Multiple myeloma is a neoplastic disease characterized by plasma cell accumulation in the bone marrow, the presence of monoclonal protein in the serum and/or urine, and related tissue damage in symptomatic patients. The growth of myeloma cells disrupts normal bone marrow function, reduces immune function, results in abnormal monoclonal protein production released into the blood and urine, and destroys and invades surrounding bone. The initial diagnostic evaluation of multiple myeloma includes examining the peripheral smear for Roulex formation, protein electrophoresis for an M spike, bone marrow aspirate and biopsy, and checking bones for lytic lesions.

1. Multiple myeloma
Dr. Umme Habiba

2. Definition:
 Multiple myeloma is a neoplastic disease characterized by
plasma cell accumulation in the bone marrow, the
presence of monoclonal protein in the serum and/or urine
and, in symptomatic patients, related tissue damage.
 Growth of myeloma cells:
1. Disrupts normal bone marrow function
2. Reduces normal immune function
3. Results in abnormal production and release of monoclonal
protein into blood and/or urine
4. Destroys and invades surrounding bone

5. Pathogenesis

6. Genetic Basis

7. Pathophysiology of clinical manifestations

10. Initial Diagnostic Evaluation Of Multiple Myeloma

11. Peripheral Smear shows: Roulex formation

12. Protein Electrophoresis-M spike

13. Bone Marrow Aspirate & Biopsy

14. Bones: Lytic Lesions

15. Stages of Multiple Myeloma