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Personalising CRISPR Genome Editing || Edward Perello || Disruptor Stories

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Edward Perello, CBO of Desktop Genetics, joins us at the Science: Disrupt London Session on Disruptor Stories to talk machine learning, CRSIPR, pivoting and his startup story.

Published in: Science
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Personalising CRISPR Genome Editing || Edward Perello || Disruptor Stories

  1. 1. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company PERSONALISING CRISPR GENOME EDITING August 2016 Edward Perello| CBO & Founder
  2. 2. @EdwardPerello | @DesktopGenetics DESKTOP GENETICS HELPING YOU MANIPULATE GENOMES LONDON EST. 2012 BIOINFORMATICS TOOLS GENE EDITING SERVICES BACKED BY LARGEST SEQUENCING PROVIDER
  3. 3. @EdwardPerello | @DesktopGenetics TWO PATHS TO DESKTOP GENETICS PRODUCTS & SERVICES  DATA
  4. 4. @EdwardPerello | @DesktopGenetics 4 TEACH AI TO PERFORM GENETIC SURGERY MACHINE INTELLIGENCE IS THE ONLY WAY TO EDIT THE GENOME SAFELY
  5. 5. @EdwardPerello | @DesktopGenetics AGENDA 1. Brief intro to CRISPR 1. Our story so far 1. Taking CRISPR to the clinic
  6. 6. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company Editing the Genome with CRISPR
  7. 7. @EdwardPerello | @DesktopGenetics GENE THERAPY TACKLES DISEASES CRISPR is used to modify the genome of a patient’s cells
  8. 8. @EdwardPerello | @DesktopGenetics CRISPR OVERVIEW Programmable two-component system CAS9 NUCLEASE RNA COMPONENT
  9. 9. @EdwardPerello | @DesktopGenetics CRISPR OVERVIEW Programmable two-component system CAS9 NUCLEASE RNA COMPONENT VARIABLE 20 BP GUIDE RNA CONSTANT REGION
  10. 10. @EdwardPerello | @DesktopGenetics CRISPR OVERVIEW Programmable two-component system CAS9 NUCLEASE RNA COMPONENT ACTIVE RNA-GUIDED CAS9 COMPLEX
  11. 11. @EdwardPerello | @DesktopGenetics CRISPR OVERVIEW Molecular find and replace for DNA Source: McGovern Brain Institute Youtube Channel
  12. 12. @EdwardPerello | @DesktopGenetics WHY EDIT GENOMES? Research & development → Clinical interventions - Degenerative blindness - Custom disease models - Humanization of heart valves - Swine fever resistance - HIV eradicated in vitro - Immuno-oncology - Clinical trials cured cancer - Clinical trials cured HIV
  13. 13. @EdwardPerello | @DesktopGenetics WHY START A BUSINESS IN THIS SPACE?Huge biotechnology, life science and clinical prospects 75M PATIENTS 3M RESEARCH EXPERIMENTS
  14. 14. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company Our Story
  15. 15. @EdwardPerello | @DesktopGenetics 2011 – MEETING AT CAMBRIDGE MPHIL BIOSCIENCE ENTERPRISE DEGREE
  16. 16. @EdwardPerello | @DesktopGenetics 2012 – SYNTHBOT, CUTEC, SEED THE BIOTECH NESPRESSO
  17. 17. @EdwardPerello | @DesktopGenetics 2013 – AUTOCLONE, TSB , RAISE HARDWARE OUT, SOFTWARE IN
  18. 18. @EdwardPerello | @DesktopGenetics 2014 – HORIZON CRISPR TOOL & TSB INTERNAL CRISPR R&D TOOL
  19. 19. @EdwardPerello | @DesktopGenetics 2014 - GUIDEBOOK CO-BRANDED CRISPR DESIGN & SALES PORTAL
  20. 20. @EdwardPerello | @DesktopGenetics 2015 – DESKGEN, CLASS, PARTNERS UNITING & OPTIMISING OUR TOOLSET
  21. 21. @EdwardPerello | @DesktopGenetics CRISPR EXPERIMENTS MODE, RICHER UI 2015 – DESKGEN, CLASS, PARTNERS
  22. 22. @EdwardPerello | @DesktopGenetics 2015 – DESKGEN, CLASS, PARTNERS PARTNERSHIPS MAKE LITERAL DESKTOP GENETICS POSSIBLE
  23. 23. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company Taking CRISPR into the clinic
  24. 24. @EdwardPerello | @DesktopGenetics INTERNATIONAL ENDEAVOUR CRISPR is a global phenomenon
  25. 25. @EdwardPerello | @DesktopGenetics 2016 – GUIDE PICKER, NGS, BEYOND MULTIDIMENSIONAL GUIDE SELECTION
  26. 26. @EdwardPerello | @DesktopGenetics 2016 – GUIDE PICKER, NGS, BEYOND USING BIOLOGICAL DATA TO TAKE OUR AI FURTHER
  27. 27. @EdwardPerello | @DesktopGenetics HUMANS VS. MACHINES MACHINES OUT-PERFORM MANUAL DESIGN CRISPRSuccessRate
  28. 28. @EdwardPerello | @DesktopGenetics 2 8 PERFORM GENETIC SURGERY WITH AI Design CRISPR for every lab, teach our algorithms, go to the clinic
  29. 29. @EdwardPerello | @DesktopGenetics LIFE AT DESKTOP GENETICS Recognition in tech, biology, and everything in between
  30. 30. @EdwardPerello | @DesktopGenetics WE’RE HIRING Join us in Shoreditch; tell your friends!
  31. 31. @EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2015© Desktop Genetics Ltd. 2 www.deskgen.com edwardp@desktopgenetics.com @edwardperello

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