This case series summarizes three cases of boys diagnosed with Reactive Attachment Disorder (RAD) whose symptoms persisted despite living in nurturing foster or adoptive placements. All three boys met criteria for RAD before age 5 and continued to display symptoms such as lack of comfort seeking, limited positive affect, and emotional withdrawal. The cases highlight how persistent RAD can profoundly impact family life and child development. Treatment is possible, as one boy showed rapid symptom improvement with psychotherapy, but early identification is important to provide support. This series contributes new evidence that RAD symptoms can in rare cases continue into adolescence and challenges the assumption that RAD always resolves with good care.
Parents perceptions of autism and theirhealth-seeking behavemelyvalg9
Parents' perceptions of autism and their
health-seeking behaviors
Maria Isabel O. Quilendrino a,*, Mary Anne R. Castor a,
Nenacia Ranali Nirena P. Mendoza b, Jacqueline R. Vea c,
Nina T. Castillo-Carandang c
a Department of Clinical Epidemiology and Department of Pediatrics, College of Medicine, University of the Philippines,
Manila, Philippines
b Department of Clinical Epidemiology and Department of Family and Community Medicine, College of Medicine,
University of the Philippines, Manila, Philippines
c Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, Philippines
c l i n i c a l e p i d e m i o l o g y a n d g l o b a l h e a l t h 3 ( 2 0 1 5 ) s 1 0 – s 1 5
a r t i c l e i n f o
Article history:
Received 15 September 2015
Accepted 13 November 2015
Available online 7 December 2015
Keywords:
Autism
Autistic disorder
Behavior
Perception
a b s t r a c t
Background: Parents' health-seeking behaviors, which in turn may be related to their per-
ceptions, are hypothesized to be the major determinant of the timing of diagnosis and
subsequent intervention for children with autism.
Objective: The primary objective of this study was to describe parental perceptions of autism
and health-seeking behaviors for urban Filipino children aged 2–6 years.
Methods: This was a cross-sectional study conducted in several phases. The first phase
involved collection of qualitative data from key informant interviews and small group
discussions. The second phase involved the development of a validated and reliable ques-
tionnaire, which was administered to 41 parents of children with autism, aged 2–6 years.
Results: Parents had varying perceptions of autism. They were generally undecided with
regard to the etiology of autism, but were in agreement that psychosocial factors, such as
parental sins and curses, were unlikely to be associated with autism. The most common
presenting symptom noted by parents was a qualitative impairment in social interaction.
There was a noted trend towards earlier age of symptom recognition (mean of 24 months)
and diagnosis of autism (mean of 39 months) among parents with younger children.
Conclusion: The results of this study showed some trends: There is improved awareness
regarding autism and the needs of children with autism. Parents tend to disagree with
previous myths about autism. There was an observable trend toward earlier diagnosis for
this group.
# 2015 INDIACLEN. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All
rights reserved.
* Corresponding author. Tel.: +63 9178033888; fax: +63 27311631.
E-mail address: [email protected] (M.I.O. Quilendrino).
Available online at www.sciencedirect.com
ScienceDirect
journal homepage: www.elsevier.com/locate/cegh
http://dx.doi.org/10.1016/j.cegh.2015.11.003
2213-3984/# 2015 INDIACLEN. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved.
http://crossmar ...
Clinical Assessment of Children and Adolescents with DepressionCarlo Carandang
“Clinical Assessment of Children and Adolescents with Depression,”
Halifax, Nova Scotia, Canada; October 1, 2008
Pediatric Grand Rounds, IWK Health Centre
*Although the core symptoms of depression are similar across the life span, developmental differences exist and should be taken into account in the assessment
*With increasing age, there generally is an increase in melancholic symptoms, delusions, substance abuse, and suicidal ideation/attempts.
