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HPV: What is it? What does it do? Natasha Press Division of Infectious Diseases St. Paul’s Hospital
What is HPV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is HPV ,[object Object],[object Object]
HPV causes warts on hands/feet ,[object Object],[object Object],University of Indiana Department of Pathology
HPV causes warts in the  anogenital area ,[object Object],[object Object],[object Object]
Risk factors for anogenital warts ,[object Object],[object Object],[object Object],[object Object]
Low-risk HPV types ,[object Object],[object Object],[object Object]
High-risk HPV types ,[object Object],[object Object],[object Object]
HPV causes cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
HPV causes cancer ,[object Object],[object Object],[object Object],[object Object]
Anal dysplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]
HPV causes cancer INFECTION CLEARANCE PERSISTENCE REGRESSION INVASION AIN 3 Severe High-grade Cancer AIN 2 AIN 1 Mild Low-grade Normal anal canal
Anogenital HPV Infection ,[object Object],[object Object],[object Object],[object Object]
Incidence of anal cancer ,[object Object],[object Object],[object Object],[object Object],[object Object]
Increasing rate of anal cancer 1997-2005 in BC  for men aged 30-60 years Cases per 100 000 Increase in ASCC p <0.02 log linear model
Anal dysplasia ,[object Object],[object Object],[object Object]
Anal Pap Procedure ,[object Object],[object Object],[object Object]
Anal Pap Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Overview of HPV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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HPV: What is it? What does it do?

  • 1. HPV: What is it? What does it do? Natasha Press Division of Infectious Diseases St. Paul’s Hospital
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12. HPV causes cancer INFECTION CLEARANCE PERSISTENCE REGRESSION INVASION AIN 3 Severe High-grade Cancer AIN 2 AIN 1 Mild Low-grade Normal anal canal
  • 13.
  • 14.
  • 15. Increasing rate of anal cancer 1997-2005 in BC for men aged 30-60 years Cases per 100 000 Increase in ASCC p <0.02 log linear model
  • 16.
  • 17.
  • 18.
  • 19.

Editor's Notes

  1. 42, 43, 44 = low-grade lesions in cervix
  2. 16 = 50% of cervical cancer, higher proportion in anal cancer 18 = 20% of cervical cancer
  3. HIV – poor immunity assoc with increased persistence
  4. Low grade squamous intraepithelial lesion