbilical cord clamping has been debated for over a century. Before the 1950s, the cord was usually cut after pulsations ceased from 1-5 minutes after birth, but views changed after studies found babies achieved most blood volume within first few breaths. Immediate clamping became routine in the US without research on health impacts. Delayed clamping may reduce infant anemia risk and have long term health benefits for both mother and baby. Guidelines recommend delaying clamping until 1-3 minutes after birth or when pulsations cease.
This document discusses nutrition guidelines for critically ill patients. It recommends starting enteral nutrition within 24-48 hours of admission to provide 25 kcal/kg/day and over 1.2 g/kg/day of protein. Enteral nutrition is preferred over parenteral nutrition when possible. Guidelines suggest not stopping nutrition without a definite medical cause and consulting nutrition support teams.
1. The patient is a 75-year-old male admitted to the EICU for septic shock due to pneumonia and colitis. He received TPN for nutrition support from admission until signs of bowel recovery were seen.
2. Enteral nutrition was started with 500 kcal/day of tube feeding once bowel sounds returned, but was reduced due to distension. IV fluids were given initially until TPN was started providing over 1300 kcal per day.
3. Laboratory findings and the patient's clinical status including hemodynamics, mottling, and ventilator settings are discussed to determine the adequacy and progression of nutrition support and management of septic shock. Further suggestions may be considered.
This document provides an overview of electrolyte disorders including hypernatremia, hyponatremia, hyperkalemia, hypokalemia, and hyperglycemia. It discusses the etiology, clinical effects, and approaches to management. Specifically, it covers how these disorders disrupt osmotic balance and cell volume, outlines factors that influence electrolyte concentrations, and provides guidelines for treatment including shifting electrolytes between intra and extracellular compartments or removing excess amounts. The document compares US and European guidelines for hyponatremia and concludes by thanking the reader.
Cardiogenic shock is a serious condition where the heart cannot pump enough blood to vital organs, causing hypotension and end-organ damage. The most common cause is acute myocardial infarction with left ventricular dysfunction. In-hospital mortality from cardiogenic shock is high, around 27-51%. Treatment involves stabilization, vasopressor support, mechanical circulatory support if needed, and identifying and treating the underlying cardiac cause, such as through coronary angiography and PCI. Despite aggressive treatment, cardiogenic shock remains a medical emergency with high mortality.
1. The document discusses definitions of sepsis, severe sepsis, septic shock from 1992, 2001, and 2016. It describes the criteria for systemic inflammatory response syndrome, sepsis, and septic shock.
2. Guidelines for management of sepsis from the Surviving Sepsis Campaign are summarized, including early goal directed therapy, resuscitation bundles, and antimicrobial therapy recommendations.
3. Key aspects of the updated 2018 Surviving Sepsis Campaign guidelines are highlighted, such as initial fluid resuscitation, hemodynamic support, antimicrobial administration, and duration of therapy.
This document discusses post-cardiac arrest syndrome (PCAS), which refers to the pathology caused by complete whole body ischemia and reperfusion following cardiac arrest. PCAS involves (1) post-cardiac arrest brain injury, (2) post-cardiac arrest myocardial dysfunction, (3) systemic ischemia/reperfusion response, and (4) persistent precipitating pathology. The document outlines recommendations for targeted temperature management, hemodynamic goals, prognostication of outcome, and organ donation for patients experiencing PCAS.
This document discusses acute kidney injury (AKI). It notes that AKI is common in ICU patients and associated with increased mortality. Sepsis and postoperative/toxic causes are common. It defines AKI and discusses causes including prerenal, postrenal, and intrarenal. For intrarenal causes, it mentions glomerulonephritis, vasculitis, interstitial nephritis, acute tubular necrosis, and sepsis-induced AKI. It reviews diagnosis and novel biomarkers. Prevention and treatment sections discuss volume expansion, diuretics, vasopressors, vasodilators, sedation, hormonal manipulation, metabolic interventions, statins, and renal replacement therapy.
This document provides an overview of acid-base principles and disorders. It discusses the normal ranges for pH, PCO2, and HCO3 and defines acid-base disorders. Primary acid-base disorders are classified as respiratory or metabolic based on changes in PCO2 or HCO3. Secondary responses to primary disorders and mixed acid-base disorders are also covered. Evaluation of acid-base disorders follows a stepwise approach identifying the primary disorder and any secondary responses. Metabolic acidosis is further evaluated using anion gap, delta gap, and urine anion gap. Causes and treatments of various acid-base disorders are outlined.
