1. Chenguang Wang, Ph.D.
Contact
Information
Division of Biostatistics and Bioinformatics
Sidney Kimmel Comprehensive Cancer Center
School of Medicine
Johns Hopkins University
550 N. Broadway Suite 1103
Baltimore, MD 21205
Office: (410)614-4961
Email: cwang68@jhmi.edu
Academic
Training
Doctor of Philosophy, Statistics, University of Florida 2010
Master of Science, Statistics, University of Nebraska-Lincoln 2004
Master of Engineering, Computer Science, Dalian University of Technology 2001
Bachelor of Engineering, Computer Science, Dalian University of Technology 1998
Professional
Experience
Assistant Professor, Johns Hopkins University 2011-present
Mathematical Statistician, FDA 2009 - 2011
Statistician, Children’s Oncology Group 2004 - 2009
Articles
Published
2016 Wang C, Scharfstein D, Colantuoni E, Girard TD, Yan Y. "Inference in Randomized
Trials With Death and Missingness". Biometrics. Accepted.
2016 Henderson NC, Louis TA, Wang C, Varadhan R. "Bayesian Analysis of Heterogeneous
Treatment Effects for Patient-Centered Outcomes Research". Health Services and Outcomes
Research Methodology. Accepted.
2016 Alvarez RD, Huh WK, Bae S, Lamb LS, Conner MG, Boyer J, Wang C, Hung C,
Sauter E, Paradis M, others. "A pilot study of pNGVL4a-CRT/E7 (detox) for the treatment
of patients with HPV16+ cervical intraepithelial neoplasia 2/3 (CIN2/3)". Gynecologic
oncology. vol. 140, pp. 245-252. PMCID:4724445.
2016 Huang C, Wang C, Wang M. "Nonparametric analysis of bivariate gap time With
competing risks". Biometrics. pp. 1-11.
2015 Peng S, Wang JW, Karanam B, Wang C, Huh WK, Alvarez RD, Pai SI, Hung C, Wu
T-, Roden RBS. "Sequential Cisplatin Therapy and Vaccination With Hpv16 E6e7l2 Fusion
Protein in Saponin Adjuvant Gpi-0100 for the Treatment of a Model Hpv16+ Cancer". PLoS
ONE. vol. 10, pp. e116389.
2014 Daniels M, Wang C, Marcus B. "Fully Bayesian inference under ignorable missingness
in the presence of auxiliary covariates". Biometrics. vol. 70, pp. 62-72. PMCID:4007313.
2014 Kharrazi H, Wang C, Scharfstein D. "Prospective EHR-based clinical trials: the chal-
lenge of missing data". Journal of general internal medicine. vol. 29, pp. 976-978. PM-
CID:4061350.
2014 Maldonado L, Teague JE, Morrow, P. M, Jotova I, Wu T, Wang C, Desmarais C, Boyer
JD, Tycko B, Robins HS, others. "Intramuscular therapeutic vaccination targeting HPV16
induces T cell responses that localize in mucosal lesions". Science translational medicine.
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2. vol. 6, pp. 221ra13-221ra13. PMCID:4086631.
2014 Wu C, Yang L, Yang H, Knoff J, Peng S, Lin Y, Wang C, Alvarez RD, Pai SI,
Roden RB, others. "Enhanced cancer radiotherapy through immunosuppressive stromal cell
destruction in tumors". Clinical cancer research. vol. 20, pp. 644-657. PMCID:3946442.
2013 Kwak K, Jiang R, Jagu S, Wang JW, Wang C, Christensen ND, Roden RB. "Multi-
valent human papillomavirus l1 DNA vaccination utilizing electroporation". PloS one. vol.
8, pp. e60507. PMCID:3607584.
2013 Liu G, Kong L, Wang Z, Wang C, Wu R. "Systems mapping of metabolic genes through
control theory". Advanced drug delivery reviews. vol. 65, pp. 918-928. PMCID:4233129.
