Orlistat is a drug used to treat obesity by preventing the absorption of fats from the diet. It works by inhibiting the pancreatic lipase enzyme needed to break down triglycerides from food. This prevents fatty acids from being absorbed and causes undigested fat to be excreted. Orlistat should be taken during or within an hour of eating a meal containing fat. Common side effects include oily rectal discharge and gastrointestinal issues like fatty/oily stool. It can interact with some other drugs so patients should discuss usage with their doctor.

1. ORLISTAT
FATIMA NUR-HIDAYAH HASSAN MATLI
CLINICAL PHARMACY

2. WHAT IS ORLISTAT?
 drug used in the treatment of obesity.
 Its primary function is preventing the absorption of
fats from the human diet, thereby reducing caloric
intake.

3. How Does it Work?
 Orlistat works by inhibiting pancreatic lipase, an enzyme that
breaks down triglycerides in the intestine. Without this
enzyme, triglycerides from the diet are prevented from being
hydrolyzed into absorbable free fatty acids and are excreted
undigested

4. Mechanism of Actions
 Orlistat is a reversible inhibitor of gastrointestinal lipases.
 It exerts its therapeutic activity in the lumen of the stomach and small intestine by
forming a covalent bond with the active serine residue site of gastric and
pancreatic lipases. The inactivated enzymes are thus unavailable to hydrolyze
dietary fat in the form of triglycerides into absorbable free fatty acids and
monoglycerides. As undigested triglycerides are not absorbed, the resulting
caloric deficit may have a positive effect on weight control.

5. How To Take Orlistat?
 Taken by mouth; With liquid during meals that
contain fat or within 1 hour after a meal; usually
thrice a day

6. BrandNames

7. Warning and Precautions
 Talk to your MD Before taking this medications
 Gallbladders Kidneys
 Liver Problems
 Cholelithiasis
 Diabetis

8. Pregnancy And BreastFeeding
 Pregnancy Factor X
 weight loss offers no potential benefit to a pregnant woman and may result in
fetal harm. A minimum weight gain, and no weight loss, is currently
recommended for all pregnant women, including those who are
already overweight or obese, due to the obligatory weight gain that occurs in
maternal tissues during pregnancy.

9. Taking Other Medicines during this
treatment
 Cyclosporine
 Beta Carotene
 Vitamin E Suppliments
 Amiodarone
 Anti Epileptic Drug
 Levothyroxine

10. Possible Side Effects
 Liver or Kidney Problems
 Lost of Appetite
 Frequent Urination
 Blood in The Urine
 Nausea and Vomiting
 Oily Rectal Discharge

11. Overdose
 Single doses of 800 mg ORLISTAT and multiple doses of up to 400 mg three
times a day for 15 days have been studied in normal weight and obese subjects
without significant adverse findings.
 Should a significant overdose of ORLISTAT occur, it is recommended that the
patient be observed for 24 hours. Based on human and animal studies, systemic
effects attributable to the lipase-inhibiting properties of ORLISTAT should be
rapidly reversible.