This study summarizes the outcomes of a surgical technique for pulmonary artery reconstruction in 56 patients who had previously failed pulmonary artery stent procedures. The surgery successfully removed prior stents in 71% of cases and repaired peripheral pulmonary arteries distal to stents in 91% of patients. Following surgery, central pulmonary artery pressures significantly decreased compared to preoperative levels. At 2 years, freedom from death or need for reintervention was 87%. The study concludes that this surgical reconstruction approach can be very effective for managing pulmonary artery stenosis in patients with a history of failed pulmonary artery stenting.
This study examined the association between preoperative left atrial volume index (LAVI) and postoperative outcomes in patients undergoing mitral valve repair for chronic mitral regurgitation. The study found that higher preoperative LAVI was associated with less left atrial reverse remodeling after surgery and marginally increased the risk of postoperative atrial fibrillation and late death, independent of age and sex. The study suggests that a LAVI threshold of less than 60mL/m2 may be a better indicator of risk than guidelines that advocate 60mL/m2. The extent of preoperative left atrial enlargement as measured by LAVI can help predict postoperative outcomes in patients undergoing mitral valve repair.
Here are my thoughts on the discussion questions:
Q1. The study found that the no-AC cohort had lower rates of hemorrhagic and thrombotic complications compared to the AC cohort, though the difference was not statistically significant.
Q2. The traditional approach is to anticoagulate patients on VA-ECMO based on ELSO guidelines to target an ACT of 180-220 seconds. This study evaluated a non-traditional approach of not routinely anticoagulating patients in the first 24 hours.
Q3. You're right that not reporting coagulation data for the no-AC cohort limits reliability. Without knowing coagulation status, it's difficult to fully evaluate thrombotic risk in that group
Biography and career history of Bruno AmezcuaBruno Amezcua
Bruno Amezcua's entry into the film and visual arts world seemed predestined. His grandfather, a distinguished film editor from the 1950s through the 1970s, profoundly influenced him. This familial mentorship early on exposed him to the nuances of film production and a broad array of fine arts, igniting a lifelong passion for narrative creation. Over 15 years, Bruno has engaged in diverse projects showcasing his dedication to the arts.
Amid the constant barrage of distractions and dwindling motivation, self-discipline emerges as the unwavering beacon that guides individuals toward triumph. This vital quality serves as the key to unlocking one’s true potential, whether the aspiration is to attain personal goals, ascend the career ladder, or refine everyday habits.
Understanding Self-Discipline
Care Instructions for Activewear & Swim Suits.pdfsundazesurf80
SunDaze Surf offers top swimwear tips: choose high-quality, UV-protective fabrics to shield your skin. Opt for secure fits that withstand waves and active movement. Bright colors enhance visibility, while adjustable straps ensure comfort. Prioritize styles with good support, like racerbacks or underwire tops, for active beach days. Always rinse swimwear after use to maintain fabric integrity.
Insanony: Watch Instagram Stories Secretly - A Complete GuideTrending Blogers
Welcome to the world of social media, where Instagram reigns supreme! Today, we're going to explore a fascinating tool called Insanony that lets you watch Instagram Stories secretly. If you've ever wanted to view someone's story without them knowing, this blog is for you. We'll delve into everything you need to know about Insanony with Trending Blogers!
MRS PUNE 2024 - WINNER AMRUTHAA UTTAM JAGDHANEDK PAGEANT
Amruthaa Uttam Jagdhane, a stunning woman from Pune, has won the esteemed title of Mrs. India 2024, which is given out by the Dk Exhibition. Her journey to this prestigious accomplishment is a confirmation of her faithful assurance, extraordinary gifts, and profound commitment to enabling women.
The Fascinating World of Bats: Unveiling the Secrets of the Nightthomasard1122
The Fascinating World of Bats: Unveiling the Secrets of the Night
Bats, the mysterious creatures of the night, have long been a source of fascination and fear for humans. With their eerie squeaks and fluttering wings, they have captured our imagination and sparked our curiosity. Yet, beyond the myths and legends, bats are fascinating creatures that play a vital role in our ecosystem.
There are over 1,300 species of bats, ranging from the tiny Kitti's hog-nosed bat to the majestic flying foxes. These winged mammals are found in almost every corner of the globe, from the scorching deserts to the lush rainforests. Their diversity is a testament to their adaptability and resilience.
Bats are insectivores, feeding on a vast array of insects, from mosquitoes to beetles. A single bat can consume up to 1,200 insects in an hour, making them a crucial part of our pest control system. By preying on insects that damage crops, bats save the agricultural industry billions of dollars each year.