2013 Zhang Z, Wang C, Nie L, Soon G. "Assessing the heterogeneity of treatment effects
via potential outcomes of individual patients". Journal of the royal statistical society: series
C (applied statistics). vol. 62, pp. 687-704. PMCID:4261197.
2013 Zhang Z, Kotz RM, Wang C, Ruan S, Ho M. "A causal model for joint evaluation of
placebo and treatment-specific effects in clinical trials". Biometrics. vol. 69, pp. 318-327.
PMCID:4133792.
2013 Lee SY, Huang Z, Kang TH, Soong R, Knoff J, Axenfeld E, Wang C, Alvarez RD,
Chen C, Hung C, others. "Histone deacetylase inhibitor Ar-42 enhances E7-specific Cd8+ T
cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination". Journal
of molecular medicine. vol. 91, pp. 1221-1231. PMCID:3783646.
2012 Daniels MJ, Chatterjee AS, Wang C. "Bayesian model selection for incomplete data
using the posterior predictive distribution". Biometrics. vol. 68, pp. 1055-1063. PM-
CID:3890150.
2012 Wang C, Li H, Wang Z, Wang Y, Wang N, Wang Z, Wu R. "A maximum likelihood
approach to functional mapping of longitudinal binary traits". Statistical applications in
genetics and molecular biology. vol. 11, pp. 1-17. PMCID:3856886.
2011 Bonangelino P, Irony T, Liang S, Li X, Mukhi V, Ruan S, Xu Y, Yang X, Wang C.
"Bayesian approaches in medical device clinical trials: a discussion with examples in the
regulatory setting". Journal of biopharmaceutical statistics. vol. 21, pp. 938-953.
2011 Wang W, Scharfstein D, Wang C, Daniels M, Needham D, Brower R. "Estimating the
causal effect of low tidal volume ventilation on survival in patients with acute lung injury".
Journal of the royal statistical society: series C (applied statistics). vol. 60, pp. 475-496.
PMCID:3197806.
2011 Wang C, Daniels MJ. "A note on MAR, identifying restrictions, model comparison,
and sensitivity analysis in pattern mixture models with and without covariates for incomplete
data". Biometrics. vol. 67, pp. 810-818. PMCID:3136648.
2011 Wang C, Wang Z, Prows DR, Wu R. "A computational framework for the inheritance
pattern of genomic imprinting for complex traits". Briefings in bioinformatics. vol. 13, pp.
34-45. PMCID:3278998.
2010 Li Q, Huang Z, Xu M, Wang C, Gai J, Huang Y, Pang X, Wu R. "Functional mapping
of genotype-environment interactions for soybean growth by a semiparametric approach".
Plant methods. vol. 6, pp. 13. PMCID:2903578.
2010 Wang C, Wang Z, Luo J, Li Q, Li Y, Ahn K, Prows DR, Wu R. "A model for
transgenerational imprinting variation in complex traits". PLoS one. vol. 5, pp. e11396.
PMCID:2904369.
2010 Wang C, Daniels M, Scharfstein DO, Land S. "A Bayesian shrinkage model for in-
complete longitudinal binary data with application to the breast cancer prevention trial".
Journal of the American statistical association. vol. 105, pp. 1333-1346. PMCID:3079242.
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3. 2009 Crawford Jr T, Eskridge K, Wang C, Maranville J. "Multi-compartmental modeling
of nitrogen translocation in sorghums differing in nitrogen use efficiency". Journal of plant
nutrition. vol. 32, pp. 335-349.
2009 Daniels MJ, Wang C. "Comments on: missing data methods in longitudinal studies:
a review". TEST (Journal of the Spanish society of statistics and operations research). vol.
18, pp. 51-58.
2009 Pinedo PJ, Wang C, Li Y, Rae, Owen D, Wu R. "Risk haplotype analysis for bovine
paratuberculosis". Mammalian genome. vol. 20, pp. 124-129.
2009 Schultz KR, Bowman WP, Aledo A, Slayton WB, Sather H, Devidas M, Wang C,
Davies SM, Gaynon PS, Trigg M, others. "Improved early event-free survival with imatinib
in Philadelphia chromosome-positive acute lymphoblastic leukemia: a Children’s Oncology
Group study". Journal of clinical oncology. vol. 27, pp. 5175-5181. PMCID:2773475.
