A group of teenagers plan to spend the day at the crowded Copenhagen market. Unbeknownst to them, a serial killer named Ivax is also at the market. Ivax kills people at crowded places so that no one notices. He crashes into one of the girls in the group, Lesley, and drops his bloody knife. Later, he follows two members of the group, Roy and Frankie, and kills them secretly in the crowd. Lesley realizes her friends are disappearing and screams for help, but no one can hear her over the noise. In the end, Ivax kills Lesley too, and will continue killing without being caught.
This is a TV show I made. It is random and funny! Yeeeeeah. It's off my first Powerpoint site (www.star-angel-productions.com). Check out my newer Powerpoint site (www.powerpointsforall.webs.com) which is shared between me and my best friend. Go onto my two pages: Andy Productions and Two For One.
This is a TV show I made. It is random and funny! Yeeeeeah. It's off my first Powerpoint site (www.star-angel-productions.com). Check out my newer Powerpoint site (www.powerpointsforall.webs.com) which is shared between me and my best friend. Go onto my two pages: Andy Productions and Two For One.
Macmillan Readers - The House on The Hill by Elizabeth LairdEka Kurnia
Paul and Maria talked for a long time. The sun went down. It was nearly dark.
'I must go home,' said Maria.
'Where do you live?' asked Paul.
'In the big white house on the hill,' said Maria. 'Where do you live?'
'In the little brown house near the market,' said Paul.
They laughed. But Paul was sad. The house on the hill was big and important. Maria was rich, and he was poor. And Paul was in love.
Macmillan Readers: Beginner level
Audio book: https://drive.google.com/file/d/0B3YGyUd8NRt5bmxBU2IzS25LRDQ
Find here the translation in english of the french magazine PHOTO, issue 457, "Special David LaChapelle". All of the texts are not there, but I will upload a completed version soon.
Macmillan Readers - The House on The Hill by Elizabeth LairdEka Kurnia
Paul and Maria talked for a long time. The sun went down. It was nearly dark.
'I must go home,' said Maria.
'Where do you live?' asked Paul.
'In the big white house on the hill,' said Maria. 'Where do you live?'
'In the little brown house near the market,' said Paul.
They laughed. But Paul was sad. The house on the hill was big and important. Maria was rich, and he was poor. And Paul was in love.
Macmillan Readers: Beginner level
Audio book: https://drive.google.com/file/d/0B3YGyUd8NRt5bmxBU2IzS25LRDQ
Find here the translation in english of the french magazine PHOTO, issue 457, "Special David LaChapelle". All of the texts are not there, but I will upload a completed version soon.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
1. Key Ideas for the Horror -group of young people are going to a market -sunny day, place is crowded Man, girl runs over the place into a guy with a suitcase, it breaks up and a bloody knife falls out unexpected. -he kills teens on the market secretly. -Some teenagers are going to a holiday house of a family - the house wasn’t used for a long time and lies in the woods. Time after time, somebody from the family returns to the house, where everybody thought was dead. The teenagers recognize, they are in big troubles... -A catholic family is moving to the old house of their grandmother. -the house of the grandmother confronts them with the fact what religion has done (history shown in the house) - The mother turns evil and shows off her bad side. - Maybe Schizophrenic - becomes a killer
2. Treatment A group of teens decided, to go to the Saturday market. They are used to go there. But they do not know that the unexpected will come. Characters: Teenagers: Killer: -Lesley, 18 -Ivax -Roy, 19 -Adam, 17 -Frankie, 18
3. Main Characters Lesley is 18, is the leader of the group, she is very intelligent, but a bit of a dreamer. Ivax the Killer. He seems quite invisible but he is very intelligent. He is emotional broken he is sick.
4. The sunny day is representing the normality of the day. The film takes place in Copenhagen. Every Saturday, there is a huge market. And there are lots of tourists. It doesn’t have lots of locals. You can by lovely little accessories of Copenhagen. But for Lesley's clique it is a nice place to hang out. Ivax lives in Copenhagen but not long time ago he lived somewhere else but nobody knows where. He comes and goes. But mostly of time, he spends time in huge markets. To kill people and nobody can ever recognize it, because on markets there is always a huge crowd. He searches young teens, because they can’t control their fear….
5. Lesley, Adam, Roy and Frankie are hanging out on the market. Lesley has something going on with Adam and Frankie is Adams sister and Roy has something going on with Frankie. They meat each other on the river, Afterwards they are going to the market. On the way, because everything is so crowded, Lesley is crashing into a man( Ivax) and the bag breaks up and a bloody knife is falling out. Lesley excuses herself and the man is very friendly and says “no problem”. Lesley doesn’t make herself a thought, because she is to nervous because of the tragic around her and the man seems very nice even though she saw the knife. In some kind of way the four teens have lost each other time after time, Roy and Frankie decided to go to the toilet. But to go there, they have to walk quite a lot because of the huge crowed. As soon they start to going, Ivax fallow them. Frankie is walking in front of Roy. Just before they reached the toilet, Roy has a knife…. Ivax is a killer. He is always going to markets on sunny days, that nobody can recognize who gets killed. He is used to go to the huge market of Copenhagen, because he was born in Copenhagen, so he knows every corner, even if there are lots of people. He never knows who his next victim is, but mostly he kills teens because he hates them, because he could never be one. As he stands in the corner of his favourite restaurant, and looks to the river, smokes his cigar he recognizes a group of teens. Before he kills them, he decides to give them a chance. He fallows them. When they reached the crowd, Ivax is crashing into Lesley, the knife falls out….and Lesley sees it, but Ivax stays friendly and smiles at her. Like Ivax knew she would be to naive to recognize the danger. He found his victim. He keeps track of the teens. A view time later, he fallows Roy And Frankie very closely….
6. The Past of The Killer Ivax, didn’t had a normal childhood. His father was Schizophrenic. He killed his own wife and Ivax saw everything, he never met other teens or children. But than Ivax killed his father and the feeling of killing him was satisfaction him. After that he staid 4 years in the house of his parents. He didn’t knew what he should do, because he was
7. so confused and lost, because something was missing time after time, the feeling of freedom, to kill somebody like he killed his father. In this 4 years. He made a plan of how he can get this satisfaction again. And he thought about travelling around the world and find different victims. Some, who looked like his father, or like his mother. But he knew this is not easy, to just kill, so he decided where is the best place to kill. After 4 years of thinking, he decided to go away from this place and travel around the world killing people. And he had a great idea. Who would expecting, that a killer would be on a sunny, lovely day market around to kill. So Ivax travelled from big markets to huge events, to kill. But time after time the satisfaction wasn’t anymore so fresh as before, so he decided to go further. He want not to kill anymore men who did looked like his father, he decided to kill teens, because he wanted to take those years away, he never had… And he hoped to get a bigger satisfaction…
8. So Ivax is killing all the teens in the crowd. And nobody ever sees it, nobody ever hears it because they are too many people. As all the teens are dead, except from Lesley, she runs into the middle of the market and shouts, but nobody can hear her because of the tragic and the music, we see a close up of her face, her fear, than the camera is going slowly away from her, we see the crowd and Ivax and than we hear a cry… And we know Ivax killed her…and he will continue….
9. The Idea of this Horror, should show a psycho back round of an emotional hurt child and how he starts to live his life, to think to get something which he never will have again. Killing his father and thinking the years will come back which the father took him away. This Horror should be a bit unusual, because everything plays on a sunny, lovely day, and you would not expect, that a mentally ill killer is around. The horror should also be on the beginning not shown as a Horror. Something is coming which nobody expects, and this also happens in real life….