Behçet’s disease is a chronic inflammatory disease characterized by its clinical polymorphism associating mucocutaneous involvement to systemic manifestations. The mucocutaneous lesions are considered the hallmark of the disease, being the most common symptoms presenting at the onset of disease. Our objective was to determine the characteristics of this skin involvement during Behçet’s disease. We conducted a descriptive study over a period of 30 years, having collected all patients with Behçet’s disease.
Periodontal therapy involves the diagnosis and treatment of plaque-associated diseases as well as non-plaque related conditions like desquamative gingivitis. Desquamative gingivitis presents as erythema, desquamation, and ulceration of the gingiva and can be caused by conditions like lichen planus, pemphigoid, and pemphigus vulgaris. The pathogenesis involves autoimmune responses against epithelial antigens that disrupt cellular junctions and cause separation of the epithelium from the underlying connective tissue. Management consists of treating the underlying cause, improving oral hygiene, and using topical or systemic corticosteroids.
Behçet's disease is a multisystem inflammatory disease characterized by recurrent oral and genital ulcers. It was first described in 1937 and is most common along the Silk Road. Diagnosis relies on clinical criteria including oral ulcers plus at least two other symptoms like genital ulcers, eye inflammation, or skin lesions. Histologically there is neutrophilic and lymphocytic infiltration of blood vessels. Common features include oral, genital, eye, skin and joint involvement. Vascular thrombosis can also occur. Treatment focuses on reducing inflammation.
Tuberculosis: A Rare Cause of Linear Labial Ulcerationkomalicarol
Oral location of tuberculosis is rare. It admits a clinical polymorphism and poses above all a problem of diagnosis. We report a
case of labial tuberculosis in a 16-year-old patient with underlying
lymph node localization.
Congenital True Leukonychia Totalis Case Report, Beyond The Skinkomalicarol
Congenital true leukonychia is an infrequent disorder characterized by a white coloration of the nail since birth without organ or
syndromic abnormalities. We present the case of a 16 years old
boy with isolated white nail coloration with psychological impact,
no syndromic or organ alterations were found.
Eosinophilic Ulcer of the Oral Cavity, Approach, and Differential Diagnosissemualkaira
Benign ulcerations of the oral mucosa may have a similar appearance to malignant lesions [1, 2]. There are several conditions, both local and systemic, that can manifest as oral ulcers, and that can correspond, on many occasions, to both infectious and autoimmune causes. Probable etiology can often be determined by a complete medical history and a careful physical examination. However, on several occasions, an exhaustive diagnostic study will be necessary, counting on a range of diagnostic suspicions
This document summarizes a study that examined oral manifestations in 100 patients with leprosy. The key findings were:
- 70% of leprosy patients showed oral manifestations. The most common was chronic generalized periodontitis (18 cases), followed by oral melanosis (9 cases) and atrophy of papillae/loss of taste sensation (7 cases each).
- 93% of patients had systemic manifestations of leprosy. The most frequent were loss of digits (40 cases) and fever/body aches (20 cases).
- Poor oral hygiene was found in 75% of leprosy patients, with 22% having fair oral hygiene and 3% good oral hygiene.
34.Vohra P, Rahman MSU, Subhada B, Tiwari RVC, Nabeel Althaf MS, Gahlawat M. Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review. J Family Med Prim Care. 2019 Nov;8(11):3689-3694. doi: 10.4103/jfmpc.jfmpc_766_19. eCollection 2019 Nov. PubMed PMID: 31803674; PubMed Central PMCID: PMC6881956.
Vohra P, Rahman MS, Subhada B, Tiwari RV, Nabeel Althaf MS, Gahlawat M. Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review. J Family Med Prim Care 2019;8:3689-94
Periodontal therapy involves the diagnosis and treatment of plaque-associated diseases as well as non-plaque related conditions like desquamative gingivitis. Desquamative gingivitis presents as erythema, desquamation, and ulceration of the gingiva and can be caused by conditions like lichen planus, pemphigoid, and pemphigus vulgaris. The pathogenesis involves autoimmune responses against epithelial antigens that disrupt cellular junctions and cause separation of the epithelium from the underlying connective tissue. Management consists of treating the underlying cause, improving oral hygiene, and using topical or systemic corticosteroids.
Behçet's disease is a multisystem inflammatory disease characterized by recurrent oral and genital ulcers. It was first described in 1937 and is most common along the Silk Road. Diagnosis relies on clinical criteria including oral ulcers plus at least two other symptoms like genital ulcers, eye inflammation, or skin lesions. Histologically there is neutrophilic and lymphocytic infiltration of blood vessels. Common features include oral, genital, eye, skin and joint involvement. Vascular thrombosis can also occur. Treatment focuses on reducing inflammation.
Tuberculosis: A Rare Cause of Linear Labial Ulcerationkomalicarol
Oral location of tuberculosis is rare. It admits a clinical polymorphism and poses above all a problem of diagnosis. We report a
case of labial tuberculosis in a 16-year-old patient with underlying
lymph node localization.
Congenital True Leukonychia Totalis Case Report, Beyond The Skinkomalicarol
Congenital true leukonychia is an infrequent disorder characterized by a white coloration of the nail since birth without organ or
syndromic abnormalities. We present the case of a 16 years old
boy with isolated white nail coloration with psychological impact,
no syndromic or organ alterations were found.
Eosinophilic Ulcer of the Oral Cavity, Approach, and Differential Diagnosissemualkaira
Benign ulcerations of the oral mucosa may have a similar appearance to malignant lesions [1, 2]. There are several conditions, both local and systemic, that can manifest as oral ulcers, and that can correspond, on many occasions, to both infectious and autoimmune causes. Probable etiology can often be determined by a complete medical history and a careful physical examination. However, on several occasions, an exhaustive diagnostic study will be necessary, counting on a range of diagnostic suspicions
This document summarizes a study that examined oral manifestations in 100 patients with leprosy. The key findings were:
- 70% of leprosy patients showed oral manifestations. The most common was chronic generalized periodontitis (18 cases), followed by oral melanosis (9 cases) and atrophy of papillae/loss of taste sensation (7 cases each).
