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Case conference
30/1/2017
Extern Chittranoot liwluck
Maharat Nakhon Ratchasima hospital
Patient profile
• Male, 15 year-old
• CC :ปวดเข่าข้างขวา 1 เดือนก่อนมาโรงพยาบาล
• PI : 1 เดือนก่อนมาโรงพยาบาล มีอาการปวดเข่าข้างขวา ปวดมาก
ขึ้นเรื่อยๆ ไม่มีปวดร้าวไปไหน เข่าขวาบวม ไม่แดงหรือร้อน สังเกตว่ามี
หนองไหล จากบาดแผลเดิม ไม่มีไข้ ไม่มีปวดตอนกลางคืน ไม่มีเบื่อ
อาหารน้าหนักลด ไม่มีปวดข้ออื่นหรือปวดย้ายข้อ ไม่มีข้อติดตอนเช้า
• Past history : 1 ปีก่อนมาโรงพยาบาลเคยได้รับอุบัติเหตุมีกระดูก
ต้นขาขวาหักร่วมกับกระดูกหน้าแข้ง ได้รับการใส่เหล็ก6 เดือน
(DX:Open fracture right distal femur and right
proximal tibia)
• Last admit 13-19 /10/2016 remove plate and
screw
• Medication
– None
– No use herb or steroid, no drug allergy
• Personal history
– No smoking ,no alcohol drinking
Physical examination
• GA : A Thai man, good conscious ,well co-
operate
• V/S BP 120/80 PR 128 RR 20 BT 37.5
• HEENT: not pale conjunctivae, anicteric sclerae
• HEART: normal s1,s2 no murmur
• Lung : clear both lung ,no adventitious sound
• Abdomen : soft ,not tenderness
• Neurology : alert ,well co-operative ,motor
grade 5 all extremity ,sensory intact , reflex 2+
all extremity
• Musculoskeletal :
– surgical wound along right anterior of femur to
anterior of tibia, there are pus from sinus tract at
right lower part of femur ,right knee swelling ,no
redness , no warm,
– tender around sinus tract ,limit ROM due to pain,
not tenderness along joint line, ballottement test
negative
• Differential diagnosis
– Infection : cellulitis , pyomyositis , osteomyelitis
,bursitis , septic arthritis
– Inflammation : gout, Charcot arthropathy
Investigation
• CBC
• ESR
• CRP
• Film X-ray
• Anti-HIV
• FBS
• Blood culture and pus culture
• CBC
– WBC 13,400 /ul HGB 13.6g/dl
– HCT 41.6% MCV 77.7fl
– Platelet 357,000/ul NE 62.4%
– LYM 19% MO 8.9%
– EO 9.2% BA 0.5%
• ESR 74mm/hr
• CRP 49.5 mg/dl
• Anti-HIV neg
• FBS 86 mg/dl
• Blood culture negative, pus culture negative
Femur AP
Femur LAT
LEG AP
LEG LAT
Diagnosis
• Chronic osteomyelitis
treatment
• Medication
– Antibiotic : cefazolin 1 g IV q 6 hour
– Pain control : morphine , paracetamol
• Surgery
– Sequestrectomy
– Debridement
Osteomyelitis
Osteomyelitis
• Osteomyelitis is an infectious process that
involves bone and its medullary cavity.
Bacteria are the usual causes of osteomyelitis
• Infecting organisms may enter bones or joints
in the following ways
– hematogenous spread
– external inoculation
– extension from an adjacent structure that is
infected
osteomyelitis
• Osteomyelitis may be classified as age ,
duration of symptoms , route of infection,
causative organism
pathophysiology
• Hematogenous
– brushing our teeth ,impetigo, otitis media,
pharyngitis, or pneumonia. Reticulo-endothelial
defense mechanisms fail, however, bacteria may
gain access to bone. In experimental studies,
previous trauma
– In children, the growth plate (transient
bacteremia)
Osteoblast
cell death
Phagocytosis cell and
endothelial cell secrete
osteoclast activating
factor>>sinus day3
Purulent exudate extend to cortex,
periosteum ( sub periosteal abscess)
and subcutaneous tissue
Involucum and sequestrum
Joint capsule
(hip,ankle,elbow
,shoulder)
Acute osteomyelitis
• osteomyelitis is an infection that is diagnosed
within 2 weeks of the onset of symptoms.
• It is more common in males (2:1 ratio), is most
often monostotic (>90%), and usually
• involves the lower extremity (90%). Parents of
children with this condition commonly
• report that their children walk with a limp, or
that they refuse to walk.
