2. Patients unable to breathe
because of acute lung failure
or an obstructed airway need
another way to get oxygen to
their blood -- and fast -- to
avoid cardiac arrest and brain
injury.
INTRODUCTION
A team led by researchers at boston children's
hospital has designed tiny, gas-filled microparticles
that can be injected directly into the bloodstream to
quickly oxygenate the blood.
2
3. The scientist began investigating the idea of injectable
oxygen many years back , after caring for a little girl
who sustained a severe brain injury resulting from a
severe pneumonia that caused bleeding into her lungs
and severely low oxygen levels. Despite the team's best
efforts, she died before they could place her on a
heart-lung machine. Frustrated by this, he formed a
team to search for another way to deliver oxygen.
BACKGROUND
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4. In the studies reported in the
paper, they used a device called
a sonicator, which uses high-
intensity sound waves to mix the
oxygen and lipids together.
The process traps oxygen gas
inside particles averaging 2 to 4
micrometers in size . The
resulting solution, with oxygen
gas making up 70 percent of the
volume, mixed efficiently with
human blood.
MICROPARTICLE FORMATION
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5. Lipidic oxygen-containing
microparticles (LOMs)
They are composed of oxygen gas
pocketed in a layer of lipids, a
natural molecule that usually
stores energy or serves as a
component to cell membranes.
Lipids can be waxes, some
vitamins, monoglycerides,
diglycerides, triglycerides,
phospholipids, or—as in this
case—fats.
WHAT THESE MICROPARTICLES ARE????
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6. The LOMs solutions are
portable and could stabilize
patients in emergency
situations, buying time for
paramedics, emergency
clinicians or intensive care
clinicians to more safely place
a breathing tube or perform
other life-saving therapies,
LOM’S SOLUTIONS
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8. HOW THEY WORK………
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After intravenous injection,
LOM suspensions mixed with
venous blood, which was then
oxygenated
9. The check the effect of LOMs to blood, they desaturated
human red blood cells using nitrogen gas and
maintained them at 37°C under continuous motion on
stir plate. LOMs were added added to the sample
results indicate that the oxygen content of the blood
increased by about 1 ml for each milliliter of O2 gas
(encapsulated by LOMs) that was added to the blood
sample.
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EX VIVO ADMINISTRATION
10. The LOMs solution was injected intravenously into
rabbits with low blood oxygen levels, which caused the
restoration of blood oxygen saturation within seconds
to near-normal levels.
When the trachea was completely blocked – a more
dangerous “real world” scenario - these microparticles
kept the animals alive and reduced the incidence of
cardiac arrest and organ injury.
IN VIVO ADMINISRARTION
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11. It sounds like magic, but it was just the start of what,
after years of investigation, became this real life-
giving liquid in a bottle.
This is what the future is about. And it's a beautiful one
indeed, one that is arriving earlier than we ever could
have expected.
CONCLUSION
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