The Nemacolin Path was an important Native American trail that connected the Potomac River valley to the Ohio River valley. It passed through what is now Pennsylvania and West Virginia, providing a route for indigenous peoples and early European settlers to travel between the eastern seaboard and the frontier lands to the west. The path, which followed Native American foot trails and helped open up the trans-Allegheny region to settlement in the late 18th century, took its name from the Delaware Indian leader Nemacolin.