- 93% of patients had systemic manifestations of leprosy. The most frequent were loss of digits (40 cases) and fever/body aches (20 cases).
- Poor oral hygiene was found in 75% of leprosy patients, with 22% having fair oral hygiene and 3% good oral hygiene.
34.Vohra P, Rahman MSU, Subhada B, Tiwari RVC, Nabeel Althaf MS, Gahlawat M. Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review. J Family Med Prim Care. 2019 Nov;8(11):3689-3694. doi: 10.4103/jfmpc.jfmpc_766_19. eCollection 2019 Nov. PubMed PMID: 31803674; PubMed Central PMCID: PMC6881956.
Vohra P, Rahman MS, Subhada B, Tiwari RV, Nabeel Althaf MS, Gahlawat M. Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review. J Family Med Prim Care 2019;8:3689-94
This document discusses bullous skin disorders, focusing on pemphigus vulgaris (PV). It defines PV as an autoimmune blistering disease caused by antibodies against desmoglein 3, resulting in fragile blisters and erosions on skin and mucous membranes. It describes the clinical presentation of PV including lesions, Nikolski's sign, and involvement of oral mucosa. It also covers pathogenesis, diagnosis via histology and immunofluorescence, and treatment primarily with corticosteroids and immunosuppressants to reduce blister formation and promote healing.
This document describes a case report of a solitary angiokeratoma lesion found on the tongue of a 38-year-old male patient. Solitary angiokeratomas of the oral mucosa are rare. The lesion was a well-circumscribed, dark brown growth on the dorsal surface of the tongue. Histopathological examination revealed numerous dilated blood vessels in the papillary dermis along with hyperkeratosis and acanthosis of the epithelium, consistent with angiokeratoma. Immunohistochemical staining was positive for CD34, confirming the lesion contained proliferating blood vessels. No other lesions were found on the patient's body. The lesion was completely excised with no recurrence after 6 months of follow up.
Relapsing Polychondritis Case: An Important Diagnosis Not to Be Delayedsemualkaira
Relapsing Polychondritis (RP) is a rare disease characterized by
inflammation of cartilage and connective tissues with destructive
episodes. Although the pathogenesis is not completely known,
there is an autoimmunity in which antibodies against mainly type
II collagen play a role. In addition to chondritis of the ear, nose,
and trachea; organs having proteoglycan structure such as eyes,
the inner ear, heart, blood vessels, and kidneys can be affected, too.
This document provides an overview of erythema multiforme (EM), a self-limited inflammatory mucocutaneous disease that commonly affects the skin and oral mucosa. It discusses the etiology, pathogenesis, clinical features, classification variants, diagnosis and management of EM. Key points include: EM results from a hypersensitivity reaction, often to infections or drugs; it ranges from mild to severe based on extent of skin and mucosal involvement; diagnosis involves clinical exam, biopsy and ruling out other conditions; treatment depends on severity but may include antivirals, corticosteroids or immunosuppressants.
This document provides information on desquamative gingivitis, including its classification, diagnosis, and associated diseases. It classifies desquamative gingivitis into 7 categories including dermatosis, endocrine imbalance, aging, metabolic disturbances, abnormal response to irritation, chronic infection, and drug reactions. Key aspects of diagnosis include clinical history, examination, biopsy, and microscopic/immunofluorescence examination. Associated diseases discussed in detail include lichen planus, pemphigoid, pemphigus vulgaris, chronic ulcerative stomatitis, and linear IgA disease. Treatment varies depending on the underlying cause and severity of symptoms.
Submucosal plasmacytosis is a rare idiopathic condition consisting of a dense plasma cell infilterate of the mucous
membrane.It presents clinically as a diffuse, erythematous and less often ulcers are present .The etiology is still
unclear,but this condition is believed to be an immunological reaction to certain allergens .Here presenting a case
report of 86 year old male complained of multiple oral lesions and bleeding from lip region since one and half month
back,also complains of pain and burning sensation.
"A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document provides information about leprosy (Hansen's disease), including:
- It is caused by Mycobacterium leprae and primarily affects the skin, nerves, and mucosa.
- There are several classification systems including paucibacillary, multibacillary, lepromatous, tuberculoid, and borderline. Classification depends on immune response and bacterial load.
- It remains a major public health problem with millions of cases worldwide, especially in India, Brazil, and African countries. Treatment involves multidrug therapy to prevent disability.
1. Behcet's disease is a systemic autoimmune vasculitis characterized by recurrent oral and genital ulcers. It can affect multiple organ systems including eyes, skin, joints, gastrointestinal tract, and nervous system.
2. The disease is named after Turkish dermatologist Hulusi Behcet who first described the triple symptom complex in 1937. It is more common in countries along the Silk Road. Genetic factors like HLA-B51 are associated with increased risk.
3. Pathogenesis involves inflammation of blood vessels due to immune dysregulation. Diagnosis is based on clinical criteria including oral/genital ulcers, skin lesions, eye inflammation, and positive pathergy test. Treatment focuses on
This document contains 10 multiple choice questions about common skin diseases, along with explanations for each answer. The questions cover topics like scabies, psoriasis, tinea capitis, bullous pemphigoid, hereditary haemorrhagic telangiectasia, and erythema induratum. The explanations provide details about the diagnoses, typical presentations, treatments, and pathogenic mechanisms of the various skin conditions.
