Tuberculosis (TB) has been declared as a health emergency due to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectively controlling TB. Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors.
Drug resistance and multiple drug therapy-by Dr.Jibachha SahDr. Jibachha Sah
Drug resistance and multiple drug therapy is lecturer notes on: Veterinary Pharmacology & Toxicology(Chemotherapy) B.V.Sc & A.H. Seventh semester students.
Protein targets in Mycobacterium tuberculosis and their inhibitors for therap...Souparnika Sreelatha
Advancement in the area of anti-tubercular drug development has been full-fledged, yet, a very less number of
drug molecules have reached phase II clinical trials, and therefore “End-TB” is still a global challenge. Inhibitors
to specific metabolic pathways of Mycobacterium tuberculosis (Mtb) gain importance in strategizing antituberculosis
drug discovery. The lead compounds that target DNA replication, protein synthesis, cell wall
biosynthesis, bacterial virulence and energy metabolism are emerging as potential chemotherapeutic options
against Mtb growth and survival within the host. In recent times, the in silico approaches have become most
promising tools in the identification of suitable inhibitors for specific protein targets of Mtb. An update in the
fundamental understanding of these inhibitors and the mechanism of interaction may bring hope to future
perspectives in novel drug development and delivery approaches. This review provides a collective impression of
the small molecules with potential antimycobacterial activities and their target pathways in Mtb such as cell wall
biosynthesis, DNA replication, transcription and translation, efflux pumps, antivirulence pathways and general
metabolism. The mechanism of interaction of specific inhibitor with their respective protein targets has been
discussed. The comprehensive knowledge of such an impactful area of research would essentially reflect in the
discovery of novel drug molecules and effective delivery approaches. This narrative review encompasses the
knowledge of emerging targets and promising chemical inhibitors that could potentially translate in to the anti-
TB-drug discovery.
Relative Properties and Relative Potency of Various Hydrazide Compounds That ...IOSRJPBS
The molecular properties of compounds expressing growth inhibition of Mycobacterium tuberculosis are determined and examined for underlying relationships by pattern recognition methods. Pattern recognition methods such as hierarchical cluster analysis will show relationships between compounds. Descriptive statistical analysis of molecular properties reveal commonality among bacteriostatic compounds. Outliers within any category of descriptor is identified by Grubb’s test. Potency of growth inhibition measured as MIC (minimum inhibitory concentration) after in vitro evaluation will be compared and analyzed. Structure moieties and their effect on activity is identified. All compounds analyzed showed substantial growth inhibition of Mycobacterium tuberculosis, having MIC values ranging from 16.7 µgrams/milliliter to 65.9 µgrams/milliliter (isoniazid MIC at 14.7 µgrams/milliliter). Ranges in values of Log P, number of atoms, and molecular weight were, respectively: -1.89 to 1.10, 11 to 25 (isoniazid at 10), and 150.18 grams/mole to 345.38 grams/mole (isoniazid at 137.14). All eight compounds and isoniazid showed favorable bioactivity within six categories of measureable bioactivity scores. The molecular properties of eight compounds and isoniazid varied, however, remained favorable in drug-likeness with zero violations of the Rule of 5. Interrelationships of the descriptors were revealed by statistical analysi
Antitumor applications of nano-traditional Chinese medicineLucyPi1
An article by Deng et al. [1] that was first published in ACS Nano in 2019 revealed that nanoparticles extracted from cuttlefish ink (CINPs) could inhibit tumor growth by synergizing immunotherapy and photothermal therapy. The researchers found that these CINPs, which had significant antitumor efficacy, could effectively reprogram tumor-associated macrophages (TAMs) from the immune-suppressive M2-like phenotype to the antitumor M1-like phenotype.
Drug resistance and multiple drug therapy-by Dr.Jibachha SahDr. Jibachha Sah
Drug resistance and multiple drug therapy is lecturer notes on: Veterinary Pharmacology & Toxicology(Chemotherapy) B.V.Sc & A.H. Seventh semester students.
