Opexa Therapeutics presented information on their Precision Immunotherapy platform and lead programs. Their lead candidate, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has shown promise in reducing reactive T-cells and relapse rates in prior studies. Their platform also supports development of OPX-212 for neuromyelitis optica, a rare disease with no approved therapies. Opexa has an option agreement with Merck Serono for Tcelna in MS and recently secured $5 million in funding to advance OPX-212 into clinical trials for NMO.
Opexa Therapeutics Corporate Presentation October 2015OpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy programs, Tcelna and OPX-212. Tcelna is in a Phase 2b clinical trial for secondary progressive multiple sclerosis and has shown a 37% reduction in relapses in prior trials. OPX-212 is being developed for neuromyelitis optica, an orphan disease with no approved therapies. Opexa expects to file an IND for OPX-212 by the end of 2015 after completing preclinical studies. The company highlighted their personalized T-cell immunotherapy platform, clinical progress, pipeline expansion opportunities, and management team experience in drug development.
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead program, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis (SPMS). If successful, Tcelna has the potential to address an unmet medical need as there is currently only one approved drug for SPMS that is not suitable for chronic use due to side effects. Opexa has an agreement with Merck Serono to develop Tcelna for MS indications worldwide, excluding Japan. Topline results from the Phase 2b SPMS trial are expected in late 2016.
Opexa Therapeutics December 2015 Corporate PresentationOpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and lead programs. Their T-cell immunotherapy Tcelna is in Phase 2b clinical trials for secondary progressive multiple sclerosis. Preclinical studies of OPX-212 showed a reduction of AQP4 reactive T-cells in a murine model of neuromyelitis optica, an orphan disease with no approved therapies. Opexa secured funding to advance OPX-212 into a Phase I/II clinical trial in 2016 pending regulatory approval. Their proprietary ImmPath platform allows for personalized T-cell therapies tailored for individual patient's disease profiles.
Opexa Therapeutics August 2015 OPXA Corporate PresentationOpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and key programs. Their lead candidate, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has shown signs of stabilizing disease progression. Tcelna works by reducing myelin reactive T-cells that damage the myelin sheath. Opexa has an option agreement with Merck Serono for the development and commercialization of Tcelna in multiple sclerosis. Additionally, Opexa is developing OPX-212 for neuromyelitis optica, an orphan indication with no approved therapies.
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead candidate, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has shown signs of stabilizing disease progression in previous trials. Opexa has an option agreement with Merck Serono for the development and commercialization of Tcelna in multiple sclerosis. Recent milestones include completing enrollment in the Tcelna Phase 2b trial for SPMS and receiving a $3 million payment from Merck Serono. Opexa is also developing OPX-212 for neuromyelitis optica and expects to file an IND by the end of 2015.
Opexa Therapeutics provides a summary of its precision immunotherapy platform and clinical programs. Key points include:
- Tcelna in development for multiple sclerosis, with a Phase 2b trial ongoing in secondary progressive MS. Topline data expected in 2016.
- Pipeline expansion includes OPX-212 for neuromyelitis optica, with IND submission planned for mid-2015.
- Clinical trials show Tcelna reduces myelin reactive T-cells and improved outcomes for relapsing remitting MS patients versus placebo in Phase 2b trials.
- Agreement with Merck Serono provides potential for commercial partnership if Phase 3 is initiated for multiple sclerosis indications.
Opexa therapeutics corporate presentation october 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, an autologous T cell immunotherapy, for the treatment of multiple sclerosis (MS). A Phase 2b clinical trial of Tcelna in secondary progressive MS (SPMS) is ongoing, with top-line results expected in late 2016. Previous clinical trials of Tcelna in relapsing-remitting MS showed a 37% reduction in relapse rate compared to placebo and reversal of disability progression in more active patients. Opexa signed an agreement with Merck Serono for development and commercialization of Tcelna in MS worldwide, excluding Japan, which could provide over $220 million in milestones to Opexa.
Opexa therapeutics corporate presentation september 2016OpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and lead programs. Their lead asset, Tcelna, is in Phase 2b development for secondary progressive multiple sclerosis and top-line data is expected in the next 1-2 months. They are also developing OPX-212 for neuromyelitis optica, an orphan indication with no approved therapies. Opexa has secured an option agreement with Merck Serono for Tcelna in MS and could receive up to $25 million in milestones if Merck exercises their option after seeing Phase 2b data.
Opexa Therapeutics Corporate Presentation October 2015OpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy programs, Tcelna and OPX-212. Tcelna is in a Phase 2b clinical trial for secondary progressive multiple sclerosis and has shown a 37% reduction in relapses in prior trials. OPX-212 is being developed for neuromyelitis optica, an orphan disease with no approved therapies. Opexa expects to file an IND for OPX-212 by the end of 2015 after completing preclinical studies. The company highlighted their personalized T-cell immunotherapy platform, clinical progress, pipeline expansion opportunities, and management team experience in drug development.
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead program, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis (SPMS). If successful, Tcelna has the potential to address an unmet medical need as there is currently only one approved drug for SPMS that is not suitable for chronic use due to side effects. Opexa has an agreement with Merck Serono to develop Tcelna for MS indications worldwide, excluding Japan. Topline results from the Phase 2b SPMS trial are expected in late 2016.
Opexa Therapeutics December 2015 Corporate PresentationOpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and lead programs. Their T-cell immunotherapy Tcelna is in Phase 2b clinical trials for secondary progressive multiple sclerosis. Preclinical studies of OPX-212 showed a reduction of AQP4 reactive T-cells in a murine model of neuromyelitis optica, an orphan disease with no approved therapies. Opexa secured funding to advance OPX-212 into a Phase I/II clinical trial in 2016 pending regulatory approval. Their proprietary ImmPath platform allows for personalized T-cell therapies tailored for individual patient's disease profiles.
Opexa Therapeutics August 2015 OPXA Corporate PresentationOpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and key programs. Their lead candidate, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has shown signs of stabilizing disease progression. Tcelna works by reducing myelin reactive T-cells that damage the myelin sheath. Opexa has an option agreement with Merck Serono for the development and commercialization of Tcelna in multiple sclerosis. Additionally, Opexa is developing OPX-212 for neuromyelitis optica, an orphan indication with no approved therapies.
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead candidate, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has shown signs of stabilizing disease progression in previous trials. Opexa has an option agreement with Merck Serono for the development and commercialization of Tcelna in multiple sclerosis. Recent milestones include completing enrollment in the Tcelna Phase 2b trial for SPMS and receiving a $3 million payment from Merck Serono. Opexa is also developing OPX-212 for neuromyelitis optica and expects to file an IND by the end of 2015.
Opexa Therapeutics provides a summary of its precision immunotherapy platform and clinical programs. Key points include:
- Tcelna in development for multiple sclerosis, with a Phase 2b trial ongoing in secondary progressive MS. Topline data expected in 2016.
- Pipeline expansion includes OPX-212 for neuromyelitis optica, with IND submission planned for mid-2015.
- Clinical trials show Tcelna reduces myelin reactive T-cells and improved outcomes for relapsing remitting MS patients versus placebo in Phase 2b trials.
- Agreement with Merck Serono provides potential for commercial partnership if Phase 3 is initiated for multiple sclerosis indications.
Opexa therapeutics corporate presentation october 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, an autologous T cell immunotherapy, for the treatment of multiple sclerosis (MS). A Phase 2b clinical trial of Tcelna in secondary progressive MS (SPMS) is ongoing, with top-line results expected in late 2016. Previous clinical trials of Tcelna in relapsing-remitting MS showed a 37% reduction in relapse rate compared to placebo and reversal of disability progression in more active patients. Opexa signed an agreement with Merck Serono for development and commercialization of Tcelna in MS worldwide, excluding Japan, which could provide over $220 million in milestones to Opexa.
