This document discusses limitations of the classical homogenization approach for modeling light absorption in tissues. It considers a two-dimensional model where light absorption occurs only within parallel, thin blood vessels and not in the surrounding tissue. The model contains three small parameters: E is the ratio of vessel spacing to tissue size, d is the ratio of vessel thickness to spacing, and v is a large parameter related to absorption strength within vessels. The paper shows that classical homogenization is valid when E→0, v→∞, d→0, and E2vd→0, but is invalid when E→0, v→∞, d→0, and E2vd2→∞, requiring non-classical asymptotic expans
The electronic band parameters calculated by the Triangular potential model f...IOSR Journals
This work reports on theoretical investigation of superlattices based on Cd1-xZnxS quantum dots
embedded in an insulating material. This system, assumed to a series of flattened cylindrical quantum dots with
a finite barrier at the boundary, is studied using the triangular potential. The electronic states and the effective
mass of 1 Γ miniband have been computed as a function of inter-quantum dot separation for different zinc
compositions. Calculations have been made for electrons, heavy holes and light holes. Results are discussed and
compared with those of the Kronig-Penney and sinusoidal potentials
This document summarizes a study that used picosecond optical tomography with a white laser and streak camera to measure changes in oxyhemoglobin and deoxyhemoglobin concentration in the brains of zebra finches in response to auditory stimulation. The technique showed submicromolar sensitivity and was able to resolve fast changes in the hippocampus and auditory forebrain with 250 μm resolution. Stimulation resulted in an early decrease in hemoglobin and oxyhemoglobin levels, followed by an increase in blood oxygen availability and pronounced vasodilation after stimulus end. The findings provide direct evidence linking blood oxygen level-dependent signals to changes in oxygen transport in birds.
1) The document discusses preliminary studies using two-photon microscopy to image brain areas of zebra finches through their thin skin and hollow skull structure for non-invasive monitoring of brain activity.
2) Experiments were conducted imaging hollow fibers filled with Rhodamine B passed through fixed zebra finch skin and skull samples to evaluate spatial resolution and distortion. Reflectance confocal measurements were also taken to determine scattering properties of fresh and fixed skin and skull.
3) The goal is to determine if two-photon microscopy can provide sufficient resolution for in vivo brain imaging and metabolism monitoring of zebra finches as a model for studying vocal recognition, without requiring craniotomy as in other small animal studies.
This document describes the construction and characterization of recombinant viruses containing the HIV-1 env gene from seminal strains. The researchers amplified the V1-V3 region of env from seminal plasma samples and used it to construct chimeric viruses by co-transfecting the V1-V3 fragment into a V1-V3 deleted vector. Four chimeric viruses were able to replicate and were characterized as using CXCR4 as a coreceptor. Confocal microscopy was used to observe the interaction of the cell-free viral particles with reporter cell lines. The recombinant viruses representing seminal strains are useful tools for studying heterosexual HIV transmission and testing microbicides.
This document describes an experiment that used near-infrared spectroscopy (NIRS) to noninvasively measure the optical properties of a songbird's brain. Researchers placed optical fibers on the head of anesthetized zebra finches to transmit laser light and collect the light after it passed through the brain tissue. They were able to measure the absorption and scattering coefficients of the caudal nidopallium region of the brain in vivo. This technique could help monitor brain activity and oxygenation levels in songbirds.
This document summarizes a study that used functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS) to measure hemodynamic changes in the brain of zebra finches in response to hypercapnia. Hypercapnia induces vasodilation and is often used to model hemodynamic responses. Both fMRI, which detects blood oxygen level-dependent (BOLD) signals, and NIRS, which measures concentrations of oxyhemoglobin and deoxyhemoglobin, clearly showed increases in blood oxygen saturation in the brain during hypercapnia. The results provide the first correlation in songbirds between hemodynamic parameter variations measured by NIRS and local BOLD signal variations measured by fMRI.
