This curriculum vitae summarizes the qualifications and experience of Weiliang Qiu. Qiu has over 12 years of experience in data analysis, especially of clinical trial and observational data. He has published over 70 peer-reviewed papers and edited two academic journals. Qiu has a Ph.D. in Statistics and is currently an Associate Biostatistician and Assistant Professor at Brigham and Women's Hospital, where he provides statistical support for clinical trials and develops novel statistical methods.

1. 1
Curriculum Vitae
Weiliang Qiu
Channing Division of Network Medicine
Brigham and Women’s Hospital/Harvard Medical School
Tel: 1-617-999-8101
Email: stwxq@channing.harvard.edu
Website: https://sites.google.com/a/channing.harvard.edu/weiliang-qiu/
Professional Summary
Highly experienced in experimental design in clinical trials, sample size/power calculations,
and statistical consultation; Strong research ability; Proven management and teamwork ability.
Core Qualifications
Ø Statistical Consult for Shenogen Pharma Group Ltd.
Ø Have 12+ years of data analysis experience (clinical trial data and observational data)
Ø Published over 70 peer-reviewed papers and 1 book chapter
Ø Editorial Board Member for Insights in Genetics and Genomics
Ø Statistical Editor for British Journal of Nutrition
Ø Reviewed manuscripts for more than 20 academic journals (e.g. JASA, Bioinformatics,
PLoS One, AJE) (Many of the manuscripts I reviewed are results of clinical trials)
Ø Published 10 R packages published in CRAN or Bioconductor (Ace, correctedAUC,
clusterGeneration, clues, GeneSelectMMD, iCheck, powerMediation, powerSurvEpi,
powerEQTL, sizepower). PowerMediation and sizepower contain functions for power
calculations in clinical trials.
Ø Experienced in SAS macro programming
Education
Ø Ph.D. in Statistics (2004), University of British Columbia, Vancouver, Canada
Ø M.Sc. in Statistics (1999), Beijing Polytechnic University, Beijing, China
Ø B.Sc. in Applied Mathematics and Software (1996), Beijing Polytechnic University,
Beijing, China
Work Experience
Ø 05/2013 – present, Associate Biostatistician/Assistant Professor, Brigham and Women's
Hospital/Harvard Medical School
o Data analysis for the clinical trial: The Vitamin D Antenatal Asthma Reduction
Trial (VDAART)
o Investigate the best treatments and evaluate risk factors for older patients with
cardiovascular diseases
o Develop novel equal-variance tests in the application of DNA methylation data
o Compare performance of equal-variance tests in the application of DNA
methylation data
o Develop novel mixture of Bayesian hierarchical models to do gene clustering for
gene expression data generated from paired/matched design
o Evaluate effects of microRNAs and DNA methylation on the response to asthma
drug treatment

2. 2
o Detect differential connectivity of gene regulatory networks that distinguishes
corticosteroid response in asthma
o Investigate epigenetic mechanism of chronic obstructive pulmonary disease and
idiopathic pulmonary fibrosis
o Develop novel statistical method to correct area under ROC for measurement
error
o Apply empirical Bayes’ methods to predict the rate of decline in
electroretinography at the individual level among patients with retinitis pigmentosa
o Investigate effect of longitudinally measured modifiable risk factors on prostate
cancer mortality
o Provide statistical support (experimental design, sample size calculation, data
preprocessing, data analysis, grant/manuscript review) to colleagues and post-doc
research fellows
o Supervise graduate students, college students, and high school interns
Ø 11/2016 – Editorial Board Member for Insights in Genetics and Genomics
o Review manuscripts
Ø 02/2016 – Statistical Editor for British Journal of Nutrition
o Review manuscripts
Ø 2015-2016 – Statistical Consult for Shenogen Pharma Group Ltd.
