The document discusses OceanSITES, a project that collects long-term, high-frequency ocean observations from fixed locations worldwide. OceanSITES aims to collect multidisciplinary data from the full water column and overlying atmosphere. It provides unique temporal behavior insights and reference data to complement other observation approaches. The network benefits members through data sharing and access to infrastructure, training, and leadership opportunities. It holds annual meetings and has over 50 observation sites making physical, optical, biological and chemical measurements globally. A microcat sensor project added more deep ocean temperature and salinity sensors. Data is managed through a format and shared using two global data centers.
Outputs and recommendations from the Mediterranean Sea-basin Checkpoint WorkshopEMODnet
Nadia Pinardi, EMODnet Mediterranean Sea Checkpoint and associate tenure professor of Oceanography at Bologna University, presents the main outputs and recommendations from the Mediterranean Sea-basin Checkpoint Workshop held on the 14th of February 2017, in Brussels during the EMODnet stakeholder conference.
DSD-INT 2017 - Coastal Hazards Adaptation Resiliency - San Francisco Bay regi...Deltares
Presentation by Rohin Saleh, Alameda County Flood Control District, USA, at the Symposium Knowledge and Innovation for Decision Making, during Delft Software Days - Edition 2017. Friday, 27 October 2017, Delft.
Findings of Baltic Coast project! by Gerald Schernewski, Head of Coastal and Marine Management group, Leibniz-Institute for Baltic Sea Research at the workshop 'What are the research needs for planning in 21st century?' at the 2nd Baltic Maritime Spatial Planning Forum in Riga, Latvia on 23-24 November 2016 (the final conference of the Baltic SCOPE collaboration).
Video and other presentations - www.balticscope.eu
www.vasab.org
Outputs and recommendations from the Mediterranean Sea-basin Checkpoint WorkshopEMODnet
Nadia Pinardi, EMODnet Mediterranean Sea Checkpoint and associate tenure professor of Oceanography at Bologna University, presents the main outputs and recommendations from the Mediterranean Sea-basin Checkpoint Workshop held on the 14th of February 2017, in Brussels during the EMODnet stakeholder conference.
DSD-INT 2017 - Coastal Hazards Adaptation Resiliency - San Francisco Bay regi...Deltares
Presentation by Rohin Saleh, Alameda County Flood Control District, USA, at the Symposium Knowledge and Innovation for Decision Making, during Delft Software Days - Edition 2017. Friday, 27 October 2017, Delft.
Findings of Baltic Coast project! by Gerald Schernewski, Head of Coastal and Marine Management group, Leibniz-Institute for Baltic Sea Research at the workshop 'What are the research needs for planning in 21st century?' at the 2nd Baltic Maritime Spatial Planning Forum in Riga, Latvia on 23-24 November 2016 (the final conference of the Baltic SCOPE collaboration).
Video and other presentations - www.balticscope.eu
www.vasab.org
Update on MCH and MSP – what is going on in the European sea basins? by Susanne Altvater, s.Pro – sustainable projects GmbH at the workshop 'The role of the maritime spatial planning to safeguard the underwater cultural heritage' at the 2nd Baltic Maritime Spatial Planning Forum in Riga, Latvia on 23-24 November 2016 (the final conference of the Baltic SCOPE collaboration).
Video and other presentations - www.balticscope.eu
www.vasab.org
Talks provided at the Scottish Fisheries Co-ordination Centre/Institute of Fisheries Management MAPPING FISHERIES workshop in Edinburgh on March 1st-2nd 2016
DSD-INT 2017 - Delft3D - Water Quality and Ecological Modeling Symposium - Fr...Deltares
Presentation by Nicky Villars, Deltares, The Netherlands, at the Delft3D - User Days (Day 3: Water quality and ecology), during Delft Software Days - Edition 2017. Wednesday, 1 November 2017, Delft.
Presented by Birhanu Zemadim (IWMI) and Emily Schmidt (IFPRI) at the Nile Basin Development Challenge (NBDC) Science Workshop, Addis Ababa, Ethiopia, 9–10 July 2013
Since the first grant that included funding for use of a Wave Glider back in 2010, researchers have received grants for Wave Gliders to collect climate change data, sample chlorophyll blooms, monitor marine life, explore polar seas, and more. See several examples of work that inspires us.