Protein targets in Mycobacterium tuberculosis and their inhibitors for therap...Souparnika Sreelatha
Advancement in the area of anti-tubercular drug development has been full-fledged, yet, a very less number of
drug molecules have reached phase II clinical trials, and therefore “End-TB” is still a global challenge. Inhibitors
to specific metabolic pathways of Mycobacterium tuberculosis (Mtb) gain importance in strategizing antituberculosis
drug discovery. The lead compounds that target DNA replication, protein synthesis, cell wall
biosynthesis, bacterial virulence and energy metabolism are emerging as potential chemotherapeutic options
against Mtb growth and survival within the host. In recent times, the in silico approaches have become most
promising tools in the identification of suitable inhibitors for specific protein targets of Mtb. An update in the
fundamental understanding of these inhibitors and the mechanism of interaction may bring hope to future
perspectives in novel drug development and delivery approaches. This review provides a collective impression of
the small molecules with potential antimycobacterial activities and their target pathways in Mtb such as cell wall
biosynthesis, DNA replication, transcription and translation, efflux pumps, antivirulence pathways and general
metabolism. The mechanism of interaction of specific inhibitor with their respective protein targets has been
discussed. The comprehensive knowledge of such an impactful area of research would essentially reflect in the
discovery of novel drug molecules and effective delivery approaches. This narrative review encompasses the
knowledge of emerging targets and promising chemical inhibitors that could potentially translate in to the anti-
TB-drug discovery.
Relative Properties and Relative Potency of Various Hydrazide Compounds That ...IOSRJPBS
The molecular properties of compounds expressing growth inhibition of Mycobacterium tuberculosis are determined and examined for underlying relationships by pattern recognition methods. Pattern recognition methods such as hierarchical cluster analysis will show relationships between compounds. Descriptive statistical analysis of molecular properties reveal commonality among bacteriostatic compounds. Outliers within any category of descriptor is identified by Grubb’s test. Potency of growth inhibition measured as MIC (minimum inhibitory concentration) after in vitro evaluation will be compared and analyzed. Structure moieties and their effect on activity is identified. All compounds analyzed showed substantial growth inhibition of Mycobacterium tuberculosis, having MIC values ranging from 16.7 µgrams/milliliter to 65.9 µgrams/milliliter (isoniazid MIC at 14.7 µgrams/milliliter). Ranges in values of Log P, number of atoms, and molecular weight were, respectively: -1.89 to 1.10, 11 to 25 (isoniazid at 10), and 150.18 grams/mole to 345.38 grams/mole (isoniazid at 137.14). All eight compounds and isoniazid showed favorable bioactivity within six categories of measureable bioactivity scores. The molecular properties of eight compounds and isoniazid varied, however, remained favorable in drug-likeness with zero violations of the Rule of 5. Interrelationships of the descriptors were revealed by statistical analysi
Antitumor applications of nano-traditional Chinese medicineLucyPi1
An article by Deng et al. [1] that was first published in ACS Nano in 2019 revealed that nanoparticles extracted from cuttlefish ink (CINPs) could inhibit tumor growth by synergizing immunotherapy and photothermal therapy. The researchers found that these CINPs, which had significant antitumor efficacy, could effectively reprogram tumor-associated macrophages (TAMs) from the immune-suppressive M2-like phenotype to the antitumor M1-like phenotype.
An Impact of Biofield Treatment: Antimycobacterial Susceptibility Potential U...albertdivis
The aim was to evaluate the impact of biofield treatment modality on mycobacterial strains in relation to antimycobacterials susceptibility. Mycobacterial sensitivity was analysed using 12 B BACTEC vials on the BACTEC 460 TB machine in 39 lab isolates (sputum samples) from stored stock cultures.