o Provide statistical supports
Ø 11/2015 – present, Webmaster, Lifetime Data Analysis (LIDA) Interest Group, American
Statistical Association
o Maintain LIDA Interest group microsite
Ø 01/2016 – 05/2016, Part-time Lecturer, Bouvé College of Health Sciences in the Health
Sciences, Northeastern University
o Teach PHTH 6210 Applied Regression Analysis to graduate students for the
Spring 2016 semester
Ø 07/2006 – 04/2013, Associate Biostatistician/Instructor, Brigham and Women's
Hospital/Harvard Medical School
o Data analysis for the clinical trial: The Vitamin D Antenatal Asthma Reduction
Trial (VDAART)
o Investigate the best treatments and evaluate risk factors for older patients with
cardiovascular diseases
o Integrate gene differential analysis and expression quantitative trait loci analysis to
identify novel loci for pharmacogenomics
o Investigate epigenetic mechanism of chronic obstructive pulmonary disease
o Investigate genetic effects on gene expression in chronic obstructive pulmonary
disease
o Develop extended Mann-Whitney U test to assess discrimination of risk prediction
rules in a clustered data setting
o Develop novel method to correct for measurement error when using cumulative
average model in the survival analysis of nutritional data
o Develop novel method to incorporate censoring and informative dropouts in HIV
viral dynamic models
o Develop novel mixture of marginal distributions to do gene clustering for gene
expression data
o Contribute to GeneticsDesign R package to calculate power for testing if disease
is associated with marker in a case-control study

3. 3
o Provide statistical support (experimental design, sample size calculation, data
preprocessing, data analysis, grant/manuscript review) to colleagues and post-doc
research fellows
Ø 10/2004 – 06/2006, Research Fellow, Brigham and Women's Hospital/Harvard Medical
School
o Develop a web-based calculator for sample size and power calculation in
microarray studies (http://sph.umd.edu/department/epib/sample-size-and-power-
calculations-microarray-studies)
o Identify antibodies to help diagnose prostate cancer based on data collected from
“reverse capture” autoantibody microarrays
o Compare generalized rank tests with multivariate rank tests for microarray data
Ø 2001 – 2003, Webmaster, Department of Statistics, University of British Columbia,
Canada
o Maintain website for Department of Statistics, UBC
Ø 09/1998 – 05/1999, Research Associate, Department of Management Sciences, City
University of Hong Kong, China
o Investigate product reliability
Ø 09/1995 – 05/1996, Intern, Institute of Software, Chinese Academy of Sciences, Beijing,
China
o Develop graph automatic vectorization software using C++
Publication
1. Qiu W, Joe H. Separation Index and Partial Membership for Clustering. Comput
Stat Data An. 2006;50(3):585-03.
2. Qiu W, Joe H. Generation of random clusters with specified degree of
separation. J Classif. 2006;23:315-34.
3. Qiu W, Lee ML. SPCalc: A Web-based calculator for sample size and power
calculations in micro-array studies. Bioinformation. 2006;1(7):251-2. PMID:
17597901; PMCID: PMC1891702.
4. Qin S, Qiu W, Ehrlich JR, Ferdinand AS, Richie JP, O'leary MP, Lee ML, Liu BC.
Development of a “reverse capture” autoantibody microarray for studies of
antigen-autoantibody profiling. Proteomics. 2006;6(10):3199-209. PMID:
16596707.
5. Ehrlich JR, Caiazzo RJ Jr, Qiu W, Tassinari OW, O’Leary MP, Richie JP, Liu BC.
A native antigen “reverse capture” microarray platform for autoantibody profiling of
prostate cancer sera. Proteomics Clin Appl. 2007;1(5):476-85. PMID: 21136699.
6. Wang S, Qiu W, Zamar RH. CLUES: A non-parametric clustering method based
on local shrinking. Comput Stat Data An. 2007;52(1):286-98.
7. Lazarus R, Taylor J, Qiu W, Nekrutenko A. Toward the commoditization of
translational genomic research: Design and implementation features of the Galaxy
genomic workbench. Summit on Translational Bioinformatics. 2008;56-60. PMID:
21347127; PMCID: PMC3041519.
8. Qiu W, He W, Wang X, Lazarus R. A Marginal mixture model for selecting
differentially expressed genes across two types of tissue samples. Int J
Biostat. 2008;4(1):Article20. PMID:20231912; PMCID: PMC2835454.