*In contrast, younger children tend to have more somatic sxs, separation anxiety, behavior problems, temper tantrums, and hallucinations
*Direct interviews with children and adolescents are critical because parents and teachers may not be aware of the youth’s depressive symptoms
*Discrepant information between parents and their children should be solve in a cordial and non judgmental way
*Assessment of suicidal and homicidal ideation and behaviors is mandatory
*The interview process and screening questions utilized by research interviews such as the Schedule for Affective Disorders and Schizophrenia for School Age Children, Present and Lifetime Version (KSADS-PL) can be useful
*Detection and diagnosis can be enhanced by available parent and child self-report measures
Parents perceptions of autism and theirhealth-seeking behavemelyvalg9
Parents' perceptions of autism and their
health-seeking behaviors
Maria Isabel O. Quilendrino a,*, Mary Anne R. Castor a,
Nenacia Ranali Nirena P. Mendoza b, Jacqueline R. Vea c,
Nina T. Castillo-Carandang c
a Department of Clinical Epidemiology and Department of Pediatrics, College of Medicine, University of the Philippines,
Manila, Philippines
b Department of Clinical Epidemiology and Department of Family and Community Medicine, College of Medicine,
University of the Philippines, Manila, Philippines
c Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, Philippines
c l i n i c a l e p i d e m i o l o g y a n d g l o b a l h e a l t h 3 ( 2 0 1 5 ) s 1 0 – s 1 5
a r t i c l e i n f o
Article history:
Received 15 September 2015
Accepted 13 November 2015
Available online 7 December 2015
Keywords:
Autism
Autistic disorder
Behavior
Perception
a b s t r a c t
Background: Parents' health-seeking behaviors, which in turn may be related to their per-
ceptions, are hypothesized to be the major determinant of the timing of diagnosis and
subsequent intervention for children with autism.
Objective: The primary objective of this study was to describe parental perceptions of autism
and health-seeking behaviors for urban Filipino children aged 2–6 years.
Methods: This was a cross-sectional study conducted in several phases. The first phase
involved collection of qualitative data from key informant interviews and small group
discussions. The second phase involved the development of a validated and reliable ques-
tionnaire, which was administered to 41 parents of children with autism, aged 2–6 years.
Results: Parents had varying perceptions of autism. They were generally undecided with
regard to the etiology of autism, but were in agreement that psychosocial factors, such as
parental sins and curses, were unlikely to be associated with autism. The most common
presenting symptom noted by parents was a qualitative impairment in social interaction.
There was a noted trend towards earlier age of symptom recognition (mean of 24 months)
and diagnosis of autism (mean of 39 months) among parents with younger children.
Conclusion: The results of this study showed some trends: There is improved awareness
regarding autism and the needs of children with autism. Parents tend to disagree with
previous myths about autism. There was an observable trend toward earlier diagnosis for
this group.
# 2015 INDIACLEN. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All
rights reserved.
* Corresponding author. Tel.: +63 9178033888; fax: +63 27311631.
E-mail address: [email protected] (M.I.O. Quilendrino).
Available online at www.sciencedirect.com
ScienceDirect
journal homepage: www.elsevier.com/locate/cegh
http://dx.doi.org/10.1016/j.cegh.2015.11.003
2213-3984/# 2015 INDIACLEN. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved.
http://crossmar ...
Clinical Assessment of Children and Adolescents with DepressionCarlo Carandang
“Clinical Assessment of Children and Adolescents with Depression,”
Halifax, Nova Scotia, Canada; October 1, 2008
Pediatric Grand Rounds, IWK Health Centre
*Although the core symptoms of depression are similar across the life span, developmental differences exist and should be taken into account in the assessment
*With increasing age, there generally is an increase in melancholic symptoms, delusions, substance abuse, and suicidal ideation/attempts.
*In contrast, younger children tend to have more somatic sxs, separation anxiety, behavior problems, temper tantrums, and hallucinations
*Direct interviews with children and adolescents are critical because parents and teachers may not be aware of the youth’s depressive symptoms
*Discrepant information between parents and their children should be solve in a cordial and non judgmental way
*Assessment of suicidal and homicidal ideation and behaviors is mandatory
*The interview process and screening questions utilized by research interviews such as the Schedule for Affective Disorders and Schizophrenia for School Age Children, Present and Lifetime Version (KSADS-PL) can be useful
*Detection and diagnosis can be enhanced by available parent and child self-report measures
Disruptive behavioral disorder & Anxiety disorder in childDr Slayer
-Is characterized by enduring pattern of NEGATIVISTIC, DISOBEDIENT and HOSTILE behavior toward authority figures as well as inability to take responsibility for mistakes, leading to placing blame on others.
-AGGRESSIONS and VIOLATIONS of the rights of the others
Violations include cruelty to people and animals, destruction of property, deceitfulness or theft and serious violation of rules
-Increased and INAPPROPRIATE ANXIETY around separation from attachment figures or home, which is developmentally abnormal and results in impaired normal functioning
Learning Resources to be used as references to support your answer.docxsmile790243
Learning Resources to be used as references to support your answer.
