Cancer is caused by the uncontrolled division of abnormal cells that are not normal. This causes cells to split abnormally and take over other tissues in the body. Leukemia is a type of cancer that affects the blood and bone marrow, causing an overproduction of immature and abnormal white blood cells. There are four main types of leukemia - acute or chronic, and lymphocytic or myelogenous - which differ in their rates of growth and the cells they affect. While leukemia cannot be prevented, certain genetic and environmental factors like radiation exposure, Down syndrome, and smoking can increase the risk of developing leukemia.
This document discusses different types of disorders that are not caused by pathogens. It categorizes disorders into three major types: inherited disorders which result from genes; injuries caused by physical damage; and organic disorders from deficiencies, environmental factors, or unknown causes. Within organic disorders, it describes benign and malignant tumors. Benign tumors are slow-growing localized growths while cancerous or malignant tumors grow and spread rapidly and chaotically. A biopsy is used to diagnose if a tumor is benign or malignant by analyzing tissue samples microscopically.
This document summarizes leukemia, an abnormal growth of white blood cells. It has no known single cause and can affect both adults and children. The main types are acute leukemia, which shows no initial symptoms, and chronic leukemia, which presents with symptoms like fever, night sweats, and frequent infections over time. Treatment involves chemotherapy and other drugs to try and induce remission and prevent relapse of the cancer.
R Sharmila prepared this document about systemic lupus erythematosus (SLE). SLE is an autoimmune disorder where the immune system attacks its own tissues, causing inflammation in connective tissues like skin and joints. Common symptoms include fatigue, joint pain and swelling, rashes, and blood disorders. The causes are not fully known but may involve genetic and environmental factors like UV exposure and stress. The condition results from a defect where the body produces antibodies against its own proteins, triggering inflammation. Treatment focuses on relieving symptoms and involves medications like anti-inflammatories, steroids, and stress reduction.
Leukemia is a group of malignant disorders affecting the blood and bone marrow that results in excess dysfunctional white blood cells. It occurs across all age groups but is often thought of as a childhood disease. Leukemia is classified as either acute or chronic depending on cell maturity and disease onset. Acute leukemias involve immature cells and a rapid onset while chronic leukemias involve mature cells and a more gradual onset. Common oral manifestations of acute leukemias include gingival bleeding, ulcers, and swelling. Dental treatment for patients with leukemia requires managing infection risks and bleeding during remission.
Down syndrome is a genetic disorder caused by the presence of an extra chromosome 21, known as trisomy 21. Individuals with Down syndrome often have characteristic physical traits such as an oblique eye, muscle hypotonia, a flat nasal bridge, and a protruding tongue. The incidence of Down syndrome is estimated to be between 1 in 800 and 1 in 1000 births, and life expectancy for those with Down syndrome averages 49 years.
This document provides an overview of multiple sclerosis (MS), including what it is, who gets it, possible causes, symptoms, and treatment options. MS is an autoimmune disease where the body's immune system attacks the protective myelin sheath surrounding the nerve fibers in the central nervous system. It is unpredictable and varies widely in symptoms and progression between individuals. While the exact cause is unknown, genetic and environmental factors like vitamin D levels and certain infections are thought to play a role. Common symptoms include fatigue, numbness, vision issues, and mobility problems. Treatment aims to reduce relapses and slow progression using medications, therapy, and lifestyle changes. No cure exists, so self-management is important given the lifelong impact of the
Presentation to American Legion Child Welfare FoundationJonathan Martin
I was invited to speak to the Grants Committee at the American Legion Child Welfare Foundation. The National Marfan Foundation, my former employer, was a frequent recipient of grants, and the purpose of the presentation was two fold: 1) To explain Marfan syndrome, and 2) to share with the group the impact on children and teens who benefit from their funding.
Cancer is caused by the uncontrolled division of abnormal cells that are not normal. This causes cells to split abnormally and take over other tissues in the body. Leukemia is a type of cancer that affects the blood and bone marrow, causing an overproduction of immature and abnormal white blood cells. There are four main types of leukemia - acute or chronic, and lymphocytic or myelogenous - which differ in their rates of growth and the cells they affect. While leukemia cannot be prevented, certain genetic and environmental factors like radiation exposure, Down syndrome, and smoking can increase the risk of developing leukemia.
This document discusses different types of disorders that are not caused by pathogens. It categorizes disorders into three major types: inherited disorders which result from genes; injuries caused by physical damage; and organic disorders from deficiencies, environmental factors, or unknown causes. Within organic disorders, it describes benign and malignant tumors. Benign tumors are slow-growing localized growths while cancerous or malignant tumors grow and spread rapidly and chaotically. A biopsy is used to diagnose if a tumor is benign or malignant by analyzing tissue samples microscopically.
