introduction
• Jaundice manifestsas yellow discolouration of the skin,
mucous membranes and sclerae.
• It is a clinical sign of hyperbilirubinemia (>2.5 mg/dl).
• It has many causes which can be largely divided into two
types:
non-obstructive, i.e. pre-hepatic and hepatic causes
obstructive, i.e. post-hepatic causes
• Imaging has a major role in detecting the obstructive causes.
3.
Causes of obstructivejaundice
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4.
Causes of ObstructiveJaundice
• Intraluminal causes:
Gall stones
Tumor.
Ascariasis & Schitosomiasis
• Mural causes:
Malignant stricture-cholangiocarcinoma
Benign stricture- Scelerosing cholangitis
• Extrinsic Causes:
Ca Head of Pancreas
Periampullary Carcinoma,
Portal LN
Cholodochal cyst
Mirizi syndrom.
5.
Imaging Modalities:
A. Directstudy :
1. Plain abdomen radiography .
2. U/S.
3. C.T., MRI.
4. ERCP .
5. Direct contrast study : operative cholangiogrophy,
P.T.C and post-operative - T-tube cholangiography.
6. Indirect contrast study : oral cholangiography is
contra-indicated in obstructive jaundice. iv
cholandiography.
7. fine needle biopsy.
B. Indirect study Ba. meal I.V.P.
6.
Plain Abdominal X-ray
Usually of little value.
It can visualise the pathology which causes the obstruction :
a. Stones radio-opaque stone in G.B. or hartmann’s pouch :
b. Calcification
Calcified bladder wall porcelain G.B potentially malignant
(consequent to chronic inflammatory change).
Calcification in the pancreas Chronic pancreatitis.
c. Gas in biliary tree gall stone ileus/ post ERCP or
sphenctrotomy.
d. Paralytic ileus acute pancreatitis and acute cholecysitis.
e. Bone erosion, 2ries, malignancy.
Ultrasound
Value
1. Demonstrationof dilated ducts.
2. Level of the obstruction.
3. Nature of the obstructed segment.
4. Deposits and Ascites.
12.
Ultrasound
a. Gall stones:
b. Chronic cholecystitis :
- Gall stones.
- Wall thickening > 4 mm.
- - Contracted G.B. with no lumen.
c. Bile duct stones : visualize the stone and the dilated
C.B.D > 9mm
d. Pancreatic lesions: Acute pancreatitis Chronic
pancreatitis Benign tumour pancreatic carcinoma.
C.T. in obstructivejaundice
1. It is of value in distinguishing between extra or intra-hepatic cholestasis.
2. Dilated bile ducts lower attenuation linear or circular structures which
don’t enhance with contrast.
3.Dilated CBD dilated tubular structure in porta-hepatis or pancreatic head.
4. In acute pancreatitis.
5. In chronic pancreatitis.
6. In pancreatic carcinoma.
7. Lymph node in the porta-hepatis can be diagnosed early by C.T.
MRI & MRCPin obstructive jaundice
• MRI and MRCP are now routinely being used as the primary imaging modalities of the
hepatobiliary system .
• Excellent non-invasive and accurate imaging technique without the use of ionising radiation
and in many cases without the need for IV contrast.
• MRCP has been shown to have an overall 96–100% accuracy for the level of obstruction and
90% accuracy for the cause of obstruction .
• The main limitations of MRI:
patients with claustrophobia
patients with pacemakers
the limited ability to offer therapeutic intervention.
22.
MRI & MRCPin obstructive jaundice
Normal MRCP Biliary obstruction
ERCP
Value:
• visualize boththe biliary and pancreatic duct systems.
• obstruction relieve by the removal of stones, sphincterotomy and placement of stents and
drains.
• The addition of cholangioscopy to the ERCP allows for biopsies and brushings within the ducts.
Limitations:
• limited capacity to image the biliary tree proximal to the site of obstruction.
• cannot be performed if altered anatomy prevents endoscopic access to the ampulla .
Complications:
• Pancreatitis
• Perforation,
Biliary Peritonitis, Sepsis,
• Hemorrhage
• Adverse Effects From The Dye And The Drug Used To Relax The Duodenum
Percutaneous Transhepatic Cholangiopancreatography(PTC)
Value:
• useful for lesions proximal to the common hepatic duct.
• Biliary obstruction relief.
Limitations:
• The technique is not easy and requires considerable experience
Complications:
• Cholangitis.
• Peritonitis, Sepsis.
• Hemorrhage.
• Subphrenic abscess, and lung collapse
• Adverse Effects From The Dye .
Endoscopic US
Value:
• combinesendoscopy and US to provide remarkably detailed images of
the pancreas and biliary tree.
• overcomes the limitation of evaluation of distal CBD by transabdominal
sonography.
• It is very accurate in diagnosing CBD calculi.
• It also picks up small resectable pancreatobilary mass with high
sensitivity (93-100%).
• allows diagnostic tissue sampling via EUS-guided fine-needle aspiration
.
Limitations:
• lack of expertise, availability of echoendoscopes, need for conscious
sedation
32.
Indirect studies (Ba.meal)
a. Tumour in the pancreatic body and head may cause obstruction in the
pyloric antrum duodenal loop extrinsic invasion or compression.
b. cancer head---- Widening of the C. loop.
d. f. Lymphoma of the stomach LN at portahepatis Jaundice.