Herpes simplex virus (HSV) is a human neurogenic dsDNA virus that has the characteristic of life-long latent infection of neurons and allows for long-term transgene expression. Creative Biolabs provides a series of herpes simplex virus products. https://www.creative-biolabs.com/oncolytic-virus/category-pre-made-oncolytic-herpes-simplex-virus-290.htm

1. Reporter-encoding Oncolytic Herpes Simplex Virus 1
(ΔICP27), CMV-Dsred
Cat. No.: RepOV-0001XY
This product is for research use only and is not intended for diagnostic use.
PRODUCT INFORMATION
SPECIFICATIONS
Product Overview This product is a Dsred encoding oncolytic herpes simplex virus, which is based on
HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary
role of preventing the splicing of pre-mRNAs in favour of translation from the
mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less
cytotoxic system when combined with other oncolytic-rendered modifications.
This product can be used in oncolytic virotherapy research and further
recombinant HSV construction.
Family Herpesviridae
Species Herpes simplex virus
Serotype Herpes simplex virus 1
Backbone HSV-1 (ΔICP27)
Backbone Background Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human
herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human
Herpesviridae family, a set of viruses that produce viral infections in the majority
of humans. Modified Herpes simplex virus is considered as a potential therapy for
cancer and has been extensively clinically tested to assess its oncolytic ability.
Gene Modification ΔICP27
Promoter CMV
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11967, USA
Email: info@creative-biolabs.com
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2. TRANSGENE INFORMATION
Transgene Dsred
Type of Transgene Reporter gene
Related Target/Protein Discosoma red fluorescent protein
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Tumor
Introduction Red fluorescent protein (RFP) is a fluorophore that fluoresces red-orange when
excited. Several variants have been developed using directed mutagenesis. The
original was isolated from Discosoma, and named DsRed. Others are now available
that fluoresce orange, red, and far-red.RFP is approximately 25.9 kDa. The
excitation maximum is 558 nm, and the emission maximum is 583 nm.
Alternative Names DsRed, Discosoma red fluorescent protein
SUITE 203, 17 Ramsey Road, Shirley, NY
11967, USA
Email: info@creative-biolabs.com
Tel: 1-631-357-2254 Fax: 1-631-207-8356 2 © Creative Biolabs All Rights Reserved