Opexa therapeutics corporate presentation september 2016OpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and lead programs. Their lead asset, Tcelna, is in Phase 2b development for secondary progressive multiple sclerosis and top-line data is expected in the next 1-2 months. They are also developing OPX-212 for neuromyelitis optica, an orphan indication with no approved therapies. Opexa has secured an option agreement with Merck Serono for Tcelna in MS and could receive up to $25 million in milestones if Merck exercises their option after seeing Phase 2b data.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are designed to program the immune system to target pathogenic myelin-reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa therapeutics corporate presentation march 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a precision immunotherapy, for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin reactive T-cell clones that are believed to trigger an immune response targeting pathogenic myelin reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa Therapeutics is conducting a Phase IIb clinical trial of its T-cell immunotherapy Tcelna to treat Secondary Progressive Multiple Sclerosis (SPMS). The company recently signed an option agreement with Merck Serono that could provide up to $225 million in payments if Merck exercises its option to acquire rights to Tcelna in MS. Opexa is also exploring opportunities to develop Tcelna and its stem cell platform in other autoimmune diseases. The ongoing Phase IIb trial is evaluating Tcelna's ability to reduce brain atrophy and progression in 180 SPMS patients over two years.
Opexa Therapeutics Corporate Presentation July 2014OpexaTherapeutics
Opexa Therapeutics is developing precision immunotherapy treatments, with its lead candidate Tcelna in Phase IIb clinical trials for secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are believed to trigger an immune response targeting pathogenic T-cells that destroy myelin. The Phase IIb trial in SPMS has fully enrolled 180 patients and top-line data is expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa therapeutics corporate presentation june 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of multiple sclerosis (MS). Tcelna consists of attenuated antigen-specific T-cell clones that are designed to program the immune system to target pathogenic myelin reactive T-cells (MRTCs) that cause damage in MS. Opexa has completed enrollment in its Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) patients and expects top-line data in mid-2016. The company has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments if certain development and commercial milestones are achieved.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of multiple sclerosis (MS). Tcelna consists of attenuated antigen-specific T-cell clones that are designed to program the immune system to target pathogenic myelin reactive T-cells (MRTC) that cause damage in MS. Opexa has completed enrollment in a Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) and expects top-line data in mid-2016. The company has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments if certain development and sales milestones are achieved.
This document provides an overview and summary of Opexa Therapeutics' rights offering. Key points include:
- Opexa is conducting a rights offering of up to 28.8 million units to fund its ongoing Phase 2b trial of Tcelna in secondary progressive multiple sclerosis and a potential Phase 1/2 trial of OPX-212 in neuromyelitis optica.
- Proceeds will also be used for general corporate purposes.
- Tcelna utilizes Opexa's proprietary precision immunotherapy platform and has received Fast Track designation from the FDA for secondary progressive MS. Prior clinical trials in both relapsing-remitting and secondary progressive MS showed encouraging results.
- The rights offering is
Opexa therapeutics corporate presentation february 2016 webOpexaTherapeutics
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead program, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has received Fast Track designation from the FDA. Opexa is also developing OPX-212 for neuromyelitis optica, an orphan disease with no approved therapies. Preclinical studies of OPX-212 showed a statistically significant reduction in pathogenic T-cells. Topline results for Tcelna in SPMS are expected in the second half of 2016, which would be a key inflection point if positive.
Opexa therapeutics corporate presentation march 2016OpexaTherapeutics
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Its lead candidate, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has potential partnerships with Merck Serono. Opexa is also developing OPX-212 for neuromyelitis optica, an orphan disease with no approved therapies. Preclinical studies show OPX-212 reduces pathogenic T-cells in animal models. Opexa's platform aims to selectively eliminate harmful immune cells while leaving the rest of the immune system intact.
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead candidate, Tcelna, is in a Phase 2b clinical trial for secondary progressive multiple sclerosis (SPMS) with top-line results expected in early Q4 2016. Tcelna uses the proprietary ImmPath platform to prime the immune system to target disease-causing T-cells. Previous clinical trials of Tcelna showed a significant reduction in myelin reactive T-cells and a 37% improvement over placebo in annualized relapse rate for relapsing-remitting MS. Opexa has an option agreement with Merck Serono for worldwide rights to develop Tcelna for MS indications.
NeoStem, Inc. (“NeoStem” or the “Company”), a biopharmaceutical company, is capitalizing on the paradigm shift occurring in medicine by engaging in the development and manufacture of cellular therapies for oncology, immunology, and regenerative medicines in the United States. The Company anticipates that cell therapy will play a significant role in the fight against chronic disease and in lessening the economic burden that these diseases pose to modern society.
Opexa therapeutics corporate presentation january 2OpexaTherapeutics
Opexa Therapeutics is developing Precision Immunotherapy called Tcelna to treat Secondary Progressive Multiple Sclerosis (SPMS). Tcelna aims to specifically target myelin-reactive T-cells that cause damage in MS, without broadly suppressing the immune system. An ongoing Phase IIb trial called Abili-T is testing Tcelna in 180 patients with SPMS over 24 months. The primary endpoint is reduction in brain atrophy. Secondary endpoints include disability progression, relapse rate, and lesion measures. Positive results could support Tcelna as a novel treatment for the underserved SPMS population.
Sutro Biopharma is conducting a Phase 1 clinical trial of STRO-002, an antibody-drug conjugate (ADC) targeting folate receptor alpha (FolRα), in patients with advanced platinum-resistant or refractory epithelial ovarian cancer, fallopian tube or primary peritoneal cancers. Interim data from the trial will be presented at the AACR virtual conference on April 27th. STRO-002 was designed using Sutro's proprietary protein engineering platform, XpressCF, to have improved stability and a widened therapeutic index compared to other FolRα-targeting ADCs. Preclinical studies demonstrated STRO-002's enhanced potency and specificity versus benchmarks. The trial will evaluate
Opexa therapeutics corporate presentation december 16OpexaTherapeutics
Tcelna is a precision immunotherapy under development by Opexa Therapeutics for the treatment of secondary progressive multiple sclerosis (SPMS). It is currently being tested in a Phase IIb clinical trial called Abili-T that aims to enroll 180 patients to receive two annual courses of treatment. The primary endpoint is reduction in whole brain atrophy, with secondary endpoints including measures of disability progression, relapse rate, and lesion activity. Positive results from previous trials support Tcelna's mechanism of reducing myelin-reactive T-cells and stabilizing disease progression in SPMS patients. An option agreement with Merck Serono provides the potential for commercialization if successful.
SciSparc is a specialty pharmaceutical company developing unique cannabinoid technologies for treatment of central nervous system disorders. The proprietary compounds capitalize on the biochemistry of receptors that specialize in modulating the central nervous system (CNS) to create therapeutics that mitigate the adverse symptoms associated with CNS disorders.
SciSparc is a specialty pharmaceutical company developing unique cannabinoid technologies for treatment of central nervous system disorders. The proprietary compounds capitalize on the biochemistry of receptors that specialize in modulating the central nervous system (CNS) to create therapeutics that mitigate the adverse symptoms associated with CNS disorders.
One in 8 U.S. women will develop invasive breast cancer over her lifetime, with approximately 266,000 new breast cancer patients and 3.1 million breast cancer survivors in 2018. Following breast cancer surgery in the adjuvant setting, a HER2/neu 3+ patient typically receives Herceptin® in the first year, with the hope that their breast cancer will not recur, and with the odds of recurrence slowly decreasing over the first 5 years after surgery. Herceptin® has been shown to reduce recurrence rates from 25% to 12% in the adjuvant setting. In the neoadjuvant setting, a patient receives treatment before surgery and based on the results of a biopsy at surgery, will receive the same or more potent treatment after surgery. Kadcyla® has been shown to reduce recurrence rates from 22% to 11% in the neoadjuvant setting. Accordingly, we believe that GP2 may be used to address the 50% of recurring patients who do not respond to either Herceptin® or Kadcyla®.
Opexa Therapeutics is developing Precision Immunotherapy using Tcelna to treat multiple sclerosis (MS). Tcelna is an antigen specific T-cell immunotherapy that targets myelin reactive T-cells (MRTCs) that cause damage in MS. Opexa is currently conducting a Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) called Abili-T. Previous clinical trials of Tcelna showed promising results in reducing brain atrophy, disability progression, and relapse rates in MS patients. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS, which could provide up to $220 million in payments if milestones are
Milestone Scientific Inc. (MLSS) is a biomedical technology research and development company that patents, designs, develops and commercializes innovative diagnostic and therapeutic injection technologies and instruments for medical and dental applications. Milestone's computer-controlled systems are designed to make injections precise, efficient, virtually painless, and less expensive. Milestone’s proprietary DPS® Dynamic Pressure Sensing technology® platform advances the development of next-generation devices, regulating flow rate and monitoring pressure from the tip of the needle, through platform extensions for local anesthesia for subcutaneous drug delivery, with specific applications for epidural space identification in regional anesthesia procedures.
