This document discusses the steps of evidence-based practice and how to formulate a clinical question using PICOTT. It outlines the five steps in evidence-based medicine: assess the patient, ask the question, acquire resources, appraise the evaluation, and apply to the patient. It also provides guidance on defining the population, intervention, comparison, outcome, and type of question. Different study types like etiology, diagnosis, therapy and prognosis are defined. Tips for effective searching like quotation marks, AND, OR, and NOT operators are reviewed.