2009 Wen S, Wang C, Berg A, Li Y, Chang MM, Fillingim RB, Wallace MR, Staud R,
Kaplan L, Wu R. "Modeling genetic imprinting effects of DNA sequences with multilocus
polymorphism data". Algorithms for molecular biology. vol. 4, pp. 1-11. PMCID:2739217.
2008 Wang C, Cheng Y, Liu T, Li Q, Fillingim RB, Wallace MR, Staud R, Kaplan L,
Wu R. "A computational model for sex-specific genetic architecture of complex traits in
humans: implications for mapping pain sensitivity". Molecular pain. vol. 4, pp. 1-10.
PMCID:2422840.
2008 Zeng Y, Li J, Wang C, Chang M, Yang R, Wu R. "Genetic mapping of quantitative
trait loci". Principles and practices of plant genomics. vol. 1, pp. 175-204.
2007 Salzer WL, Devidas M, Shuster, J. J, Wang C, Chauvenet A, Asselin BL, Camitta BM,
Kurtzberg J. "Intensified PEG-L-asparaginase and antimetabolite-based therapy for treat-
ment of higher risk precursor-B acute lymphoblastic leukemia: a report from the Children’s
Oncology Group". Journal of pediatric hematology oncology. vol. 29, pp. 369-375.
2007 Wu S, Yang J, Wang C, Wu R. "A general quantitative genetic model for haplotyping
a complex trait in humans". Current genomics. vol. 8, pp. 343-350. PMCID:2652406.
2007 Yap JS, Wang C, Wu R. "A computational approach for functional mapping of quan-
titative trait loci that regulate thermal performance curves". PLoS One. vol. 2, pp. e554.
PMCID:1892808.
2001 Chi Z, Quan X, Wang C, Wang Z. "Using multiagent adapter to design component
software". Journal of Chinese computer systems. vol. 22, pp. 608-610.
2000 Chi Z, Quan X, Wang C, Wang Z. "An implementation of a MultiSac model based
distributed GIS system". Mini-macro system. vol. 21, pp. 40-42.
1999 Wang Z, Chi Z, Wang C. "Hypermedia management system on distributed object".
Journal of dalian university of technology. vol. 39, pp. 572-576.
Statistical
Software
"Inference in Randomized Controlled Trials with Death and Missingness". R package idem
on CRAN with web graphical user interface.
"Bayesian Analysis of Heterogeneous Treatment Effect". R package beanz on CRAN with
web graphical user interface.
Book Chapter 2000 Zeng Y, Li J, Wang C, Chang M, Yang R, Wu L. "Genetic Mapping of Quantitative
Trait Loci" in Principles and Practices of Plant Genomics. vol. 1, pp. 175-204.
2007 Adamchuk VI, Wang C. "Col-locating multiple self-generated data layers" in GIS
Applications in Agriculture, CRC Press, pp. 185-196.
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4. Presentations 2016 Wang C. "A Bayesian Non-Parametric Causal Inference Model for Comparative Ef-
fectiveness Research". JSM, Chicago, IL
2016 Wang C. "BEANZ: A Web-Based Software for Bayesian Analysis of Heterogeneous
Treatment Effect". The 2nd International iCSA conference, Suzhou, China
2016 Wang C. "Global Sensitivity Analysis for Studies with Intermittent Missing Data and
Death". 34th Graduate Summer Institute of Epidemiology and Biostatistics, Baltimore, MD
2016 Wang C. "Design and Analysis of Traditional Therapy Studies". ICSA, Organizer and
chair, Atlanta, GA
2016 Wang C. "Discussion of subgroup identification and analysis". ICSA, Atlanta, GA
2016 Wang C. "BEANZ: A Web-Based Software for Bayesian Analysis of Heterogeneous
Treatment Effect". ICSA, Atlanta, GA
2016 Wang C, Varadhan R. "Introduction to web-application BEANZ". FDA, Washington
D.C.