9. Ma J, Li H, Giovannucci E, Mucci L, Qiu W, Nguyen PL, Gaziano JM, Pollak M,
Stampfer MJ. Prediagnostic body-mass index, plasma C-peptide concentration,

4. 4
and prostate cancer-specific mortality in men with prostate cancer: a long-term
survival analysis. Lancet Oncol. 2008;9(11):1039-47. PMID:18835745; PMCID:
PMC2651222.
10.Shappley WV 3rd, Kenfield SA, Kasperzyk JL, Qiu W, Stampfer MJ, Sanda MG,
Chan JM. Prospective study of determinants and outcomes of deferred treatment
or watchful waiting among men with prostate cancer in a nationwide cohort. J Clin
Oncol. 2009;27(30):4980-5. PMID: 19720918; PMCID: PMC2799054.
11.Estes SJ, Ye B, Qiu W, Cramer D, Hornstein MD, Missmer SA. A proteomic
analysis of IVF follicular fluid in women <or=32 years old. Fertil Steril.
2009;92(5):1569-78. PMID: 18980758; PMCID: PMC2915999.
12.Qiu W, Rosner B. Measurement error correction for the cumulative average model
in the survival analysis of nutritional data: application to Nurses' Health
Study. Lifetime Data Anal. 2010;16(1):136-53. PMID: 19757039; PMCID:
PMC2809827.
13.Qiu W, Wu L. HIV Viral Dynamic Models with Censoring and Informative
Dropouts. Statistics in Biopharmaceutical Research. 2010;2(2):220-8.
14.Chang F, Qiu W, Zamar RH, Lazarus R, Wang X. CLUES: An R package for
nonparametric clustering based on local shrinking. J Stat Softw. 2010;33(4):1-16.
15.Li H, Stampfer MJ, Mucci L, Rifai N, Qiu W, Kurth T, Ma J. A 25-year prospective
study of plasma adiponectin and leptin concentrations and prostate cancer risk
and survival. Clin Chem. 2010;56(1):34-43. PMID: 19910504; PMCID:
PMC2858593.
16.Zhang L, Wang D, Jiang W, Edwards D, Qiu W, Barroilhet LM, Rho JH, Jin L,
Seethappan V, Vitonis A, Wang J, Mok SC, Crum C, Cramer DW, Ye B. Activated
networking of platelet activating factor receptor and FAK/STAT1 induces malignant
potential in BRCA1-mutant at-risk ovarian epithelium. Reprod Biol Endocrinol.
2010;8:74. PMID: 20576130; PMCID: PMC2903602.
17.Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W,
Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA,
Stampfer MJ, Giovannucci E, Loda M. Fatty acid synthase polymorphisms, tumor
expression, body mass index, prostate cancer risk, and survival. J Clin Oncol.
2010;28(25):3958-64. PMID: 20679621; PMCID: PMC2940394.
18.Kunadian V, Zaman A, Spyridopoulos I, Qiu W. Sodium bicarbonate for the
prevention of contrast induced nephropathy: a meta-analysis of published clinical
trials. Eur J Radiol. 2011;79(1):48-55. PMID: 20074886.
19.Kunadian V, Zaman A, Qiu W. Revascularization among patients with severe left
ventricular dysfunction: a meta-analysis of observational studies. Eur J Heart Fail.
2011;13(7):773-84. PMID: 21478241; PMCID: PMC3125123.
20.Jiang W, Qiu W, Wang Y, Cong Q, Edwards D, Ye B, Xu C. Ginkgo may prevent
genetic-associated ovarian cancer risk: multiple biomarkers and anticancer
pathways induced by ginkgolide B in BRCA1-mutant ovarian epithelial cells. Eur J
Cancer Prev. 2011;20(6):508-17. PMID: 21857521.
21.Wang S, Zhao X, Khimji I, Akbas R, Qiu W, Edwards D, Cramer DW, Ye B,
Demirci U. Integration of cell phone imaging with microchip ELISA to detect
ovarian cancer HE4 biomarker in urine at the point-of-care. Lab Chip.
2011;11(20):3411-8. PMID: 21881677.