But bats are not just useful; they are also fascinating creatures. Their ability to fly in complete darkness, using echolocation to navigate and hunt, is a remarkable feat of evolution. They are also social animals, living in colonies and communicating with each other through a complex system of calls and body language.
Despite their importance, bats face numerous threats, from habitat destruction to climate change. Many species are endangered, and conservation efforts are necessary to protect these magnificent creatures.
In conclusion, bats are more than just creatures of the night; they are a vital part of our ecosystem, playing a crucial role in maintaining the balance of nature. By learning more about these fascinating animals, we can appreciate their importance and work to protect them for generations to come. So, let us embrace the beauty and mystery of bats, and celebrate their unique place in our world.
At Affordable Garage Door Repair, we specialize in both residential and commercial garage door services, ensuring your property is secure and your doors are running smoothly.
3. Prolonged MV associated with significant morbidity & mortality
- Ventilator associated pneumonia (VAP)
- Respiratory & general muscle weakness
- Length of stay↑ (ICU & Hospital)
- Long term care facility use↑
Why weaning is important ?
8. 원인 질환의 급성기에서 호전된 상태인가?
적절한 기침이 가능한가?
기관지 분비물이 과다하지는 않은가?
Suspicion : 임상적 평가
9. Lancet 2008; 371: 126–34
Wake Up & Breathe protocol
Spontaneous Awakening Trials (SATs)
+
Spontaneous Breathing Trials (SBTs)
All sedatives and analgesics used for sedation are interrupted
Analgesics needed for active pain are continued
Monitored for up to 4h
[SAT + SBT] [Usual care + SBT]
16. Best ventilator mode to wean on ?
Evidence would suggest :
PSV ≈ Intermittent T-piece trial > SIMV
T-piece trial : 30min trial ≈ 2 hour trial
SBT (Spontaneous Breathing Trial)
Weaning method
SBT or Gradual reduction (= decreasing level of pressure support, 2~4 cmH2O per day)
SBT is generally preferred, but gradual reduction may be better in certain situation
(장기간의 기계 호흡 사용을 사용으로 호흡근 약화가 예상되는 환자는 gradual reduction를 고려할 수 있음)
SIMV alone not be used for weaning (not recommend for weaning mode)
적절한 모니터링과 감시로 weaning failure를 일찍 감지하고 full MV support로 복귀시킨다면 complication은 발생하지 않음
Weaning 실패시 원인을 파악하고 교정해야 함 & Daily assess for readiness to wean + SBT (Once daily, Not multiple times)
17. Daily SBT
1. Spontaneous breathing with T-piece
2. Spontaneous breathing with PS Mode 5 ~ 7 cmH2O (If ET tube size #7, use PS of 8~10 cmH2O)
3. Spontaneous breathing with Tube compensation Mode
4. Spontaneous breathing with CPAP (PEEP 5 cmH2O)
Duration : 30min ~ 2hrs
SBT (Spontaneous Breathing Trial)
SBT with T-piece SBT with PS or TC or CPAP
19. SBT failure
RR > 35 회/분 for 5 min
SaO2 < 90% for 30sec
HR > 140 회/분 (or change of ±20% of baseline) for 5 min
sBP > 180 or < 90 mmHg (sBP 30mmHg↑ or 20mmHg↓) for 5 min
Agitation, Anxiety, Diaphoresis
Chest pain or SOB (shortness of breath)
SBT (Spontaneous Breathing Trial)
적절한 모니터링과 감시로 weaning failure를 일찍 감지하고 full MV support로 복귀시킨다면 complication은 발생하지 않음
Weaning 실패시 원인을 파악하고 교정해야 함
Daily assess for readiness to wean + SBT (Once daily, Not multiple times)
Sudden onset of PVC (> 4~6 회/min)
20. SBT (Spontaneous Breathing Trial)
적절한 모니터링과 감시로 weaning failure를 일찍 감지하고 종료 후
full MV support (이전 mode)로 복귀시킨다면 complication은 발생하지 않음
Daily assess for readiness to wean + SBT (Once daily, Not multiple times)
Weaning 실패시 원인을 파악하고 교정해야 함
21. Simple wean : 첫 SBT에 성공한 경우 (약 50~66%)
Difficult to wean : 첫 SBT 실패 + SBT 성공에 최대 3회 + 6일 이내의 시간이 소요되는 경우 (약 26~40%)
Prolonged weaning : 최소 3번 SBT 실패 or SBT 성공에 7일 이상이 소요 (약 10~20%)
Prolonged weaning : In hospital & overall mortaliy ↑
Prolonged weaning → Progressive reduction of PS level, progressive increasing duration of SBT, tracheostomy is performed
Difficult to wean