This document summarizes leukemia, an abnormal growth of white blood cells. It has no known single cause and can affect both adults and children. The main types are acute leukemia, which shows no initial symptoms, and chronic leukemia, which presents with symptoms like fever, night sweats, and frequent infections over time. Treatment involves chemotherapy and other drugs to try and induce remission and prevent relapse of the cancer.
R Sharmila prepared this document about systemic lupus erythematosus (SLE). SLE is an autoimmune disorder where the immune system attacks its own tissues, causing inflammation in connective tissues like skin and joints. Common symptoms include fatigue, joint pain and swelling, rashes, and blood disorders. The causes are not fully known but may involve genetic and environmental factors like UV exposure and stress. The condition results from a defect where the body produces antibodies against its own proteins, triggering inflammation. Treatment focuses on relieving symptoms and involves medications like anti-inflammatories, steroids, and stress reduction.
Leukemia is a group of malignant disorders affecting the blood and bone marrow that results in excess dysfunctional white blood cells. It occurs across all age groups but is often thought of as a childhood disease. Leukemia is classified as either acute or chronic depending on cell maturity and disease onset. Acute leukemias involve immature cells and a rapid onset while chronic leukemias involve mature cells and a more gradual onset. Common oral manifestations of acute leukemias include gingival bleeding, ulcers, and swelling. Dental treatment for patients with leukemia requires managing infection risks and bleeding during remission.
Down syndrome is a genetic disorder caused by the presence of an extra chromosome 21, known as trisomy 21. Individuals with Down syndrome often have characteristic physical traits such as an oblique eye, muscle hypotonia, a flat nasal bridge, and a protruding tongue. The incidence of Down syndrome is estimated to be between 1 in 800 and 1 in 1000 births, and life expectancy for those with Down syndrome averages 49 years.
This document provides an overview of multiple sclerosis (MS), including what it is, who gets it, possible causes, symptoms, and treatment options. MS is an autoimmune disease where the body's immune system attacks the protective myelin sheath surrounding the nerve fibers in the central nervous system. It is unpredictable and varies widely in symptoms and progression between individuals. While the exact cause is unknown, genetic and environmental factors like vitamin D levels and certain infections are thought to play a role. Common symptoms include fatigue, numbness, vision issues, and mobility problems. Treatment aims to reduce relapses and slow progression using medications, therapy, and lifestyle changes. No cure exists, so self-management is important given the lifelong impact of the
Presentation to American Legion Child Welfare FoundationJonathan Martin
I was invited to speak to the Grants Committee at the American Legion Child Welfare Foundation. The National Marfan Foundation, my former employer, was a frequent recipient of grants, and the purpose of the presentation was two fold: 1) To explain Marfan syndrome, and 2) to share with the group the impact on children and teens who benefit from their funding.
Cancer is caused by uncontrolled cell growth and can spread throughout the body. The three main properties of cancer cells are that they grow aggressively, can invade nearby tissues, and may spread (metastasize) to distant areas. Nearly all cancers are caused by genetic abnormalities within cells that affect genes regulating cell growth and death. Some genetic changes are inherited, but many are acquired from environmental exposures like tobacco smoke, radiation, chemicals or infectious agents. Cancer development involves multiple genetic mutations that cause cells to proliferate uncontrollably and evade the immune system.
“Neoplasia refers to the abnormal growth and proliferation of cells, resulting in the formation of a neoplasm, commonly known as a tumor”.
Neoplasms can be benign or malignant, and they can occur in various tissues and organs throughout the body.
Examples:
Benign Neoplasms: Fibroids (leiomyomas) in the uterus, moles (nevi) on the skin, and lipomas (fatty tumors).
Malignant Neoplasms: Breast cancer, lung cancer, colorectal cancer, leukemia, and melanoma.
Causes:
The causes of neoplasia can be multifactorial and involve both genetic and environmental factors. Some common causes include:
Genetic Mutations: Alterations in the DNA sequence of genes can lead to uncontrolled cell growth and division. These mutations can be inherited or acquired during a person's lifetime.
Carcinogens: Exposure to certain environmental factors such as chemicals, radiation, tobacco smoke, and some viruses (e.g., human papillomavirus, hepatitis B virus) can increase the risk of neoplasia.
Hormonal Imbalances: Some hormones, like estrogen in breast and ovarian cancer, can contribute to the development of neoplasms.
Immune Dysfunction: Impairment in the immune system's ability to recognize and eliminate abnormal cells can result in the growth of neoplastic cells.
“Abnormal growth or development of cells or tissues, characterized by the alteration in their size, shape, and organization”.
It is often considered as a precancerous condition, as dysplastic cells have a higher tendency to mutate and transform into cancerous cells over time.
Dysplasia can occur in various tissues and organs of the body, including the skin, respiratory tract, digestive tract, urinary tract, and others.
Cancer is caused by genetic mutations that cause uncontrolled cell growth. It is diagnosed through medical exams, imaging, biopsies and tumor marker tests. Treatment may involve surgery, chemotherapy and radiation. Surgery removes tumors while chemotherapy uses drugs to destroy cancer cells. Prevention focuses on healthy behaviors and cancer screening to detect cancers early. Ongoing research aims to better understand and treat cancer.