1) Male zebra finches were found to respond differently to calls from their mate versus other females depending on their social context. Specifically, males responded much more to their mate's call when with a mated pair compared to when alone or with other unmated males.
2) Previous studies found male zebra finches did not show mate recognition from female calls. However, the new study found female calls contain identifiable acoustic features allowing for individual recognition.
3) The results suggest social context can influence mate recognition in birds, challenging the view that complex social assessments are unique to primates.
This study examines the effects of the antibiotic chloramphenicol (CAP) on brain metabolism in freely moving rats using picosecond time-resolved fluorescence spectroscopy. The researchers found that CAP, in addition to inhibiting mitochondrial protein synthesis, also influences redox processes in the respiratory chain by producing a marked increase in fluorescent signal in the nucleus raphe dorsalis, indicating a rise in NADH concentration. This suggests CAP efficiently inhibits complex I of the respiratory chain, which could explain why it suppresses paradoxical sleep. The approach provides a novel method for evaluating drug effects on deep brain structures in vivo.
The electronic band parameters calculated by the Triangular potential model f...IOSR Journals
This work reports on theoretical investigation of superlattices based on Cd1-xZnxS quantum dots
embedded in an insulating material. This system, assumed to a series of flattened cylindrical quantum dots with
a finite barrier at the boundary, is studied using the triangular potential. The electronic states and the effective
mass of 1 Γ miniband have been computed as a function of inter-quantum dot separation for different zinc
compositions. Calculations have been made for electrons, heavy holes and light holes. Results are discussed and
compared with those of the Kronig-Penney and sinusoidal potentials
This document summarizes a study that used picosecond optical tomography with a white laser and streak camera to measure changes in oxyhemoglobin and deoxyhemoglobin concentration in the brains of zebra finches in response to auditory stimulation. The technique showed submicromolar sensitivity and was able to resolve fast changes in the hippocampus and auditory forebrain with 250 μm resolution. Stimulation resulted in an early decrease in hemoglobin and oxyhemoglobin levels, followed by an increase in blood oxygen availability and pronounced vasodilation after stimulus end. The findings provide direct evidence linking blood oxygen level-dependent signals to changes in oxygen transport in birds.
1) The document discusses preliminary studies using two-photon microscopy to image brain areas of zebra finches through their thin skin and hollow skull structure for non-invasive monitoring of brain activity.
2) Experiments were conducted imaging hollow fibers filled with Rhodamine B passed through fixed zebra finch skin and skull samples to evaluate spatial resolution and distortion. Reflectance confocal measurements were also taken to determine scattering properties of fresh and fixed skin and skull.
3) The goal is to determine if two-photon microscopy can provide sufficient resolution for in vivo brain imaging and metabolism monitoring of zebra finches as a model for studying vocal recognition, without requiring craniotomy as in other small animal studies.
This document describes the construction and characterization of recombinant viruses containing the HIV-1 env gene from seminal strains. The researchers amplified the V1-V3 region of env from seminal plasma samples and used it to construct chimeric viruses by co-transfecting the V1-V3 fragment into a V1-V3 deleted vector. Four chimeric viruses were able to replicate and were characterized as using CXCR4 as a coreceptor. Confocal microscopy was used to observe the interaction of the cell-free viral particles with reporter cell lines. The recombinant viruses representing seminal strains are useful tools for studying heterosexual HIV transmission and testing microbicides.
This document describes an experiment that used near-infrared spectroscopy (NIRS) to noninvasively measure the optical properties of a songbird's brain. Researchers placed optical fibers on the head of anesthetized zebra finches to transmit laser light and collect the light after it passed through the brain tissue. They were able to measure the absorption and scattering coefficients of the caudal nidopallium region of the brain in vivo. This technique could help monitor brain activity and oxygenation levels in songbirds.