Clinical manifestation
investigation
• CBC
• ESR(48-72hr,3-5day) ,CRP(6hr,1week)
• Film antero-posterior and lateral radiographs
of the affected area
• blood culture(30%)
• aspiration of the affected area.(30-50%)
• Urine analysis
• Other : CT ,MRI, bone scan
Differential diagnosis
• Soft tissue infection
• Charcot arthropathy
• Osteonecrosis
• Gout
• Fracture
• Bursitis
• Malignancy
• Synovitis, acne, pustulosis, hyperostosis, and
osteitis (SAPHO)
Management
S.aureus
All age
group
Age group pathogen antibiotics
Neonate-6 month Group B streptococci,
Gram-negative organisms
flucloxacillin plus a third-
generation cephalosporin like
cefotaxime +- gentamycin
6month-6 years Haemophilus influenzae flucloxacillin and cefotaxime or
cefuroxime.
Older children and previously fit
adult
Staphylococcal infections intravenous flucloxacillin
and fusidic acid.
Elderly and previously unfit
patients
Gram-negative
infections
flucloxacillin and
a second- or third-generation
cephalosporin
Patients with sickle-cell disease salmonella and/or other Gram-
negative organisms
third-generation cephalosporin
or a fluoroquinolone
like ciprofloxacin.
Heroin addicts and
immunocompromised patients
Pseudomonas aeruginosa,
Proteus mirabilis or anaerobic
Bacteroides
species)
third-generation cephalosporins
or a fluoroquinolone
Management
• ATB3-6 week or ESR<25mm/hr 3 week
• IV ATB until the patient’s condition begins to
improve and the CRP values return to normal
levels which usually takes 2–4 weeks
complication
• Epiphyseal damage
• Suppurative arthritis
• Metastatic infection
• Pathological fracture
• Chronic osteomyelitis
Subacute osteomyelitis
• Clinical :fever , pain
• ESR , CRP สูงไม่มาก H/C neg
• Film lytic ,sclerotic border
• IV ATB 1 week then oral high dose4-6 week
Chronic osteomyelitis
• Sequestrum , involucum , chronic sinus
drainage
• Surgery: debridement sequestrectomy
,saucerization
• IV ATB pre-op,post-op 7days then high does
oral ATB untill 6 weeks or ESR<25
Take home message
• Osteomyelitis , involucum , sequestrum
• Early detection, prevention
• Clinical fever, sign of inflammation (septic
arthritis, juvenile rheumatoid arthritis ,
cellulitis, pyomyositis )
• ATB 3-6 week (IV 2-4 week then high dose oral
form) broad-spectrum empiric therapy
Reference
Osteomyelitis

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Osteomyelitis

  • 1. Case conference 30/1/2017 Extern Chittranoot liwluck Maharat Nakhon Ratchasima hospital
  • 2. Patient profile • Male, 15 year-old • CC :ปวดเข่าข้างขวา 1 เดือนก่อนมาโรงพยาบาล • PI : 1 เดือนก่อนมาโรงพยาบาล มีอาการปวดเข่าข้างขวา ปวดมาก ขึ้นเรื่อยๆ ไม่มีปวดร้าวไปไหน เข่าขวาบวม ไม่แดงหรือร้อน สังเกตว่ามี หนองไหล จากบาดแผลเดิม ไม่มีไข้ ไม่มีปวดตอนกลางคืน ไม่มีเบื่อ อาหารน้าหนักลด ไม่มีปวดข้ออื่นหรือปวดย้ายข้อ ไม่มีข้อติดตอนเช้า
  • 3. • Past history : 1 ปีก่อนมาโรงพยาบาลเคยได้รับอุบัติเหตุมีกระดูก ต้นขาขวาหักร่วมกับกระดูกหน้าแข้ง ได้รับการใส่เหล็ก6 เดือน (DX:Open fracture right distal femur and right proximal tibia) • Last admit 13-19 /10/2016 remove plate and screw • Medication – None – No use herb or steroid, no drug allergy • Personal history – No smoking ,no alcohol drinking
  • 4. Physical examination • GA : A Thai man, good conscious ,well co- operate • V/S BP 120/80 PR 128 RR 20 BT 37.5 • HEENT: not pale conjunctivae, anicteric sclerae • HEART: normal s1,s2 no murmur • Lung : clear both lung ,no adventitious sound • Abdomen : soft ,not tenderness
  • 5. • Neurology : alert ,well co-operative ,motor grade 5 all extremity ,sensory intact , reflex 2+ all extremity • Musculoskeletal : – surgical wound along right anterior of femur to anterior of tibia, there are pus from sinus tract at right lower part of femur ,right knee swelling ,no redness , no warm, – tender around sinus tract ,limit ROM due to pain, not tenderness along joint line, ballottement test negative
  • 6. • Differential diagnosis – Infection : cellulitis , pyomyositis , osteomyelitis ,bursitis , septic arthritis – Inflammation : gout, Charcot arthropathy
  • 7. Investigation • CBC • ESR • CRP • Film X-ray • Anti-HIV • FBS • Blood culture and pus culture
  • 8. • CBC – WBC 13,400 /ul HGB 13.6g/dl – HCT 41.6% MCV 77.7fl – Platelet 357,000/ul NE 62.4% – LYM 19% MO 8.9% – EO 9.2% BA 0.5% • ESR 74mm/hr • CRP 49.5 mg/dl • Anti-HIV neg • FBS 86 mg/dl • Blood culture negative, pus culture negative
  • 14. treatment • Medication – Antibiotic : cefazolin 1 g IV q 6 hour – Pain control : morphine , paracetamol • Surgery – Sequestrectomy – Debridement
  • 16. Osteomyelitis • Osteomyelitis is an infectious process that involves bone and its medullary cavity. Bacteria are the usual causes of osteomyelitis • Infecting organisms may enter bones or joints in the following ways – hematogenous spread – external inoculation – extension from an adjacent structure that is infected
  • 17. osteomyelitis • Osteomyelitis may be classified as age , duration of symptoms , route of infection, causative organism
  • 18.