22.Qiu W, Cho MH, Riley JH, Anderson WH, Singh D, Bakke P, Gulsvik A, Litonjua
AA, Lomas DA, Crapo JD, Beaty TH, Celli BR, Rennard S, Tal-Singer R, Fox SM,

5. 5
Silverman EK, Hersh CP; ECLIPSE Investigators. Genetics of sputum gene
expression in chronic obstructive pulmonary disease. PLoS One.
2011;6(9):e24395. PMID: 21949713. PMCID: PMC3174957.
23.Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C,
Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD,
Mauger D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF Jr, Peters SP, Lima
JJ, Nakamura Y, Tamari M, Weiss ST. Genomewide association between GLCCI1
and response to glucocorticoid therapy in asthma. N Engl J Med.
2011;365(13):1173-83. PMID: 21991891 [PubMed - indexed for MEDLINE]
PMCID: PMC3667396.
24.Cao Y, Kenfield S, Song Y, Rosner B, Qiu W, Sesso HD, Gaziano JM, Ma J.
Cigarette smoking cessation and total and cause-specific mortality: a 22-year
follow-up study among US male physicians. Arch Intern Med. 2011;171(21):1956-
9. PMID: 22123811; PMCID: PMC3229033.
25.Aschard H, Qiu W, Pasaniuc B, Zaitlen N, Cho MH, Carey V. Combining effects
from rare and common genetic variants in an exome-wide association study of
sequence data. BMC Proc. 2011;5 Suppl 9:S44. PMID: 22373328; PMCID:
PMC3287881.
26.Qiu W, Baccarelli A, Carey VJ, Boutaoui N, Bacherman H, Klanderman B,
Rennard S, Agusti A, Anderson W, Lomas DA, Demeo DL. Variable DNA
methylation is associated with chronic obstructive pulmonary disease and lung
function. Am J Respir Crit Care Med. 2012;185(4):373-81. PMID: 22161163;
PMCID: PMC3297093.
27.Wan ES, Qiu W, Baccarelli A, Carey VJ, Bacherman H, Rennard SI, Agusti A,
Anderson W, Lomas DA, DeMeo DL. Cigarette smoking behaviors and time since
quitting are associated with differential DNA methylation across the human
genome. Human Molecular Genetics. 2012;21(13):3073-82. PMID: 22492999;
PMCID: PMC3373248.
28.Carpe N, Mandeville I, Kho AT, Qiu W, Martin JG, Tantisira KG, Raby BA, Weiss
ST, Kaplan F. Maternal allergen exposure reprograms the developmental lung
transcriptome in atopic and normo-responsive rat pups. American Journal of
Physiology - Lung Cellular and Molecular Physiology. 2012;303(10):L899-911
PMID: 22983352; PMCID: PMC3517678
29.Kunadian V, Pugh A, Zaman AG, Qiu WL. Percutaneous Coronary Intervention in
Patients with Severe Left Ventricular Dysfunction: A Meta-analysis of 19
Studies. Coronary Artery Disease. 2012 Nov;23(7):469-79. PMID: 22960383
30.Wan E.S., Qiu W., Baccarelli A, Carey V.J., Bacherman H., Rennard S.I., Agusti
A., Anderson W., Lomas D.A., DeMeo D.L., Systemic Steroid Exposure is
Associated with Differential Methylation in Chronic Obstructive Pulmonary
Disease. American Journal of Respiratory and Critical Care Medicine. 2012;
186(12):1248-55. PMID: 23065012 PMCID: PMC3622442
31.Kim DK, Cho MH, Hersh CP, Lomas DA, Miller BE, Kong X, Bakke P, Gulsvik A,
Agustí A, Wouters E, Celli B, Coxson H, Vestbo J, Macnee W, Yates JC, Rennard
S, Litonjua A, Qiu W, Beaty TH, Crapo JD, Riley JH, Tal-Singer R, Silverman EK;
on behalf of the ECLIPSE, ICGN, and COPDGene Investigators. Genome-Wide
Association Analysis of Blood Biomarkers in Chronic Obstructive Pulmonary
Disease. American Journal of Respiratory and Critical Care Medicine.