Cancer is a group of diseases involving abnormal cell growth that can spread to other parts of the body. The most common cancers vary by sex, with lung, prostate, colorectal, and stomach cancers most common in men, and breast, colorectal, lung, and cervical cancers most common in women. Cancer is caused by factors like chemicals, diet, infection, radiation, heredity, and hormones. Diagnosis involves medical tests to examine tissue samples. Prevention methods include diet, medication, and vaccination, while treatments include chemotherapy, radiation, surgery, palliative care, immunotherapy, and alternative medicine.
This document discusses cancer and its treatment. It defines cancer as uncontrolled cell growth that can spread through the body. It describes the characteristics of cancerous cells and lists common causes like smoking. It also discusses cell types involved in cancer like progenitor and stem cells, as well as genes that can promote or suppress cancer like oncogenes and tumor suppressor genes. The document concludes by outlining several common therapeutic interventions for uncontrolled cell growth, including surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, and hormonal therapy.
Cancer is defined as abnormal cells that divide uncontrollably and can invade other tissues or spread to other parts of the body. The development of cancer is thought to be a multistage process involving genetic changes that alter normal cell growth mechanisms. Primary risk factors for cancer include exposure to carcinogens like radiation, chemicals, and certain viruses or bacteria. Common childhood cancers include leukemia, which affects blood cells; lymphoma like Hodgkin's disease affecting lymph nodes; and tumors of the kidney (Wilms'), brain, bone (osteosarcoma), and neuroblastoma originating in nerve tissue. Treatment involves chemotherapy, radiation therapy, and surgery depending on the cancer type and stage.
1. Cancer is a disease where cells grow uncontrollably and spread to other parts of the body. It is caused by genetic changes that affect genes controlling cell growth.
2. There are over 100 types of cancer named after the organs or tissues where they form, such as lung cancer or brain cancer. The main types are carcinomas, sarcomas, leukemias, lymphomas, and myelomas.
3. Cancer cells behave abnormally by growing without signals, ignoring signals to stop growing, invading nearby tissue and spreading to distant areas via metastasis. Not all abnormal cell growth or changes are cancer; some may develop into cancer if not treated.
Cancer develops due to genetic mutations that cause cells to multiply uncontrollably. There are several known causes of genetic mutations, including carcinogens such as tobacco, radiation, and viruses. Cancer treatment options include surgery, chemotherapy, radiation therapy, hormone therapy, biological therapy, and lifestyle changes to prevent cancer. The goal of treatment is to kill cancer cells or stop their growth and division while limiting side effects to healthy cells.
Today, no one of us is unaware of the term cancer, which affects not only adults but also children. There are chances that anyone of us may gets diagnosed with cancer, irrespective of age & gender. There is no single cause for the development of cancer in your body. But early and proper treatment can help you ease its symptoms.
Our bodies are made up of millions of cells, grouped together to form tissues and organs such as muscles and bones, the lungs and the liver. Genes inside each cell order it to grow, work, reproduce and die. Normally, our cells obey these orders and we remain healthy. But sometimes the instructions get mixed up, causing the cells to form lumps or tumors, or spread through the bloodstream and lymphatic system to other parts of the body.
This document discusses tumor pathogenesis and the general development of tumors. It describes how tumors progress through initiation, promotion and progression stages due to the effects of various growth factors, genes, mutagens and epigenetic factors. The main causes of cancer are identified as smoking, dietary imbalances, and chronic infections leading to inflammation. Benign and malignant tumors are defined, and the characteristics of neoplasms, including loss of growth control, unlimited division, invasion and metastasis, are outlined.
Cancer is caused by genetic mutations that lead to uncontrolled cell growth. A person's cancer risk is influenced by both inherited genetic factors and environmental exposures. Cancer begins as a single abnormal cell that grows into a primary tumor, and can then metastasize by spreading to other areas of the body. The document defines various cancer terminology and describes the stages of cancer progression from initiation to metastasis. It also discusses cancer causes, detection methods, grading systems, and treatment approaches.
This document provides an overview of cancer including types, causes, diagnosis, staging, treatment and prognosis. It discusses the major types of cancer that commonly affect men, women and children in the US. The pathophysiology section describes how genetic and epigenetic factors can cause normal cells to transform into cancer cells through mutations in oncogenes and tumor suppressor genes. Environmental exposures and lifestyle factors can increase the risk of mutations accumulating. Once cancer develops, ongoing clonal evolution drives progression to more advanced stages.
