This document discusses considerations for teaching online audiences from multiple cultures. It begins by noting the increasing diversity in the US and how globalization leads to more culturally diverse online learners. It then reviews several cultural theorists and their dimensions of culture. Research studies on distance learning and multi-cultural audiences are examined. Guidelines are provided for developing culturally inclusive online content, including accounting for differences in communication style, interaction style, authority, and goal of learning across high- and low-context cultures. The document concludes by emphasizing the need to consider how culture influences thinking, learning and teaching when designing online learning.