2012;186(12):1238-1247. PMID: 23144326

6. 6
32.Rosner B, Qiu W, Lee MT. Assessing Discrimination of Risk Prediction Rules in a
Clustered Data Setting. Lifetime Data Analysis. 2013;19(2):242-56 PMID:
23263872; PMCID: PMC3622772
33.Song Y, Chavarro JE, Cao Y, Qiu W, Mucci L, Sesso HD, Stampfer MJ,
Giovannucci E, Pollak M, Liu S, and Ma J. Whole Milk Intake Is Associated with
Prostate Cancer-Specific Mortality among U.S. Male Physicians. Journal of
Nutrition. 2013;143(2):189-96 PMID: 23256145.
34.Bawamia B, Mehran R, Qiu W, Kunadian V. Risk Scores in Acute Coronary
Syndrome and Percutaneous Coronary Intervention: A Review. American Heart
Journal. 2013; 165(4):441-450 PMID: 23537960
35.Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM,
Litonjua A, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C,
Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AM, Quackenbush J,
Silverman EK. Gene expression analysis uncovers novel Hedgehog interacting
protein (HHIP) effects in human bronchial epithelial cells. Genomics.
2013;101(5):263-72. PMID: 23459001; PMCID: PMC3659826
36.Kunadian V, Qiu W, Bawamia B, Veerasamy M, Jamieson S, Zaman A. Gender
Comparisons in Cardiogenic Shock During ST Elevation Myocardial Infarction
Treated by Primary Percutaneous Coronary Intervention. The American Journal of
Cardiology. 2013; 112(5):636-41.PMID: 23711807.
37.Himes BE, Qiu W, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske
RF Jr, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E,
Mauger D, Koppelman GH, Nieuwenhuis MA, Postma DS, Vonk JM, Rafaels N,
Hansel NN, Barnes K, Raby B, Tantisira KG, Weiss ST. ITGB5 and AGFG1
variants are associated with severity of airway responsiveness. BMC Med Genet.
2013 Aug 28;14(1):86. PMID: 23984888; PMCID: PMC3765944
38.Kho AT, Sharma S, Qiu W, Gaedigk R, Klanderman B, Niu S, Anderson C, Leeder
JS, Weiss ST, Tantisira KG. Vitamin D related genes in lung development and
asthma pathogenesis. BMC Medical Genomics. 2013; 6:47. PMID: 24188128
39.Duan QL, Lasky-Su J, Himes BE, Qiu W, Litonjua AA, Damask A, Lazarus R,
Klanderman B, Irvin CG, Peters SP, Hanrahan JP, Lima JJ, Martinez FD, Mauger
D, Chinchilli VM, Soto-Quiros M, Avila L, Celedón JC, Lange C, Weiss ST,
Tantisira KG. A genome-wide association study of bronchodilator response in
asthmatics. Pharmacogenomics J. 2014; 14(1):41-7. PMID: 23508266; PMCID:
PMC3706515
40.Wu AC, Himes BE, Lasky-Su J, Litonjua A, Peters SP, Lima J, Kubo M, Tamari M,
Nakamura Y, Qiu W, Weiss ST, Tantisira K. Inhaled corticosteroid treatment
modulates ZNF432 gene variant's effect on bronchodilator response in
asthmatics. American Academy of Allergy, Asthma and Immunology. 2014;
133(3):723-728. PMID: 24280104
41.Kunadian V, Ford GA; Jones DE; Bawamia B, Qiu W; Manson JE. Vitamin D
Deficiency and Coronary Artery Disease: A Review of the Evidence. The American
Heart Journal. 2014 Mar;167(3):283-291. PMID: 24576510.