This document provides an overview of cancer including types, causes, diagnosis, staging, treatment and prognosis. It discusses the major types of cancer that commonly affect men, women and children in the US. The pathophysiology section describes how genetic and epigenetic factors can cause normal cells to transform into cancer cells through mutations in oncogenes and tumor suppressor genes. Environmental exposures and lifestyle factors can also increase cancer risk by damaging DNA or altering gene expression through epigenetic changes. The progression of cancer involves a chain reaction of accumulating errors that allow cancer cells to evade controls on growth and spread.
Cancer is caused by abnormal cell growth and can affect any part of the body. The key causes are changes to a cell's DNA that allow damaged cells to continue growing instead of dying. Cancer cells can spread through the body via the bloodstream and lymph vessels in a process called metastasis. Common treatments include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapy, but signs and symptoms vary depending on the type and location of cancer.
Mutations can be inherited from parents or acquired during one's lifetime. Hereditary mutations exist in reproductive cells and can be passed down generations. While cells have mechanisms to repair mutations, these mechanisms can fail over time, allowing mistakes to accumulate. Down syndrome is caused by an extra copy of chromosome 21, leading to physical and mental retardation symptoms. Klinefelter syndrome results from an extra X chromosome in males, causing breast growth and infertility. Turner syndrome occurs in females missing a single X chromosome. Sickle cell anemia is an inherited blood disorder most common in people of African descent. Genetic testing can detect mutations that cause diseases and determine cancer risk or carrier status for inherited conditions.
Introduction to Cancer Epidemiology and CarcinogenesisPUBH 6.docxbagotjesusa
Introduction to Cancer Epidemiology and Carcinogenesis
PUBH 6550/8550
Chronic Disease Epidemiology
1
Cancer is a term describing malignant diseases. Cancer should not be thought of as a single disease but rather a group of diseases which may have many characteristics in common but not necessarily the same causative agents, etiology or molecular profiles. In general, cancer defines diseases that have the capacity to invade surrounding normal tissue, metastasize (spread to distant sites) and kill the host in which it originates.
Objectives
What is the definition of cancer?
Benign vs. Malignant
Most common cancer types in men and women
Learn how to obtain cancer-related data using Internet sources
Understand cancer staging
Understand the basics of how carcinogenesis occurs
Describe inherited cancer syndromes
2
Causation and Cancer
Examples of Identified Causes and
Future Efforts in Cancer Prevention
Tobacco use and lung cancer
Infectious agents (e.g., HPV) and cervical cancer
Ionizing radiation and leukemia
Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor
4
4
The concept of causation has long had a central role in the application of epidemiologic evidence for controlling cancer. Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor. Though the concept of causation remains a matter of continuing discussion, use of the term in public health implies that the evidence supporting causality of association has reached a critical threshold of certainty and that reduced exposure can be expected to be followed by reduced disease occurrence. In other words, if there is “enough” evidence supporting a particular risk factor (or a preventive or prognostic factor), it seems to be considered ‘causal’. Keep in mind, though, that risk factor is the most proper term.
What is cancer?
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death.
Characteristics: Abnormality, Uncontrollability, invasiveness
5
5
According to the American Cancer Society (ACS), cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Although cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. These diseases are characterized by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. Breast cancer, for example, has different characteristics than lung cancer. It is important to understand that cancer originating in one body organ takes its characteristics with it even if it spreads to another part of the body. For example, metastatic br.
Cancer is caused by genetic mutations that cause uncontrolled cell growth. It is not a single disease but rather a group of diseases that can affect any organ. The main factors that contribute to cancer development are heredity, environment, and lifestyle. Cancer prevention focuses on reducing risk factors through behaviors like quitting smoking, limiting sun exposure, and vaccinations. Cancer is detected through screening tests and diagnosed using tumor markers, genetic profiling, and imaging tests. Treatment options include surgery, chemotherapy, radiation therapy, and targeted drug therapies, with the goal of curing, controlling, or palliating the cancer.
Cancer arises from genetic changes in cells that cause uncontrolled growth and spread. The document discusses cancer pathogenesis, classification, stages, risk factors like carcinogens, and prevention strategies. It notes that in 2012 there were estimated 14 million new cancer cases worldwide resulting in 7.6 million deaths, with lung, breast, colorectal, and stomach cancer being most common. Prevention involves controlling risk factors like tobacco, promoting hygiene, vaccinations, and treating precancerous lesions.
Cancer, also called malignancy, is an abnormal growth of cells. There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type. Cancer treatment may include chemotherapy, radiation, and/or surgery.
Cancer, also called malignancy, is an abnormal growth of cells. There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type. Cancer treatment may include chemotherapy, radiation, and/or surgery.
Cancer is caused by uncontrolled cell growth and can spread throughout the body. The three main properties of cancer cells are that they grow aggressively, can invade nearby tissues, and may spread (metastasize) to distant areas. Nearly all cancers are caused by genetic abnormalities within cells that affect genes regulating cell growth and death. Some genetic changes are inherited, but many are acquired from environmental exposures like tobacco smoke, radiation, chemicals or infectious agents. Cancer development involves multiple genetic mutations that cause cells to proliferate uncontrollably and evade the immune system.