USW1_SOCW_6090_howToWriteADiagnosisInDSM5.pdfUSW1_SOCW_6090_WK03_Chase.pdf
Note: To access this week’s required library resources, please click on the link to the Course Readings List, found in the Course Materials section of your Syllabus.
Required Readings
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
· “Neurodevelopmental Disorders” (pp. 31–86)
· “Other Conditions That May Be a Focus of Clinical Attention” (pp. 715–727)
Bell, A. S. (2011). A critical review of ADHD diagnostic criteria: What to address in the DSM-V. Journal of Attention Disorders, 15(1), 3–10.
Note: You will access this article from the Walden Library databases.
How to Write a Diagnosis According to DSM-5 and ICD-10-CM (PDF)
Teicher, M. H., Samson, J. A., Polcari, A., & McGreenery, C. E. (2006). Sticks, stones, and hurtful words: Relative effects of various forms of childhood maltreatment. American Journal of Psychiatry, 163(6), 993–1000.
Note: You will access this article from the Walden Library databases.
Working With Children and Adolescents: The Case of Chase (PDF)
Wing, L., Gould, J., & Gillberg, C. (2011). Autism spectrum disorders in the DSM-V: Better or worse than the DSM-IV? Research in Developmental Disabilities, 32, 768–773.
Note: You will access this article from the Walden Library databases.
Wiki Assignment Instructions (PDF)
Kieling, C., Kieling, R. R., Frick, P. J., Rohde, L. A., Moffitt, T., Nigg, J. T., Tannock, R., & Castellanos, F. X. (2010) The age at onset of attention deficit hyperactivity disorder. American Journal of Psychiatry, 167, 14–15.
Note: You will access this article from the Walden Library databases.
Murphy, C., & Taylor, E. (2006). Need to know ADHD. Pulse, 66(34), 38–42.
Note: You will access this article from the Walden Library databases.
Discussion - Week 3
Collapse
Top of Form
Total views: 35 (Your views: 4)
Discussion: Influences on Diagnosis and Outcome
The addition of more Z Codes to the DSM-5 is congruent to how a social worker as a clinician should conduct an assessment and determine the appropriate treatment.
For this Discussion, review The Case of Chase, analyze Chase’s story, and note his original DSM-IV diagnosis. Using the DSM-5 diagnostic criteria, determine Chase’s primary clinical diagnosis. Next, note the changes in the Autism Spectrum disorders, and include the Other Conditions That May Be a Focus of Clinical Attention (ICD-10-CM, Z codes) in your diagnosis. Then identify the potential risk and prognostic factors from both the biological and environmental perspective.
By Day 3
Post your response to the following:
· What should Chase’s diagnosis be according to the DSM-5 criteria?
· What predisposing and risk factors led to the outcome of this case?
· What potential protective factors could have been introduced to address this situation?
· ...
Taking away taboos and assist the people who grief: Living a long, happy and ...eshaasini
grief may encompass various symptoms and can be re- garded as a specific, severe form of sorrow. People being circum- vented by the right people and atmosphere, generally experience less difficulties while going through the different phases that em- brace bereavement compared to people who are not. It suggests that besides approaching the symptoms associated with grief, the social elements to combat grief are rather important too. Although social support is acknowledged to be helpful during (traumatic) grief, little information is available about the type of support and behavior that is considered helpful.
Involvement of Interleukin-6 induced PI3K/Akt/mTor pathway in the regulation ...eshaasini
Hepatocellular Carcinoma (HCC) is an invasive cancer. Alphafoetoprotein (AFP) is a diagnostic marker for HCC directly related to the disease agressivity. Telomerase, is expressed by 90% of HCC. PI3K/Akt/mTOR pathway wich is regulated by IL-6 is activated in the HCC. Our aim is to investigate the effect of IL-6 on AFP and telomerase secretion in HepG2/C3A and PLC/ PRF/5 cell lines.
The Prognostic Model of Differentiation-Related Lncrna Based on Bioinformatic...eshaasini
Differentiation status of glioma cells correlated with prognosis and Tumor-Immune Microenvironment (TIME) in patients with gliomas. This study aimed to identify difDifferentiation status of glioma cells correlated with prognosis and Tumor-Immune Microenvironment (TIME) in patients with gliomas. This study aimed to identify differentiation-related long non-coding RNAs (DRlncRNAs) that can be used to predict the outcome and the response to immunotherapy in patients with gliomas.ferentiation-related long non-coding RNAs (DRlncRNAs) that can be used to predict the outcome and the response to immunotherapy in patients with gliomas.