Barbara Ryan @OECD - 21 Sept 2015 - Water Policy in the Age of Big DataOECD Governance
Presentation of Dr. Barbara Ryan [Secretariat Director of the Intergovernmental Group on Earth Observations] at the OECD event "Water Policy in the Age of Big Data on 21 September 2015.
Baltic SCOPE workshop discussion on ENVIRONMENT at Baltic SCOPE Central Baltic case (involving Latvia, Estonia and Sweden) stakeholder conference on 31 May - 1 June 2016 in Jurmala, LATVIA
Read more on: www.balticscope.eu
* The information presented is the working exercise on the cross-border maritime spatial planning discussions and can not be treated as the official opinion of the European Commission and the Member States involved in the consortium of the Baltic SCOPE project.
Baltic SCOPE workshop discussion on SHIPPING at Baltic SCOPE Central Baltic case (involving Latvia, Estonia and Sweden) stakeholder conference on 31 May - 1 June 2016 in Jurmala, LATVIA
Read more on: www.balticscope.eu
* The information presented is the working exercise on the cross-border maritime spatial planning discussions and can not be treated as the official opinion of the European Commission and the Member States involved in the consortium of the Baltic SCOPE project.
David Maidment & Richard Hooper @OECD - 21 Sept 2015 - Water Policy in the Ag...OECD Governance
Presentation of Dr. David Maidment [Hussein M. Alharthy Centennial Chair in Civil Engineering and Director of the Center for Research in Water Resources at the University of Texas at Austin] and Dr. Richard Hooper [President of the Consortium of Universities for the Advancement of Hydrologic Science, Inc.] at the OECD event "Water Policy in the Age of Big Data on 21 September 2015.
C1.08A: The OceanSITES program of fixed open-ocean sustained timeseries - Uwe...Blue Planet Symposium
Time series at critical or representative locations are an essential element of the global ocean observing system. They can provide a unique view of the full temporal behavior of a system; accurate reference and long-time baseline data; and the maximum possible range of interlinked variables from the seafloor to the atmosphere while enabling shared resources.
The mission of the international OceanSITES program is to collect, deliver and promote the use of high-quality data from long-term, high-frequency observations at fixed locations in the open ocean. OceanSITES typically aim to collect multidisciplinary data worldwide from the full-depth water column as well as the overlying atmosphere.
The presentation will cover the status, benefits, and structure of OceanSITES, some prominent examples of long fixed timeseries in the system, and plans for the future including the OceanSITES contribution to the Deep Ocean Observing System. Some emphasis will also be placed on the data management system, delivering homogeneous data sets in a unified format from single data portals.
Update on MCH and MSP – what is going on in the European sea basins? by Susanne Altvater, s.Pro – sustainable projects GmbH at the workshop 'The role of the maritime spatial planning to safeguard the underwater cultural heritage' at the 2nd Baltic Maritime Spatial Planning Forum in Riga, Latvia on 23-24 November 2016 (the final conference of the Baltic SCOPE collaboration).
Video and other presentations - www.balticscope.eu
www.vasab.org
Talks provided at the Scottish Fisheries Co-ordination Centre/Institute of Fisheries Management MAPPING FISHERIES workshop in Edinburgh on March 1st-2nd 2016
DSD-INT 2017 - Delft3D - Water Quality and Ecological Modeling Symposium - Fr...Deltares
Presentation by Nicky Villars, Deltares, The Netherlands, at the Delft3D - User Days (Day 3: Water quality and ecology), during Delft Software Days - Edition 2017. Wednesday, 1 November 2017, Delft.
Presented by Birhanu Zemadim (IWMI) and Emily Schmidt (IFPRI) at the Nile Basin Development Challenge (NBDC) Science Workshop, Addis Ababa, Ethiopia, 9–10 July 2013
Since the first grant that included funding for use of a Wave Glider back in 2010, researchers have received grants for Wave Gliders to collect climate change data, sample chlorophyll blooms, monitor marine life, explore polar seas, and more. See several examples of work that inspires us.