“Neoplasia refers to the abnormal growth and proliferation of cells, resulting in the formation of a neoplasm, commonly known as a tumor”.
Neoplasms can be benign or malignant, and they can occur in various tissues and organs throughout the body.
Examples:
Benign Neoplasms: Fibroids (leiomyomas) in the uterus, moles (nevi) on the skin, and lipomas (fatty tumors).
Malignant Neoplasms: Breast cancer, lung cancer, colorectal cancer, leukemia, and melanoma.
Causes:
The causes of neoplasia can be multifactorial and involve both genetic and environmental factors. Some common causes include:
Genetic Mutations: Alterations in the DNA sequence of genes can lead to uncontrolled cell growth and division. These mutations can be inherited or acquired during a person's lifetime.
Carcinogens: Exposure to certain environmental factors such as chemicals, radiation, tobacco smoke, and some viruses (e.g., human papillomavirus, hepatitis B virus) can increase the risk of neoplasia.
Hormonal Imbalances: Some hormones, like estrogen in breast and ovarian cancer, can contribute to the development of neoplasms.
Immune Dysfunction: Impairment in the immune system's ability to recognize and eliminate abnormal cells can result in the growth of neoplastic cells.
“Abnormal growth or development of cells or tissues, characterized by the alteration in their size, shape, and organization”.
It is often considered as a precancerous condition, as dysplastic cells have a higher tendency to mutate and transform into cancerous cells over time.
Dysplasia can occur in various tissues and organs of the body, including the skin, respiratory tract, digestive tract, urinary tract, and others.
Cancer is caused by genetic mutations that cause uncontrolled cell growth. It is diagnosed through medical exams, imaging, biopsies and tumor marker tests. Treatment may involve surgery, chemotherapy and radiation. Surgery removes tumors while chemotherapy uses drugs to destroy cancer cells. Prevention focuses on healthy behaviors and cancer screening to detect cancers early. Ongoing research aims to better understand and treat cancer.
Cancer is a group of diseases involving abnormal cell growth that can spread to other parts of the body. The most common cancers vary by sex, with lung, prostate, colorectal, and stomach cancers most common in men, and breast, colorectal, lung, and cervical cancers most common in women. Cancer is caused by factors like chemicals, diet, infection, radiation, heredity, and hormones. Diagnosis involves medical tests to examine tissue samples. Prevention methods include diet, medication, and vaccination, while treatments include chemotherapy, radiation, surgery, palliative care, immunotherapy, and alternative medicine.
This document discusses cancer and its treatment. It defines cancer as uncontrolled cell growth that can spread through the body. It describes the characteristics of cancerous cells and lists common causes like smoking. It also discusses cell types involved in cancer like progenitor and stem cells, as well as genes that can promote or suppress cancer like oncogenes and tumor suppressor genes. The document concludes by outlining several common therapeutic interventions for uncontrolled cell growth, including surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, and hormonal therapy.
Cancer is defined as abnormal cells that divide uncontrollably and can invade other tissues or spread to other parts of the body. The development of cancer is thought to be a multistage process involving genetic changes that alter normal cell growth mechanisms. Primary risk factors for cancer include exposure to carcinogens like radiation, chemicals, and certain viruses or bacteria. Common childhood cancers include leukemia, which affects blood cells; lymphoma like Hodgkin's disease affecting lymph nodes; and tumors of the kidney (Wilms'), brain, bone (osteosarcoma), and neuroblastoma originating in nerve tissue. Treatment involves chemotherapy, radiation therapy, and surgery depending on the cancer type and stage.
1. Cancer is a disease where cells grow uncontrollably and spread to other parts of the body. It is caused by genetic changes that affect genes controlling cell growth.
2. There are over 100 types of cancer named after the organs or tissues where they form, such as lung cancer or brain cancer. The main types are carcinomas, sarcomas, leukemias, lymphomas, and myelomas.
3. Cancer cells behave abnormally by growing without signals, ignoring signals to stop growing, invading nearby tissue and spreading to distant areas via metastasis. Not all abnormal cell growth or changes are cancer; some may develop into cancer if not treated.
Cancer develops due to genetic mutations that cause cells to multiply uncontrollably. There are several known causes of genetic mutations, including carcinogens such as tobacco, radiation, and viruses. Cancer treatment options include surgery, chemotherapy, radiation therapy, hormone therapy, biological therapy, and lifestyle changes to prevent cancer. The goal of treatment is to kill cancer cells or stop their growth and division while limiting side effects to healthy cells.
Today, no one of us is unaware of the term cancer, which affects not only adults but also children. There are chances that anyone of us may gets diagnosed with cancer, irrespective of age & gender. There is no single cause for the development of cancer in your body. But early and proper treatment can help you ease its symptoms.