— Acute Generalized Exanthematous Pustulosis (AGEP) is a rare severe cutaneous adverse reaction mainly caused by drugs. It is characterized by an acute pustular eruption over the body along with fever and leukocytosis. It has been known to resolve spontaneously over a period of 2-3 weeks without long term sequelae. However it is of utmost importance for the physicians to clinically identify this condition as to prevent unwanted extensive management. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAIDs) prescribed over the counter for pain relief. A sixteen year old boy is reported here who developed AGEP after taking mefenamic acid for fever and joint pain. It was diagnosed with the help of history, clinicopathological correlation, AGEP validation score and recovery on withdrawal of the drug. To the best of our knowledge this is the first case report of mefenamic acid causing AGEP in the literature.
This document summarizes a case report on the neoplastic transformation of oral lichen planus. It describes a case of a 60-year old female patient who presented with sharp widespread pain in the oral cavity for a year. A biopsy showed features consistent with oral lichen planus as well as areas of dysplasia and squamous cell carcinoma. The document then reviews lichen planus, including that it is a common premalignant condition affecting the oral mucosa. It has a small risk of malignant transformation over time, especially in the erosive forms. Close monitoring is recommended for early cancer detection.
This document discusses onychomycosis, a common nail fungus. It begins by defining onychomycosis and describing the most common causes as dermatophytes (fungi that infect skin, hair, and nails) such as Trichophyton rubrum, yeasts such as Candida species, and other molds. It then discusses the different clinical presentations of onychomycosis and outlines the primary diagnostic methods of direct microscopic examination, culture, and histopathology to confirm the presence of fungi in the nail. The document focuses on proper sampling techniques for these diagnostic tests and stresses the importance of culture to identify the infecting species and determine appropriate treatment.
Ectoparasites on genitalia in this Era - a study at tertiary care center in T...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Give five presentation tips used when doing presentationDQ-1.docxgilbertkpeters11344
Give five presentation tips used when doing presentation
DQ-1
Impetigo is a disease characterized by superficial infection of the skin that begins as small vesicles. These vesicles rupture and for crust. The crust is honey colored with a presentation of bullous or non-bullous. The risk factors in developing impetigo are being exposed to humind environment , insect bites, minor cuts and poor hygiene. Non-bullous vesicles are 1 to 2mm in diameter that rupture and form a honey colored crust. These wound often time weep and present as red colored shallow ulcerations. These are common on the patients mouth, face, nose,eyes. They can arise from insect bites or trauma. Bullous type most common in newborn babies presented on their diaper area or neck folds. These infections if left untreated may become systemin infections such as sepsis (Moes-Wójtowicz, Wachnicka-Bąk, Agnieszka Opałka,Kalicki, Jung,2015). These vesicles are fluid filled blisters that become limp and then burst open. Upon assessment of the patient history and chief complaint I will assess for risks mentioned above and see if the patient has any of these risks. Second, I will identify if the vesicles are as described above. If the patient meets criteria, I will then swab the area for culture. These skin conditions often are associated with bacterial infections such as in group Strep infections (Corredor-Osorio,Corredor-Osorio,Corredor-Osorio, 2016). Differential diagnosis consists of herpes simplex, insect bites and dermatitis. The treatment for this are topic antibiotics and frequently washing of the area that is infected. In severe cases systeming antibitics may be required for this infection. Children that are infected may not return to school until infection is controlled.
Corredor-Osorio, R., Corredor-Osorio, M., & Corredor-Osorio, A. (2016). Eyelid nonbullous impetigo. Our Dermatology Online / Nasza Dermatologia Online, 7(3), 291–293. https://doi.org/10.7241/ourd.20163.78
Alicja Moes-Wójtowicz, Anna Wachnicka-Bąk, Agnieszka Lipińska-Opałka, Bolesław Kalicki, & Anna Jung. (2015). Impetigo asacause of sepsis ininfants. Pediatria i Medycyna Rodzinna, 11(2), 220–226. https://doi.org/10.15557/PiMR.2015.0021
DQ-2
Basal cell carcinoma
Basal cell carcinoma (BCC) is the most common malignant epithelial neoplasm skin cancer worldwide (Liu, Liu, & Bian, 2020). Risk factors include gender, age, immunosuppression, chemicals (arsenic), and ultraviolet light exposure. BCC is more prevalent in Caucasian males, typically, after the age of 40 years, and develops slowly in exposed areas of the body, such as the scalp, face, ears, neck, and trunk (Liu et al., 2020). Ultraviolet radiation exposure is the most common cause of BCC. There are various presentations of BCC. Typically, nodular BCC presents as a pearly, translucent nodule with a firm elevated border, visible telangiectatic vessels, and a depressed center with or without ulceration (Balaji, Duraisamy, & Kumar, 2019). Other BCCs can incl.
1. Juvenile dermatomyositis differs from adult DM in that it lacks calcinosis cutis, malignancy, and has less sex predominance and vasculitis. Adults can develop malignancy and positive anti-synthetase antibodies.
2. Two medications that can induce dermatomyositis are statins and hydroxyurea. Two features that differ DM lesions from LE are their violaceous hue and pruritus.
3. Indications for treatment of hemangiomas include obscuring vision, compromising airway, ulceration and pain, and being in a cosmetically sensitive area. The approach for starting propranolol includes testing for contraindications and slowly
This study reviewed 84 cases of pediatric staphylococcal scalded skin syndrome (SSSS) at a single hospital over 22 years. It found that suspected culprit pathogens were more often obtained from periorificial swabs though these were not tested for exfoliative toxin. Surgical debridement of skin lesions was associated with longer hospital stays. Adding the antibiotic clindamycin, which has anti-toxin effects, did not impact clinical course or length of hospitalization. Most cases were treated effectively with supportive care and antibiotics targeting Staphylococcus aureus such as cloxacillin.