Toxicological advances of traditional medicine in 2019LucyPi1
Abstract There were many researches concerning toxicology of traditional medicine (TM) and active natural products during the past 12 months. This annual toxicology review summarized target organs of TM like liver, kidney and heart. Safety medication of TM has been concerned to different kinds of people, including infants, children, pregnancy and the postnatal period. Besides rodents, zebrafish embryoes have been regarded as common models to evaluate the safety of TM. New technologies in toxicology focus on rapidly screening and identification of toxins in TM. Multispectral optoacoustic tomography imaging the precise location of TM-induced liver injury with 3D information and integrating serum exosomal microRNA and liver microRNA profiles are used to explain the mechanism of TM-induced hepatotoxicity. Taken together, study on the toxicity mechanism of other target organs, drug safety in elders, new models and methods should be paid attention to in the prevention of TM toxicology in the future.
DRUG RESISTANT TUBERCULOSIS,DIAGNOSIS AND TREATMENTDr.Lalit Kumar
VERY USEFUL PRESENTATION TO LEARN THE BASICS OF MDR/XDR-TB AS WELL AS THEIR MANAGEMENT.MOST OF THE CONTENT ARE BASED ON THE RNTCP GUIDELINES AND WHO 2013 UPDATE....
Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended...Ratnakaram Venkata Nadh
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good
to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT
assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in
vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole
nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine
kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have
been discussed
Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended...Ratnakaram Venkata Nadh
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good
to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT
assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in
vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole
nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine
kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have
been discussed
An Overview of Chemotherapy of Tuberculosis: A ReviewJing Zang
Tuberculosis (TB) is a major global health threat in the current Era. The emergence of human immunodeficiency virus (HIV) and also multi drug resistant (MDR) and extremely drug resistant (XDR)-TB posses a vital challenge to the control of the disease. This literature review provides a brief discussion of existing drugs and emerging drug targets, and also of the advantages of incorporating modern drug delivery systems and immune modulators in order to improve the existing treatment regimen in terms of better efficacy, reduced drug administration frequency, shortened period of treatment and reduced drug related toxicity. The investigation for a new drug target is essential to continue the battle against MDR and XDR-TB. However, owing to the enormous cost and time involved in new drug development, improvement of the existing treatment regimen is seen to be a valid alternative.
Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact...Mahendra Kumar Trivedi
The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy.Methods: The study was performed in two groups (control and treatment) of each antibiotic. The control groups remained as untreated, and biofield treatment was given to treatment groups.
Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact...albertdivis
The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy.
Paper publications details of all Staff-2019-20(Other).xlsx - M R Talware.pdfaissmsblogs
Video Analytics applications like security and
surveillance face a critical problem of person re-identification
abbreviated as re-ID. The last decade witnessed the emergence of
large-scale datasets and deep learning methods to use these huge
data volumes. Most current re-ID methods are classified into
either image-based or video-based re-ID
The input a.c. the signal is applied across the base-emitter terminals of the transistor & output is taken across collector-emitter terminals of the transistor.
An Impact of Biofield Treatment: Antimycobacterial Susceptibility Potential U...albertdivis
The aim was to evaluate the impact of biofield treatment modality on mycobacterial strains in relation to antimycobacterials susceptibility. Mycobacterial sensitivity was analysed using 12 B BACTEC vials on the BACTEC 460 TB machine in 39 lab isolates (sputum samples) from stored stock cultures.
Toxicological advances of traditional medicine in 2019LucyPi1
Abstract There were many researches concerning toxicology of traditional medicine (TM) and active natural products during the past 12 months. This annual toxicology review summarized target organs of TM like liver, kidney and heart. Safety medication of TM has been concerned to different kinds of people, including infants, children, pregnancy and the postnatal period. Besides rodents, zebrafish embryoes have been regarded as common models to evaluate the safety of TM. New technologies in toxicology focus on rapidly screening and identification of toxins in TM. Multispectral optoacoustic tomography imaging the precise location of TM-induced liver injury with 3D information and integrating serum exosomal microRNA and liver microRNA profiles are used to explain the mechanism of TM-induced hepatotoxicity. Taken together, study on the toxicity mechanism of other target organs, drug safety in elders, new models and methods should be paid attention to in the prevention of TM toxicology in the future.