This document summarizes a study that used functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS) to measure hemodynamic changes in the brain of zebra finches in response to hypercapnia. Hypercapnia induces vasodilation and is often used to model hemodynamic responses. Both fMRI, which detects blood oxygen level-dependent (BOLD) signals, and NIRS, which measures concentrations of oxyhemoglobin and deoxyhemoglobin, clearly showed increases in blood oxygen saturation in the brain during hypercapnia. The results provide the first correlation in songbirds between hemodynamic parameter variations measured by NIRS and local BOLD signal variations measured by fMRI.
1) Male zebra finches were found to respond differently to calls from their mate versus other females depending on their social context. Specifically, males responded much more to their mate's call when with a mated pair compared to when alone or with other unmated males.
2) Previous studies found male zebra finches did not show mate recognition from female calls. However, the new study found female calls contain identifiable acoustic features allowing for individual recognition.
3) The results suggest social context can influence mate recognition in birds, challenging the view that complex social assessments are unique to primates.
This study examines the effects of the antibiotic chloramphenicol (CAP) on brain metabolism in freely moving rats using picosecond time-resolved fluorescence spectroscopy. The researchers found that CAP, in addition to inhibiting mitochondrial protein synthesis, also influences redox processes in the respiratory chain by producing a marked increase in fluorescent signal in the nucleus raphe dorsalis, indicating a rise in NADH concentration. This suggests CAP efficiently inhibits complex I of the respiratory chain, which could explain why it suppresses paradoxical sleep. The approach provides a novel method for evaluating drug effects on deep brain structures in vivo.
This document provides an itinerary and overview for a 3-day sharing session on characterization of powders and porous solids. The itinerary outlines topics to be covered each day, including gas sorption, mercury porosimetry, chemisorption, microporosity, and more. The document also provides brief histories of sorption science and techniques for measuring properties like particle size, porosity, and specific surface area. Methods discussed include gas adsorption, mercury porosimetry, microscopy, and light scattering.
This document discusses computer simulations of the structure and thermodynamics of colloidal solutions interacting through Yukawa or Lu-Marlow potentials. It presents:
1) A new attractive potential proposed by Lu and Marlow that takes into account particle size and is proportional to the inverse sixth power of distance for large separations.
2) Use of this potential and a repulsive electrostatic potential in a variational method to calculate theoretical structure factors, finding good agreement with experimental data.
3) Choice of hard spheres as a reference system and use of the Gibbs-Bogoliubov inequality to obtain an upper bound for the free energy of the colloidal system.
In search of multipath interference using large moleculesGabriel O'Brien
This document summarizes an experiment that tested the quantum mechanical principle of superposition using large dye molecules. The experiment measured interference patterns when the molecules passed through single, double, and triple slits. It observed less than 1% deviation from the expected interference patterns based on quantum mechanics, providing evidence that the superposition principle applies even to massive particles like these large molecules. The experiment is one of the first to directly observe quantum interference using massive particles rather than light or single particles.
Mate 280 characterization of powders and porous materialsSami Ali
Particle size, surface area, and porosity are important characteristics that control many properties of materials. Particle size can be measured using techniques like sieving, sedimentation, light scattering, and gas adsorption which measure different parameters like size, surface area, or settling rate depending on the technique. Gas adsorption is commonly used to measure specific surface area and porosity by adsorbing gas molecules on the internal surface of porous materials.
UV-Visible spectroscopy involves absorption of ultraviolet or visible light by molecules. This absorption causes electrons to move to higher energy molecular orbitals. The Beer-Lambert law states that absorbance is directly proportional to concentration and path length. Deviations from Beer-Lambert law can occur at high concentrations due to interactions between molecules, or if non-monochromatic light is used. UV-Visible spectroscopy is used to study electronic transitions and structure of molecules.
Laser Physics Department -ALNeelain University 5 thGazy Khatmi
The document discusses a new approach for laser surgery and cancer treatment using COMSOL Multiphysics simulation software. Physicians would be able to specify various parameters like tissue type, tumor size, laser properties, and treatment time to simulate scenarios. COMSOL would then be developed into an app for physicians to access and run simulations remotely on their laptops or smartphones. This would allow physicians to interactively plan laser procedures digitally before performing treatments.