Fournier’s Gangrene in a 9 Yrs. Old Patient; A Rare Presentation in Paediatri...semualkaira
Necrotizing fasciitis of the perineum and external genitalia is a
life-threatening infective gangrene, primarily seen in adults but
relatively rare in children. We present a nine-year-old male child
with spinal bifida and double incontence who was admitted at our
hospital due to gangrenous right hemi-scrotal ulcer extending to
the right thigh. It was proceeded with painful swollen hemi-scrotum 2wks prior to admission. We treated him aggressively with
broad spectrum antibiotics and early surgical debridement. Being
paraplegic with double incontinence hence spending most of the
time dressed with diapers we therefore think of poor hygiene and
the diaper rash as the etiological factors. Early surgical debridement with appropriate antibiotics and aggressive supportive care
usually gave good results.
Fournier’s Gangrene in a 9 Yrs. Old Patient; A Rare Presentation in Paediatri...semualkaira
Necrotizing fasciitis of the perineum and external genitalia is a
life-threatening infective gangrene, primarily seen in adults but
relatively rare in children. We present a nine-year-old male child
with spinal bifida and double incontence who was admitted at our
hospital due to gangrenous right hemi-scrotal ulcer extending to
the right thigh. It was proceeded with painful swollen hemi-scrotum 2wks prior to admission. We treated him aggressively with
broad spectrum antibiotics and early surgical debridement. Being
paraplegic with double incontinence hence spending most of the
time dressed with diapers we therefore think of poor hygiene and
the diaper rash as the etiological factors. Early surgical debridement with appropriate antibiotics and aggressive supportive care
usually gave good results.
This paper continues the authors investigation into AD. We find that hydrogen peroxide appears to be the culprit in attacking the Papez circuit, especially in women. Familiarity with AT Math is assumed.
Eosinophilic Enterocolitis: A Rare Nosological Entitynavasreni
Eosinophilic enterocolitis is an exceptionally rare disease with few cases described in the literature. It is the least frequent manifestation of the broad spectrum of gastrointestinal eosinophilic diseases. We describe a case of a female patient presenting with a form of the disease manifested by Koenig’s syndrome and diarrhea.
More Related Content
Similar to Mucocutaneous Involvement in Behcets Disease
This document discusses bullous skin disorders, focusing on pemphigus vulgaris (PV). It defines PV as an autoimmune blistering disease caused by antibodies against desmoglein 3, resulting in fragile blisters and erosions on skin and mucous membranes. It describes the clinical presentation of PV including lesions, Nikolski's sign, and involvement of oral mucosa. It also covers pathogenesis, diagnosis via histology and immunofluorescence, and treatment primarily with corticosteroids and immunosuppressants to reduce blister formation and promote healing.
This document describes a case report of a solitary angiokeratoma lesion found on the tongue of a 38-year-old male patient. Solitary angiokeratomas of the oral mucosa are rare. The lesion was a well-circumscribed, dark brown growth on the dorsal surface of the tongue. Histopathological examination revealed numerous dilated blood vessels in the papillary dermis along with hyperkeratosis and acanthosis of the epithelium, consistent with angiokeratoma. Immunohistochemical staining was positive for CD34, confirming the lesion contained proliferating blood vessels. No other lesions were found on the patient's body. The lesion was completely excised with no recurrence after 6 months of follow up.
Relapsing Polychondritis Case: An Important Diagnosis Not to Be Delayedsemualkaira
Relapsing Polychondritis (RP) is a rare disease characterized by
inflammation of cartilage and connective tissues with destructive
episodes. Although the pathogenesis is not completely known,
there is an autoimmunity in which antibodies against mainly type
II collagen play a role. In addition to chondritis of the ear, nose,
and trachea; organs having proteoglycan structure such as eyes,
the inner ear, heart, blood vessels, and kidneys can be affected, too.
This document provides an overview of erythema multiforme (EM), a self-limited inflammatory mucocutaneous disease that commonly affects the skin and oral mucosa. It discusses the etiology, pathogenesis, clinical features, classification variants, diagnosis and management of EM. Key points include: EM results from a hypersensitivity reaction, often to infections or drugs; it ranges from mild to severe based on extent of skin and mucosal involvement; diagnosis involves clinical exam, biopsy and ruling out other conditions; treatment depends on severity but may include antivirals, corticosteroids or immunosuppressants.
This document provides information on desquamative gingivitis, including its classification, diagnosis, and associated diseases. It classifies desquamative gingivitis into 7 categories including dermatosis, endocrine imbalance, aging, metabolic disturbances, abnormal response to irritation, chronic infection, and drug reactions. Key aspects of diagnosis include clinical history, examination, biopsy, and microscopic/immunofluorescence examination. Associated diseases discussed in detail include lichen planus, pemphigoid, pemphigus vulgaris, chronic ulcerative stomatitis, and linear IgA disease. Treatment varies depending on the underlying cause and severity of symptoms.
Submucosal plasmacytosis is a rare idiopathic condition consisting of a dense plasma cell infilterate of the mucous
membrane.It presents clinically as a diffuse, erythematous and less often ulcers are present .The etiology is still
unclear,but this condition is believed to be an immunological reaction to certain allergens .Here presenting a case
report of 86 year old male complained of multiple oral lesions and bleeding from lip region since one and half month
back,also complains of pain and burning sensation.
"A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document provides information about leprosy (Hansen's disease), including:
- It is caused by Mycobacterium leprae and primarily affects the skin, nerves, and mucosa.
- There are several classification systems including paucibacillary, multibacillary, lepromatous, tuberculoid, and borderline. Classification depends on immune response and bacterial load.
- It remains a major public health problem with millions of cases worldwide, especially in India, Brazil, and African countries. Treatment involves multidrug therapy to prevent disability.
1. Behcet's disease is a systemic autoimmune vasculitis characterized by recurrent oral and genital ulcers. It can affect multiple organ systems including eyes, skin, joints, gastrointestinal tract, and nervous system.