Our bodies are made up of millions of cells, grouped together to form tissues and organs such as muscles and bones, the lungs and the liver. Genes inside each cell order it to grow, work, reproduce and die. Normally, our cells obey these orders and we remain healthy. But sometimes the instructions get mixed up, causing the cells to form lumps or tumors, or spread through the bloodstream and lymphatic system to other parts of the body.
This document discusses tumor pathogenesis and the general development of tumors. It describes how tumors progress through initiation, promotion and progression stages due to the effects of various growth factors, genes, mutagens and epigenetic factors. The main causes of cancer are identified as smoking, dietary imbalances, and chronic infections leading to inflammation. Benign and malignant tumors are defined, and the characteristics of neoplasms, including loss of growth control, unlimited division, invasion and metastasis, are outlined.
Cancer is caused by genetic mutations that lead to uncontrolled cell growth. A person's cancer risk is influenced by both inherited genetic factors and environmental exposures. Cancer begins as a single abnormal cell that grows into a primary tumor, and can then metastasize by spreading to other areas of the body. The document defines various cancer terminology and describes the stages of cancer progression from initiation to metastasis. It also discusses cancer causes, detection methods, grading systems, and treatment approaches.
This document provides an overview of cancer including types, causes, diagnosis, staging, treatment and prognosis. It discusses the major types of cancer that commonly affect men, women and children in the US. The pathophysiology section describes how genetic and epigenetic factors can cause normal cells to transform into cancer cells through mutations in oncogenes and tumor suppressor genes. Environmental exposures and lifestyle factors can increase the risk of mutations accumulating. Once cancer develops, ongoing clonal evolution drives progression to more advanced stages.
This document provides an overview of cancer including types, causes, diagnosis, staging, treatment and prognosis. It discusses the major types of cancer that commonly affect men, women and children in the US. The pathophysiology section describes how genetic and epigenetic factors can cause normal cells to transform into cancer cells through mutations in oncogenes and tumor suppressor genes. Environmental exposures and lifestyle factors can also increase cancer risk by damaging DNA or altering gene expression through epigenetic changes. The progression of cancer involves a chain reaction of accumulating errors that allow cancer cells to evade controls on growth and spread.
Cancer is caused by abnormal cell growth and can affect any part of the body. The key causes are changes to a cell's DNA that allow damaged cells to continue growing instead of dying. Cancer cells can spread through the body via the bloodstream and lymph vessels in a process called metastasis. Common treatments include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapy, but signs and symptoms vary depending on the type and location of cancer.
Mutations can be inherited from parents or acquired during one's lifetime. Hereditary mutations exist in reproductive cells and can be passed down generations. While cells have mechanisms to repair mutations, these mechanisms can fail over time, allowing mistakes to accumulate. Down syndrome is caused by an extra copy of chromosome 21, leading to physical and mental retardation symptoms. Klinefelter syndrome results from an extra X chromosome in males, causing breast growth and infertility. Turner syndrome occurs in females missing a single X chromosome. Sickle cell anemia is an inherited blood disorder most common in people of African descent. Genetic testing can detect mutations that cause diseases and determine cancer risk or carrier status for inherited conditions.
Introduction to Cancer Epidemiology and CarcinogenesisPUBH 6.docxbagotjesusa
Introduction to Cancer Epidemiology and Carcinogenesis
PUBH 6550/8550
Chronic Disease Epidemiology
1
Cancer is a term describing malignant diseases. Cancer should not be thought of as a single disease but rather a group of diseases which may have many characteristics in common but not necessarily the same causative agents, etiology or molecular profiles. In general, cancer defines diseases that have the capacity to invade surrounding normal tissue, metastasize (spread to distant sites) and kill the host in which it originates.
Objectives
What is the definition of cancer?
Benign vs. Malignant
Most common cancer types in men and women
Learn how to obtain cancer-related data using Internet sources
Understand cancer staging
Understand the basics of how carcinogenesis occurs
Describe inherited cancer syndromes
2
Causation and Cancer
Examples of Identified Causes and
Future Efforts in Cancer Prevention
Tobacco use and lung cancer
Infectious agents (e.g., HPV) and cervical cancer
Ionizing radiation and leukemia
Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor
4
4
The concept of causation has long had a central role in the application of epidemiologic evidence for controlling cancer. Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor. Though the concept of causation remains a matter of continuing discussion, use of the term in public health implies that the evidence supporting causality of association has reached a critical threshold of certainty and that reduced exposure can be expected to be followed by reduced disease occurrence. In other words, if there is “enough” evidence supporting a particular risk factor (or a preventive or prognostic factor), it seems to be considered ‘causal’. Keep in mind, though, that risk factor is the most proper term.
What is cancer?
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death.
Characteristics: Abnormality, Uncontrollability, invasiveness
5
5
According to the American Cancer Society (ACS), cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Although cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. These diseases are characterized by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. Breast cancer, for example, has different characteristics than lung cancer. It is important to understand that cancer originating in one body organ takes its characteristics with it even if it spreads to another part of the body. For example, metastatic br.