An improved economy and lower fuel prices will likely increase demand for gasoline in 2015, boosting Sunoco LP's revenues. Expansion through acquisitions from its parent company, Energy Transfer Partners, will also continue to increase revenues. Acquisitions in 2014 substantially grew Sunoco's sales and margins. Maintaining long-term contracts with affiliates like Susser Holdings provides guaranteed growth as they open new stores.
THIS DOCUMENT DISCUSSES EXECUTIVE ORDERS 13514 & 13423 AND LOOKS AT HOW THE GOALS, OBJECTIVES AND SUSTAINABLE PRACTICES OUTLINED IN THE EXECUTIVE ORDERS CAN BE MET BY USING SIMPLE BUT INTELLIGENT SOLUTIONS.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are designed to program the immune system to target pathogenic myelin-reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa therapeutics corporate presentation march 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a precision immunotherapy, for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin reactive T-cell clones that are believed to trigger an immune response targeting pathogenic myelin reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa Therapeutics is conducting a Phase IIb clinical trial of its T-cell immunotherapy Tcelna to treat Secondary Progressive Multiple Sclerosis (SPMS). The company recently signed an option agreement with Merck Serono that could provide up to $225 million in payments if Merck exercises its option to acquire rights to Tcelna in MS. Opexa is also exploring opportunities to develop Tcelna and its stem cell platform in other autoimmune diseases. The ongoing Phase IIb trial is evaluating Tcelna's ability to reduce brain atrophy and progression in 180 SPMS patients over two years.
Opexa Therapeutics Corporate Presentation July 2014OpexaTherapeutics
Opexa Therapeutics is developing precision immunotherapy treatments, with its lead candidate Tcelna in Phase IIb clinical trials for secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are believed to trigger an immune response targeting pathogenic T-cells that destroy myelin. The Phase IIb trial in SPMS has fully enrolled 180 patients and top-line data is expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa therapeutics corporate presentation june 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of multiple sclerosis (MS). Tcelna consists of attenuated antigen-specific T-cell clones that are designed to program the immune system to target pathogenic myelin reactive T-cells (MRTCs) that cause damage in MS. Opexa has completed enrollment in its Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) patients and expects top-line data in mid-2016. The company has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments if certain development and commercial milestones are achieved.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of multiple sclerosis (MS). Tcelna consists of attenuated antigen-specific T-cell clones that are designed to program the immune system to target pathogenic myelin reactive T-cells (MRTC) that cause damage in MS. Opexa has completed enrollment in a Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) and expects top-line data in mid-2016. The company has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments if certain development and sales milestones are achieved.
This document provides an overview and summary of Opexa Therapeutics' rights offering. Key points include:
- Opexa is conducting a rights offering of up to 28.8 million units to fund its ongoing Phase 2b trial of Tcelna in secondary progressive multiple sclerosis and a potential Phase 1/2 trial of OPX-212 in neuromyelitis optica.
- Proceeds will also be used for general corporate purposes.
- Tcelna utilizes Opexa's proprietary precision immunotherapy platform and has received Fast Track designation from the FDA for secondary progressive MS. Prior clinical trials in both relapsing-remitting and secondary progressive MS showed encouraging results.
- The rights offering is
Opexa therapeutics corporate presentation february 2016 webOpexaTherapeutics
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead program, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has received Fast Track designation from the FDA. Opexa is also developing OPX-212 for neuromyelitis optica, an orphan disease with no approved therapies. Preclinical studies of OPX-212 showed a statistically significant reduction in pathogenic T-cells. Topline results for Tcelna in SPMS are expected in the second half of 2016, which would be a key inflection point if positive.
Opexa therapeutics corporate presentation march 2016OpexaTherapeutics
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Its lead candidate, Tcelna, is in Phase 2b clinical trials for secondary progressive multiple sclerosis and has potential partnerships with Merck Serono. Opexa is also developing OPX-212 for neuromyelitis optica, an orphan disease with no approved therapies. Preclinical studies show OPX-212 reduces pathogenic T-cells in animal models. Opexa's platform aims to selectively eliminate harmful immune cells while leaving the rest of the immune system intact.
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead candidate, Tcelna, is in a Phase 2b clinical trial for secondary progressive multiple sclerosis (SPMS) with top-line results expected in early Q4 2016. Tcelna uses the proprietary ImmPath platform to prime the immune system to target disease-causing T-cells. Previous clinical trials of Tcelna showed a significant reduction in myelin reactive T-cells and a 37% improvement over placebo in annualized relapse rate for relapsing-remitting MS. Opexa has an option agreement with Merck Serono for worldwide rights to develop Tcelna for MS indications.
NeoStem, Inc. (“NeoStem” or the “Company”), a biopharmaceutical company, is capitalizing on the paradigm shift occurring in medicine by engaging in the development and manufacture of cellular therapies for oncology, immunology, and regenerative medicines in the United States. The Company anticipates that cell therapy will play a significant role in the fight against chronic disease and in lessening the economic burden that these diseases pose to modern society.
Opexa therapeutics corporate presentation january 2OpexaTherapeutics
Opexa Therapeutics is developing Precision Immunotherapy called Tcelna to treat Secondary Progressive Multiple Sclerosis (SPMS). Tcelna aims to specifically target myelin-reactive T-cells that cause damage in MS, without broadly suppressing the immune system. An ongoing Phase IIb trial called Abili-T is testing Tcelna in 180 patients with SPMS over 24 months. The primary endpoint is reduction in brain atrophy. Secondary endpoints include disability progression, relapse rate, and lesion measures. Positive results could support Tcelna as a novel treatment for the underserved SPMS population.
Sutro Biopharma is conducting a Phase 1 clinical trial of STRO-002, an antibody-drug conjugate (ADC) targeting folate receptor alpha (FolRα), in patients with advanced platinum-resistant or refractory epithelial ovarian cancer, fallopian tube or primary peritoneal cancers. Interim data from the trial will be presented at the AACR virtual conference on April 27th. STRO-002 was designed using Sutro's proprietary protein engineering platform, XpressCF, to have improved stability and a widened therapeutic index compared to other FolRα-targeting ADCs. Preclinical studies demonstrated STRO-002's enhanced potency and specificity versus benchmarks. The trial will evaluate
Opexa therapeutics corporate presentation december 16OpexaTherapeutics
Tcelna is a precision immunotherapy under development by Opexa Therapeutics for the treatment of secondary progressive multiple sclerosis (SPMS). It is currently being tested in a Phase IIb clinical trial called Abili-T that aims to enroll 180 patients to receive two annual courses of treatment. The primary endpoint is reduction in whole brain atrophy, with secondary endpoints including measures of disability progression, relapse rate, and lesion activity. Positive results from previous trials support Tcelna's mechanism of reducing myelin-reactive T-cells and stabilizing disease progression in SPMS patients. An option agreement with Merck Serono provides the potential for commercialization if successful.
SciSparc is a specialty pharmaceutical company developing unique cannabinoid technologies for treatment of central nervous system disorders. The proprietary compounds capitalize on the biochemistry of receptors that specialize in modulating the central nervous system (CNS) to create therapeutics that mitigate the adverse symptoms associated with CNS disorders.
SciSparc is a specialty pharmaceutical company developing unique cannabinoid technologies for treatment of central nervous system disorders. The proprietary compounds capitalize on the biochemistry of receptors that specialize in modulating the central nervous system (CNS) to create therapeutics that mitigate the adverse symptoms associated with CNS disorders.
