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Multiple myeloma
Dr. Umme Habiba
Definition:
 Multiple myeloma is a neoplastic disease characterized by
plasma cell accumulation in the bone marrow, the
presence of monoclonal protein in the serum and/or urine
and, in symptomatic patients, related tissue damage.
 Growth of myeloma cells:
1. Disrupts normal bone marrow function
2. Reduces normal immune function
3. Results in abnormal production and release of monoclonal
protein into blood and/or urine
4. Destroys and invades surrounding bone
Pathogenesis
Genetic Basis
Pathophysiology of clinical manifestations
Initial Diagnostic Evaluation Of Multiple Myeloma
Peripheral Smear shows: Roulex formation
Protein Electrophoresis-M spike
Bone Marrow Aspirate & Biopsy
Bones: Lytic Lesions
Stages of Multiple Myeloma
Multiple myeloma
Multiple myeloma

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Multiple myeloma