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REGULATION
Bilal Sami Al-Mosheqah
Parasympathetic Nervous
System
Parasympathetic
NS
(Rest and digest)
 Work in relaxed state
 Involuntary control
 Two neurons
 Discrete and localized effect
Parasympathetic NS
Receptors Neurotransmitter
Nicotinic
Muscarinic
 Ach
{acetylcholine]
M1,M2,M3
M4,M5
The Eyes (M3)
 Stimulate lacrimal gland → ↑ lacrimal secretion
 Contraction of constrictor pupillae (circular muscle of
the iris)→ miosis
 Contraction of ciliary muscle → accommodation for
near vision
 ↓ intraocular pressure (IOP)
Miosis
Heart (M2) and Arteries (M3)
↓heart rate
 ↓ force of contraction (atria)
 ↓ conduction
 Arteries (M3) → Vasodilatation
NB: Vessels have no parasympathetic supply
Decrease BP
Lung (M3)
Bronchial secretion
↑
Bronchial muscles Contraction
Bronchial
gland
Gastrointestinal tract
Motility
Sphincters
gastric secretion
Smooth muscles
Contraction
Relaxation
Increase
Acceleration
Digestion
(M1)
(M3)
(M3)
(M3)
Liver and Pancreas
 Stimulates bile release
 Contraction of the gall bladder
 Increase pancreatic secretions
Urinary Bladder (M3)
 Contraction of the bladder muscle (Detrusor muscle)
 Relaxation of the external sphincter
Urination
What happens if the
parasympathetic NS is blocked
Eye
Salivary
gland
Bronchi Intestine
Urinary
Tract
Heart
Tachycardia Urine retention
Constipation
Broncho-
dilatation
Dry mouth
mydriasis,
cycloplegia
, ↑
IOP
The Absence of Parasympathetic Supply
Adrenal
medulla
Piloerector
Muscle
Sweat gland Kidney
Ventricles of the
heart
Here is the summary . . .
Thanks for listening
Lippincott Illustrated Reviews, Pharmacology -Whalen, Karen
Medical Physiology for Undergraduate Students - book44-1
Guyton and HallTextbook of Medical Physiology, 13th edition
Lippincott’s Illustrated Reviews Physiology 1st Edition

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Parasympathetic Nervous System