Difficult to wean의 원인 (기계 호흡을 적용하게 한 원인을 완전히 치료하지 못한 상태 or 추가적인 새로운 문제의 발생)
- Respiratory/Ventilatory causes : Ventilator demand↓, Reistive load↓, Compliance↓, Neuromuscular capacity↓, Ventilatory drive↓,
Auto-PEEP(COPD), Overventilation (COPD),
- Cardiac causes : Weaning induced myocardial ischemia (or HF), Pulmonary edema with HF (or ischemia), Fluid overload in normal heart
- Psychological causes : Depression, Anxiety, Delirium, Pain, Over-sedation
- Ventilator causes : Equipment dead space, ET tube luminal narrowing, Circuit compliance, Exhalation valve dysfx
- Nutritional causes : Underfeeding & protein catabolism → Respiratory m weakness, Overfeeding CO2 → production & Ventilatory load ↑
23. Extubation Screening
Is patient awake & responsive to verbal command ? (consider sedation interruption, SAT)
Can patient protect airway ? (Cough reflex intact ? Voluntary cough (strength) adequate to clear secretion ?)
Suction frequency ? (check documentation in the prior 6~8 hrs, < q2h)
Quantity & Quality of secretions ? (< 2.5 cc/h)
Concerns about the patency of upper airway ? Perform standard cuff-leak test
If NMD, Can patient sustain head life maneuver against resistance ?
If patient failed repeatedly (to weaning trial or extubation screening), consider tracheostomy if intubated > 2 weeks
Tracheostomy : Early airway suctioning, WOB↓, Patient comfort↑, Need for sedation↓, Communication↑
Early tracheostomy (<4days) : No proven benefit (mortality, VAP, aspiration pneumonia, duration of MV)
Extubation screening
25. Cuff leak test & laryngeal edema
1. VC mode를 선택 후 setting 한다
2. ET tube의 cuff 를 deflation 한다
3. 이 후 연속되는 6번의 호기 tidal volume을 체크
4. 이중 가장 수치가 낮은 tidal volume 3개의 평균을 구함
5. VT (setting값) – 호기 평균 VT = cuff leak volume
6. Cuff leak volume < 110 mL (< 12~24 % of VT)
→ laryngeal edema risk↑ → IV steroid
No audiable leak → laryngeal edema risk↑
26. Laryngeal edema & US
Laryngeal ultrasound in intubated pts at the level of cricothyroid membrane
Square-shaped air-column with
hyper-echoic air-column bands
Ding et al. Eur Respir J 2006; 27: 384–389
ET tube
27. US during ballon-cuff inflation US during ballon-cuff deflation
Normal patient (no stridor) Laryngeal edema patient (stridor)
US during ballon-cuff inflation US during ballon-cuff deflation
No change in air column width
Shape of the laryngeal air column was as square as the
image of cuff inflation
The true cords and arytenoid cartilage were not
masked by the air column
Laryngeal edema & US
Ding et al. Eur Respir J 2006; 27: 384–389
28. Air-column width (0.57 cm)
immediately after intubation
with cuff deflated
Air-column width (0.42 cm) of 3h
before extubation
with cuff deflated
(Air column width ratio = 0.73)
Air column width ratio ≤ 0.8 : may be helpful in predicting post-extubation stridor
Laryngeal edema & US
This patient had stridor after extubation
33. Approximately 15% of patients required re-intubation within 48h
Patients who required intubation : Risk of death↑, Hospital stay↑, Likehood of returning home↓
Risk factor for re-intubation : inadequate cough, excessive secretion, poor mental state,
Positive fluid balance before extubation, diagnosis of pneumonia, RSBI↑ at the end of a SBT
Physician’s judgment and experience are essential components in successful extubation
Re-Intubation
34. Post-Extubation & NIV + Reintubation
Aggressive Approach
Extubation & Use of preemptive NIPPV (who had successful SBT + Risk of re-intubation)
Reassess the patient within 30 min after initiating NIPPV
If the RR is elevated or patient is in mild distress → Immediate re-intubation
(Delayed time to reintubation : associated with mortality among pts in whom discontinuation of ventilation has been unsuccessful)
Benefits of earlier discontinuation of ventilation > Risk associated with waiting another 12~24 hours for continued clinical improvement