Barbara Ryan @OECD - 21 Sept 2015 - Water Policy in the Age of Big DataOECD Governance
Presentation of Dr. Barbara Ryan [Secretariat Director of the Intergovernmental Group on Earth Observations] at the OECD event "Water Policy in the Age of Big Data on 21 September 2015.
Baltic SCOPE workshop discussion on ENVIRONMENT at Baltic SCOPE Central Baltic case (involving Latvia, Estonia and Sweden) stakeholder conference on 31 May - 1 June 2016 in Jurmala, LATVIA
Read more on: www.balticscope.eu
* The information presented is the working exercise on the cross-border maritime spatial planning discussions and can not be treated as the official opinion of the European Commission and the Member States involved in the consortium of the Baltic SCOPE project.
Baltic SCOPE workshop discussion on SHIPPING at Baltic SCOPE Central Baltic case (involving Latvia, Estonia and Sweden) stakeholder conference on 31 May - 1 June 2016 in Jurmala, LATVIA
Read more on: www.balticscope.eu
* The information presented is the working exercise on the cross-border maritime spatial planning discussions and can not be treated as the official opinion of the European Commission and the Member States involved in the consortium of the Baltic SCOPE project.
David Maidment & Richard Hooper @OECD - 21 Sept 2015 - Water Policy in the Ag...OECD Governance
Presentation of Dr. David Maidment [Hussein M. Alharthy Centennial Chair in Civil Engineering and Director of the Center for Research in Water Resources at the University of Texas at Austin] and Dr. Richard Hooper [President of the Consortium of Universities for the Advancement of Hydrologic Science, Inc.] at the OECD event "Water Policy in the Age of Big Data on 21 September 2015.
C1.08A: The OceanSITES program of fixed open-ocean sustained timeseries - Uwe...Blue Planet Symposium
Time series at critical or representative locations are an essential element of the global ocean observing system. They can provide a unique view of the full temporal behavior of a system; accurate reference and long-time baseline data; and the maximum possible range of interlinked variables from the seafloor to the atmosphere while enabling shared resources.
The mission of the international OceanSITES program is to collect, deliver and promote the use of high-quality data from long-term, high-frequency observations at fixed locations in the open ocean. OceanSITES typically aim to collect multidisciplinary data worldwide from the full-depth water column as well as the overlying atmosphere.
The presentation will cover the status, benefits, and structure of OceanSITES, some prominent examples of long fixed timeseries in the system, and plans for the future including the OceanSITES contribution to the Deep Ocean Observing System. Some emphasis will also be placed on the data management system, delivering homogeneous data sets in a unified format from single data portals.
C1.05: Sustained observations for many users - a perspective from Australia’s...Blue Planet Symposium
Australia is a ‘marine nation’ – an island continent with the third largest ocean territory on the ‘Blue Planet’. Our borders are maritime and we generate massive wealth from marine industries. Most of our population lives in highly urbanised centres on or near the coast, and we are extremely sensitive to ocean-influenced climate and weather, through drought, flood, and tropical cyclones. Our ocean territory contains marine biodiversity of globally significant conservation and tourism value, ranging from the high tropics to Antarctica. These factors combine to establish the need for sustained ocean observing in the Australian context, for many uses and users.
Despite this clear, national need, responsibility for ocean observing and management is fragmented and dispersed. A National Oceans Policy and independent National Oceans Office were established in 1998, but were subsumed into the Federal Environment portfolio by 2005. The Bureau of Meteorology is Australia's national weather agency, and while its role has expanded to encompass climate and water services over the last decade, it is only now beginning to consider an expanded role in marine services. Jurisdiction of the marine environment, including responsibility for marine monitoring, is shared across Federal, State and Territory Governments, across different Departments within those various Governments, and between industrial users and regulators in areas like offshore oil and gas and commercial fishing. It is also significant to note that Australia has no earth observation from space (EOS) capability of its own.
Since 2006, Australia has put in place a national Integrated Marine Observing System (IMOS). Established as a research infrastructure, IMOS routinely operates a wide range of observing equipment, making all of its data openly accessible to the marine and climate science community, other stakeholders and users, and international collaborators. It is integrated from open-ocean to coast, and across physical, chemical and biological ocean variables.
This talk will focus on what has been learnt through the experience of building IMOS as a research infrastructure in a context where sustained ocean observations are needed by many users.