Modeling ultrasonic attenuation coefficient and comparative study with the pr...IOSR Journals
Many phenomena can be responsible for the attenuation of sound through the suspensions depending on the nature of the particles of the fluid and the frequency range of interest. In particular we can make a distinction between the diffusion mechanisms corresponding to a geometric redirection of the incident wave and the dissipative phenomena, like the thermal and viscous losses. In this work, we are interested in propagation of the ultrasonic waves into suspensions of clay rigid particles with a size between 1 and 50 microns, for which the thermal phenomena and visco-inertial dominate. In this case the dipole diffusion of the wave induced differential motion between the dispersed phase (clay grain) and the continuous phase (distilled water) is coupled to the viscous dissipation in the matching motion of this brake. In this paper, we present the main theories known in calculating the ultrasonic attenuation and velocity coefficient. Such theories permit to take accounts all the orders of interaction, unlike the theoretical of multiple diffusion that remains limited to lower concentrations. Finally, the results calculated by the principal theories will be compared against earlier experimental results obtained from this work.
UV-visible spectroscopy is a fast analytical technique that measures the absorbance or transmittance of light. Although the UV wavelength ranges from 100–380 nm and the visible component goes up to 800 nm, most of the spectrophotometers have a working wavelength range between 200–1100 nm.
The practical range for UV-vis spectroscopy varies from 200–800 nm; above 800 nm is infrared, while below 200 nm is known as vacuum UV. The ability of matter to absorb and to emit light is what defines its color and the human eye is capable of differentiating up to 10 million unique colors. Light passes through media (transmission), reflects off both opaque and transparent surfaces, and is refracted by crystals. Covalently unsaturated compounds with electronic transition energy differences equivalent to the energy of the UV-visible light absorb at specific wavelengths. These compounds are known as chromophores and are responsible for their color. Covalently saturated groups that do not absorb UV-visible electromagnetic radiation but affect the absorption of chromophore groups are called auxochromes. When UV-vis radiation hits chromophores, electrons in the ground state jump to an excited state, which we refer to as electron-excitation, while auxochromes are electron-donating and have the capacity to affect the color of choromophores while they do not change color themselves. Water and alcohols are mostly transparent and do not absorb in the UV-vis range and so are excellent mediums for UV-visible spectroscopy. Acetone and dimethylformamide (DMF) are good solvents for compounds insoluble in water and alcohol, but they absorb light below 320 and 275 nm, respectively, so are appropriate only above these cut-off wavelengths.
By tracking the Brownian trajectory of a sphere of 1 p,m radius in a suspension of 35 nm radius
beads, we probe the depth of the entropic potential experienced by a large sphere close to the cell
wall. This potential is caused by the pressure exerted by the Quid of small beads when they cannot fit
in the gap between the large bead and the wall. We find that the potential depth is of order kT. Its
dependence on the volume fraction of small spheres is significantly overestimated by a theory which
treats the small beads as an ideal gas.
- Molecular absorption spectroscopy measures the transmittance (T) or absorbance (A) of solutions in transparent cells to quantify inorganic, organic, and biological species.
- Beer's law states that absorbance is linearly proportional to concentration, expressed as A= εbc, where ε is the molar absorptivity, b is the path length, and c is the concentration.
- However, deviations from Beer's law can occur at high concentrations due to solute-solute interactions altering absorptivity, or due to changes in refractive index with concentration.
This seminal experiment addresses the issue of the generalization of Fick’s Law in the case of a spatially inhomogeneous diffusion coefficient. In Finance this is akin to the problem of a volatility dependent on the price of the underlying asset. We demonstrate deviation from the Stokes-Einstein law. In particular this relates to the Ito versus Stratonovitch controversy in stochastic calculus.
