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WWW.OXSTEM.CO.UK
AN INTRODUCTION TO
OXSTEM
NOVEL APPROACHES TO CELL THERAPIES AND REGENERATIVE MEDICINE
MARCH 2017
WWW.OXSTEM.CO.UK
AGENDA
1.  OUR MISSION
2.  OUR GROUP
3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4.  THE “STEMS”
2
WWW.OXSTEM.CO.UK
OXSTEM
•  OXSTEM IS A DEVELOPER OF CELL PROGRAMMING THERAPIES, WORKING IN CLOSE COLLABORATION
WITH THE UNIVERSITY OF OXFORD.
•  OXSTEM’S UNIQUE APPROACH TO REGENERATIVE MEDICINE WILL:
Ø  DELIVER SMALL MOLECULE THERAPEUTICS THAT ACTIVATE REPAIR MECHANISMS THAT ALREADY
EXIST WITHIN THE BODY
Ø  EXPLOIT A DEEP UNDERSTANDING OF THE CHEMICAL UNDERPINNINGS OF STEM AND
PROGENITOR CELL FUNCTION AND DIFFERENTIATION
Ø  GENERATE A COLLECTION OF DRUG CANDIDATES TO AWAKEN ENDOGENOUS CELLS TO REPAIR
TISSUES AFFECTED BY DISEASE OR INJURY
•  TO BETTER HUMAN HEALTH BY DIRECTLY IMPACTING THE QUALITY AND DURATION OF LIFE
•  OXSTEM WILL REVOLUTIONIZE THE REGENERATIVE MEDICINE FIELD BY DEVELOPING UNIQUE CELL
PROGRAMMING THERAPIES TO TREAT DEGENERATIVE DISEASES WITH HIGH UNMET NEED
WHAT WE DO
OUR PURPOSE
3
WWW.OXSTEM.CO.UK
AGENDA
1.  OUR MISSION
2.  OUR GROUP
3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4.  THE “STEMS”
4
WWW.OXSTEM.CO.UK
PROFESSOR STEVE DAVIES
WAYNFLETE PROFESSOR OF CHEMISTRY
OXFORD UNIVERSITY
PROFESSOR ANGELA RUSSELL
ASSOC. PROFESSOR OF CHEMISTRY & PHARMACOLOGY
OXFORD UNIVERSITY
PROFESSOR DAME KAY DAVIES
DR LEE’S PROFESSOR OF ANATOMY
OXFORD UNIVERSITY
DR MICHAEL STEIN
CHAIRMAN & CHIEF EXECUTIVE OFFICER
RAYMOND SPENCER, CFA
CHIEF FINANCIAL OFFICER
EXECUTIVE FOUNDERS
SCIENTIFIC FOUNDERS
FOUNDING TEAM
5
WWW.OXSTEM.CO.UK
“SPIN-IN”
RAISED £16.9M IN MAY 2016
ACUTE MYELOID LEUKEMIA AND
MYELO-DYSPLASTIC SYNDROME
ALZHEIMER’S DISEASE
TRAUMATIC BRAIN INJURY
AGE RELATED
MACULAR DEGENERATION
MYOCARDIAL INFARCTION /
HEART FAILURE
“OxStem 4D”
3D STEM CELL SUSPENSION
CULTURE
GROUP STRUCTURE
ALL >90% OWNED SUBSIDIARIES
SPIN-OUT
6
WWW.OXSTEM.CO.UK
INITIAL FUNDRAISE AND EARLY SUCCESS
TIMELINE FOR YEAR 2016
7
MAY 2016: £16.9M
($20M) RAISED, A
RECORD FOR
OXFORD UNIVERSITY
SPIN-OUTS
MAY 2016:
ESTABLISHMENT OF
OXSTEM
ONCOLOGY AND
LAUNCH OF
OXSTEM 4D
OCTOBER 2016:
WINNER OF THE
NATIONAL BEST
BIOTECHNOLOGY
START-UP AT THE
OBN AWARDS,
UK
DECEMBER 2016:
PROOF-OF-
PRINCIPLE
DEMONSTRATED.