The United States Integrated Ocean Observing System (IOOS®) is a user-driven, coordinated network of people, organizations, and technology that generate and disseminate continuous data about our coastal waters, Great Lakes, and oceans supported by strong research and development activities. IOOS enables decision making every day and fosters advances in science and technology. US IOOS is the United States’ contribution to the Global Ocean Observing System which is part of the ocean contribution to the Global Earth Observation Systems of Systems (GEOSS).
C1.04: GOOS Biology and Ecosystems Panel - In a complex space can we fit a si...Blue Planet Symposium
There is no single model that describes how marine biodiversity and ecosystems are fairing or predict how they will change in the future under increasing anthropogenic pressures. Thus there is no unique set of Essential Ocean Variables (EOVs) for biological components of the ecosystem that will satisfy the scientific understanding needed to support and monitor management actions. Yet there is a need to come to international agreement on a set of variables that can be developed globally to support advanced and advancing countries and international conventions in understanding and managing the marine environment. The DPSIR framework is a commonly accepted framework used to identify the information needs to understand and manage human impacts on the environment and provides one high level model that can guide the process to identify EOVs. It is a complex space with many existing initiatives that we need to integrate with and build on. In this talk we are seeking input and feedback on our early progress in filling in this framework:
D what are the societal questions, sectoral trends, national and international obligations and that Drive the need to monitor marine biodiversity and ecosystem health
P what are the human Pressures affecting the environment that are or will impact marine biodiversity and ecosystem health
S what are the existing initiatives that could be built on to measure the State of the marine environment
I what are the priority Impacts on the marine environment that need to be monitored and how well do existing initiatives address those needs – what are the key gaps
R which monitoring information is most likely to be used to help society Respond to identified impacts
C1.01: GOOS: an essential collaborative system enabling societal benefit - Jo...Blue Planet Symposium
A sustained ocean observing system forms a basis, along with capacity development, enabling societal benefit from ocean information. The Global Ocean Observing System (GOOS) is driven by societal requirements, including:
- adapting to and mitigating climate variability and change
- preparing for ocean-related hazards and supporting development of the ocean economy, and
- monitoring and promoting stewardship of ocean health.
GOOS is a key contributor to the GEO Blue Planet task. We are a collaborative programme, connecting a community and organizations working on many aspects of a Framework for Ocean Observations: identifying requirements focused on Essential Ocean Variables, coordinating observing networks and monitoring progress towards targets, and connecting to data and information generation activities that create scientific and societal value.
At the global level, these processes are led by three GOOS Panels focused on physics, biogeochemistry, and biology. The panels evaluate the readiness of the observing system, promoting strategic investment by identifying what is essential, and encouraging the development of new capabilities. They work closely with the ocean observing community. A Strategic Mapping is helping to identify how elements integrate into the system. GOOS development projects are evaluating and where necessary will improve and change parts of the sustained ocean observing system.
The combined satellite and in situ observing networks contributing to GOOS have strengthened in recent years.
At the regional level, GOOS Regional Alliances individually focus on local priorities and requirements. Collectively, they work to develop institutional and human capacity to make and benefit from sustained ocean observations.
GOOS both supports and relies on many partners, including other contributors to the GEO Blue Planet, in seeking to sustain present observations, while integrating new essential ocean observations into a sustained observing system.
The GEOSS is a social and software ecosystem connecting a large array of observing systems, data systems and processing services to strengthen monitoring of the state of the Earth. It facilitates data and information accessibility and interoperability to support the Sustainable Development Goals (SDG) agenda and the Disaster Risk Reduction.
https://www.geoportal.org/about
IOC Data systems and capacity development related to BBNJ, MGR workshop 21-22...wardappeltans
Marine Genetic Resources, Access and Benefit Sharing, Capacity Development and Transfer of Marine Technology, Biodiversity in Areas Beyond National Jurisdiction
C4.04: Design of a GEO Coastal Ocean Pilot Project for the Caribbean Region -...Blue Planet Symposium
The Group on Earth Observations (GEO) Oceans and Society Coastal Ocean Pilot Project for the Caribbean Region is a response to the need for a Pilot Project to demonstrate the added value of an end-to-end System of Systems for Ecosystem-Based Approaches for monitoring and managing the coastal zone (GEO 2012 – 2015 Work Plan, SB-01-C4-02 [1]).