42.Kunadian V, Bawamia B, Maznyczka A, Zaman A, and Qiu W. Outcomes
following primary percutaneous coronary intervention in the setting of cardiac
arrest: A registry database study. European Heart Journal: Acute Cardiovascular
Care. 2015; 4(1): 6-15 PMID: 24818951

7. 7
43.Qiu W, Rogers AJ, Damask A, Raby BA; Klanderman BJ, Duan QL, Tyagi S, Niu
S, Anderson C, Cahir-McFarland E, Mariani TJ, Carey V, Tantisira
KG. Pharmacogenomics: Novel Loci Identification via Integrating Gene Differential
Analysis and eQTL Analysis. Human Molecular Genetics 2014 Sep
15;23(18):5017-24. PMID: 24770851 [PubMed - in process] PMCID: PMC4140460
[Available on 2015/9/15]
44.Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP,
Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M,
Padhukasahasram B, Yang JJ, Mathias RA, Beaty TH, Li X, Graves P, Romieu I,
Del Rio Navarro B, Salam MT, Vora H, Nicolae DL, Ober C, Martinez FD, Bleecker
ER, Meyers DA, Gauderman WJ, Gilliland F, Burchard EG, Barnes KC, Williams
LK, London SJ, Zhang B, Raby BA, Weiss ST. Integrated Genome-wide
Association, Coexpression Network, and Expression Single Nucleotide
Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis. BMC Med
Genomics. 2014 Aug 2;7(1):48. [Epub ahead of print] PMID: 25085501 [PubMed -
as supplied by publisher]
45.Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM,
Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka
DC, Del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E,
Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H,
Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC; on
behalf of GRAAD, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae
DL. Genome-wide interaction studies reveal sex-specific asthma risk
alleles. Hum Mol Genet. 2014 May 13. pii: ddu222. [Epub ahead of print] PMID:
24824216 [PubMed - as supplied by publisher]
46.Sharma S, Kho AT, Chhabra D, Qiu W, Gaedigk R, Vyhlidal CA, Leeder JS,
Barraza-Villarreal A, London SJ, Gilliland F, Raby BA, Weiss ST, Tantisira KG.
Glucocorticoid Genes and the Developmental Origins of Asthma Susceptibility and
Treatment Response. Am J Respir Cell Mol Biol. 2014 Sep 5. [Epub ahead of
print] PMID: 25192440 [PubMed - as supplied by publisher]
47.Morrow JD, Qiu W, Chhabra D, Rennard SI, Belloni P, Belousov A, Pillai SG,
Hersh CP. Identifying a gene expression signature of frequent COPD
exacerbations in peripheral blood using network methods. BMC Med
Genomics. 2015 Jan 13;8(1):1. PMID: 25582225 PMCID: PMC4302028
48.Sharma A, Menche J, Huang C, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D,
Voung L, Guo F, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H,
Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss
ST, Barabási AL. A disease module in the interactome explains disease
heterogeneity, drug response and captures novel pathways and genes. Hum Mol
Genet. 2015 Jan 12. pii: ddv001. [Epub ahead of print] PMID: 25586491
49.Wan ES, Qiu W, Carey VJ, Morrow J, Bacherman H, Foreman MG, Hokanson JE,
Bowler RP, Crapo JD, DeMeo DL. Smoking Associated Site Specific Differential
Methylation in Buccal Mucosa in the COPDGene Study. Am J Respir Cell Mol
Biol. 2014 Dec 17. [Epub ahead of print] PMID: 25517428
50.Kunadian V, Qiu W, Ludman P, Redwood S, Curzen N, Stables R, Gunn J,
Gershlick A; National Institute for Cardiovascular Outcomes Research. Outcomes
in Patients With Cardiogenic Shock Following Percutaneous Coronary Intervention
in the Contemporary Era: An Analysis From the BCIS Database (British

8. 8
Cardiovascular Intervention Society). JACC Cardiovasc Interv. 2014
Dec;7(12):1374-85. doi: 10.1016/j.jcin.2014.06.017. PMID: 25523531
51.Breton CV, Siegmund KD, Joubert BR, Wang X, Qui W, Carey V, Nystad W,
Håberg SE, Ober C, Nicolae D, Barnes KC, Martinez F, Liu A, Lemanske R,
Strunk R, Weiss S, London S, Gilliland F, Raby B; Asthma BRIDGE consortium.