More Related Content
Similar to Parallel Lives: A Case Series of Three Boys with Persistent Reactive Attachment Disorder
Disruptive behavioral disorder & Anxiety disorder in childDr Slayer
-Is characterized by enduring pattern of NEGATIVISTIC, DISOBEDIENT and HOSTILE behavior toward authority figures as well as inability to take responsibility for mistakes, leading to placing blame on others.
-AGGRESSIONS and VIOLATIONS of the rights of the others
Violations include cruelty to people and animals, destruction of property, deceitfulness or theft and serious violation of rules
-Increased and INAPPROPRIATE ANXIETY around separation from attachment figures or home, which is developmentally abnormal and results in impaired normal functioning
Learning Resources to be used as references to support your answer.docxsmile790243
Learning Resources to be used as references to support your answer.
USW1_SOCW_6090_howToWriteADiagnosisInDSM5.pdfUSW1_SOCW_6090_WK03_Chase.pdf
Note: To access this week’s required library resources, please click on the link to the Course Readings List, found in the Course Materials section of your Syllabus.
Required Readings
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
· “Neurodevelopmental Disorders” (pp. 31–86)
· “Other Conditions That May Be a Focus of Clinical Attention” (pp. 715–727)
Bell, A. S. (2011). A critical review of ADHD diagnostic criteria: What to address in the DSM-V. Journal of Attention Disorders, 15(1), 3–10.
Note: You will access this article from the Walden Library databases.
How to Write a Diagnosis According to DSM-5 and ICD-10-CM (PDF)
Teicher, M. H., Samson, J. A., Polcari, A., & McGreenery, C. E. (2006). Sticks, stones, and hurtful words: Relative effects of various forms of childhood maltreatment. American Journal of Psychiatry, 163(6), 993–1000.
Note: You will access this article from the Walden Library databases.
Working With Children and Adolescents: The Case of Chase (PDF)
Wing, L., Gould, J., & Gillberg, C. (2011). Autism spectrum disorders in the DSM-V: Better or worse than the DSM-IV? Research in Developmental Disabilities, 32, 768–773.
Note: You will access this article from the Walden Library databases.
Wiki Assignment Instructions (PDF)
Kieling, C., Kieling, R. R., Frick, P. J., Rohde, L. A., Moffitt, T., Nigg, J. T., Tannock, R., & Castellanos, F. X. (2010) The age at onset of attention deficit hyperactivity disorder. American Journal of Psychiatry, 167, 14–15.
Note: You will access this article from the Walden Library databases.
Murphy, C., & Taylor, E. (2006). Need to know ADHD. Pulse, 66(34), 38–42.
Note: You will access this article from the Walden Library databases.
Discussion - Week 3
Collapse
Top of Form
Total views: 35 (Your views: 4)
Discussion: Influences on Diagnosis and Outcome
The addition of more Z Codes to the DSM-5 is congruent to how a social worker as a clinician should conduct an assessment and determine the appropriate treatment.
For this Discussion, review The Case of Chase, analyze Chase’s story, and note his original DSM-IV diagnosis. Using the DSM-5 diagnostic criteria, determine Chase’s primary clinical diagnosis. Next, note the changes in the Autism Spectrum disorders, and include the Other Conditions That May Be a Focus of Clinical Attention (ICD-10-CM, Z codes) in your diagnosis. Then identify the potential risk and prognostic factors from both the biological and environmental perspective.
By Day 3
Post your response to the following:
· What should Chase’s diagnosis be according to the DSM-5 criteria?
· What predisposing and risk factors led to the outcome of this case?
· What potential protective factors could have been introduced to address this situation?
· ...
Taking away taboos and assist the people who grief: Living a long, happy and ...eshaasini
grief may encompass various symptoms and can be re- garded as a specific, severe form of sorrow. People being circum- vented by the right people and atmosphere, generally experience less difficulties while going through the different phases that em- brace bereavement compared to people who are not. It suggests that besides approaching the symptoms associated with grief, the social elements to combat grief are rather important too. Although social support is acknowledged to be helpful during (traumatic) grief, little information is available about the type of support and behavior that is considered helpful.
Involvement of Interleukin-6 induced PI3K/Akt/mTor pathway in the regulation ...eshaasini
Hepatocellular Carcinoma (HCC) is an invasive cancer. Alphafoetoprotein (AFP) is a diagnostic marker for HCC directly related to the disease agressivity. Telomerase, is expressed by 90% of HCC. PI3K/Akt/mTOR pathway wich is regulated by IL-6 is activated in the HCC. Our aim is to investigate the effect of IL-6 on AFP and telomerase secretion in HepG2/C3A and PLC/ PRF/5 cell lines.