The Pilot Project design will be based on principles established by the Group on Earth Observations “Oceans and Society: Blue Planet [2]” task and developed in collaboration with the Global Ocean Observing System (GOOS) Regional Alliance (GRA) for the Caribbean, IOCARIBE-GOOS [3]. It will incorporate concepts and recommendations from GOOS Pub. 193, Requirements for Global Implementation of the Strategic Plan for Coastal GOOS [4], and will be tailored to provide meaningful and sustainable value for Caribbean Region marine ecosystems and the populations they impact. The Design document will be developed in increasingly detailed stages, with distribution, review, and comment at each stage, leading to a final Design Plan, at which time we will seek approval to move ahead with GEO support for implementation planning and financing.
C7.01: Current activities of the International Ocean Colour Coordinating Grou...Blue Planet Symposium
The International Ocean Colour Coordinating Group (IOCCG) was established in 1996 with the aim of developing consensus and synthesis on a global scale in the subject area of satellite ocean colour radiometry (OCR). It operates as an Affiliated Program of the Scientific Committee on Oceanic Research (SCOR) and comprises a rotating committee of representatives from each of the major international space agencies that provide ocean colour data, as well as representatives from the scientific community that use ocean colour data for research and applications. Space agencies contribute financially to the IOCCG and carry out the decisions endorsed by the group, while the scientific members address current research issues and make recommendations. Currently, IOCCG works towards ensuring Continuity and Consistency of the Ocean Colour Data Stream in the framework of the CEOS Ocean Colour virtual constellation. Within the OCR-VC framework, the International Network for Sensor Inter-comparison and Uncertainty Assessment for Ocean Color Radiometry (INSITU-OCR) initiative aims at integrating and rationalizing inter-agency efforts on satellite sensor inter-comparisons and uncertainty assessment for remote sensing products, with particular emphasis on requirements addressing the generation of ocean colour Essential Climate Variables (ECV) as proposed by the Global Climate Observing System (GCOS). Since 2013, IOCCG organises a bi-annual International Ocean Colour Science Meeting, where the global OCR community can gather and exchange with peers and space agency representatives. In parallel to these new initiatives, the IOCCG has a continuing capacity building and training activity, and continues to increase its record of monographs, based on the work of its working groups (currently 5 WG are active).
C1.02: The activities and Work Plan of the GOOS Physics and Climate Panel (OO...Blue Planet Symposium
The GOOS Physics and Climate Panel* coordinates requirements for the physical variables for GOOS, and also leads the climate theme, reporting to the United Nations Framework Convention for Climate Change (UNFCCC), through the Global Climate Observing System (GCOS).
Due to the many links that need to be made, the panel has a 5 year Work Plan (2013-2018), which is reviewed and updated annually. The Work Plan focusses on developing requirements for physics Essential Ocean Variables (EOVs) and ocean Essential Climate Variables (ECVs) through the development of variable specifications, the evaluation of network design to meet requirements, and the development and application of observing system performance metrics.
Where there is a need to evolve or expand the observing system, the panel conducts thematic systems based evaluations: for example, the Tropical Pacific observing system (TPOS) review, and evaluation of physics and climate aspects of the Deep Ocean Observing Strategy. Future plans and priorities include; Boundary Currents, and boundary current/shelf interactions, observations for reducing uncertainties in air sea fluxes, and observing ocean/ice interactions.
Systems based evaluations are designed to assess requirements for observations of EOVs, and assess approaches to meeting requirements with existing and emerging observing technologies. Some of these evaluations can and will lead to stand alone finite lifetime projects to oversee the transition or expansion of the observing system. For instance, a new project has been established following the TPOS review, called TPOS 2020 to oversee transition of the TPOS to become more robust, integrated and sustainable (see www.tpos2020.org).