DRUG RESISTANT TUBERCULOSIS,DIAGNOSIS AND TREATMENTDr.Lalit Kumar
VERY USEFUL PRESENTATION TO LEARN THE BASICS OF MDR/XDR-TB AS WELL AS THEIR MANAGEMENT.MOST OF THE CONTENT ARE BASED ON THE RNTCP GUIDELINES AND WHO 2013 UPDATE....
Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended...Ratnakaram Venkata Nadh
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good
to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT
assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in
vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole
nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine
kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have
been discussed
Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended...Ratnakaram Venkata Nadh
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good
to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT
assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in
vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole
nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine
kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have
been discussed
An Overview of Chemotherapy of Tuberculosis: A ReviewJing Zang
Tuberculosis (TB) is a major global health threat in the current Era. The emergence of human immunodeficiency virus (HIV) and also multi drug resistant (MDR) and extremely drug resistant (XDR)-TB posses a vital challenge to the control of the disease. This literature review provides a brief discussion of existing drugs and emerging drug targets, and also of the advantages of incorporating modern drug delivery systems and immune modulators in order to improve the existing treatment regimen in terms of better efficacy, reduced drug administration frequency, shortened period of treatment and reduced drug related toxicity. The investigation for a new drug target is essential to continue the battle against MDR and XDR-TB. However, owing to the enormous cost and time involved in new drug development, improvement of the existing treatment regimen is seen to be a valid alternative.
Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact...Mahendra Kumar Trivedi
The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy.Methods: The study was performed in two groups (control and treatment) of each antibiotic. The control groups remained as untreated, and biofield treatment was given to treatment groups.
Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact...albertdivis
The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy.
Paper publications details of all Staff-2019-20(Other).xlsx - M R Talware.pdfaissmsblogs
Video Analytics applications like security and
surveillance face a critical problem of person re-identification
abbreviated as re-ID. The last decade witnessed the emergence of
large-scale datasets and deep learning methods to use these huge
data volumes. Most current re-ID methods are classified into
either image-based or video-based re-ID
The input a.c. the signal is applied across the base-emitter terminals of the transistor & output is taken across collector-emitter terminals of the transistor.
The health-care system has considerably improved over time. However, with today's technology, it is
possible to link medical services with internet systems to make the lives of patients easier. Our software,
LifeCare will assist a patient in locating a specialized doctor based on their requirements, availability,
distance, and consulting fees. .
Mesua ferrea Linn. is used traditionally in India and South East Asian countries as an antiseptic, antidote
and a brain tonic. Recent pharmacological studies on the plant have highlighted M. ferrea to be a rich
source of secondary metabolites, with proven therapeutic applications
Efavirenz is a key drug used for treatment of Acquired Immuno Deficiency Syndrome (AIDS). It produces burning mouth syndrome which results in under dosing and plasma level fluctuations. Efavirenz also has poor solubility and resulting poor bioavailability. The present research employed self nano emulsifying drug delivery system (SNEDDS) to provide dual benefits of taste masking and bioavailability enhancement.
With the rapid development of smartphone industry,
various positioning-enabled sensors such as GPS receivers,
accelerometers, gyroscopes, digital compasses, cameras, WiFi and Bluetooth have been built in smartphones for
communication, entertainment and location-based services.
Smartphone users can get their locations fixed according to
the function of GPS receiver.
With the rapid development of
smartphone industry, various positioning-enabled
sensors such as GPS receivers, accelerometers,
gyroscopes, digital compasses, cameras, Wi-Fi and
Bluetooth have been built in smartphones for
communication, entertainment and location-based
services. Smartphone users can get their locations
fixed according to the function of GPS receiver.