FIRST EVER
SMALL-MOLECULE
DEMONSTRATING
CELL-TO-WHOLE
ANIMAL EFFICACY
IN NEUROGENESIS
AUGUST 2016:
ESTABLISHMENT
OF OXSTEM
NEURO AND
OXSTEM OCULAR
NOVEMBER 2016:
ESTABLISHMENT
OF OXSTEM
CARDIO
2016
WWW.OXSTEM.CO.UK
AGENDA
1.  OUR MISSION
2.  OUR GROUP
3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4.  THE “STEMS”
8
WWW.OXSTEM.CO.UK
PLAGUED WITH TOLERANCE ISSUES AND REJECTION; REQUIRE SPECIALIST FACILITIES FOR THERAPEUTIC DELIVERY
INTRODUCTION TO CELL THERAPY AND REGENERATIVE
MEDICINE
CURRENT THERAPEUTIC PARADIGMS
TISSUE ENGINEERING THERAPY
VIA IMPLANTATION
CELL TRANSPLANTATION THERAPY
VIA IMPLANTATION
SOURCE: CULME-SEYMOUR ET AL., REGEN. MED. 2012
9
WWW.OXSTEM.CO.UK
DRUG HERE
TO INFLUENCE PROGRESS
DRUG HERE
TO INFLUENCE PROGRESS
NATURALLY OCCURRING
COMMITTED ADULT STEM CELLS
NATURALLY OCCURRING
ADULT STEM CELLS
FUNCTIONAL CELLS FOR
REGENERATIVE TREATMENT
NATURALLY OCCURRING
ADULT STEM CELLS
OXSTEM’S APPROACH: PROGRAMMABLE CELL CHEMISTRY
10
WWW.OXSTEM.CO.UK
ACTIVATION OF RESIDENT CELLS IN VIVO TO ALLEVIATE DISEASE
•  SALAMANDERS, AND OTHER AMPHIBIANS, REGENERATE TISSUE AND REGROW DETACHED LIMBS
•  IN HUMANS MANY CELL TYPES ARE CONTINUOUSLY REPLACED INTO ADULTHOOD:
Ø  BLOOD/BONE
Ø  GUT EPITHELIUM
Ø  SKIN/HAIR
•  OTHER TISSUES RETAIN A LIMITED REGENERATIVE CAPACITY (IN RESPONSE TO INJURY):
Ø  CARDIAC MUSCLE
Ø  NEURONS
Ø  RETINA
•  IN ONCOLOGY, CANCER STEM-LIKE CELLS BECOME ABERRANT à UNLIMITED GROWTH AND/OR
ARREST OF DIFFERENTIATION
OXSTEM WILL ACTIVATE AND ENHANCE NATURAL REPAIR PROCESSES IN THE BODY,
THAT ARE USUALLY VERY SLOW BY USING SMALL MOLECULE DRUGS AS WELL AS
REDIRECTING CANCER STEM-LIKE CELLS TOWARDS A BENIGN (DIFFERENTIATED)
PHENOTYPE
11
WWW.OXSTEM.CO.UK
AGENDA
1.  OUR MISSION
2.  OUR GROUP
3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE
4.  THE “STEMS” – SEE WEBSITE: WWW.OXSTEM.CO.UK
12

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OxStem || Dr Amy Varney || Novel Approaches to Cell Therapeutics and Regenerative Medicine

  • 1. WWW.OXSTEM.CO.UK AN INTRODUCTION TO OXSTEM NOVEL APPROACHES TO CELL THERAPIES AND REGENERATIVE MEDICINE MARCH 2017
  • 2. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” 2
  • 3. WWW.OXSTEM.CO.UK OXSTEM •  OXSTEM IS A DEVELOPER OF CELL PROGRAMMING THERAPIES, WORKING IN CLOSE COLLABORATION WITH THE UNIVERSITY OF OXFORD. •  OXSTEM’S UNIQUE APPROACH TO REGENERATIVE MEDICINE WILL: Ø  DELIVER SMALL MOLECULE THERAPEUTICS THAT ACTIVATE REPAIR MECHANISMS THAT ALREADY EXIST WITHIN THE BODY Ø  EXPLOIT A DEEP UNDERSTANDING OF THE CHEMICAL UNDERPINNINGS OF STEM AND PROGENITOR CELL FUNCTION AND DIFFERENTIATION Ø  GENERATE A COLLECTION OF DRUG CANDIDATES TO AWAKEN ENDOGENOUS CELLS TO REPAIR TISSUES AFFECTED BY DISEASE OR INJURY •  TO BETTER HUMAN HEALTH BY DIRECTLY IMPACTING THE QUALITY AND DURATION OF LIFE •  OXSTEM WILL REVOLUTIONIZE THE REGENERATIVE MEDICINE FIELD BY DEVELOPING UNIQUE CELL PROGRAMMING THERAPIES TO TREAT DEGENERATIVE DISEASES WITH HIGH UNMET NEED WHAT WE DO OUR PURPOSE 3