The Prognostic Model of Differentiation-Related Lncrna Based on Bioinformatic...eshaasini
Differentiation status of glioma cells correlated with prognosis and Tumor-Immune Microenvironment (TIME) in patients with gliomas. This study aimed to identify difDifferentiation status of glioma cells correlated with prognosis and Tumor-Immune Microenvironment (TIME) in patients with gliomas. This study aimed to identify differentiation-related long non-coding RNAs (DRlncRNAs) that can be used to predict the outcome and the response to immunotherapy in patients with gliomas.ferentiation-related long non-coding RNAs (DRlncRNAs) that can be used to predict the outcome and the response to immunotherapy in patients with gliomas.
Involvement of Interleukin-6 induced PI3K/Akt/mTor pathway in the regulation ...eshaasini
Hepatocellular Carcinoma (HCC) is an invasive cancer. Alphafoetoprotein (AFP) is a diagnostic marker for HCC directly related to the disease agressivity. Telomerase, is expressed by 90% of HCC. PI3K/Akt/mTOR pathway wich is regulated by IL-6 is activated in the HCC. Our aim is to investigate the effect of IL-6 on AFP and telomerase secretion in HepG2/C3A and PLC/ PRF/5 cell lines.
Taking away taboos and assist the people who grief: Living a long, happy and ...eshaasini
grief may encompass various symptoms and can be re- garded as a specific, severe form of sorrow. People being circum- vented by the right people and atmosphere, generally experience less difficulties while going through the different phases that em- brace bereavement compared to people who are not. It suggests that besides approaching the symptoms associated with grief, the social elements to combat grief are rather important too. Although social support is acknowledged to be helpful during (traumatic) grief, little information is available about the type of support and behavior that is considered helpful
The ApoB/A-1 ratio is independently associated with subclinical arteriosclero...eshaasini
The ApoB/ApoA-1 (ApoB/A1) ratio is a pre- dictor of atherosclerotic vascular disease. In this study, we aimed to explore whether ApoB/A1 ratio is related to arteriosclerosis parameters, including subclinical atherosclerosis and arterial stiff- ness, in type 2 diabetic patients.
The Meta-Analysis about the Expression and Prognosis of anti-Ro-52, anti-CENP...eshaasini
We constructed the Meta-analysis to evaluate the existing experimental data and obtain the advantages of the three antinuclear antibodies compared with traditional test items using specific data processing methods and evaluated their value in the diagnosis as well as the differential diagnosis of Sjogren's syndrome and systemic sclerosis. During the process of paper collection, we strictly followed the principle of PICOS to screen the literature, trying to include the literature with a large sample size, controversial and influential results which would make the results of this Meta-analysis more valuable. In this study, Revman and Stata software was used for data processing, and the forest map was drawn to analyze the difference in antibody-positive rate, age, and gender distribution, and other factors. At the same time, a funnel plot was used to evaluate the bias of literature results.
Types of Breast Tissues
•
Fibrous
•
Fibro glandular
•
Adipose (Fatty)
What is Tomosynthesis?
•
Is a 3 dimensional projection
•
Reduces overlapping tissue seen with 2D only
•
15 projections are taken with each combo exposure (7.5) (-7.5)
•
With an average breast (18*24) 3D dose is 1.34, combo is 2.56 Milligrey. (3 Milligrey FDA) (2D is 1.2)
Systematic Review and Meta-Analysis of the Association between β-Blocker Use ...eshaasini
β-blockers are drugs frequently prescribed for various indications in cardiology and for which anticancer properties have been suggested. We aimed to evaluate the association between the use of β-blockers and survival of women with OC.
1.2. Methods: A systematic literature search of relevant databases through September 2020 was conducted to identify studies assessing the association between β-blockers use and prognostic in women with OC. The inverse variance weighting method with random-effects model was used to calculate pooled hazard ratios (HR) and 95% confidence intervals (95% CI). We assessed the risk of immortal time bias (ITB) and the quality of the studies with the Newcastle–Ottawa scale. Subanalyses were performed based on quality scores and the risk for ITB.