2015 Wang C. "Next generation clinical trials". International symposium focused on clinical
research of anesthesiology and traditional Chinese medicine, Beijing, China
2015 Wang C. "A novel design for phase I cancer vaccine trials". FDA, CBER, Washington
D.C.
2015 Wang C, Varadhan R. "BEANZ: A web-based software for Bayesian analysis of HTE
in PCOR". ICHPS, Providence, RI
2015 Wang C, Scharfstein D. "Short course: global sensitivity analysis for studies with
intermittent missing data and death". FDA, Washington D.C.
2015 Wang C, Scharfstein D. "Short course: global sensitivity analysis for studies with
intermittent missing data and death". Johns Hopkins University, Baltimore, MD
2015 Wang C, Rosner G. "A Bayesian non-parametric model for synergy assessment in drug
combination studies ". ICSA/Graybill Joint Conference, Fort Collins, CO
2014 Wang C. "A novel design for phase I cancer vaccine trials". Duke-NUS, Singapore
2014 Wang C, Scharfstein D. "An intermittent missing data analysis strategy: for clinical
trials with death-truncated data". FDA Industry Statistical Workshop, Washington D.C.
2014 Wang C, Rosner G. "A Bayesian Dirichelet process mixture model for comparative
effectiveness research". IMS, Sydney, Australia
2014 Wang C, Rosner G. "A Bayesian non-parametric causal inference model for compar-
ative effectiveness research". SRCOS, Galveston, TX
2014 Zhang Z, Wang C, Nie L, Soon G. "Assessing the heterogeneity of treatment effects
via potential outcomes of individual patients". ENAR, Baltimore, MD
2014 Wang C, Hua Y. "A Bayesian missing data analysis model for estimating and com-
paring diagnostic test accuracy". ENAR, Baltimore, MD
2014 Wang J, Wang C. "An R package for sensitivity analysis on longitudinal data with
non-ignorable intermittent missingness". ENAR, Baltimore, MD
2014 Scharfstein D, Wang C. "Case study: death and missing data in a randomized trial".
Clinical Research Grand Rounds at the Welch Centre, Johns Hopkins University, Baltimore,
MD
2013 Wang C. "Statistical genetics: concepts and application". Ocean University of China,
Qingdao, China
2013 Wang C. "Missing data modeling and analysis concept and example". Tianjin University
of Finance and Economics, Tianjin, China
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5. 2013 Wang C. "Missing data modeling and analysis". Shandong Coal Technology College,
