The document provides information about the National Institutes of Health Public Access Policy which requires that investigators funded by NIH submit electronic versions of their final peer-reviewed manuscripts to PubMed Central, a free archive of biomedical literature managed by the National Library of Medicine, to be made publicly available no later than 12 months after official publication. It describes PubMed Central, the NIH Manuscript Submission System which is used to deposit manuscripts, and compliance with the policy for NIH grant funding.