Estimation Of Vitamin Content In Fruit Juices By Ultrasonic Techniqueinventionjournals
ABSTRACT : Fruits are more essential and have many health benifits. Fruits has vitaminewihch is made up of an organic compound. Vitamin must be through diet. Vitamin C is required for the properdevelopment& function of many parts of the body . It also plays an important role in maintaining proper immune function. In this research the Selected fruits are apple and orange and they have Vitamin ‘C’. Estimation of Vitamin content have been done by studying Ultrasonic Velocity, Viscosity, Density and adiabatic Compressibility. Further the experimental values are confirmed by FTIR.
This document summarizes a study examining the Casimir force between two parallel plates confining a biomembrane. The researchers first develop a field theory model to describe the interactions of the confined biomembrane, which depends on the bending rigidity of the membrane and an elastic constant related to the plate separation. They then use this model to calculate the static and dynamic Casimir forces. They find that the static force decays with plate separation as D-3 and is significant for membranes with low bending rigidity. The dynamic force and membrane roughness are also calculated, finding both increase as power laws of time until equilibrium is reached. Hydrodynamic interactions are shown to increase the growth rates.
A spectrophotometer measures the amount of light that passes through a solution, allowing quantification of light absorption. It works by focusing a light source through the solution and measuring the intensity of the transmitted light. Spectrophotometers are used to precisely measure absorbance, which is related to analyte concentration according to Beer's Law. They contain components that focus light, select wavelengths, hold samples, and detect transmitted light intensities.
The enhancement of sub-barrier fusion has been interpreted due to coupling between the relative motion and other degrees of freedom. The coupling gives rise to the distribution of fusion barriers and passage over the lowest barrier which is responsible for fusion enhancement at energies below the barrier. There are several orders of magnitude could be considered due to the tunneling through the barrier. The barrier height could be deduced from the measured cross section data for different energies, as well as using many empirical forms for incomplete and complete fusion of two massive nuclei. Firstly, we present a formula for barrier height (ODEFF) and check, over wide ranges of interacting pairs the percentage agreement with those calculated or measured values for all pairs within ZP ZT ≤ 3000. Secondly, the more recently measured excitation functions are studied using four models of nuclear forces, indicating that most of them can be used for wide energy range while the others failed to do so .We refer this notice to the theory deducing the model . For this, the 14 undertaken pairs recover the range18 ≤ ZP ZT ≤ 1320
Dynamic light scattering can be used to measure the diffusion of small particles undergoing Brownian motion. An experiment is described that uses a laser, sample cell containing diffusing particles, lenses, photodetector, and photon correlator. The photodetector records the scattered light as pulses, which are clustered for moving particles due to the Doppler effect. The photon correlator measures the intensity correlation function over time to determine the decay time of fluctuations, which relates to particle size and diffusion coefficient according to equations presented. Dynamic light scattering is a powerful technique for studying phenomena involving fluctuations at the microscopic scale.
Life Expectancy Estimate with Bivariate Weibull Distribution using Archimedea...CSCJournals
Archimedean copulas are used to construct bivariate Weibull distributions. Co-movement structures of variables are analyzed through the copulas, where the tail dependence between the variables is explored with more flexibility. Based on the distance between the copula distribution and its empirical version, a copula that may best fit data is selected. With extra computing costs, the adequacy of the copula chosen is then assessed. When multiple myeloma data are considered, it is found that relationship between survival time of a patient and the hemoglobin level is well described by the Clayton copula. The bivariate Weibull distribution constructed by the copula is used to estimate value at risk from which we investigate the anticipated longest life expectancy of a patient with the disease over the treatment period.
Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
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This document provides an itinerary and overview for a 3-day sharing session on characterization of powders and porous solids. The itinerary outlines topics to be covered each day, including gas sorption, mercury porosimetry, chemisorption, microporosity, and more. The document also provides brief histories of sorption science and techniques for measuring properties like particle size, porosity, and specific surface area. Methods discussed include gas adsorption, mercury porosimetry, microscopy, and light scattering.