IRF5 Promotes the Progression of Hepatocellular Carcinoma and is Regulated by...eshaasini
The IRF family of proteins involves in the tumor progression. However, but the functions of IRF5 in the tumorigenesis are largely unknown. Here, IRF5 was found to be up-regulated in hepatocellular carcinoma (HCC). Interfering with IRF5 inhibited the growth and tumorigenic ability of HCC cells. When studying the molecular mechanism, it was found that TRIM35 interacted with IRF5, promoting the ubiquitination and degradation of IRF5. In the clinical specimens of HCC, TRIM35 was negatively correlated with the expression of IRF5. These observations reveal the oncogenic function of IRF5 in the progression of HCC, suggesting that IRF5 is a promising target for the therapy of HCC.
Benefit of Serum-Thymidine Kinase 1 Concentration for Risk Assessment from Ga...eshaasini
Human Thymidine kinase 1 (hTK1), a key enzyme involved in the DNA synthesis during S-phase of the cell cycle and upregulation of cell proliferation, thus it is reliable tumor proliferating biomarker for assessment of tumor proliferation rate in serum and in tissue in oncology. This meta-analysis is investigation whether the serum TK1 concentration(STK1p)based on hTK1-IgY-polyclonal-antibody can provide a benefit for risk assessment from gastric neoplasm progression to gastric carcinoma (GC) as well as for evaluation of treatment effect in GC.
Prognosis of Invasive Micropapillary Carcinoma of the Breast Analyzed by Usin...eshaasini
Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database
Relevant Features and Treatment Options of DLBCL Patients with Late Relapse A...eshaasini
Diffuse large B cell lymphoma (DLBCL) represents the most common type of non-Hodgkin lymphoma (NHL) and it is a potentially curable disease with the current standard of care of immunochemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) especially the addition of rituximab.
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomaeshaasini
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers
Clinic Correlation and Prognostic Value of P4HB and GRP78 Expression in Gastr...eshaasini
Prolyl 4-hydroxylase, beta polypeptide (P4HB) and Glucose‑regulated protein 78 (GRP78) represent for poor prognosis of various cancers, while rare research investigate correlation of them. This study aimed to explore correlation and prognostic value of them in gastric cancer
Combined Analysis of Micro RNA and Proteomic Profiles and Interactions in Pat...eshaasini
The Liquid Mass System(LMS) includes an Easy nLC1000 (Thermo Fisher) coupled ultra-high resolution mass spectrometer Orbitrap Fusion Lumos (Thermo Fisher) with a Thermo Fisher electrospray source. Each injection is sent to a preset column (Acclaim PepMap C18, 100 μm x 2 cm, Thermo Scientific) for adsorption at a flow rate of 3 L/min. The sample is then sent to the analyzer column (Acclaim PepMap C18, 75 μm x 15 cm, Thermo Scientific) for separation.
Το assess CureCancer’s feasibility and patients’ and Oncologists’ satisfaction. CureCancer is a patient-centric/driven platform, which enables patients to self-create their profile, report symptoms, and communicate with physicians.
1.2. Methods: Patients from 9 Centers were asked to register at CureCancer, upload their data and complete a questionnaire on demographics, disease and treatment characteristics, and their satisfaction.
Skeletal muscle channelopathy are rare heterogeneous episodic disorders with marked genotypic and phenotypic variability resulting in periodic paralysis, and falls in young people which often misdiagnosed or undiagnosed due to its rarity, often the symptoms are miscommunicated to the treating phycision due to its episodic nature and not uncommonly physical examination by the time patient attend the clinic or hospital will be unremarkable apart from periodic muscle paralysis where patient will presented to ED with flaccid weakness,
Prevalence of Hpv Infection in the Lekoumou and Niari Departments (Congo Braz...eshaasini
We carried out a descriptive and cross-sectional study over a period of 7 months from January to July 2019 in the department of Lekoumou. 100 women ranging in age from 16 to 73 years old. The variables studied were as follows: age, marital status, level of education, risk factors for the onset of HPV infection, age at first sexual intercourse, number of sexual partners, parity, gesture. The multivariate analysis was done between age, number of level of instruction, parity, age of first sexual intercourse and number of sexual Partners. The statistical analysis and the data processing were carried out by the Excel 2016 software and the graph pad prism version 5 software. The statistical test used was the chi-square test.