2. The disease is named after Turkish dermatologist Hulusi Behcet who first described the triple symptom complex in 1937. It is more common in countries along the Silk Road. Genetic factors like HLA-B51 are associated with increased risk.
3. Pathogenesis involves inflammation of blood vessels due to immune dysregulation. Diagnosis is based on clinical criteria including oral/genital ulcers, skin lesions, eye inflammation, and positive pathergy test. Treatment focuses on
This document contains 10 multiple choice questions about common skin diseases, along with explanations for each answer. The questions cover topics like scabies, psoriasis, tinea capitis, bullous pemphigoid, hereditary haemorrhagic telangiectasia, and erythema induratum. The explanations provide details about the diagnoses, typical presentations, treatments, and pathogenic mechanisms of the various skin conditions.
— Acute Generalized Exanthematous Pustulosis (AGEP) is a rare severe cutaneous adverse reaction mainly caused by drugs. It is characterized by an acute pustular eruption over the body along with fever and leukocytosis. It has been known to resolve spontaneously over a period of 2-3 weeks without long term sequelae. However it is of utmost importance for the physicians to clinically identify this condition as to prevent unwanted extensive management. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAIDs) prescribed over the counter for pain relief. A sixteen year old boy is reported here who developed AGEP after taking mefenamic acid for fever and joint pain. It was diagnosed with the help of history, clinicopathological correlation, AGEP validation score and recovery on withdrawal of the drug. To the best of our knowledge this is the first case report of mefenamic acid causing AGEP in the literature.
This document summarizes a case report on the neoplastic transformation of oral lichen planus. It describes a case of a 60-year old female patient who presented with sharp widespread pain in the oral cavity for a year. A biopsy showed features consistent with oral lichen planus as well as areas of dysplasia and squamous cell carcinoma. The document then reviews lichen planus, including that it is a common premalignant condition affecting the oral mucosa. It has a small risk of malignant transformation over time, especially in the erosive forms. Close monitoring is recommended for early cancer detection.
This document discusses onychomycosis, a common nail fungus. It begins by defining onychomycosis and describing the most common causes as dermatophytes (fungi that infect skin, hair, and nails) such as Trichophyton rubrum, yeasts such as Candida species, and other molds. It then discusses the different clinical presentations of onychomycosis and outlines the primary diagnostic methods of direct microscopic examination, culture, and histopathology to confirm the presence of fungi in the nail. The document focuses on proper sampling techniques for these diagnostic tests and stresses the importance of culture to identify the infecting species and determine appropriate treatment.
Ectoparasites on genitalia in this Era - a study at tertiary care center in T...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Give five presentation tips used when doing presentationDQ-1.docxgilbertkpeters11344
Give five presentation tips used when doing presentation
DQ-1
Impetigo is a disease characterized by superficial infection of the skin that begins as small vesicles. These vesicles rupture and for crust. The crust is honey colored with a presentation of bullous or non-bullous. The risk factors in developing impetigo are being exposed to humind environment , insect bites, minor cuts and poor hygiene. Non-bullous vesicles are 1 to 2mm in diameter that rupture and form a honey colored crust. These wound often time weep and present as red colored shallow ulcerations. These are common on the patients mouth, face, nose,eyes. They can arise from insect bites or trauma. Bullous type most common in newborn babies presented on their diaper area or neck folds. These infections if left untreated may become systemin infections such as sepsis (Moes-Wójtowicz, Wachnicka-Bąk, Agnieszka Opałka,Kalicki, Jung,2015). These vesicles are fluid filled blisters that become limp and then burst open. Upon assessment of the patient history and chief complaint I will assess for risks mentioned above and see if the patient has any of these risks. Second, I will identify if the vesicles are as described above. If the patient meets criteria, I will then swab the area for culture. These skin conditions often are associated with bacterial infections such as in group Strep infections (Corredor-Osorio,Corredor-Osorio,Corredor-Osorio, 2016). Differential diagnosis consists of herpes simplex, insect bites and dermatitis. The treatment for this are topic antibiotics and frequently washing of the area that is infected. In severe cases systeming antibitics may be required for this infection. Children that are infected may not return to school until infection is controlled.
Corredor-Osorio, R., Corredor-Osorio, M., & Corredor-Osorio, A. (2016). Eyelid nonbullous impetigo. Our Dermatology Online / Nasza Dermatologia Online, 7(3), 291–293. https://doi.org/10.7241/ourd.20163.78
Alicja Moes-Wójtowicz, Anna Wachnicka-Bąk, Agnieszka Lipińska-Opałka, Bolesław Kalicki, & Anna Jung. (2015). Impetigo asacause of sepsis ininfants. Pediatria i Medycyna Rodzinna, 11(2), 220–226. https://doi.org/10.15557/PiMR.2015.0021
DQ-2
Basal cell carcinoma
Basal cell carcinoma (BCC) is the most common malignant epithelial neoplasm skin cancer worldwide (Liu, Liu, & Bian, 2020). Risk factors include gender, age, immunosuppression, chemicals (arsenic), and ultraviolet light exposure. BCC is more prevalent in Caucasian males, typically, after the age of 40 years, and develops slowly in exposed areas of the body, such as the scalp, face, ears, neck, and trunk (Liu et al., 2020). Ultraviolet radiation exposure is the most common cause of BCC. There are various presentations of BCC. Typically, nodular BCC presents as a pearly, translucent nodule with a firm elevated border, visible telangiectatic vessels, and a depressed center with or without ulceration (Balaji, Duraisamy, & Kumar, 2019). Other BCCs can incl.
1. Juvenile dermatomyositis differs from adult DM in that it lacks calcinosis cutis, malignancy, and has less sex predominance and vasculitis. Adults can develop malignancy and positive anti-synthetase antibodies.
2. Two medications that can induce dermatomyositis are statins and hydroxyurea. Two features that differ DM lesions from LE are their violaceous hue and pruritus.