This document discusses computer simulations of the structure and thermodynamics of colloidal solutions interacting through Yukawa or Lu-Marlow potentials. It presents:
1) A new attractive potential proposed by Lu and Marlow that takes into account particle size and is proportional to the inverse sixth power of distance for large separations.
2) Use of this potential and a repulsive electrostatic potential in a variational method to calculate theoretical structure factors, finding good agreement with experimental data.
3) Choice of hard spheres as a reference system and use of the Gibbs-Bogoliubov inequality to obtain an upper bound for the free energy of the colloidal system.
In search of multipath interference using large moleculesGabriel O'Brien
This document summarizes an experiment that tested the quantum mechanical principle of superposition using large dye molecules. The experiment measured interference patterns when the molecules passed through single, double, and triple slits. It observed less than 1% deviation from the expected interference patterns based on quantum mechanics, providing evidence that the superposition principle applies even to massive particles like these large molecules. The experiment is one of the first to directly observe quantum interference using massive particles rather than light or single particles.
Mate 280 characterization of powders and porous materialsSami Ali
Particle size, surface area, and porosity are important characteristics that control many properties of materials. Particle size can be measured using techniques like sieving, sedimentation, light scattering, and gas adsorption which measure different parameters like size, surface area, or settling rate depending on the technique. Gas adsorption is commonly used to measure specific surface area and porosity by adsorbing gas molecules on the internal surface of porous materials.
UV-Visible spectroscopy involves absorption of ultraviolet or visible light by molecules. This absorption causes electrons to move to higher energy molecular orbitals. The Beer-Lambert law states that absorbance is directly proportional to concentration and path length. Deviations from Beer-Lambert law can occur at high concentrations due to interactions between molecules, or if non-monochromatic light is used. UV-Visible spectroscopy is used to study electronic transitions and structure of molecules.
Laser Physics Department -ALNeelain University 5 thGazy Khatmi
The document discusses a new approach for laser surgery and cancer treatment using COMSOL Multiphysics simulation software. Physicians would be able to specify various parameters like tissue type, tumor size, laser properties, and treatment time to simulate scenarios. COMSOL would then be developed into an app for physicians to access and run simulations remotely on their laptops or smartphones. This would allow physicians to interactively plan laser procedures digitally before performing treatments.
Modeling ultrasonic attenuation coefficient and comparative study with the pr...IOSR Journals
Many phenomena can be responsible for the attenuation of sound through the suspensions depending on the nature of the particles of the fluid and the frequency range of interest. In particular we can make a distinction between the diffusion mechanisms corresponding to a geometric redirection of the incident wave and the dissipative phenomena, like the thermal and viscous losses. In this work, we are interested in propagation of the ultrasonic waves into suspensions of clay rigid particles with a size between 1 and 50 microns, for which the thermal phenomena and visco-inertial dominate. In this case the dipole diffusion of the wave induced differential motion between the dispersed phase (clay grain) and the continuous phase (distilled water) is coupled to the viscous dissipation in the matching motion of this brake. In this paper, we present the main theories known in calculating the ultrasonic attenuation and velocity coefficient. Such theories permit to take accounts all the orders of interaction, unlike the theoretical of multiple diffusion that remains limited to lower concentrations. Finally, the results calculated by the principal theories will be compared against earlier experimental results obtained from this work.
UV-visible spectroscopy is a fast analytical technique that measures the absorbance or transmittance of light. Although the UV wavelength ranges from 100–380 nm and the visible component goes up to 800 nm, most of the spectrophotometers have a working wavelength range between 200–1100 nm.