One in 8 U.S. women will develop invasive breast cancer over her lifetime, with approximately 266,000 new breast cancer patients and 3.1 million breast cancer survivors in 2018. Following breast cancer surgery in the adjuvant setting, a HER2/neu 3+ patient typically receives Herceptin® in the first year, with the hope that their breast cancer will not recur, and with the odds of recurrence slowly decreasing over the first 5 years after surgery. Herceptin® has been shown to reduce recurrence rates from 25% to 12% in the adjuvant setting. In the neoadjuvant setting, a patient receives treatment before surgery and based on the results of a biopsy at surgery, will receive the same or more potent treatment after surgery. Kadcyla® has been shown to reduce recurrence rates from 22% to 11% in the neoadjuvant setting. Accordingly, we believe that GP2 may be used to address the 50% of recurring patients who do not respond to either Herceptin® or Kadcyla®.
Opexa Therapeutics is developing Precision Immunotherapy using Tcelna to treat multiple sclerosis (MS). Tcelna is an antigen specific T-cell immunotherapy that targets myelin reactive T-cells (MRTCs) that cause damage in MS. Opexa is currently conducting a Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) called Abili-T. Previous clinical trials of Tcelna showed promising results in reducing brain atrophy, disability progression, and relapse rates in MS patients. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS, which could provide up to $220 million in payments if milestones are
Milestone Scientific Inc. (MLSS) is a biomedical technology research and development company that patents, designs, develops and commercializes innovative diagnostic and therapeutic injection technologies and instruments for medical and dental applications. Milestone's computer-controlled systems are designed to make injections precise, efficient, virtually painless, and less expensive. Milestone’s proprietary DPS® Dynamic Pressure Sensing technology® platform advances the development of next-generation devices, regulating flow rate and monitoring pressure from the tip of the needle, through platform extensions for local anesthesia for subcutaneous drug delivery, with specific applications for epidural space identification in regional anesthesia procedures.
An improved economy and lower fuel prices will likely increase demand for gasoline in 2015, boosting Sunoco LP's revenues. Expansion through acquisitions from its parent company, Energy Transfer Partners, will also continue to increase revenues. Acquisitions in 2014 substantially grew Sunoco's sales and margins. Maintaining long-term contracts with affiliates like Susser Holdings provides guaranteed growth as they open new stores.
THIS DOCUMENT DISCUSSES EXECUTIVE ORDERS 13514 & 13423 AND LOOKS AT HOW THE GOALS, OBJECTIVES AND SUSTAINABLE PRACTICES OUTLINED IN THE EXECUTIVE ORDERS CAN BE MET BY USING SIMPLE BUT INTELLIGENT SOLUTIONS.
This document discusses how CEOs can identify growth drivers in challenging industries. It recommends that CEOs:
1) Implement a repeatable process to evaluate how internal foundations impact growth;
2) Develop a prioritized list of the most impactful growth enablers to drive change; and
3) Achieve clarity on what activities truly drive versus detract from growth.
This approach provides objectivity and actionable insights to optimize organizations for sustainable growth.
Rixongile Granny Chavalala's curriculum vitae provides personal and contact information, along with details about her education and work experience. She holds a diploma in Criminal Justice from Intec College obtained in 2014. Her work experience includes positions as a general worker for Pcs Assignment from 2009 to 2015 and a current role as a laboratory assistant at Anglo Research since 2015. Her duties in her current role include sample reception, logging, weighing, and profiling samples from various mining clients.
The derivatives market is the financial market for derivatives, financial instruments like futures contracts or options, which are derived from other forms of assets. The market can be divided into two, that for exchange-traded derivatives and that for over-the-counter derivatives.
Ruairi was diagnosed with several metabolic diseases at a young age, including Addison's disease and Adrenoleukodystrophy (ALD). ALD is an inherited disorder where the fatty covering of nerve fibers (myelin sheath) is progressively damaged due to a genetic defect. Ruairi experienced repeated hospitalizations as a child due to infections exacerbating his Addison's disease symptoms. In 2001 he was diagnosed with ALD, which helped explain his recurring health issues. His family embarked on learning about metabolic diseases after his ALD diagnosis.
Romy Romanza is a Network Planning & Optimization Engineer for ZTE - Telkomsel project in Jakarta, Indonesia. He has worked in this role since March 2011. Prior to this, he held roles as a 3G Core Engineer for Telkomsel and an intern in the Technical Operations & Transmission department of Metro TV. Romy received a Bachelor's degree in Electrical Engineering/Telecommunication Engineering from Pancasila University in 2015 and a Polytechnic Diploma in the same fields from State Polytechnic of Jakarta in 2010. He is proficient in English, OSS monitoring tools, radio network planning tools, and Microsoft Office applications.
Black berry jamun Lecture By Allah Dad Khan Provincial Coordinator IPM KPK ...Mr.Allah Dad Khan
This document summarizes several common diseases that affect blackberries: anthracnose caused by Elsinoe veneta which causes purple lesions on canes; Botrytis fruit rot caused by Botrytis cinerea which causes a watery rot of infected berries; crown gall caused by Agrobacterium tumefaciens which forms galls on canes and roots reducing vigor; orange rust caused by Gymnoconia peckiana which stunts leaves and causes waxy orange pustules; blackberry rosette caused by Cercosporella rubi which distorts flowers and prevents fruiting; and powdery mildew caused by Podosphaera macularis which causes chlorotic and powder
This document defines positional asphyxia as obstructing an restrained individual's airway or interfering with respiration, depriving them of oxygen. It can result from impaired movement of the chest wall, rib cage, diaphragm or abdominal muscles. Positional asphyxia has been associated with deaths during physical and mechanical restraint. Risk factors include prone positioning, prolonged struggle, intoxication, obesity, psychosis, pre-existing medical conditions, and drugs affecting respiration or cardiovascular systems. Signs may include labored breathing, cyanosis, weakness, and loss of consciousness. Safety requires avoiding chest/back pressure and head compression, monitoring vitals, and getting medical help for any respiratory distress concerns.
Opexa therapeutics corporate presentation july 2016OpexaTherapeutics
Opexa Therapeutics is developing personalized T-cell immunotherapies for autoimmune diseases. Their lead candidate, Tcelna, is in a Phase 2b clinical trial for secondary progressive multiple sclerosis, with top-line results expected in early Q4 2016. Their platform also supports OPX-212 for neuromyelitis optica, an orphan disease with no approved therapies. Opexa has secured an option agreement with Merck Serono for Tcelna in multiple sclerosis and has established preclinical validation of their approach in animal models of disease.
Opexa Therapeutics Corporate Presentation - May 2013OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a personalized immunotherapy for the treatment of multiple sclerosis (MS). Tcelna aims to specifically target myelin-reactive T-cells (MRTCs) that cause damage to the myelin sheath in MS patients. Clinical trials have shown Tcelna reduces MRTCs and relapses in both relapsing-remitting and secondary progressive MS patients. Opexa has an agreement with Merck for the development of Tcelna in MS that could provide up to $220 million in milestones for Opexa.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are designed to program the immune system to target pathogenic myelin-reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa Therapeutics is developing Tcelna, an autologous T-cell immunotherapy, for the treatment of secondary progressive multiple sclerosis (SPMS). They are currently conducting a Phase IIb clinical trial of Tcelna in SPMS patients. Preliminary data from earlier trials in both relapsing-remitting and SPMS patients showed signs of efficacy, including reduced disability progression, brain atrophy, and relapse rates. If successful, Tcelna has the potential to be the first approved treatment specifically for SPMS, an underserved market with no approved therapies. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $
Opexa Therapeutics is developing Precision Immunotherapy using Tcelna to treat multiple sclerosis (MS). Tcelna is an antigen-specific T-cell immunotherapy that targets myelin-reactive T-cells that cause damage in MS. It is currently in a Phase IIb clinical trial called Abili-T for secondary progressive MS (SPMS), which has limited treatment options. Previous clinical trials of Tcelna showed reductions in brain atrophy, disability progression, and relapse rates in SPMS patients. If successful, Abili-T could support Tcelna becoming the first approved treatment for SPMS.
Opexa Therapeutics is developing Precision Immunotherapy using attenuated myelin reactive T-cell clones (Tcelna) to treat multiple sclerosis. Tcelna is designed to program the immune system to target pathogenic myelin reactive T-cells that cause demyelination. Opexa has completed enrollment in a Phase IIb clinical trial of Tcelna in 190 patients with secondary progressive multiple sclerosis, with top-line data expected in late 2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in multiple sclerosis that could provide up to $220 million in payments if milestones are achieved.