3. Indications for treatment of hemangiomas include obscuring vision, compromising airway, ulceration and pain, and being in a cosmetically sensitive area. The approach for starting propranolol includes testing for contraindications and slowly
This study reviewed 84 cases of pediatric staphylococcal scalded skin syndrome (SSSS) at a single hospital over 22 years. It found that suspected culprit pathogens were more often obtained from periorificial swabs though these were not tested for exfoliative toxin. Surgical debridement of skin lesions was associated with longer hospital stays. Adding the antibiotic clindamycin, which has anti-toxin effects, did not impact clinical course or length of hospitalization. Most cases were treated effectively with supportive care and antibiotics targeting Staphylococcus aureus such as cloxacillin.
Fournier’s Gangrene in a 9 Yrs. Old Patient; A Rare Presentation in Paediatri...semualkaira
Necrotizing fasciitis of the perineum and external genitalia is a
life-threatening infective gangrene, primarily seen in adults but
relatively rare in children. We present a nine-year-old male child
with spinal bifida and double incontence who was admitted at our
hospital due to gangrenous right hemi-scrotal ulcer extending to
the right thigh. It was proceeded with painful swollen hemi-scrotum 2wks prior to admission. We treated him aggressively with
broad spectrum antibiotics and early surgical debridement. Being
paraplegic with double incontinence hence spending most of the
time dressed with diapers we therefore think of poor hygiene and
the diaper rash as the etiological factors. Early surgical debridement with appropriate antibiotics and aggressive supportive care
usually gave good results.
Fournier’s Gangrene in a 9 Yrs. Old Patient; A Rare Presentation in Paediatri...semualkaira
Necrotizing fasciitis of the perineum and external genitalia is a
life-threatening infective gangrene, primarily seen in adults but
relatively rare in children. We present a nine-year-old male child
with spinal bifida and double incontence who was admitted at our
hospital due to gangrenous right hemi-scrotal ulcer extending to
the right thigh. It was proceeded with painful swollen hemi-scrotum 2wks prior to admission. We treated him aggressively with
broad spectrum antibiotics and early surgical debridement. Being
paraplegic with double incontinence hence spending most of the
time dressed with diapers we therefore think of poor hygiene and
the diaper rash as the etiological factors. Early surgical debridement with appropriate antibiotics and aggressive supportive care
usually gave good results.
Similar to Mucocutaneous Involvement in Behcets Disease (20)
This paper continues the authors investigation into AD. We find that hydrogen peroxide appears to be the culprit in attacking the Papez circuit, especially in women. Familiarity with AT Math is assumed.
Eosinophilic Enterocolitis: A Rare Nosological Entitynavasreni
Eosinophilic enterocolitis is an exceptionally rare disease with few cases described in the literature. It is the least frequent manifestation of the broad spectrum of gastrointestinal eosinophilic diseases. We describe a case of a female patient presenting with a form of the disease manifested by Koenig’s syndrome and diarrhea.
This paper provides some simple calculations from AT Math and Physics on how stuttering may occur. We see that adrenaline affects the frequency of the human mind resulting in a nerve signal velocity that is too slow for the tongue muscle to respond, thus no clear speech.
Ethics Review Preparedness During COVID-19 Outbreak and Local IRBs in Pakista...navasreni
Current COVID-19 outbreak has shaken almost all aspects of health. Pakistan is lower middle income
country where health system is fragmented due to chronic state of underinvestment in health. Provision
of basic health care during the current COVID-19 outbreak remains daunting task. Ethics and
regulatory systems are not fully mature [1]
Dynamics of the COVID-19 Comparison between the Theoretical Predictions and t...navasreni
A new coronavirus disease, called COVID-19, appeared in the Chinese region of Wuhan at the end of
last year; since then the virus spread to other countries, including most of Europe. We propose a
differential equation governing the evolution of the COVID-19.
A 51-year-old man presented with abdominal pain and cessation of bowel movements for three days. Imaging showed pneumoperitoneum and distension of the small intestine upstream of a large mass. Exploratory laparotomy revealed gas cysts in the small intestine and a volvulus. Resection of the affected small intestine segment showed intestinal cystic pneumatosis. Intestinal cystic pneumatosis is a rare condition characterized by gas-filled cysts in the intestinal wall. It is usually mild but can cause complications like volvulus requiring surgery. Treatment is typically medical but surgery is needed for complicated cases.
Pontocerebellar Hypoplasia: Literature Review and Clinical Studynavasreni
AbstractPontocerebellar Hypoplasia (PCH) refers to a group of rare, progressive, and hereditary neurode- generative disorders with prenatal onset. Different subtypes have been identified based on the mu- tations present, and all share common characteristics, such as severe cognitive, linguistic, and motor disabilities.
Aorto-Esophageal Fistula and Metallic Stentnavasreni
Esophageal metallic stents are indicated in the palliative treatment of malignant dysphagia [1]. The ones usually used are covered or partially covered. They have a low mortality rate directly asso- ciated (0.5-2%) [2]. As with any endoscopic therapeutic procedure, it can get complicated.
A Mild form of Familial Mediterranean Fever Associated with a Polymorphisms C...navasreni
This case report describes a patient with a mild form of familial Mediterranean fever (FMF) associated with a polymorphism in the MEFV gene. The patient experienced recurrent fever episodes accompanied by mild skin rashes and joint pain. Genetic testing identified a c.1588-69G>A polymorphism in intron 5 of the MEFV gene. The patient responded well to treatment with corticosteroids and colchicine, though had to discontinue colchicine due to side effects. The polymorphism is not rare and has been found in healthy subjects, suggesting it is associated with a milder form of FMF that requires other triggers to induce symptoms.
