Nicardia Retard tablets contain the active ingredient nifedipine. They are used to treat hypertension and chest pain by relaxing blood vessels. Common side effects include headaches, dizziness, and edema. The tablets must be taken once daily on an empty stomach and swallowed whole. Nifedipine is classified as pregnancy category C and may cause adverse effects in animal studies. Overdose can lead to hypotension, acidosis, and loss of consciousness.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Nicardia Retard Tablets(Generic Nifedipine Sustained Release
Tablets) are used to prevent certain types of chest pain
(angina) and for the treatment of hypertension ( high blood
pressure).It can also be used to treat disorder called Raynaud's
phenomenon, and premature labor.
This medication may allow you to exercise more and decrease
the frequency of angina attacks. Nifedipine belongs to a group
of medications known as calcium channel blockers. It works by
relaxing blood vessels so blood can flow more easily. This
medication should be taken regularly to be effective. Nicardia
Retard must not be used to treat attacks of chest pain after
they have occured.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Active Ingredient
The active ingredient present in Nicardia Retard tablets is
Nifedipine. Each tablet of Nicardia contains 10 mg, 20 mg or 30 mg
of Nifedipine.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Chemical Structure
The structure of Nifedipine is given below:

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Nicardia Retard, manufactured by J B Chemicals and
Pharmaceuticals Limited, India is available as tablets of 10
mg, 20 mg and 30 mg.
(Website: https://jbpharma.com/)
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Nifedipine Tablets – Brand Names
Nifedipine tablets are available under
various drug trade names that include
Adalat, Adalat Retard, Procardia, Nicardia,
Nicardia Retard, Nifedine, Nifelat,
Calbloc, Calcigard and Depin.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Uses of Nicardia Retard Tablets
Nicardia Retard (Generic Nifedipine Sustained Release Tablets) is
used alone or in combination with other drugs to treat high blood
pressure (hypertension). Lowering high blood pressure helps
prevent strokes, heart attacks, and kidney problems.
This medication is also used for certain types of chest pain (angina).
It may help increase your ability to exercise and decrease the
frequency of chest pain attacks. It should not be used to treat chest
pain when it occurs. Use other medications (such as sublingual
nitroglycerin) to relieve attacks of chest pain as directed by your
doctor.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Uses of Nicardia Retard Tablets
Chronic Stable Angina: Nicardia Retard (Nifedipine extended-
release tablets) is indicated in the management of chronic stable
angina (effort-associated angina) without evidence of vasospasm
in patients who remain symptomatic despite adequate doses of
beta blockers and/or nitrates, or who cannot tolerate these
agents.
Hypertension: Nicardia Retard is indicated in the management of
mild to moderate essential hypertension. Nicardia Retard should
normally be used in those patients in whom treatment with
diuretics or beta blocker has been ineffective, or has been
associated with unacceptable adverse effects.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Nicardia Retard Tablets Dosage
The recommended dosage of Nicardia Retard tablets (Generic
Nifedipine Sustained Release tablets) is orally once a day, on an
empty stomach.
Nicardia Retard is a sustained release dosage form and the tablets must
be swallowed whole, not bitten or divided. Normally, titration should
proceed over a 7 to 14 day period starting with 30 mg once daily.
Upward titration must be based on therapeutic efficacy and safety and
will have to be suited to the needs of the patient under treatment.
The usual maintenance dose is 30 mg to 60 mg once daily. Titration to
doses more than 90 mg daily is not recommended.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Contraindications
Nicardia Retard tablets are contraindicated in persons with a
hypersensitivity (allergy) to Nifedipine or any of the other
ingredients of this medicine.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Storage Instructions
Nicardia Retard Tablets(Generic Nifedipine
Sustained Release Tablets) have to be stored at
controlled room temperature i.e. from 20°C to
25°C (68°F to 77°F) with excursions permitted
between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away
from children and pets.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Warnings
Excessive Hypotension: Normally in most patients the hypotensive effect of
Nifedipine is modest and well tolerated, occasional patients have had excessive
and poorly tolerated hypotension.
Increased Angina and/or Myocardial Infarction: Rarely, patients, particularly
those who have severe obstructive coronary artery disease, have developed well-
documented increased frequency, duration and/or severity of angina or acute
myocardial infarction upon starting therapy with Nifedipine tablets or at the time
of dosage increase.
Beta-Blocker Withdrawal: When stopping a beta-blocker it is important to taper
its dose, if possible, rather than stopping abruptly before starting treatment with
Nifedipine. Patients recently withdrawn from beta blockers may develop a
withdrawal syndrome with increased angina, which is most probably related to
increased sensitivity to catecholamines.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Warnings
Congestive Heart Failure: Rarely, patients have developed heart failure after
starting Nifedipine.