Opexa therapeutics corporate presentation november 21OpexaTherapeutics
Opexa Therapeutics is developing Precision Immunotherapy using their T-cell platform to treat autoimmune diseases like multiple sclerosis. Their lead product Tcelna is in Phase 2 clinical trials for secondary progressive multiple sclerosis, a later stage form of MS with limited treatment options. Tcelna works by specifically targeting and reducing myelin reactive T-cells that cause damage to the protective myelin sheath surrounding nerves. If successful, Tcelna has the potential to be the first treatment approved for secondary progressive MS and generate over $7 billion in annual sales. Opexa has an option agreement with Merck for the development of Tcelna in MS.
Opexa Therapeutics is developing Precision Immunotherapy using their T-cell platform to treat autoimmune diseases like multiple sclerosis (MS). Their lead product, Tcelna, is in Phase II clinical trials for secondary progressive MS (SPMS), which affects around 30-45% of MS patients. Tcelna works by programming the immune system to specifically recognize and inhibit myelin reactive T-cells that cause damage to the protective myelin sheath surrounding nerves. If successful, Tcelna could be the first approved treatment for SPMS, representing a potential $7 billion market in North America alone. Opexa has an option agreement with Merck for the development of Tcelna in MS.
Ocata Therapeutics is developing regenerative ophthalmology therapies using retinal pigment epithelium (RPE) cells derived from pluripotent stem cells. Data from completed Phase 1/2 studies in Stargardt's macular degeneration and dry age-related macular degeneration showed long-term safety and evidence that transplanted RPE cells engrafted and persisted. Ocata is initiating pivotal and Phase 2 studies to further evaluate these RPE therapies with the goal of commercial launches beginning in 2019.
This presentation discusses Eleven Biotherapeutics' development pipeline and upcoming milestones. Eleven is developing two protein therapeutics: Isunakinra, a topical IL-1 receptor blocker in Phase 3 for allergic conjunctivitis, with topline data expected in 1Q16; and EBI-031, a long-acting intravitreal IL-6 antibody planned to enter IND in 1H16 for diabetic macular edema and uveitis. The company highlighted opportunities for these programs to address unmet needs in large ophthalmic markets and provided an overview of upcoming clinical trial timelines and goals.
CLBS Corporate Slide Presentation March 2018Steve Sizer
This corporate presentation discusses Caladrius Biosciences' business model evolution and future plans. It summarizes that Caladrius has transitioned to focus solely on clinical-stage therapeutics development using two technology platforms: autologous T-regulatory cells for immune modulation and CD34 cells for ischemic repair. Key programs outlined include an ongoing Phase 2 trial of T-regulatory cells for recent-onset type 1 diabetes and planned Phase 2 trials of CD34 cells for critical limb ischemia and coronary microvascular dysfunction. The presentation positions Caladrius for continued growth with a well-funded pipeline and strategic partnerships.
Tcelna is a precision immunotherapy under development by Opexa Therapeutics for the treatment of multiple sclerosis (MS). Opexa is currently conducting a Phase IIb clinical trial of Tcelna in patients with secondary progressive MS (SPMS). Previous clinical trials of Tcelna in both relapsing-remitting and SPMS patients showed promising results, including a 37% reduction in annualized relapse rate in a Phase IIb RRMS trial. Opexa has an option agreement with Merck Serono for the development and commercialization of Tcelna in MS that could provide over $220 million in payments if milestones are achieved.
Dr. Patrick Soon-Shiong Presents at the 37th Annual J.P. Morgan Healthcare Co...DV4416
- The document is an investor presentation by Dr. Patrick Soon-Shiong for NantKwest discussing the company's immunotherapy strategies and product candidates.
- It outlines NantKwest's approach of harnessing the entire immune system through activating immune killer cells, blocking immune suppressor cells, and targeting tumor cells.
- The presentation highlights several of NantKwest's platform technologies and product candidates including activated NK cells, CIML NK cells, T memory stem cells, and their proprietary cell engineering and manufacturing capabilities.
1) Imugene is developing B-cell peptide cancer immunotherapy vaccines targeting the HER-2 receptor, which is the target of Roche's $6.4 billion breast cancer drug Herceptin.
2) Imugene has completed a Phase 1 clinical trial of its lead HER-Vaxx vaccine in HER-2 positive breast cancer patients, and plans to begin a Phase 1b/2 gastric cancer trial in early 2016.
3) HER-Vaxx induces polyclonal antibody responses against HER-2, unlike monoclonal antibodies, and has the potential to provide long-lasting immunity through immune memory activation.
Based in Ann Arbor, Michigan, Zomedica is a veterinary health company creating diagnostic and therapeutic products for horses, dogs, and cats by focusing on the unmet needs of clinical veterinarians. With modest cash burn and a strong balance sheet, including $142.4 million cash and cash equivalents as of June 30, 2023, Zomedica is well-positioned to fund both organic growth and acquisitions.
Docola has developed a healthcare communication platform that utilizes asynchronous telehealth to deliver patient education and support. Their proprietary platform currently has over 55,000 patient users and over 1,100 clinician users. Docola seeks to raise up to $500,000 through a convertible note to fund working capital, research and development, and costs associated with an upcoming IPO.
- INNO Holdings is presenting an IPO investor presentation for an initial public offering on the NASDAQ Capital Market.
- The company manufactures prefabricated steel building components and systems using proprietary technology to reduce construction costs and environmental impact.
- INNO Holdings has four initial product lines - metal studs, prefabricated housing units, modular apartment buildings, and a mobile factory system. It aims to disrupt the construction industry through standardized, sustainable construction methods.
Everything Blockchain builds platforms of trust for the modern enterprise and is on a mission to ensure every organization has access to the tools and platforms that enable them to manage, store, and protect data without the cost and complexity that holds them back today. The Company’s patented advances in engineering deliver the essential elements needed for real-world business use: speed, security, and efficiency. Everything Blockchain’s current business lines include: EB Advise, Build DB and EB Control.
ASP Isotope is an isotope enrichment company utilizing technology developed in South Africa over the past 20 years to enrich isotopes of elements or molecules with low atomic masses. Many of these elements are unsuitable for enrichment using traditional methods such as centrifuges. The Company’s initial focus is on producing and commercializing highly enriched isotopes for the healthcare and technology industries.
MDNA Life Sciences is a pioneer in the science of mitochondrial DNA. It’s our mission to create an extensive portfolio of proprietary tests that dramatically improve diagnosis, treatment, prognosis and monitoring. Putting an end to the unnecessary surgical procedures, pain and uncertainty that affect patients across the world.
Digital Ally, Inc. is a diversified holding company with operations in video solution technology, human and animal health protection products, healthcare revenue cycle management, ticket brokering and marketing, and event production. The Company pursues an acquisition strategy that targets organizations with positive earnings, strong growth potential, innovation, and operational synergies. To maximize long-term shareholder value, Digital Ally intends to spin-off its ticketing and entertainment business lines into a separate public company in 2023. The spin-off will create two optimized, tech-driven public companies with strong growth opportunities and operating metrics.
Lantern Pharma is an AI company transforming the cost, pace, and timeline of oncology drug discovery and development. Our proprietary AI and machine learning (ML) platform, RADR®, leverages over 25 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development. By harnessing the power of AI and with input from world-class scientific advisors and collaborators, we have accelerated the development of our growing pipeline of therapies including eleven cancer indications and an antibody-drug conjugate (ADC) program. On average, our newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0-2.0 million per program.
Sharps Technology is a medical device and pharmaceutical packaging company specializing in the development and manufacturing of innovative drug delivery systems. The Company’s product lines focus on low waste and ultra-low waste syringe technologies that incorporate both passive and active safety features. These features protect front line healthcare workers from life-threatening needle stick injuries and protect the public from needle re-use. Sharps Technology has extensive expertise in specialized prefilled syringe systems and is on track to launch this new product line in Q4 2023. The Company has a manufacturing facility in Hungary and has partnered with Nephron Pharmaceuticals to expand its manufacturing capacity in the US.