  • 19. pathophysiology • Hematogenous – brushing our teeth ,impetigo, otitis media, pharyngitis, or pneumonia. Reticulo-endothelial defense mechanisms fail, however, bacteria may gain access to bone. In experimental studies, previous trauma – In children, the growth plate (transient bacteremia)
  • 20. Osteoblast cell death Phagocytosis cell and endothelial cell secrete osteoclast activating factor>>sinus day3 Purulent exudate extend to cortex, periosteum ( sub periosteal abscess) and subcutaneous tissue Involucum and sequestrum Joint capsule (hip,ankle,elbow ,shoulder)
  • 21.
  • 22.
  • 23.
  • 24. Acute osteomyelitis • osteomyelitis is an infection that is diagnosed within 2 weeks of the onset of symptoms. • It is more common in males (2:1 ratio), is most often monostotic (>90%), and usually • involves the lower extremity (90%). Parents of children with this condition commonly • report that their children walk with a limp, or that they refuse to walk.
  • 26. investigation • CBC • ESR(48-72hr,3-5day) ,CRP(6hr,1week) • Film antero-posterior and lateral radiographs of the affected area • blood culture(30%) • aspiration of the affected area.(30-50%) • Urine analysis • Other : CT ,MRI, bone scan
  • 27.
  • 28.
  • 29. Differential diagnosis • Soft tissue infection • Charcot arthropathy • Osteonecrosis • Gout • Fracture • Bursitis • Malignancy • Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO)
  • 31. Age group pathogen antibiotics Neonate-6 month Group B streptococci, Gram-negative organisms flucloxacillin plus a third- generation cephalosporin like cefotaxime +- gentamycin 6month-6 years Haemophilus influenzae flucloxacillin and cefotaxime or cefuroxime. Older children and previously fit adult Staphylococcal infections intravenous flucloxacillin and fusidic acid. Elderly and previously unfit patients Gram-negative infections flucloxacillin and a second- or third-generation cephalosporin Patients with sickle-cell disease salmonella and/or other Gram- negative organisms third-generation cephalosporin or a fluoroquinolone like ciprofloxacin. Heroin addicts and immunocompromised patients Pseudomonas aeruginosa, Proteus mirabilis or anaerobic Bacteroides species) third-generation cephalosporins or a fluoroquinolone
  • 32. Management • ATB3-6 week or ESR<25mm/hr 3 week • IV ATB until the patient’s condition begins to improve and the CRP values return to normal levels which usually takes 2–4 weeks
  • 33.
  • 34. complication • Epiphyseal damage • Suppurative arthritis • Metastatic infection • Pathological fracture • Chronic osteomyelitis
  • 35. Subacute osteomyelitis • Clinical :fever , pain • ESR , CRP สูงไม่มาก H/C neg • Film lytic ,sclerotic border • IV ATB 1 week then oral high dose4-6 week
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  • 37.
  • 38. Chronic osteomyelitis • Sequestrum , involucum , chronic sinus drainage • Surgery: debridement sequestrectomy ,saucerization • IV ATB pre-op,post-op 7days then high does oral ATB untill 6 weeks or ESR<25
  • 39.
  • 40.
  • 41. Take home message • Osteomyelitis , involucum , sequestrum • Early detection, prevention • Clinical fever, sign of inflammation (septic arthritis, juvenile rheumatoid arthritis , cellulitis, pyomyositis ) • ATB 3-6 week (IV 2-4 week then high dose oral form) broad-spectrum empiric therapy