Yantai, China
2013 Wang C, Scharfstein D. "A sensitivity analysis model for longitudinal data with non-
ignorable intermittent missingness". ICSA, Hongkong, China
2013 Wang C. "Short course: missing data analysis". SLAM, Johns Hopkins University,
Baltimore, MD
2013 Wang C. "Blinding and placebo effects in randomized clinical trials". Joint Statistical
Meeting, co-organizer and discussant, Montreal, Canada
2013 Wang C. "Causal inference in clinical trials". ICSA, chair, Washington D.C.
2013 Wang C. "A Bayesian missing data model for evaluating diagnostic medical devices".
ENAR, Orlando, FL
2012 Wang C. "A causal effect model with stochastic monotonicity assumption for clinical
trials with incomplete longitudinal outcome". JSM, San Diego, CA
2012 Wang C. "Traps of assumptions: Wilcoxon signed-rank test and more". The 4th
International Statistical Genetics Symposium, Beijing, China
2012 Wang C. "Short course: maximum likelihood approach, experimental design". The
4th International Statistical Genetics Symposium, Beijing, China
2012 Wang C. "A Bayesian causal effect model with weak monotonicity assumptions for
clinical trials". ISBA, Kyoto, Japan
2012 Wang C. "Fully Bayesian inference under ignorable missingness in the presence of
auxiliary covariates". SLAM, Johns Hopkins University, Baltimore, MD
2011 Wang C. "A Bayesian shrinkage model for incomplete longitudinal binary data".
Tianjin University of Finance and Economics, Tianjin, China
2011 Wang C. "Clinical significance in statistical hypothesis testing". International Drug
Discovery Science and Technology, Shenzhen, China
2011 Wang C. "A causal effect model with stochastic monotonicity assumption". ICSA,
New York, NY
2010 Wang C, Daniels M, Scharfstein D, Land S. "A Bayesian shrinkage model for incom-
plete longitudinal binary data with application to the breast cancer prevention trial". Joint
Statistical Meeting, Vancouver, Canada
2010 Wang C, Daniels M, Scharfstein D, Land S. "A Bayesian shrinkage model for incom-
plete longitudinal binary data". ENAR, New Orleans, LA
2010 Wang C, Scharfstein D, Daniels M. "Using R and OpenBUGS for evaluating the causal
effect of dynamic treatments regimes". Johns Hopkins University, Baltimore, MD
2010 Wang C, Scharfstein D, Daniels M. "Estimating the causal effect of dynamic treatment
regimes with application to an acute lung injury trial". FDA Industry Statistics Workshop,
Washington D.C.
2010 Wang C. "Missing data". FDA/MTLI Medical Device and IVD Statistics Workshop,
chair, Washington D.C.
2010 Wang C, Daniels M. "Bayesian shrinkage models for incomplete longitudinal binary
data". FDA, CDRH, Washington D.C.
2010 Wang C, Daniels M. "Bayesian shrinkage models for incomplete longitudinal binary
data". Yahoo, Sunnyvale, CA
2009 Wang C, Daniels M. "A note on MAR, identifying restrictions, and sensitivity analysis
in pattern mixture models". South Regional Conference on Statistics (SRCOS): Summer
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6. Research Conferences (SRC), poster, Jekyll Island, GA
2009 Daniels M, Wang C, Scharfstein D. "Bayesian semi-parametric selection models with
application to a breast cancer prevention trial". ENAR, San Antonio, TX
2009 Wang C, Daniels M. "Identification strategies for pattern mixture models with covari-
ates". ENAR, San Antonio, TX
2008 Wang C, Daniels M, Scharfstein D. "Bayesian semi-parametric selection models with
application to a breast cancer prevention trial". South Regional Conference on Statistics
(SRCOS): Summer Research Conferences (SRC), poster, Charleston, SC
2007 Wang C, Berg A, Li Q, Wu R. "A statistical strategy for mapping imprinted quan-
titative trait loci: implications for genetic mapping in mice". Florida Genetics Symposium,
poster, Gainesville, FL
2007 Wang C, Li Q, Wu R. "High dimensional model for understanding the genetic network
of ontogenetic allometry". ENAR, Atlanta, GA
2005 Crawford T, Eskridge K, Wang C, Maryville J. "Nitrogen translocation in N-efficient
and N-inefficient cultivars of sorghum". North American Grain Congress, poster, Reno, NV
2004 Crawford T, Eskridge K, Wang C, Maryville J. "Nitrogen translocation in N-efficient
and N-inefficient cultivars of sorghum". American Society of Agronomy annual meeting,
poster, Seattle, WA
Awards Outstanding Junior Investigator, FDA, 2011
Professional
Activities
Associate Editor of Communications for Statistical Applications and Methods
Statistical Advisory Board Member of PLOS ONE
Review Editor of Frontiers in Statistical Genetics and Methodology
Reviewer of Biometrics, Biostatistics, Statistics in Medicine, Journal of Biopharmaceutical
Statistics
Reviewer of Statistical Modelling, Statistics and Its Interface, Journal of Biomedical Science
Reviewer of BMC Genetics, PLoS Genetics, Evolution, Theoretical Biology
Reviewer of Cancer Research, Clinical Trials, Advanced Drug Delivery
Professional
Membership
Society for Clinical Trials (SCT)
American Statistical Association (ASA)
Institute of Mathmatical Statistics (IMS)
International Society for Bayesian Analysis (ISBA)
Eastern North American Region/International Biometric Society (ENAR)
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