Prenatal tobacco smoke exposure is associated with childhood DNA CpG
methylation. PLoS One. 2014 Jun 25;9(6):e99716 PMID: 24964093 [PubMed - in
process] PMCID: PMC4070909
52.Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A,
Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-
Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh
CP. Genetic control of gene expression at novel and established chronic
obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15;24(4):1200-10.
doi: 10.1093/hmg/ddu525. Epub 2014 Oct 14. PMID: 25315895
53.Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L,
Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou
X. Haploinsufficiency of Hedgehog interacting protein causes increased
emphysema induced by cigarette smoke through network rewiring. Genome Med.
2015 Feb 14;7(1):12. PMID: 25763110
54.Sordillo JE, Kelly R, Bunyavanich S, McGeachie M, Qiu W, Croteau-Chonka DC,
Soto-Quiros M, Avila L, Celedón JC, Brehm JM, Weiss ST, Gold DR, Litonjua AA.
Genome-wide expression profiles identify potential targets for gene-environment
interactions in asthma severity. J Allergy Clin Immunol. 2015 Apr 24. pii: S0091-
6749(15)00341-3. doi: 10.1016/j.jaci.2015.02.035. [Epub ahead of print] PMID:
25913104
55.Wang, X, Qiu W, Wu J. Convergence and Stability Analysis of Mean-Shift
Algorithm on Large Data Sets. Statistics and Its Interface. 2016 9:159-170.
56.Qiu W, Wan E, Morrow J, Cho MH, Crapo JD, Silverman EK, DeMeo DL. The
impact of genetic variation and cigarette smoke on DNA methylation in current and
former smokers from the COPDGene study. Epigenetics 2015;10(11):1064-73.
doi: 10.1080/15592294.2015.1106672, PMID: 26646902
57.Li X, Qiu W, Morrow J, DeMeo DL, Weiss ST, Fu Y, Wang X. (2015) A
Comparative Study of Tests for Homogeneity of Variances with Application to DNA
Methylation Data. PLoS ONE 10(12): e0145295. PMID: 26683022.
58.Kho AT, Chhabra D, Sharma S, Qiu W, Carey VJ, Gaedigk R, Vyhlidal CA, Leeder
JS, Tantisira KG, Weiss ST. (2015) Age, Sexual Dimorphism and Disease
Associations in the Developing Human Fetal Lung Transcriptome. Am J Respir
Cell Mol Biol. 2015 Nov 19. [Epub ahead of print] PMID: 26584061
59.Croteau-Chonka DC, Rogers AJ, Raj T, McGeachie MJ, Qiu W, Ziniti JP, Stubbs
BJ, Liang L, Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Stranger BE,
Carey VJ, Raby BA. (2015) Expression Quantitative Trait Loci Information
Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic
Variation. PLoS One. 2015 Oct 16;10(10):e0140758. PMID: 26474488
60.McGeachie MJ, Dahlin A, Qiu W, Croteau-Chonka DC, Savage J, Wu AC, Wan
ES, Sordillo JE, Al-Garawi A, Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH,
Raby BA, Weiss S, Clish CB, Lasky-Su JA. (2015) The metabolomics of asthma
control: a promising link between genetics and disease. Immun Inflamm Dis. 2015
Sep;3(3):224-38. doi: 10.1002/iid3.61. Epub 2015 May 7. PMID: 26421150

9. 9
61.Wan ES, Qiu W, Morrow J, Beaty TH, Hetmanski J, Make BJ, Lomas DA,
Silverman EK, DeMeo DL. (2015) Genome-wide site-specific differential
methylation in the blood of individuals with Klinefelter syndrome. Mol Reprod
Dev. 2015 May;82(5):377-86. doi: 10.1002/mrd.22483. Epub 2015 Apr 30. PMID:
25988574
62.Rosner B, Tworoger S, Qiu W (2015) Correcting AUC for Measurement Error. J
Biom Biostat 6:270. doi:10.4172/2155-6180.1000270.
