Developing a new nuclear site in the UK faces challenges in three main areas: strategic and economic regulatory issues, supply chain and operational delivery issues, and intangible reputational and human resource issues. Key challenges include high costs, gaining public acceptance, managing the project lifecycle, developing the nuclear supply chain and workforce skills, and navigating the regulatory process. Nuclear power presents an option for reducing carbon emissions but developing new sites will require overcoming substantial political, economic, and social hurdles.