This document discusses nicotine addiction from tobacco use. It notes that nicotine is the addictive substance in tobacco, and that one cigarette contains enough nicotine to cause addiction. Nicotine acts on the brain quickly after inhalation, increasing dopamine and causing pleasurable effects. However, this wears off rapidly, leading to cravings for more smoking. Long-term tobacco use leads to tolerance and withdrawal symptoms when stopping. Tobacco addiction is best treated through both pharmacological therapies like nicotine replacements and behavioral therapies to address the psychological components of addiction. The document encourages those wanting to quit to seek help from trusted individuals.

1. Mansoura University
Faculty of medicine
Clinical toxicology and forensic medicine
department

2. Nicotine

3. Source:-
Tobacco plant

4. Abuse:-
Smoking

5. What is tobacco Addiction?
• Addiction mean dire need of substance despite danger.
• Tobacco products are addictive.
• Many people attempt to ,but in most cases relapse
occur

6. Is Nicotine Addictive?
Nicotine is the addictive substance of
tobacco.
One cigarette contains 10 mg of nicotine ,but
smokers get only about 1 to 2 mg .
This amount is enough for addiction .

7. Is Nicotine the Only Harmful Part of Tobacco?
Not only nicotine is the harmful Ingredient.
There are many other substances as tar, carbon
monoxide ,acetaldehyde, nitrosamines and many
carcinogenic substances that cause lung cancer.

9. How Does Tobacco Deliver Its Effects?
After inhalation of smoke ,nicotine takes just 8
seconds to reach the brain .
Nicotine fits into Ach receptors causing changes
in brain and body as increasing Bp and
respiratory rate .

10.  Nicotine increases dopamine release causing
pleasurable effect ,but this wear off rapidly which in
turn lead to urgent desire for smoking again.
 Long term use of nicotine causes addiction .

11. What Happens When Someone Uses
Tobacco for Long Periods of Time?
Rapid distribution and effect of nicotine enhances its
addiction .
Its effect ends rapidly with development of tolerance.
Some of this tolerance is lost during night so ,the 1st
cigarette is most effective .

12. Withdrawal
Sudden stopping of smoking lead to withdrawal
symptoms as irritability ,cognitive and attention
defect ,sleep disturbance ,increased appetite and
craving

13. How Is Tobacco Addiction
Treated?
o Bupropion (zyban).
o Varenicline tartrate (Chantix).
o The most effective way is both pharmacological
and behavioral therapy.

14. What If a Person Wants To Quit?
 someone you know is smoking or using tobacco
in another way, encourage him or her to talk to a
parent, school guidance counselor, or other
trusted adult.

17. Done by
Maged Hemaid Mohamed Salem

18. Thank you!