A hookah (shisha, waterpipe) use may increase the risk of suffering from serious symptoms due to
COVID-19. Like smoking, hookahs may exacerbate the risk for severe COVID-19 through shared use
and being difficult-to-clean the long pipes and having a cold water reservoir. Social gatherings also
provide an opportunity for the virus to spread.
Can Lung Ultrasound in Patients with Fever of Unknown Origin Detect Early Sig...navasreni
The increasing interest in Lung Ultrasound (LUS) over the last years led to a great diffusion and better experience in using this technique, which became an essential tool for clinicians. During the current Coronavirus Disease 2019 (COVID-19) pandemic, LUS is being extensively applied to the evaluation and monitoring....
Postpartum Meningitis by Enterococcus Faecalis Secondary to Neuraxial Anesthesianavasreni
Meningitis is an infrequent and serious cause of postpartum fever that requires early diagnosis and treatment to prevent serious complications and to reduce the high mortality rate. Neuraxial anesthesia is a frequently used technique in obstetrics. Meningitis is a very rare complication of neuraxial an- esthesia and enterococcus....
Superior Mesenteric Artery Syndrome Treated by Laparoscopic Duodenojejunostomynavasreni
Superior Mesenteric Artery syndrome (SMA Sd) is a very rare disease. It is suspected in the case of intestinal obstruction in severely underweight patients.
Colopleural Fistula. A Case Report and Review of Literaturenavasreni
The presence of a colopleural fistula is a rare event related to several factors, inadequate placement of drains, poor surgical technique, infection or dehiscence of a GI anastomosis.
Colopleural Fistula. A Case Report and Review of Literaturenavasreni
The presence of a colopleural fistula is a rare event related to several factors, inadequate placement of drains, poor surgical technique, infection or dehiscence of a GI anastomosis. Only a small percentage occurs as a complication of inflammatory bowel disease, cancer, trauma or radiation...
Atypical Presentation of Post-Kala Azar Dermal Leishmaniasis in Bhutannavasreni
This article describes an atypical case of post-kala azar dermal leishmaniasis associated with complications due to delayed diagnosis and poor case management
Cutaneous Larva Migrans: A Case Report in a Traveler Childnavasreni
Cutaneous Larva Migrans (CLM) is the most common skin disease of tropical origincaused by hookworms larvae, occurring in international travelers. Typical manifestations consist of erythematous, serpiginous slightly elevated linear cutaneous lesions. We describe the case of an 8-year-old boy, with CLM infection acquired during travel to Burkina-Faso, and successfully treated...
Since receiving unexplained pneumonia patients at the Jinyintan Hospital in Wu- han, China in December 2019, the new coronavirus (COVID-19) has rapidly spread in Wuhan, China and spread to the entire China and some neighboring countries.
Fetal Vascular Rings: Beyond The Anomalies of The Aortic Archnavasreni
Different anomalies related to the inappropriate development of the ductus arteriosus or the aortic arch have been described, in some cases accompanied with chromosomal or morphological anomalies, and also being able to form a vascular ring that can compromise the postnatal life.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
2. one mucocutaneous involvement. Oral aphthosis was present in all
patients, whose different locations were at the level of: the internal
surface of the lip (68%), the internal surface of the cheek (24%), the
tongue (8 %) and gums (4%) (Figure 1).
Figure 1: Shows a picture of oral aphthosis in the tongue
Genital ulcers were observed in 81 cases (82.7%). Genital aphthosis
were noted in 63 patients (64.3%) (Figure 2). Inaddition to bipolar
aphthosis, other mucocutaneous manifestations were noted in 66
cases (67.3%). Pseudofolliculitis was observed in 61 cases (62.2%),
located in the back, thighs, trunk and face (Figure 3).
The other mucocutaneous manifestations were erythema nodosum
in 7 cases, cutaneous aphthosis in 4 cases, acneiform lesions in 2
cases, perianal aphthosis, skin ulceration and erythema multiforme
in one case respectively. Skin hypersensibility was demonstrated by
the skin pathergy test in 76% of cases (Figure 4).
Figure 2: Illustrates the image of genital aphthae in the scrotom.
Figure 3: Shows a picture of pseudofolliculitis in the thigh.
Figure 4: Shows a positive pathergy test.
All of our patients were treated with colchicine. Nonsteroidal
anti-inflammatory drugs were indicated in one case of colchicine-
resistant erythema nodosum. Topical corticosteroids were started
in a patient with genital ulcers resistant to colchicine.
The most common manifestation is mucocutaneous involvement
in BD. Our study confirms this finding. The presence of specific
skin signs is a precious help for a definite diagnosis. Histologically,
the lesions are frequently perivascular with proeminent infiltrates
of neutrophils and/or lymphocytes. Among the international
classification criteria for BD, four criteria are dermatological
(oral aphthosis, genital aphthosis, positive pathergy test and skin
involvement) [1]. Skin manifestations may precede or occur
concomitantly with other systemic manifestations. But can also
occur after the systemic manifestations which makes the diagnosis
of BD difficult, explaining the important diagnostic delays.
Oral ulcers are observed in 92 to 100% of cases [2, 3]. Their
Volume 5 Issue 3 -2020 Original Article
http://www.acmcasereport.com/ 2
3. evolution is marked by disappearance without scars but recurrences
are frequent [2]. The entire oral cavity may be concerned (inner
face of the cheeks, inner face of the lips, tongue, palate, pharynx).
Genital ulcers, reported in 60% to 87% of cases [4-6], are lesions
very suggestive of BM which leave depigmented scars allowing
retrospective diagnosis of the disease. However, relapses are less
common compared to mouth ulcers.
Aphthae can also be found throughout the digestive tract from
the mouth to the anal mucosa [7]. Cutaneous aphthosis is rare
and occurs between 0.9% and 6% of cases [3, 8, 9]. It is the most
characteristic skin lesion in BD and usually leaves scars. Its seat is
variable [10].