Cancer is caused by genetic mutations that cause uncontrolled cell growth. It is not a single disease but rather a group of diseases that can affect any organ. The main factors that contribute to cancer development are heredity, environment, and lifestyle. Cancer prevention focuses on reducing risk factors through behaviors like quitting smoking, limiting sun exposure, and vaccinations. Cancer is detected through screening tests and diagnosed using tumor markers, genetic profiling, and imaging tests. Treatment options include surgery, chemotherapy, radiation therapy, and targeted drug therapies, with the goal of curing, controlling, or palliating the cancer.
Cancer arises from genetic changes in cells that cause uncontrolled growth and spread. The document discusses cancer pathogenesis, classification, stages, risk factors like carcinogens, and prevention strategies. It notes that in 2012 there were estimated 14 million new cancer cases worldwide resulting in 7.6 million deaths, with lung, breast, colorectal, and stomach cancer being most common. Prevention involves controlling risk factors like tobacco, promoting hygiene, vaccinations, and treating precancerous lesions.
Cancer, also called malignancy, is an abnormal growth of cells. There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type. Cancer treatment may include chemotherapy, radiation, and/or surgery.
Cancer, also called malignancy, is an abnormal growth of cells. There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type. Cancer treatment may include chemotherapy, radiation, and/or surgery.
Hepatitis is an inflammation of the liver. The condition can be self-limiting or can progress to fibrosis (scarring), cirrhosis or liver cancer. Hepatitis viruses are the most common cause of hepatitis in the world but other infections, toxic substances (e.g. alcohol, certain drugs), and autoimmune diseases can also cause hepatitis.
There are 5 main hepatitis viruses, referred to as types A, B, C, D and E. These 5 types are of greatest concern because of the burden of illness and death they cause and the potential for outbreaks and epidemic spread. In particular, types B and C lead to chronic disease in hundreds of millions of people and, together, are the most common cause of liver cirrhosis and cancer.
A potentially serious infectious bacterial disease that mainly affects the lungs.
The bacteria that cause TB are spread when an infected person coughs or sneezes.
Most people infected with the bacteria that cause tuberculosis don't have symptoms. When symptoms do occur, they usually include a cough (sometimes blood-tinged), weight loss, night sweats and fever.
Treatment isn't always required for those without symptoms. Patients with active symptoms will require a long course of treatment involving multiple antibiotics
The document discusses syphilis, a sexually transmitted infection caused by bacteria. It describes the four stages of syphilis as primary, secondary, latent, and tertiary. The primary stage involves a painless sore while secondary sees skin rashes and sore throat. Latent syphilis has no symptoms but the bacteria remains active. Tertiary syphilis, occurring years later for 15-30% of untreated cases, can damage organs and cause life-threatening issues like blindness. Penicillin is usually effective at treating early stages of syphilis.
A group of disorders that cause red blood cells to become misshapen and break down.
With sickle cell disease, an inherited group of disorders, red blood cells contort into a sickle shape. The cells die early, leaving a shortage of healthy red blood cells (sickle cell anaemia) and can block blood flow causing pain (sickle cell crisis).
Infections, pain and fatigue are symptoms of sickle cell disease.
Treatments include medication, blood transfusions and rarely a bone-marrow transplant
Depression is a mood disorder characterized by feelings of sadness, loss, or anger that interfere with daily activities. Around 8% of American adults experience depression. It can impact work productivity and relationships. There are several forms of depressive disorders including major depression, dysthymia, minor depression, psychotic depression, postpartum depression, and seasonal affective disorder. Risk factors include family history, childhood trauma, brain structure, medical conditions, and drug use. Treatments include antidepressants, antianxiety medications, and antipsychotic medications.
Alzheimer's disease is a progressive disorder that causes brain cells to waste away (degenerate) and die. Alzheimer's disease is the most common cause of dementia — a continuous decline in thinking, behavioral and social skills that disrupts a person's ability to function independently.
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV). Following initial infection a person may not notice any symptoms, or may experience a brief period of influenza-like illness.
Industry visits play an important role in the MITSOM College education programme. Students are taken for industry visits in and around Pune where they interact with the company people and have a first-hand experience of how a corporate entity actually works. The crucial purpose behind this programme is to accustom students to the industrial practices and the workings of the corporate world. Students are exposed to practical situations and events in companies thereby honing their corporate skills and industry understanding.
The document is a report on an industrial visit to Patanjali Food and Herbal Park Pvt. Ltd. It discusses the company's vision, mission, and leadership. The company's main products include natural foods, healthcare products, personal care items, Ayurvedic medicines, and herbal home care products. The report also describes the company's internal control system and framework, including an audit committee and internal/statutory audits. It provides details on Ayurvedic medicine formulations, including preparation methods, market potential, implementation schedule, and quality control standards.