Aditxt is a biotech company developing immune monitoring and immune modulation platforms. Its AditxtScore platform can provide comprehensive immune profiles to monitor responses to pathogens, vaccines, drugs and transplants. Its Adimune platform aims to modulate the immune system to treat conditions like psoriasis, type 1 diabetes, and increase skin allograft survival. The company is working to develop, operate and commercialize these platforms. It currently generates revenue from immune monitoring tests and expects revenue from licensing deals for immune modulation programs as they advance in clinical trials towards commercialization.
1847 Holdings LLC, a publicly traded diversified acquisition holding company, was founded by Ellery W. Roberts, a former partner of Parallel Investment Partners, Saunders Karp & Megrue and Principal of Lazard Freres Strategic Realty Investors. EFSH's investment thesis is that capital market inefficiencies have left the founders and/or stakeholders of many small business enterprises and lower-middle market businesses with limited exit options, despite the intrinsic value of their business. Given this dynamic, EFSH can consistently acquire "solid" businesses for reasonable multiples of cash flow and then deploy resources to strengthen the infrastructure and systems to improve operations. These improvements may lead to a sale or IPO of an operating subsidiary at considerably higher valuations than the purchase price (as successfully demonstrated with the mid-2020 IPO of 1847 Goedeker on the NYSE American) and/or alternatively, an operating subsidiary may be held in perpetuity and contribute to EFSH's ability to pay regular and special dividends to shareholders.
Sharps Technology is a medical device and pharmaceutical packaging company specializing in the development and manufacturing of innovative drug delivery systems. The Company’s product lines focus on low waste and ultra-low waste syringe technologies that incorporate both passive and active safety features. These features protect front line healthcare workers from life-threatening needle stick injuries and protect the public from needle re-use. Sharps Technology has extensive expertise in specialized prefilled syringe systems and is on track to launch this new product line in Q4 2023. The Company has a manufacturing facility in Hungary and has partnered with Nephron Pharmaceuticals to expand its manufacturing capacity in the US.
SPI Energy is a global renewable energy company and provider of solar storage and electric vehicle (EV) solutions that was founded in 2006 in Roseville, California and is headquartered in McClellan Park, California. The Company has three core divisions: SolarJuice which has solar wholesale distribution, as well as residential solar and roofing installation and solar module manufacturing (Solar4America & SEM Wafertech), SPI Solar and Orange Power which operates a commercial & utility solar division, and the EdisonFuture/Phoenix Motor EV division. SolarJuice is the leader in renewable energy system solutions for residential and small commercial markets and has extensive operations in the Asia Pacific and North America markets. The SPI Solar commercial & utility solar division provides a full spectrum of EPC services to third party project developers, and develops, owns and operates solar projects that sell electricity to the grid in multiple regions, including the U.S., U.K., and Europe. Phoenix Motor is a leader in medium-duty commercial electric vehicles, and is developing EV charger solutions, electric pickup trucks, electric forklifts, and other EV products. SPI maintains global operations in North America, Australia, Asia and Europe and is also targeting strategic investment opportunities in fast growing green energy industries such as battery storage, charging stations, and other EVs which leverage the Company's expertise and substantial solar cash flow.
BullFrog AI is a technology enabled drug development company using machine learning to usher in a new era of precision medicine. Through its collaborations with leading research institutions, including Johns Hopkins University and J. Craig Venter Institute, BullFrog AI is at the forefront of AI-driven drug development. Using its proprietary bfLEAP™ artificial intelligence platform, BullFrog AI aims to enable the successful development of pharmaceuticals and biologics by predicting which patients will respond to therapies in development. BullFrog AI is deploying bfLEAP™ for use at several critical stages of development with the intention of streamlining data analytics in therapeutics development, decreasing the overall development costs by decreasing failure rates for new therapeutics, and impacting the lives of countless patients that may have otherwise not received the therapies they need.
BullFrog AI is a technology enabled drug development company using machine learning to usher in a new era of precision medicine. Through its collaborations with leading research institutions, including Johns Hopkins University and J. Craig Venter Institute, BullFrog AI is at the forefront of AI-driven drug development. Using its proprietary bfLEAP™ artificial intelligence platform, BullFrog AI aims to enable the successful development of pharmaceuticals and biologics by predicting which patients will respond to therapies in development. BullFrog AI is deploying bfLEAP™ for use at several critical stages of development with the intention of streamlining data analytics in therapeutics development, decreasing the overall development costs by decreasing failure rates for new therapeutics, and impacting the lives of countless patients that may have otherwise not received the therapies they need.
BioVie is a clinical-stage company developing what it believes will be transformative therapies to overcome unmet medical needs in neurodegeneration and liver disease. The Company is developing NE3107 for Alzheimer’s (AD) and Parkinson’s (PD) and BIV201 for refractory ascites and HRS-AKI.
Lantern Pharma is an AI company transforming the cost, pace, and timeline of oncology drug discovery and development. Our proprietary AI and machine learning (ML) platform, RADR®, leverages over 25 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development. By harnessing the power of AI and with input from world-class scientific advisors and collaborators, we have accelerated the development of our growing pipeline of therapies including eleven cancer indications and an antibody-drug conjugate (ADC) program. On average, our newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0-2.0 million per program.
Genetic Technologies is a diversified molecular diagnostics company. A global leader in genomics-based tests in health, wellness and serious disease through its geneType and EasyDNA brands. GENE offers cancer predictive testing and assessment tools to help physicians to improve health outcomes for people around the world. The Company has a proprietary risk stratification platform that has been developed over the past decade and integrates clinical and genetic risk to deliver actionable outcomes to physicians and individuals. Leading the world in risk prediction in oncology, cardiovascular and metabolic diseases, Genetic Technologies continues to develop risk assessment products.
Splash Beverage Group, an innovator in the beverage industry, owns a growing portfolio of alcoholic and non-alcoholic beverage brands including Copa di Vino wines by the glass, SALT naturally flavored tequilas, Pulpoloco Sangria, and TapouT performance hydration and recovery drinks and TapouT Cognitive Energy Drink. Splash’s strategy is to rapidly develop early-stage brands already in its portfolio as well as acquire and then accelerate brands that have high visibility or are innovators in their categories. Led by a management team that has built and managed some of the top brands in the beverage industry and led sales from product launch into the billions, Splash is rapidly expanding its brand portfolio and global distribution.
Splash Beverage Group, an innovator in the beverage industry, owns a growing portfolio of alcoholic and non-alcoholic beverage brands including Copa di Vino wines by the glass, SALT naturally flavored tequilas, Pulpoloco Sangria, and TapouT performance hydration and recovery drinks and TapouT Cognitive Energy Drink. Splash’s strategy is to rapidly develop early-stage brands already in its portfolio as well as acquire and then accelerate brands that have high visibility or are innovators in their categories. Led by a management team that has built and managed some of the top brands in the beverage industry and led sales from product launch into the billions, Splash is rapidly expanding its brand portfolio and global distribution.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
- Video recording of this lecture in English language: https://youtu.be/RvdYsTzgQq8
- Video recording of this lecture in Arabic language: https://youtu.be/ECILGWtgZko
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
Congestive Heart failure is caused by low cardiac output and high sympathetic discharge. Diuretics reduce preload, ACE inhibitors lower afterload, beta blockers reduce sympathetic activity, and digitalis has inotropic effects. Newer medications target vasodilation and myosin activation to improve heart efficiency while lowering energy requirements. Combination therapy, following an assessment of cardiac function and volume status, is the most effective strategy to heart failure care.