63.Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho
MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi
AM, Perrella MA, Owen CA, Silverman EK, Zhou X. A Chronic Obstructive
Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-
catenin. Am J Respir Crit Care Med. 2016 Feb 10. [Epub ahead of print]
64.Kho AT, Sharma S, Davis JS, Spina J, Howard D, McEnroy K, Moore K, Sylvia
J, Qiu W, Weiss ST, Tantisira KG. Circulating MicroRNAs: Association with Lung
Function in Asthma. PLoS One. 2016 Jun 30;11(6):e0157998. doi:
10.1371/journal.pone.0157998. eCollection 2016. PMID: 27362794
65.Croteau-Chonka DC, Qiu W, Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH,
Gilliland FD, Millstein J, Gauderman WJ, Ober C, Krishnan JA, White SR,
Naureckas ET, Nicolae DL, Barnes KC, London SJ, Barraza-Villarreal A, Carey
VJ, Weiss ST, Raby BA; Asthma BioRepository for Integrative Genomic
Exploration (Asthma BRIDGE) Consortium. Gene Expression Profiling in Blood
Provides Reproducible Molecular Insights into Asthma Control. Am J Respir Crit
Care Med. 2016 Aug 5. PMID: 27494826
66.Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-
Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou
X. Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl
Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113.
Epub 2016 Jul 21. PMID: 27444019
67.Sinclair H, Batty JA, Qiu W, Kunadian V. Engaging older patients in cardiovascular
research: observational analysis of the ICON-1 study. Open Heart. 2016 Aug
3;3(2):e000436. doi: 10.1136/openhrt-2016-000436. eCollection 2016. PMID:
27547431
68.Kunadian V, Neely RD, Sinclair H, Batty JA, Veerasamy M, Ford GA, Qiu W.
Study to Improve Cardiovascular Outcomes in high-risk older patieNts (ICON1)
with acute coronary syndrome: study design and protocol of a prospective
observational study. BMJ Open. 2016 Aug 23;6(8):e012091. doi:
10.1136/bmjopen-2016-012091. PMID: 27554105
69.Zhu W, Xu H, Ma J, Guo J, Xue W, Gu B, Sheng L, Yao X, Sun F, Gong J, Qiu W,
Ding Q, Jiang H. An Open-Label Pilot Study of Metformin as a Concomitant
Therapy on Patients with Prostate Cancer Undergoing Androgen Deprivation
Treatment. Urol Int. 2016 Sep 30. [Epub ahead of print] PMID: 27684440
70.Al-Garawi A, Carey VJ, Chhabra D, Mirzakhani H, Morrow J, Lasky-Su J, Qiu W,
Laranjo N, Litonjua AA, Weiss ST. The Role of Vitamin D in the Transcriptional

10. 1
0
Program of Human Pregnancy. PLoS One. 2016 Oct 6;11(10):e0163832. PMID:
27711190
71.Kelly RS, Dahlin A, McGeachie MJ, Qiu W, Sordillo J, Wan ES, Wu AC, Lasky-Su
J. Asthma metabolomics and the potential for integrative omics in research and
the clinic. Chest. 2016 Oct 21. pii: S0012-3692(16)60777-8. PMID: 27776981
72.Busch R, Qiu W, Lasky-Su J, Morrow J, Criner G, DeMeo D. Differential DNA
methylation marks and gene comethylation of COPD in African-Americans with
COPD exacerbations. Respir Res. 2016 Nov 5;17(1):143. PMID: 27814717
73.Kunadian V, Qiu W, Lagerqvist B, Johnston N, Sinclair H, Tan Y, Ludman P,
James S, Sarno G; National Institute for Cardiovascular Outcomes Research and
Swedish Coronary Angiography and Angioplasty Registries. Gender Differences in
Outcomes and Predictors of All-Cause Mortality After Percutaneous Coronary
Intervention (Data from United Kingdom and Sweden). Am J Cardiol. 2017 Jan
15;119(2):210-216. PMID: 27816119
74.Zhu W, Xu H, Ma J, Guo J, Xue W, Gu B, Sheng L, Yao X, Sun F, Gong J, Qiu W,
Ding Q, Jiang H. An Open-Label Pilot Study of Metformin as a Concomitant
Therapy on Patients with Prostate Cancer Undergoing Androgen Deprivation
Treatment. Urol Int. 2017;98(1):79-84. PMID: 27684440