Advances in molecular pharmacology and an improved understanding of the mechanism of most diseases have created the need to specifically target the cells involved in the initiation and progression of diseases. This is especially true for most life-threatening diseases requiring therapeutic agents which have numerous side effects, thus requiring accurate tissue targeting to minimize systemic exposure. Recent drug delivery systems (DDS) are formulated using advanced technology to accelerate systemic drug delivery to the specific target site, maximizing therapeutic efficacy and minimizing off-target accumulation in the body. As a result, they play an important role in disease management and treatment. Recent DDS offer greater advantages when compared to conventional drug delivery systems due to their enhanced performance, automation, precision, and efficacy. They are made of nanomaterials or miniaturized devices with multifunctional components that are biocompatible, biodegradable, and have high viscoelasticity with an extended circulating half-life. This review, therefore, provides a comprehensive insight into the history and technological advancement of drug delivery systems. It updates the most recent drug delivery systems, their therapeutic applications, challenges associated with their use, and future directions for improved performance and use.
Ahmedabad Call Girls Book Now 9630942363 Top Class Ahmedabad Escort Service A...
Newer Drug Delivery System_31-01-2024_Dr. Jeenal Mistry.pdf
1. Nuevo sistema de
administración de
medicamentos
Dr. Jeenal Mistry
Senior resident,
Dept. of Pharmacology,
GMERS Medical College, Navsari.
Date: 31st January 2024
NEWER
DRUG
DELIVERY
SYSTEM
3. What is NDDS ?
Drug delivery systems are technological systems
that formulate and store drug molecules into
suitable forms like tablets or solutions for
administration.
They hasten the reach of drugs to the specific
targeted site in the body, thereby maximizing
therapeutic efficacy and minimizing off-target
accumulation in the body.
3
4. Challenges with Current Therapy!!!
✓ Physicochemical and biological barriers
✓ Inactivation by gastric pH
✓ First pass metabolism
✓ Adverse effect- more
✓ Long-term depot formulations
✓ Constant drug release rates
✓ Self-regulating
✓ Therapeutic concentration- Not maintained
✓ Less patient compliance
✓ Fluctuation of drug concentration in blood
4
5. Newer Drug Delivery System
‘’Therapeutic systems that incorporate drugs in a
dosage form that releases the medication at a
predeterminer cite at a predetermined rate over an
extended period of time from a single application.’’
9/3/20XX
5
6. Types
✓Oral Drug Delivery System
✓Ophthalmic Drug Delivery System
✓Transdermal Drug Delivery System
✓Pulmonary Drug Delivery System
✓Intravaginal Drug Delivery System
✓Intravesical Drug Delivery
✓Urethral administration
✓Implants
✓Topical Administration
✓Prodrugs
✓Pulsatile Drug Delivery System
✓Gene therapy
✓Targeted Drug Delivery System
✓Carrier systems
6
7. Oral Drug
Delivery
System
9/3/20XX
7
[1] Oral Controlled Release System
(A) Continuous release systems
• Dissolution-controlled release systems
• Diffusion-controlled release systems
• Dissolution- and diffusion-controlled release systems
• Ion exchange resin-drug complexes
• Osmotic pressure-controlled systems
(B) Delayed Transit and Continuous Release Systems
a) High-density (sinking) system or non-floating drug delivery system
b) Floating drug delivery systems
• Non-effervescent systems
• Effervescent (gas-generating) systems
c) Bioadhesive or mucoadhesive drug delivery systems
d) Expandable, unfoldable, and swellable systems
e) Superporous hydrogel systems
(C) Delayed release systems
[2] Chewable dosage forms
[3] Genetically modified microorganisms
29. 1. B.M. Rayaprolu, J.J. Strawser, G. Anyarambhatla, Excipients in parenteral formulations: selection
considerations and effective utilization with small molecules and biologics, Drug Dev. Ind. Pharm.
44 (2018) 1565–1571, https://doi.org/10.1080/03639045.2018.1483392.
2. A.M. Vargason, A.C. Anselmo, S. Mitragotri, The evolution of commercial drug delivery
technologies, Nat. Biomed. Eng. 5 (2021) 951–967, https://doi.org/10.1038/s41551-021-00698-
w.
3. Wong, W.F.; Ang, K.P.; Sethi, G.; Looi, C.Y. Recent Advancement of Medical Patch for Transdermal
Drug Delivery. Medicina 2023, 59, 778. https://doi.org/10.3390/ medicina59040778
4. G.A. Hebbink, M. Jaspers, Harry J.W. Peters et al, Recent developments in lactose blend
formulations for carrier-based dry powder inhalation, Advanced Drug Delivery Reviews 189
(2022) 11452. https://doi.org/10.1016/j.addr.2022.114527
Recursos
29