Advances in information and communication technologies have led to the emergence of Internet of Things
(IoT). In the modern health care environment, the usage of IoT technologies brings convenience to physicians and
patients since they are applied to various medical areas (such as real-time monitoring, patient information and healthcare
management). The body sensor network (BSN) technology is one of the core technologies of IoT developments in
healthcare system, where a patient can be monitored using a collection of tiny-powered and lightweight wireless sensor
nodes
In our every day’s life, safety and time is a major
issue. LPG is highly flammable and if not used carefully they
can be dangerous and can be sufficient to cause death. Even
fire accidents occur due to leakage of gas. LPG is an
odourless gas, as a result leakage detection of this gas cannot
be detected by a person via smell
E-Learning is transfer of skills and knowledge by
the computer and network enabled. It includes out of & in
classroom educational experiences with the help of
technology. Early E-Learning systems are based on computer
based learning& training often which attempted to replicate
autocratic teaching styles where the role of the e-Learning
systems was to transfer knowledge, as opposed to this
systems developed later which were based on computer
supportive collaborative learning which encouraged the
shared development of knowledge.
The objective of emotion recognition is
identifying emotions of a human. The emotion can be
captured either from face or from verbal communication. In
this work we focus on identifying human emotion from
facial expressions. Facial emotion recognition is one of the
useful task and can be used as a base for many real-time
applications.
As the music has the high impact on the human
brain activity the recent studies has proved that human
respond and react to music and has high impact on human
body. The average human being listens to music that they
love for four hours in a day based on their mood and
interest.
Many security primitives are supported hard
mathematical problems. Passwords remain the foremost
widely used authentication method despite their well-known
security weaknesses. CAPTCHA authentication is clearly a
practical problem.
A Web Link (Teacher-student portal) project that
acts as an online portal between students and the Teacher.
The system is designed for a particular branch such as
diploma. Teacher can ad Notes, Assignment, e-book.
This paper aims to provide an overview of the
contents and design of the all newspapers. Majority of the
newspapers use Blog, RSS and Facebook to connect with
their readers. An online newspaper service providing project.
In this software system users may register as users to read
newspapers online. Once they register they may pay via
dummy credit cards and get access to reading newspapers
online for a month
“Helpdroid” we inspire by movie-Prema the
project we provide the accident detection in any place. We
provide the help to injuries peoples. When the car or bike
crash together then the GPS and GMS with the crash sensor
send the digital signal and send the message and call to near
police station, ambulance and there related persons.
Digital image security and integrity are the top
prioritized issue in today’s information World. Watermarking
is a famous technique that is used for copyright protection and
authentication. Watermark Should be robust and
imperceptible.
Mobile security is one of the most important
aspect when it comes to keeping our data secure from any
external attack like phishing, data hacking and many other
attacks that can have very disastrous effects that may also
lead to social disturbance, as in one’s private data can be
made public by the attackers.
Mobile applications are software applications
which are designed to run on mobile smart phones, &
tablets, and other mobile electronic devices, during this
generation of rapid technological advances, these
applications became one altogether the predominant tools
we use daily both in our personal furthermore as
professional lives
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
1. Researchpaper of Dr. Trupti Chitre
Title: ExploringPyrimidinePharmacophoreasThymidineMonophosphate Kinase Inhibitorsfor
AntitubercularActivity:A Review
Authors: Trupti SameerChitre*,Kalyani DhirendraAsgaonkar,Shital Manoj Patil , Muthu
KumaradossKathiravanandSubhashBalkrishnaPadhye
Journal Details: CurrentTopicsin Medicinal Chemistry,2016, 16, 3211-3223
Publisher: BenthamScience Publishers
Description:
Tuberculosis(TB) hasbeen declaredasahealthemergencydue to emergence of resistant strains of
M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally
drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the
current situation necessitates developing new antitubercular agents acting on novel targets for
effectivelycontrollingTB.Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target,
which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and
computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs
reported as TMPKmt inhibitors.
Photographs :
