Tizan Tablets (Generic Tizanidine Hydrochloride Tablets)

Tizan (Generic Tizanidine Hydrochloride Tablets)
© The Swiss Pharmacy

Tizan (Generic Tizanidine Hydrochloride Tablets) is a
short-acting muscle relaxer. It works by blocking nerve
impulses (pain sensations) that are sent to your brain.
Tizanidine is used to treat spasticity by temporarily
relaxing muscle tone.
Because of the short duration of effect, treatment with
Tizanidine tablets should be reserved for those daily
activities and times when relief of spasticity is most
important.

Tizan Tablets are manufactured by
Sun Pharmaceutical Industries
Limited in the strength of 2mg.

Chemical Structure - Tizanidine Hydrochloride

The active ingredient contained in Tizan tablets is
Tizanidine Hydrochloride.
Each Tizan tablet contains Tizanidine
Hydrochloride equivalent to 2 mg of Tizanidine.

Uses of Tizan 2mg tablets:
Tizan (Generic Tizanidine Hydrochloride Tablets) is used to help relax certain
muscles in your body. It relieves spasms, cramping, and tightness of the muscles
caused by medical problems, such as multiple sclerosis, painful muscle spasms
associated with static and functional disorders of the spine (cervical and lumbar
syndromes) or certain injuries to the spine or following surgery, e.g. for herniated
intervertebral disc or osteoarthritis of the hip.
Tizanidine does not cure these problems, but it may allow other treatment, such
as physical therapy, to be more helpful in improving your condition.
This medicine is also used for treatment of spasticity due to neurological disorders
such as multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases,
cerebrovascular accidents, and cerebral palsy.
Tizanidine acts on the central nervous system (CNS) to produce its muscle
relaxant effects.

Recommended Adult Dosage
For most patients, the starting dose of
Tizan (Generic Tizanidine Hydrochloride Tablets) is 2 mg.
The dose can be repeated at 6 to 8 hour intervals, up to a
maximum of 3 doses in 24 hours.
Dosage can be increased by 2 mg to 4 mg per dose, with 1 to
4 days between increases. The total daily dose should not
exceed 36 mg.

Recommended Adult Dosage
Tizanidine pharmacokinetics differs when taken with or without
food. These differences could result in a change in tolerability and
control of symptoms.
To discontinue Tizan tablets (Generic Tizanidine Hydrochloride
tablets), decrease dose slowly to minimize the risk of withdrawal
and rebound hypertension, tachycardia, and hypertonia.

Contraindications
➔
Tizan is contraindicated in patients with a known hypersensitivity
to Tizanidine Hydrochloride or any component of the tablet.
➔
Concomitant use of Tizan tablets with potent inhibitors of CYP1A2,
such as Fluvoxamine or Ciprofloxacin is contraindicated.

Storage Instructions
Tizan (Generic Tizanidine Hydrochloride Tablets) have
to be stored at controlled room temperature i.e. from
20°C to 25°C (68°F to 77°F) with excursions permitted
between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

Tizan Tablets - Warnings
Hypotension: monitor for signs and symptoms of hypotension, in
particular in patients receiving concurrent antihypertensives; Tizan
tablets should not be used with other alpha2-adrenergic agonists
Risk of liver injury: monitor ALTs; discontinue Tizan if liver injury
occurs
Sedation: Tizan tablets may interfere with everyday activities;
sedative effects of Tizan, alcohol, and other CNS depressants are
additive
Hallucinations: consider discontinuation of Tizan tablets.

Tizan Tablets - Warnings
Less potent inhibitors of CYP1A2: may cause hypotension,
bradycardia, or excessive drowsiness, use caution if Tizan is used
with less potent inhibitors of CYP1A2, e.g., Zileuton, other
Fluoroquinolones, Antiarrythmics , Cimetidine, Famotidine, Oral
Contraceptives, Acyclovir, and Ticlopidine
Renal impairment (creatinine clearance less than 25 mL/min): use
Tizan with caution, and monitor closely for dry mouth,
somnolence, asthenia and dizziness as indicators of potential
overdose

Driving or Hazardous Activity
Avoid driving or hazardous activity until you know how Tizan (Generic
Tizanidine Hydrochloride Tablets) will affect you. Your reactions could be
impaired.
Avoid getting up too fast from a sitting or lying position, or you may feel
dizzy.
Drinking alcohol with this medicine can cause side effects.

Possible Side Effects
Most common Tizanidine Hydrochloride (Tizan Tablets) side
effects with an incidence rate of greater than or equal to 2%
taking Tizanidine and greater than in placebo-treated patients in
three multiple dose, placebo-controlled studies) were dry mouth,
somnolence, asthenia, dizziness, urinary tract infection,
constipation, liver function tests abnormal, vomiting, speech
disorder, amblyopia, urinary frequency, flu syndrome, SGPT/ALT
increased, dyskinesia, nervousness, pharyngitis, and rhinitis

Possible Side Effects
The following side effects have been identified as occurring in the post
marketing experience of Tizanidine Hydrochloride (Tizan Tablets).
Based on the information provided regarding these reactions, a causal
relationship with Tizan cannot be entirely excluded.
The events are listed in order of decreasing clinical significance,
severity in the post marketing setting is not reported:
Stevens Johnson Syndrome, Anaphylactic Reaction, Exfoliative
Dermatitis, Ventricular Tachycardia, Hepatitis, Convulsion,
Depression, Arthralgia, Paresthesia, Rash, and Tremor

Tizan Tablets Overdosage
The clinical manifestations of Tizanidine Hydrochloride (Tizan
Tablets) overdose were consistent with its known
pharmacology. In the majority of cases a decrease in sensorium
was observed including lethargy, somnolence, confusion and
coma.
Depressed cardiac function is also observed including most
often bradycardia and hypotension. Respiratory depression is
another common feature of Tizanidine (Tizan tablets)
overdose.

Treatment of Tizan Tablets Overdosage
Should Tizan overdose occur, basic steps to ensure the adequacy of
an airway and the monitoring of cardiovascular and respiratory
systems should be undertaken. Tizanidine is a lipid-soluble drug,
which is only slightly soluble in water and methanol. Therefore,
dialysis is not likely to be an efficient method of removing drug
from the body.
In general, symptoms resolve within one to three days following
discontinuation of Tizanidine and administration of appropriate
therapy. Due to the similar mechanism of action, symptoms and
management of Tizanidine overdose are similar to that following
Clonidine overdose.

Tizan Tablets during Pregnancy
Tizanidine Hydrochloride (Tizan Tablets) has been classified by the US
FDA as Pregnancy Category C.
Tizanidine Hydrochloride (Tizan Tablets) has not been studied in
pregnant women. Tizan should be given to pregnant women only if the
benefit outweighs the risk to the unborn fetus. Reproduction studies
performed in rats at a dose of 3 mg/kg, equal to the maximum
recommended human dose on a mg/m2 basis, and in rabbits at 30 mg/kg,
16 times the maximum recommended human dose on a mg/m2 basis, did
not show evidence of teratogenicity. Tizanidine at doses that are equal to
and up to 8 times the maximum recommended human dose on a mg/m2
basis increased gestation duration in rats. Prenatal and postnatal pup loss
was increased and developmental retardation occurred.

Tizan Tablets are manufactured by Sun
Pharmaceutical Industries Limited, India.
For More details Click Here

Tizan Tablets (Generic Tizanidine Hydrochloride Tablets)

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