This document provides guidance on developing and using standard operating procedures (SOPs) within an organization. It discusses that SOPs are written instructions that document routine processes and promote consistent and proper execution. The benefits of SOPs include minimizing variation, ensuring compliance, and facilitating training. SOPs should be written clearly and concisely with a standardized format including a title, version number, and approval signatures. They need to be reviewed periodically and revised as processes change to maintain usefulness. Developing high-quality, up-to-date SOPs is an important part of maintaining an effective quality management system.
a detailed project on standard oprating procedure (SOP) in the elective subject of GMP
A standard operating procedure (SOP) is a set of step-by-step instructions compiled by an organization to help workers carry out complex routine operations. SOPs aim to achieve efficiency, quality output and uniformity of performance, while reducing miscommunication and failure to comply with industry regulations.
The document contains contact information for Dr. Brijesh Singh, who is the head of the pharmacy department. It lists his name, title as Pharmacy HOD, and phone number 9936243810. The document provides brief contact details for Dr. Brijesh Singh in a leadership role within the pharmacy department.
Harish Sharma completed an industrial training report at Naxpar Pharmaceuticals in Baddi, Himachal Pradesh, India to fulfill requirements for his B.Pharm degree. The report provides details about Naxpar's production processes, equipment, quality control procedures, and storage and distribution operations. It describes the company's manufacturing of tablets including active and inactive ingredients, unit operations like wet and dry granulation, and tableting. Quality control testing and standard operating procedures are also outlined. The training gave Harish valuable experience in pharmaceutical production and distribution that he can apply to further his career.
A pharmacist is the person of drugs or the expert on drugs. He is the only expert on drugs, for expertise regarding drugs requires knowledge in depth in all the facts of pharmacy. It is her professional responsibility to know all about the drugs. No educational program other than that in pharmacy provides the background to understand completely all about drugs.
Among the professions of pharmacists like community pharmacy, institutional pharmacy, whole sale pharmacy, industrial pharmacy, government service, pharmaceutical education, organizational management, in my country industrial pharmacy offers great opportunity to the pharmacists.
Industrial pharmacy is a profession of unique hybrid of business and profession.
So an industrial pharmacist should have proper knowledge about drugs and also about medical progress, commence marketing and technology. To be a self-sufficient pharmacist beside academic knowledge, practical knowledge is essential.
This is why after appearing the Bachelor of Pharmacy examination in-plant training was arranged by the department in renowned pharmaceuticals industries. This training has sharpened my academic knowledge what I learnt in the last four years .I have completed my training in Popular Pharmaceuticals Limited a fast growing pharmaceutical company in Bangladesh.
This document is a hospital training report submitted by Harish Sharma, a student completing their B.Pharm degree. The report provides an overview of Harish's training at District Hospital in Chandauli, including acknowledging the individuals who supported their training. It then describes the various departments observed, such as the dispensary, surgical ward, pathology laboratory, and blood bank. The report also covers topics like routes of drug administration, first aid, and waste management. The objective was to study the hospital structure and functions of different departments to gain experience as a healthcare professional.
This document summarizes common tablet processing problems including capping, lamination, cracking, chipping, sticking, picking, binding, and double impression. For each problem, the document identifies potential formulation-related and machine-related causes and recommended remedies. It also discusses problems that can occur during tablet coating like blistering, cratering, picking and sticking, pitting, blooming, and color variation as well as their causes and remedies. The document provides a concise overview of common tablet defects and approaches to address them.
More from Vishwanath Institute Of Pharmacy Ghazipur (19)
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
2. What is a Neoplasm?
The term neoplasm refers to an abnormal growth of tissue
caused by the rapid division of cells that have undergone
some form of mutation.
The body is made up of trillions of cells that grow, divide,
and die in an orderly fashion. This process is a tightly
regulated one that is controlled by the DNA machinery
within the cell. When a person is growing up, the cells of
the body rapidly divide, but once adulthood is reached,
cells generally only divide to replace worn-out, dying
cells or to repair injured cells.
3. Causes
There are a number of contributing factors that can cause your
genes to mutate and result in benign or malignant tumor growth.
Some common factors include:
genetics
age
hormones
smoking
drinking
obesity
sun overexposure
immune disorders
viruses
overexposure to radiation
chemical toxins
4. symptoms
Symptoms of neoplastic disease greatly depend on where the neoplasm is
located.
Regardless of type, there are some common symptoms of neoplastic
disease:
anemia
shortness of breath
abdominal pain
persistent fatigue
loss of appetite
chills
diarrhea
fever
bloody stools
lesions
skin masses
5. Diagnosing
To properly diagnose neoplastic disease, your doctor will first
determine if the neoplasms are benign or malignant. Your doctors
will conduct a thorough examination of your medical history, blood
tests, and possibly a biopsy on visible masses.
Other tests used to diagnose neoplastic diseases and cancers include:
CT scans
MRI scans
PET scans
mammograms
ultrasounds
X-rays
endoscopy