The Use of the Infrared Laser Therapy of 890-910 NM for the Treatment Breast ...eshaasini
The experimental studies were conducted with Walker's carcinosarcoma n256 (from the U.S.A. bank), cancer of the mammary gland (RMK-1). Spontaneous –mice with mammary glands cancer (type B). The tasks were as follows: to study the effect of different doses LLLT on the growth of experimental tumors. Evaluation of the effectiveness by applying LLLT in combination with various chemotherapeutic agents
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
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Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
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2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
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Parallel Lives: A Case Series of Three Boys with Persistent Reactive Attachment Disorder
1. Parallel Lives: A Case Series of Three Boys with Persistent Reac-
tive Attachment Disorder
Nelson R1*
, Chadwick G1
, Bruce M2
and Minnis H1
1
University of Glasgow, Glasgow, UK
2
NHS Lothian, Lothian, Scotland
Volume 1 Issue 4- 2018
Received Date: 10 Oct 2018
Accepted Date: 30 Oct 2018
Published Date: 06 Nov 2018
1. Abstract
Reactive Attachment Disorder (RAD), only diagnosed in the context of early abuse and neglect, is
characterised by failure to seek and accept comfort. It involves lack of activation of the - develop-
mentally essential - attachment system, hence has profound developmental disadvantages. RAD
usually resolves quickly in the context of adequate care and has been assumed never to persist
once the child is in a nurturing placement. We challenge this existing paradigm by presenting
three cases of children whose RAD symptoms have persisted despite living in placements judged,
by both social and child health services, to be of good quality. All three boys met DSM 5 criteria
for RAD in late childhood/early adolescence and had had stable RAD symptoms since before age
5. In the absence of longitudinal data, except from unusual institutionalised samples, it has been
impossible to evidence RAD beyond pre-school and virtually nothing is known about factors pre-
dicting its stability. This case series and systematic review provides the first opportunity to generate
testable hypotheses about environmental circumstances and coexisting symptomatology that may
influence RAD trajectories. As predicted more than a decade ago, persistence of RAD has had pro-
foundly negative developmental implications for the children and an extremely detrimental effect
on family life and relationships. Recognition of RAD symptoms is challenging because symptoms
are classically internalising and therefore easy to miss. This case series will allow paediatricians to
better recognise the subtle symptoms of RAD in order to improve their care of these children and
their families.
Annals of Clinical and Medical
Case Reports
Citation: Nelson R, Chadwick G, Bruce M and Minnis H, Parallel Lives: A Case Series of Three Boys with
Persistent Reactive Attachment Disorder. Annals of Clinical and Medical Case Reports. 2018; 1(4): 1-5.
United Prime Publications: http://unitedprimepub.com
*Corresponding Author (s): Rebecca Nelson, ACE Centre, Academic CAMHS, Level 4 West
Ambulatory Care Hospital, Glasgow, G3 8SJ, University of Glasgow, UK, E-mail: Rebecca.
nelson@glasgow.ac.uk
Case Report
2. Abbreviations
ADHD - Attention-Deficit/Hyperactivity Disorder
ASD - Autism Spectrum Disorder
CAMHS - Child and Adolescent Mental Health Services
DSED - Disinhibited Social Engagement Disorder
DSM-V - Diagnostic and Statistical Manual version 5
PTSD - Post-traumatic Stress Disorder
RAD - Reactive Attachment Disorder
WASI - Weschler Abbreviated Scale of Intelligence
WISC - Weschler Intelligence Scale for Children
WPPSI - Weschler Pre-school and Primary Scale of Intelligence
3. Introduction
Reactive Attachment Disorder (RAD) represents a closing down
of the attachment system [1-3], therefore is associated with pro-
found developmental disadvantages [1, 5, 6]. Because of its rar-
ity, large scale longitudinal studies are impossible and persistence
beyond early childhood has never been proven out-with institu-
tionalised populations [7].
For rare diseases, the case series can provide the most robust
methodology available [8]. We present three cases, following
CARE guidelines [8], all of whom experienced severe maltreat-
ment in early life and were then placed, between age three and
five, with adoptive or foster parents who had undergone stringent
background checks and had ongoing support. All boys and their
families gave informed consent to the inclusion of their case re-
ports. Names have been changed to protect identity.
3. 4.1. Case 1, John
When assessed at age 9, RAD symptoms were noted since age 4.
In addition, John was also diagnosed with Post-traumatic stress
disorder (PTSD), Conduct Disorder and Attention deficit/Hy-
peractivity Disorder (ADHD). He had intensive relationship-fo-
cused psychotherapeutic treatment, with his adoptive mother, but
symptoms persisted.