2. 2
Forward-Looking Statements
All statements in this presentation other than those of historical fact, including statements regarding our preclinical and
clinical development plans for Tcelna® and OPX-212, our research and other development programs, our ability to
undertake certain activities and accomplish certain goals, projected timelines for our research and development
activities and possible regulatory approvals, if any, our expectations regarding the relative benefits of our product
candidates versus competitive therapies, our expectations regarding the possibility of licensing or collaborating with
third parties regarding our product candidates or research, and our expectations regarding the therapeutic and
commercial potential of our product candidates, research, technologies and intellectual property, are forward-looking
statements. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “design,” “intend,” “expect,”
“potential” and similar expressions, as well as the negative version of these words and similar expressions, are intended
to identify forward-looking statements. Our forward-looking statements do not constitute guarantees of future
performance, and are subject to a number of risks and uncertainties that could cause actual results to differ materially
and adversely from those anticipated or implied in such statements. Our forward-looking statements are based upon
our current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual
results and the timing of events could differ materially from those anticipated as a result of various risks and
uncertainties which include, without limitation, risks associated with the process of discovering, developing and
commercializing drugs that are safe and effective for use as human therapeutics and risks inherent in the effort to build
a business around such drugs. Although we believe our expectations are reasonable, we do not in any way guarantee
future results, level of activity, performance or achievements. In addition, neither we nor any other person assumes
responsibility for the accuracy and completeness of any forward-looking statements. Our forward-looking statements in
this presentation speak only as of the date of this presentation. We assume no obligation or undertaking to update or
revise any statements to reflect any changes in our expectations or any change in events, conditions or circumstances on
which any such statement is based. You should, however, review additional disclosures we make that further describe
risks and uncertainties relevant to us in additional detail in our filings with the Securities and Exchange Commission
including our Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. You may get these documents for free
by visiting EDGAR on the SEC web site at http://www.sec.gov.
3. 3
Opexa Investment Highlights
PIPELINE
• Tcelna®: Phase 2b for secondary progressive multiple sclerosis (SPMS), limited
competition, $7BN overall market potential
• OPX-212: Pre-IND for neuromyelitis optica (NMO), no approved therapies, orphan
indication
TECHNOLOGY
• Personalized T-cell immunotherapy platform for autoimmune diseases
• Potential to yield multiple candidates tailored to each patient’s disease profile
• Company owned and scalable cGMP manufacturing facility
• Strong patent estate (98 domestic and international)
VALIDATION
• Option agreement secured with Merck Serono for Tcelna – strong potential partner
• FDA Fast Track designation for Tcelna in SPMS
• Esteemed Scientific Advisory Board
4. 4
Recent and Upcoming Expected Milestones
Tcelna: Multiple Sclerosis
1H 2014: Completed Enrollment in Phase 2b SPMS trial
Q1 2015: Received additional $3M payment from Merck Serono for Tcelna
development
Q3 2015: 85% of all patient visits in Abili-T trial have been completed
• 2H 2016: Top line results expected for Abili-T Phase 2b SPMS trial
OPX-212: Neuromyelitis Optica
1H 2014: Initiated Early Development Plan
Q3 2015: Secured $5 million in milestone funding to support OPX-212 NMO
development, including Phase I/II proof-of-concept clinical trial
• 2015: Expect to complete preclinical and IND enabling studies and file IND by
year-end
5. 5
Financials
Cash and Cash Equivalents (MM) as of June 30, 2015 ~$18.3
Shares outstanding (MM) as of June 30, 2015 ~53.4
Warrants (MM) outstanding as of June 30, 2015 ~28.4(1)
Stock Options (MM) outstanding as of June 30, 2015 ~3.3(2)
Debt None
(1) Weighted average exercise price =$.80 as of June 30, 2015
(2) Weighted average exercise price = $2.28 as of June 30, 2015
7. 7
Root cause of MS: Activated T-cells degrade myelin and
damage myelin producing cells
Adapted by permission from Macmillan Publishers Ltd: NATURE REVIEWS
IMMUNOLOGY 3, 483-492 (June 2003), copyright (2003)
Cytokines
Damage
Damage
• In MS patients, the faulty immune system is
not able to prevent the attack of a small sub-
population of myelin reactive T-cells (MRTC)
• MRTCs cross the blood brain barrier, enter
the brain, and bind to antigen presenting
cells (APC), causing a release of pro-
inflammatory cytokines which lead to a two
pronged attack through:
1. Destruction of myelin sheath, the protective
coating of nerve fibers
2. Destruction of oligodendroglial cells, which
are responsible for producing myelin
Myelin peptide
Result
Destruction of the myelin sheath and myelin producing cells,
thereby preventing remyelination
8. 8
Tcelna could address the root cause of MS by preventing
demyelination and enabling remyelination
Adapted by permission from Macmillan Publishers Ltd: NATURE REVIEWS
IMMUNOLOGY 3, 483-492 (June 2003), copyright (2003)
Opexa’s Strategy
Tcelna programs the immune system to specifically
recognize MRTC as pathogenic, thereby inhibiting further
destruction of the myelin sheath and potentially enabling
remyelination
• Therapeutic dose of Tcelna (attenuated T-cell
clones) is injected subcutaneously
• This triggers an immune response specifically
targeting circulating MRTC
• Immune cells, including Tregs, have been primed,
or sensitized, we believe, to specifically target the
pathogenic MRTC for elimination or regulation
• Elimination of harmful MRTC may lead to:
1. Stabilization of disease by preventing further
destruction of myelin
2. Improvement in condition by allowing
oligodendroglial cells to remyelinate axons
(neuroprotection)
9. 9
ImmPath® manufacturing platform
Cryopreservation
Formulation/
Irradiation of
each dose as
required
Administration: 5
subcutaneous
injections/year
Manufacturing and QC Dispensation
35 days
Epitope Profiling
1 day14 days
- Red Cross
- Blood Group Alliance
Epitope Profiling Expansion of antigen specific T-cells
Annual course of treatment consists of 5 doses manufactured
from a single procurement of blood product
10. 10
Clinical evidence for Tcelna MoA
T-cell technology demonstrated a significant reduction in reactive T-cells (52 week study results of MS)
0%
-92%
-87%
-79%
-77%
-65%
-100%
-90%
-80%
-70%
-60%
-50%
-40%
-30%
-20%
-10%
0%
Week 0 Week 5 Week 13 Week 21 Week 28 Week 52
• Results from Tcelna dose ranging studies:
Published in Clinical Immunology
(2009) 131, 202-215
• Each dose consisting of 30-45 x 106 cells
ReductioninMRTC
Dose 1 Dose 2 Dose 3 Dose 4
MRTC: Myelin Reactive T-cells
13. 13
Leveraging ImmPath® platform in new
indications
Potential New Targets:
Certain diseases with known antigen profile
• Grave’s Disease
• Idiotypic thrombocytopenic purpura
• Myasthenia Gravis
• Pemphigus vulgaris/foliaceus
• Primary Biliary Cirrhosis
• Type 1 Diabetes
• Hashimoto’s thyroiditis
• Vitiligo
Certain diseases with unknown antigen profile
• RA
• Celiac
• Psoriasis
• Uveitis
• IBD
• Sjögren’s
Secondary Progressive
Multiple Sclerosis
Neuromyelitis
optica
ImmPath®: Personalized, Precision Immunotherapy Platform
Phase 2b
Preclinical
14. 14
Expansion of Pipeline Increases
Partnering Opportunities
Autoimmune
diseases with
known antigens
• Development stage programs
- i.e. OPX-212 for NMO
• Orphan disease benefits
Autoimmune
diseases with
unknown antigens
• Discovery stage programs
• Possible expansion to large
markets (e.g. RA, Psoriasis)
Multiple Sclerosis
Japan
• Quick access to market
• Leverage U.S. trial success
16. 16
Tcelna in Secondary Progressive MS
SPMS
450,000 Individuals in North America diagnosed with MS;
30-45 % potentially have an SPMS diagnosis
Market Size:
$7 Billion (est.)