  • 4. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” 4
  • 5. WWW.OXSTEM.CO.UK PROFESSOR STEVE DAVIES WAYNFLETE PROFESSOR OF CHEMISTRY OXFORD UNIVERSITY PROFESSOR ANGELA RUSSELL ASSOC. PROFESSOR OF CHEMISTRY & PHARMACOLOGY OXFORD UNIVERSITY PROFESSOR DAME KAY DAVIES DR LEE’S PROFESSOR OF ANATOMY OXFORD UNIVERSITY DR MICHAEL STEIN CHAIRMAN & CHIEF EXECUTIVE OFFICER RAYMOND SPENCER, CFA CHIEF FINANCIAL OFFICER EXECUTIVE FOUNDERS SCIENTIFIC FOUNDERS FOUNDING TEAM 5
  • 6. WWW.OXSTEM.CO.UK “SPIN-IN” RAISED £16.9M IN MAY 2016 ACUTE MYELOID LEUKEMIA AND MYELO-DYSPLASTIC SYNDROME ALZHEIMER’S DISEASE TRAUMATIC BRAIN INJURY AGE RELATED MACULAR DEGENERATION MYOCARDIAL INFARCTION / HEART FAILURE “OxStem 4D” 3D STEM CELL SUSPENSION CULTURE GROUP STRUCTURE ALL >90% OWNED SUBSIDIARIES SPIN-OUT 6
  • 7. WWW.OXSTEM.CO.UK INITIAL FUNDRAISE AND EARLY SUCCESS TIMELINE FOR YEAR 2016 7 MAY 2016: £16.9M ($20M) RAISED, A RECORD FOR OXFORD UNIVERSITY SPIN-OUTS MAY 2016: ESTABLISHMENT OF OXSTEM ONCOLOGY AND LAUNCH OF OXSTEM 4D OCTOBER 2016: WINNER OF THE NATIONAL BEST BIOTECHNOLOGY START-UP AT THE OBN AWARDS, UK DECEMBER 2016: PROOF-OF- PRINCIPLE DEMONSTRATED. FIRST EVER SMALL-MOLECULE DEMONSTRATING CELL-TO-WHOLE ANIMAL EFFICACY IN NEUROGENESIS AUGUST 2016: ESTABLISHMENT OF OXSTEM NEURO AND OXSTEM OCULAR NOVEMBER 2016: ESTABLISHMENT OF OXSTEM CARDIO 2016
  • 8. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” 8
  • 9. WWW.OXSTEM.CO.UK PLAGUED WITH TOLERANCE ISSUES AND REJECTION; REQUIRE SPECIALIST FACILITIES FOR THERAPEUTIC DELIVERY INTRODUCTION TO CELL THERAPY AND REGENERATIVE MEDICINE CURRENT THERAPEUTIC PARADIGMS TISSUE ENGINEERING THERAPY VIA IMPLANTATION CELL TRANSPLANTATION THERAPY VIA IMPLANTATION SOURCE: CULME-SEYMOUR ET AL., REGEN. MED. 2012 9
  • 10. WWW.OXSTEM.CO.UK DRUG HERE TO INFLUENCE PROGRESS DRUG HERE TO INFLUENCE PROGRESS NATURALLY OCCURRING COMMITTED ADULT STEM CELLS NATURALLY OCCURRING ADULT STEM CELLS FUNCTIONAL CELLS FOR REGENERATIVE TREATMENT NATURALLY OCCURRING ADULT STEM CELLS OXSTEM’S APPROACH: PROGRAMMABLE CELL CHEMISTRY 10
  • 11. WWW.OXSTEM.CO.UK ACTIVATION OF RESIDENT CELLS IN VIVO TO ALLEVIATE DISEASE •  SALAMANDERS, AND OTHER AMPHIBIANS, REGENERATE TISSUE AND REGROW DETACHED LIMBS •  IN HUMANS MANY CELL TYPES ARE CONTINUOUSLY REPLACED INTO ADULTHOOD: Ø  BLOOD/BONE Ø  GUT EPITHELIUM Ø  SKIN/HAIR •  OTHER TISSUES RETAIN A LIMITED REGENERATIVE CAPACITY (IN RESPONSE TO INJURY): Ø  CARDIAC MUSCLE Ø  NEURONS Ø  RETINA •  IN ONCOLOGY, CANCER STEM-LIKE CELLS BECOME ABERRANT à UNLIMITED GROWTH AND/OR ARREST OF DIFFERENTIATION OXSTEM WILL ACTIVATE AND ENHANCE NATURAL REPAIR PROCESSES IN THE BODY, THAT ARE USUALLY VERY SLOW BY USING SMALL MOLECULE DRUGS AS WELL AS REDIRECTING CANCER STEM-LIKE CELLS TOWARDS A BENIGN (DIFFERENTIATED) PHENOTYPE 11
  • 12. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” – SEE WEBSITE: WWW.OXSTEM.CO.UK 12