4.2. Case 2, Brian
When assessed at age 12, RAD symptoms were noted since age
3.At age thirteen, Brian was moved to a small residential unit
where he continued to have problems seeking and accepting
comfort from his keyworkers and his parents, who continued to
visit. At age fifteen he continued to demonstrate RAD symptoms
and difficult behaviour and was moved into a residential place-
ment where he was the only child, and received intensive one to
one care from a small team of staff. Involvement with his parents
increased resulting in leading to weekend home passes. By age
sixteen, when last assessed, Brian was no longer violent, no lon-
ger met criteria for RAD and was being investigated for possible
ADHD.
4.3. Case 3, Andrew
When assessed at age 14, RAD symptoms were noted since age 4
years and the foster placement was in jeopardy. Ongoing health
concerns relating to his premature birth included mild left-sided
hemiplegia, talipes and partial sightedness. At first assessment, his
foster carer had never considered whether or how Andrew had
sought comfort as a young child, but described how he would
stand silently by while physical care was provided to other foster
children, all of whom had severe or profound physical and learn-
ing disabilities.
After two sessions of psychotherapy in which the therapist en-
couraged both Andrew and his foster mother to notice and re-
spond to each other’s signals, symptoms improved markedly.
None of the boys had symptoms of Autism Spectrum Disorder:
during assessment, social communication was typical apart from
emotional withdrawal and none had repetitive or stereotyped in-
terests.
5. Family Perspective
Parents took part in qualitative interviews to explore the impact
of RAD symptoms on the family. Transcripts were read indepen-
dently by RN and GC and three common themes were extracted
across families [13].
5.1. Family strain
High levels of stress characterised all aspects of family life. Bur-
densome child behaviours included lack of understanding of
social cues, violence and eliciting negative attention. There was
emotional separation between the child and the rest of the family.
This was described, by John’s mother, as living “parallel lives; one
life with my husband, biological son and dog, and the other with
John.”
5.2. Frustration
A key frustration for families was lack of understanding of the
child’s emotions and the child’s emotional unresponsiveness and
abnormal interactions. Another frustration was the significant
delay in identification of the problem and the associated lack of
support, resulting in years of isolated suffering.
Resentment: Feelings of resentment were evident in all three fami-
lies due to the significant strain that RAD had put on their family
and their relationships. Both adoptive couples had experienced
marital difficulties ascribed to the burden of their child’s prob-
lems.
6. Discussion
Persistent RAD is rare: only a handful of cases were diagnosed by
HM in over 20 years of clinical practice. All had associated devel-
opmental/neurodevelopmental problems, as previously described
[5, 6, 14, 15]. All placements had been threatened with break-
down. John has persistent symptoms despite treatment, Andrew
had rapid symptom resolution after psychotherapy in adolescence
and Brian had symptom resolution after intensive one-to-one
residential support. This provides the new insights that persistent
RAD, while rare, threatens family life - but treatment is possible,
even in adolescence.
Our systematic literature review found individual and contextual
factors to be associated with RAD. Contextual factors include
institutionalization [16], quality of care giving in the institution
[16-19], harsh parenting, parental negativity [20], parental mental
health problems [21, 22] and longer exposure to the maltreating
pre-care environment [23]. Individual factors include male gen-
der [22], reduced grey matter volume [24], lower cognitive ability
[25], dopaminergic dysfunction [18, 26]; and genetic factors, par-
ticularly for males [21]. RAD is associated with depressive symp-
toms [18], social and emotional difficulties [18, 27], functional
impairment [17, 18, 22], behavioural and conduct problems [22,
27, 28], hyperactivity [20, 28]; internalising symptoms [17, 28,
29], externalising symptoms [28], stereotypies [17], help seeking
from services [22], callous-unemotional traits [27] and symptoms
of Disinhibited Social Engagement Disorder (DSED) [17, 18, 22,
27]. Studies were of moderate to high quality, but findings were
not always consistent across studies, possibly due to a lack of con-
sistent measures for RAD, confounding, differing sample types
and modest sample sizes.
United Prime Publications: http://unitedprimepub.com 3
Volume 1 Issue 4 -2018 Case Report
4. To conclude, in rare cases RAD can persist despite years of nur-
turing care. Symptoms are easy to miss but are associated with se-
vere family stress and other developmental problems. Paediatri-
cians should always consider RAD when assessing children with
a maltreatment history.
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5. 26. Tomoda A. Preliminary Evidence for Impaired Brain Activity of
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Volume 1 Issue 4 -2018 Case Report