Relapsing Remitting MS;
Clinically Isolated Syndrome;
Primary Progressive MS
• Secondary Progressive MS market
potential in North America could
exceed $7 billion (for all therapies)
• Roughly 150,000 SPMS patients in
North America
• Only one drug approved for SPMS in
U.S. (none in EU or Asia)
- Drug not suitable for chronic use
due to severe side effects
Tcelna being developed to be a
potential therapy of choice in SPMS
17. 17
Tcelna®
Lead Program Targeting Secondary Progressive MS patients
Fast Track Designation by FDA
• Phase 2b is fully enrolled: 190 patients with SPMS
• Top line data expected in 2H 2016
• Design
– Double-blind, 1:1 randomized, placebo-controlled
– 35 clinical sites in USA and Canada
– Two annual courses of personalized therapy
– Efficacy Endpoints: Primary-Whole Brain Atrophy, Secondary-Disease Progression
• Immune Monitoring being conducted in parallel
– Comprehensive biomarker analysis
18. 18
Merck Serono Agreement
Agreement signed 2013; strong potential partner
• Option and License Agreement for worldwide rights to all Multiple
Sclerosis indications, excluding Japan
• If Merck Serono exercises option:
– Merck Serono to fund Phase 3, pre-commercial and commercial activities
– Opexa has potential to receive up to an additional $220 million in option
exercise and milestone payments
– Opexa has potential to receive royalties ranging from 8% to 15% of annual net
sales, with step-ups occurring if net sales exceed $500 million, $1 B & $2 B
• Merck Serono increased their commitment to Opexa’s MS program this
year
– In anticipation of the Phase IIb trial results expected in 2H 2016, Merck
Serono gave Opexa $3 million of support in March 2015 to begin planning for
Phase III studies
20. 20
NMO: A rare disease of the Central Nervous System
• Neuromyelitis optica (NMO) is a rare or orphan
autoimmune disease
• Immune system cells and antibodies mistakenly attack
and destroy myelin cells in the optic nerves and the
spinal cord
• Individuals with NMO develop optic neuritis, which
causes pain in the eye and vision loss, and transverse
myelitis, which causes weakness, numbness, and
sometimes paralysis of the arms and legs
• There are no FDA-approved therapies for NMO
• Affects any age varying from 3 to 90 years, the average
age of onset ~41 years
An orphan disease with no FDA-approved therapy
Image reprinted with permission from MultiView, Inc.
21. 21
Key Milestones Achieved to Date in OPX-212
Development Program
Funding support
• Recently secured $5 million private funding for OPX-212 to advance further
NMO development, including Phase I/II clinical study
KOL support
• Engaged key thought leaders to validate scientific hypothesis and discuss
clinical trial design
– Benjamin Greenberg, M.D., University of Texas, Southwestern Medical Center
– Michael Levy, M.D., Ph.D., The Johns Hopkins Hospital
FDA feedback
• Conducted Pre-IND meeting to discuss pre-clinical and clinical program to
support OPX-212 development in NMO
Patient support
• Collected NMO patient blood samples to conduct pre-IND activities, process
development and research into mechanism of action
22. 22
NMO disease pathogenesis
NMO
Pathogenic T-Cells
Anti-AQP-4
Plasma
Cell
Binding to AQP4
channels on the
astrocytes
Increase astrocyte
permeability
Neuroinflammation
AQP-4
expression
Complement
activation
Axonal loss
CD4+ T-cell CD69 Infiltration of
macrophages and
granulocytes
Neutrophils Eosinophils
↑ IL-17/IL-8
B-cell
Macrophages
Demyelination
Activated T-cell/Th-17
Necrosis
B-Cells
Inflammatory Cells
NMO Lesion
AQP4 antibodies that penetrate
the CNS and bind to AQP4
channels on the astrocyte
Astrocyte damage leads to
• Inflammation
• Oligodendrocyte injury
• Demyelination
• Neuronal loss
Migration of
inflammatory cells
leads to localized
inflammation
23. 23
Potential intervention points for T-cell therapy
T-cell therapy believed to inhibit AQP-4 autoantibody, pro-inflammatory cytokines and
prevent infiltration of macrophages and granulocytes
Without the pathogenic T-cell, the
B-cell does not signal the
production of the AQP-4 antibody
Possible results:
• Reduce tissue damage
• May favor repair and
remyelination of axons
• Reduce frequency and severity of
Relapses of clinical disease
OPX-212 expected to down
regulate pathogenic AQP-4 T-cells
NMO
Pathogenic T-Cells
Anti-AQP-4
Plasma
Cell
Binding to AQP4
channels on the
astrocytes
Increase astrocyte
permeability
Neuroinflammation
AQP-4
expression
Complement
activation
Axonal loss
CD4+ T-cell CD69 Infiltration of
macrophages and
granulocytes
Neutrophils Eosinophils
↑ IL-17/IL-8
B-cell
Macrophages
Demyelination
Activated T-cell/Th-17
Necrosis
B-Cells
Inflammatory Cells
Expected to prevent
infiltration of
Neutrophils,
Eosinophils and
Macrophages
Preventing the damage of the
AQP-4 channel of the astrocyte
NMO Lesion
OPX-212 OPX-212
24. 24
NMO Investment Thesis
• Any therapy that could achieve tolerization of the AQP-4 reactive T-
cells may offer a cure for NMO
• OPX-212 has the potential to address the root cause of NMO
• OPX-212 leverages Opexa’s T-cell platform to B-cell mediated
orphan diseases
• Opexa currently retains world wide rights to OPX-212
• Higher prevalence of NMO in Asia could complement Opexa’s MS
rights in Japan
• IND filing expected by 12/31/15
25. 25
Experienced Management Team and Board of Directors
Neil Warma, President & CEO, Director
› 19+ years international healthcare experience with large Pharma and emerging
biotechnology companies
› Former Senior Management, Novartis Pharmaceuticals, Basel, Switzerland
› Former CEO, Viron Therapeutics, Inc.
› Co-founder and President of MedExact Inc., a company subsequently acquired
Karthik Radhakrishnan, Chief Financial Officer
› 10+ years of health care capital markets experience
› Formerly, Vice President at ING Investment Management
› MBA, MS in Engineering, CFA charter holder
Don Healey, Ph.D., Chief Scientific Officer
› 25+ years of experience in cellular immunology and immune regulation
› Former Director of Immunology, Argos Therapeutics
Donna Rill, Chief Development Officer
› 30 years in cell and gene therapy research and clinical application
› Designed and validated cGMP Cell & Gene Therapy Laboratories, Vector Production
facilities, and Translational Research Labs
Jason Kralic, Ph.D., VP, Business Development
› Former Head of Business Development for the Neurosciences Therapy Area
Unit at GlaxoSmithKline
› Ph.D. in Pharmacology from University of N. Carolina at Chapel Hill School of
Medicine
Board of Directors
Timothy Barabe
Board member of Arqule, Inc.; Former
CFO of Affymetrix, Human Genome
Sciences, Inc., Regent Medical UK and
Sandoz GmbH
Dr. Hans-Peter Hartung
Chair of Neurology at Heinrich-Heine
University, Germany; Executive Board
member of ECTRIMS
Gail J. Maderis
Former CEO, BayBio, Former CEO of
Five Prime Therapeutics, Founder of
Genzyme Molecular Oncology
Michael S. Richman
CEO, Amplimmune
Scott B. Seaman
Executive Director,
Alkek Foundation
Neil K. Warma
President & CEO, Opexa
26. 26
SPMS Scientific Advisory Board
Dawn McGuire, M.D., FAAN (Chair)
• Advisory Council of the Gill Heart Institute
• Former Vice President of Clinical Research at Elan Pharmaceuticals
Hans-Peter Hartung, M.D
• Chair of Neurology at Heinrich-Heine University, Düsseldorf
• Executive Board member of ECTRIMS, World Health Organization Advisory Board on MS
Mark S. Freedman, M.D.
• Director of the Multiple Sclerosis Research Unit at Ottawa Hospital
• Multiple Sclerosis Society of Canada, National MS Society (USA)
• ACTRIMS committee member
Clyde Markowitz, M.D.
• Director of MS Center at the University of Pennsylvania
Doug Arnold, M.D.
• James McGill Professor Neurology and Neurosurgery at the Montreal Neurological Institute
Edward Fox, M.D., Ph.D.
• Director of Multiple Sclerosis Clinic of Central Texas
• Advisory Committee, Lone Star Chapter of the National Multiple Sclerosis Society
27. 27
Opexa Investment Thesis
PIPELINE
• Tcelna: Secondary Progressive MS, limited competition, $7BN potential market
• OPX-212: Recently launched development program in NMO, no approved
therapies, orphan indication
• Precision Immunotherapy potentially optimizes benefit-risk profile
VALIDATION
• Option agreement secured with Merck Serono – strong potential partner
• FDA Fast track designation for Tcelna in SPMS
• Esteemed Scientific Advisory Board
TECHNOLOGY
• Proprietary Platform: potential to yield multiple drug candidates
• Differentiated, personalized approach
• Strong patent estate (98 domestic and international)