Concomitant administration with strong P450 inducers, such as Rifampin, are
contraindicated. Nifedipine should not be used in cases of cardiogenic shock.
Since Nifedipine decreases peripheral vascular resistance, careful monitoring of
blood pressure during the initial administration and titration of Nicardia
Retard is recommended.
Mild to moderate peripheral edema occurs in a dose-dependent manner with
Nifedipine.
Clearance of Nifedipine is decreased and systemic exposure increased in
patients with cirrhosis. It is unknown how systemic exposure may be altered in
patients with moderate or severe liver impairment. Careful monitoring and
dose reduction may be necessary in such patients.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Warnings
Do not start therapy with Nicardia Retard (Nifedipine Tablets)
within 3 days of drinking grapefruit juice or eating grapefruit.
Inform your doctor if you have had grapefruit or grapefruit juice in
this time.
Also, do not drink grapefruit juice or eat grapefruit whilst
taking Nicardia Retard Tablets. Grapefruit juice has been
observed to increase the blood levels of the active ingredient,
Nifedipine. This effect can last for at least 3 days.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Side Effects
The most common side effects of Nifedipine (Nicardia Retard Tablets)
include Dizziness, lightheadedness, giddiness, Flushing, heat sensation,
Headache, Weakness, Nausea, heartburn, Muscle cramps, tremor, Peripheral
edema, Nervousness, mood changes, Palpitation, Dyspnea, cough,
wheezing, Nasal congestion and sore throat. other side effects include:
Incidence Approximately 10%
Cardiovascular: peripheral edema
Central Nervous System: dizziness or lightheadedness
Gastrointestinal: nausea
Systemic: headache and flushing, weakness.
Incidence Approximately 5%
Cardiovascular: transient hypotension
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Side Effects
Incidence 2% or Less
Cardiovascular: palpitation
Respiratory: nasal and chest congestion, shortness of breath
Gastrointestinal: diarrhea, constipation, cramps, flatulence
Musculoskeletal: inflammation, joint stiffness, muscle cramps
Central Nervous System: shakiness, nervousness, jitteriness, sleep
disturbances, blurred vision, difficulties in balance.
Other: dermatitis, pruritus, urticaria, fever, sweating, chills, sexual
difficulties.
Incidence Approximately 0.5%
Cardiovascular: syncope (mostly with initial dosing and/or an increase in
dose), erythromelalgia
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Side Effects
Incidence Less Than 0.5%
Hematologic: thrombocytopenia, anemia, leukopenia, purpura
Gastrointestinal: allergic hepatitis
Face and Throat: angioedema (mostly oropharyngeal edema with breathing
difficulty in a few patients), gingival hyperplasia
CNS: depression, paranoid syndrome
Special Senses: transient blindness at the peak of plasma level, tinnitus
Urogenital: nocturia, polyuria
Other: arthritis with ANA (+), exfoliative dermatitis, gynecomastia
Musculoskeletal: myalgia
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Overdose
A number of persons have developed toxicity due to acute overdosage
with Nifedipine, either accidentally or intentionally, and via either oral or
parenteral administration. The adverse effects include heart rhythm
disturbances, metabolic acidosis, hypoxia, cardiogenic shock with
pulmonary edema, lethargy, bradycardia, marked hypotension (drop in
blood pressure) and loss of consciousness.
Usually, Nifedipine overdose leading to pronounced hypotension calls
for active cardiovascular support including monitoring of cardiovascular
and respiratory function, elevation of extremities, judicious use of calcium
infusion, pressor agents (medication that tends to raise reduced blood
pressure) as well as fluids.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Overdose
After oral ingestion, thorough gastric lavage is
recommended, in case necessary in combination with
irrigation of the small intestine.
In cases involving overdosage of a slow-release product like
Nicardia Retard, removal should be as complete as
possible, including from the small intestine, to prevent the
subsequent absorption of the active substance.
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
Nicardia Retard Tablets During Pregnancy
Nifedipine (Nicardia Retard Tablets) is classified by the US FDA as
Pregnancy Category C.
During animal studies conducted in rodents, rabbits and monkeys,
Nifedipine has been observed to have a variety of embryotoxic,
placentotoxic, teratogenic and fetotoxic effects, including including
stunted fetuses (rats, mice and rabbits), digital anomalies (rats and
rabbits), rib deformities (mice), cleft palate (mice), small placentas
and underdeveloped chorionic villi (monkeys), embryonic and fetal
deaths (rats, mice and rabbits), prolonged pregnancy (rats; not
evaluated in other species), and decreased neonatal survival (rats;
not evaluated in other species).
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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)
For more details on
Nicardia Retard Tablets click here
Nicardia Retard Tablets(Generic Nifedipine Sustained Release Tablets) by
J B Chemicals and Pharmaceuticals Limited, India.
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