* The GOOS Physics and Climate Panel is also known as the GCOS-GOOS-WCRP Ocean Observations panel for Physics and Climate, OOPC. See more details at www.oopc.info
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Cancer cell metabolism: special Reference to Lactate Pathway
OceanSITES
1. OceanSITES
Taking the pulse of the global ocean
Co-chairs: Robert Weller (WHOI)
Uwe Send (SCRIPS)
projectoffice@oceansites.org
2. OceanSITES Mission
2
Mission:
The mission of OceanSITES is to collect, deliver and
promote the use of high-quality data from long-term, high-
frequency observations at fixed locations in the open
ocean.
OceanSITES typically aim to collect multidisciplinary data
worldwide from the full-depth water column as well as the
overlying atmosphere.
Rationale:
Time series observations at critical or representative locations are one essential
element of a global ocean observing system to complement a range of other
approaches. They can provide: a unique view of the full temporal behavior of a
system; accurate reference and long-time baseline data; and the maximum
possible range of interlinked variables from the seafloor to the atmosphere while
enabling shared resources.
3. Benefits for PI or program to join
OceanSITES
A. Be part of a large network of partners which
B. Gain access to and enhance usership of infrastructure
C. Get assistance for initiating new sustained time-series
programs
D. Gain access to and assistance with
E. Through GDAC mechanism
F. Impacts of your observations
G. Contribute to or become part of other regional or international
programs
H. Gain access to training and student resources
I. Gain access to OceanSITES leadership opportunities (Steering
Committee, Executive Committee, Chair candidature)
J. Contribute to socioeconomic value/benefits/issues
4. OceanSITES Documents
Developed new structure for communicating the project with a
sequence of separate documents:
– Mission Statement
– Benefits of joining the network
– What is an OceanSITES
– Goals and Objectives of OceanSITES
– Governance document
– How to become an OceanSITES
– Performance metrics
5. OceanSITES Community
• Executive committee , Co-chairs
Robert Weller, Woods Hole Oceanographic Institution
Uwe Send, Scripps Institution of Oceanography
• Data Management Team, Chair
Derrick Snowden, of NOAA/US Integrated Ocean Observing System
• Hold annual meetings to discuss issues, develop procedures
and information exchange with other groups.
2014 10th Steering Committee and 7th Data Management Team Meetings in Recife,
Brazil jointly with the Tropical Atlantic Variability/PIRATA and the Brazil-
European Union (EU) Dialogues in Marine Research Meeting.
11th Steering Committee and 8th Data Management Team Meetings planned for
Southampton, U.K., April 2016
6. Status of OceanSITES
• Most of the sites are occupied by moorings, either
surface or subsurface. Many sites make the basic
physical measurements (pressure, temperature,
conductivity, and velocity).
• Some sites includes optical, biological, and chemical
sensors.
• At selected sites, arrays for the purpose of observing
transport or regional processes (e.g., the equatorial
moored arrays).
13. OceanSITES- Microcat Project
• At the 2011 07th OceanSITES SC meeting, it was decided to make use of the many
existing OceanSITES platforms in deep water to make an "instant" contribution towards the
gap in deep- ocean observations. OceanSITES at over 50 sites around the world already
carry deep temperature/salinity (T/S) sensors. OceanSITES members had a goal to deploy
another 50, which requires 50 sensors for the initial deployments and another 50 for
swapping out and calibrations
• OceanSITES PIs have pledged to add such sensors to their existing moorings and as of
August 2015 26 sensors were installed with an additional 10 are planned in the coming
year(s).
• In addition to the sensor contribution by PIs, OceanSITES has a pool of matching sensors
for the swap-outs via donations from institutions, agencies and companies. The community
has nearly 50 instruments in the “pool” for exchanging and adding to sites around the
world.
• This map shows the sites with previously existed temp/salinity sensors in pink. Newly
installed under the temp/salinity project in blue and planned installations in yellow.
15. OceanSITES – Data Management
• OceanSITES has an active Data Management Team (DMT) that
works with site PIs to share data in a common NetCDF format.
• The format specifications have been developed by the DMT in
collaboration with the Steering Committee and Exec Board.
• DMT developed two documents and are available on website
Data Format Reference Manual (formerly User’s Guide)
Data Providers Guide
• Two global data centers (GDACs) are
IFREMER ftp://ftp.ifremer.fr/ifremer/oceansites/
NOAA/NDBC ftp://data.ndbc.noaa.gov/data/oceansites/