A synapse is the gap between neurons where neurotransmitters are released from the axon terminal of the first neuron and received by the dendrite of the next neuron. The average neuron has around 1,000 synapses. Neurotransmitters such as dopamine, GABA, and glutamate are released into the synaptic cleft and bind to receptors, either exciting or inhibiting the next neuron. Drugs like methamphetamine, nicotine, and alcohol can interfere with neurotransmission by altering neurotransmitter release or receptor binding.