Pseudofolliculitis is the most common skin lesion in BD [11]. It is
seen in 31 to 66% of cases [3, 5, 9, 12]. It is a papule not centered
by a hair, located mainly at the back, the front of the thighs, the
face and the lower limbs [13]. Erythema nodosum is very painful
and occurs mainly in the lower limbs and disappears within a few
days. It is seen in a third of cases of BD according to the literature
[5, 6 ,14].
Acneiform papulopustular lesions can be seen during BD in 0.4 to
8% of cases [8, 14]. erythema multiforme [8], vascular purpura [11],
leg ulcer [6], pyoderma gangrenosum [15], and sweet syndrome
[15] have also been described in BD.
Skin hypersensibility at the injection sites is common during BD. It
is explored by the pathergy test, described for the first time in 1937
[11], resulting in a papular lesion, which becomes papulo-vesicular
then papulo-pustular. This skin hypersensitivity is one of the most
specificsignsofBD.Severalauthorsthereforegiveitgreatdiagnostic
value, which justifies its inclusion among the classification criteria
for BD [1]. The positivity of this test varies between 45% and 70%
of cases according to the different series published [3-5, 12]. The
dispersion of the results can be explained by the ethnic origin of
the patients, the heterogeneity of the techniques for carrying out
the pathergy test between the teams and the taking of colchicine or
anti-inflammatory drugs before performing this test.
When there is no systemic lesions requiring oral corticosteroids
or immunosuppressive therapy, the treatment of dermatological
lesions is based on colchicine and topical corticosteroids, possibly
thalidomide and dapsone for refractory lesions.
6. Conclusion
The main clinical manifestation of the Behçet’s disease is
mucocutaneous involvement. It is polymorphic but it is
fundamental to find for a diagnosis of certainty. Oral and genital
aphthae are the main clinical dermatologic manifestations.
Cutaneous lesions mainly include pseudofolliculitis, erythema
nodosum and pyoderma gangrenosum. Histologically, these
lesions are essentially perivascular with proeminent infiltrates
of neutrophils and/or lymphocytes. Hypersensibility to needle
pricks is explored by the skin pathergy test. But the frequency of
its positivity varies depending on the country. In the absence of
systematic lesions justiciable of aggressive treatment, the treatment
of dermatological lesions is based on colchicine.
7. Conflict of Interests
The authors declare that they have no conflict of interests regarding
the publication of this paper.
Volume 5 Issue 3 -2020 Original Article
http://www.acmcasereport.com/ 3
References
1. The International Criteria for Behçet’s Disease (ICBD): a collabora-
tive study of 27 countries on the sensitivity and specificity of the new
criteria. J Eur Acad Dermatol Venereol. 2014 Mar; 28(3): 338-47.
2. Davatchi F, Chams-Davatchi C, Shams H, Shahram F, Nadji A, Akh-
laghi M, et al. Behcet’s disease: epidemiology, clinical manifestations,
and diagnosis. Expert Rev Clin Immunol. 2017; 13(1): 57‑65.
3. B’chir Hamzaoui S, Harmel A, Bouslama K, Abdallah M, Ennafaa M,
M’rad S, et al. La maladie de Behçet en Tunisie. Étude clinique de 519
cases. Rev Médecine Interne. 2006; 27(10): 742‑50.
4. Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Abdolahi BS,
Nadji A, et al. Behcet’s disease in Iran: Analysis of 7641 cases. Mod
Rheumatol. 2019; 29(6): 1023‑30.
5. Balta I, Akbay G, Kalkan G, Eksioglu M. Demographic and clinical
features of 521 Turkish patients with Behçet’s disease. Int J Dermatol.
2014; 53(5): 564‑9.
6. Vaiopoulos G, Konstantopoulou P, Evangelatos N, Kaklamanis P.
The spectrum of mucocutaneous manifestations in Adamantia-
des-Behçet’s disease in Greece. J Eur Acad Dermatol Venereol. 2010;
24(4): 434‑8.
7. Skef W. Gastrointestinal Behçet’s disease: A review. World J Gastro-
enterol. 2015; 21(13): 3801.
8. Bang D, Oh S, Lee K-H, Lee E-S, Lee S. Influence of Sex on Patients
with Behcet’s Disease in Korea. J Korean Med Sci. 2003; 18(2): 231.
9. Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akh-
laghi M, et al. Behcet’s disease in Iran: analysis of 6500 cases: Behcet’s
disease in Iran. Int J Rheum Dis. 2010; 13(4): 367‑73.
10. Alpsoy E. Behçet’s disease: A comprehensive review with a focus on
epidemiology, etiology and clinical features, and management of
mucocutaneous lesions. J Dermatol. 2016; 43(6): 620‑32.
11. Scherrer MAR, Rocha VB, Garcia LC. Behçet’s disease: review with
emphasis on dermatological aspects. An Bras Dermatol. 2017; 92(4):
452‑64.
12. Shang Y, Han S, Li J, Ren Q, Song F, Chen H. The Clinical Feature of
Behçet’s Disease in Northeastern China. Yonsei Med J. 2009; 50(5):
630.
13. Alpsoy E, Aktekin M, Er H, Durusoy Ç, Yilmaz E. A randomized,
controlled and blinded study of papulopustular lesions in Turkish
Behçet’s patients: Papulopustular lesions in Behçet’s disease. Int J
Dermatol. 1998; 37(11): 839‑42.
4. Volume 5 Issue 3 -2020 Original Article
http://www.acmcasereport.com/ 4
14. Oliveira ACD, Buosi ALP, Dutra LA, de Souza AWS. Behçet Disease:
Clinical Features and Management in a Brazilian Tertiary Hospital.
JCR J Clin Rheumatol. 2011; 17(8): 416‑20.
15. Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akh-
laghi M, et al. Behcet’s disease: from east to west. Clin Rheumatol.
2010; 29(8): 823‑33.