The practical range for UV-vis spectroscopy varies from 200–800 nm; above 800 nm is infrared, while below 200 nm is known as vacuum UV. The ability of matter to absorb and to emit light is what defines its color and the human eye is capable of differentiating up to 10 million unique colors. Light passes through media (transmission), reflects off both opaque and transparent surfaces, and is refracted by crystals. Covalently unsaturated compounds with electronic transition energy differences equivalent to the energy of the UV-visible light absorb at specific wavelengths. These compounds are known as chromophores and are responsible for their color. Covalently saturated groups that do not absorb UV-visible electromagnetic radiation but affect the absorption of chromophore groups are called auxochromes. When UV-vis radiation hits chromophores, electrons in the ground state jump to an excited state, which we refer to as electron-excitation, while auxochromes are electron-donating and have the capacity to affect the color of choromophores while they do not change color themselves. Water and alcohols are mostly transparent and do not absorb in the UV-vis range and so are excellent mediums for UV-visible spectroscopy. Acetone and dimethylformamide (DMF) are good solvents for compounds insoluble in water and alcohol, but they absorb light below 320 and 275 nm, respectively, so are appropriate only above these cut-off wavelengths.
By tracking the Brownian trajectory of a sphere of 1 p,m radius in a suspension of 35 nm radius
beads, we probe the depth of the entropic potential experienced by a large sphere close to the cell
wall. This potential is caused by the pressure exerted by the Quid of small beads when they cannot fit
in the gap between the large bead and the wall. We find that the potential depth is of order kT. Its
dependence on the volume fraction of small spheres is significantly overestimated by a theory which
treats the small beads as an ideal gas.
- Molecular absorption spectroscopy measures the transmittance (T) or absorbance (A) of solutions in transparent cells to quantify inorganic, organic, and biological species.
- Beer's law states that absorbance is linearly proportional to concentration, expressed as A= εbc, where ε is the molar absorptivity, b is the path length, and c is the concentration.
- However, deviations from Beer's law can occur at high concentrations due to solute-solute interactions altering absorptivity, or due to changes in refractive index with concentration.
This seminal experiment addresses the issue of the generalization of Fick’s Law in the case of a spatially inhomogeneous diffusion coefficient. In Finance this is akin to the problem of a volatility dependent on the price of the underlying asset. We demonstrate deviation from the Stokes-Einstein law. In particular this relates to the Ito versus Stratonovitch controversy in stochastic calculus.
Estimation Of Vitamin Content In Fruit Juices By Ultrasonic Techniqueinventionjournals
ABSTRACT : Fruits are more essential and have many health benifits. Fruits has vitaminewihch is made up of an organic compound. Vitamin must be through diet. Vitamin C is required for the properdevelopment& function of many parts of the body . It also plays an important role in maintaining proper immune function. In this research the Selected fruits are apple and orange and they have Vitamin ‘C’. Estimation of Vitamin content have been done by studying Ultrasonic Velocity, Viscosity, Density and adiabatic Compressibility. Further the experimental values are confirmed by FTIR.
This document summarizes a study examining the Casimir force between two parallel plates confining a biomembrane. The researchers first develop a field theory model to describe the interactions of the confined biomembrane, which depends on the bending rigidity of the membrane and an elastic constant related to the plate separation. They then use this model to calculate the static and dynamic Casimir forces. They find that the static force decays with plate separation as D-3 and is significant for membranes with low bending rigidity. The dynamic force and membrane roughness are also calculated, finding both increase as power laws of time until equilibrium is reached. Hydrodynamic interactions are shown to increase the growth rates.
A spectrophotometer measures the amount of light that passes through a solution, allowing quantification of light absorption. It works by focusing a light source through the solution and measuring the intensity of the transmitted light. Spectrophotometers are used to precisely measure absorbance, which is related to analyte concentration according to Beer's Law. They contain components that focus light, select wavelengths, hold samples, and detect transmitted light intensities.
The enhancement of sub-barrier fusion has been interpreted due to coupling between the relative motion and other degrees of freedom. The coupling gives rise to the distribution of fusion barriers and passage over the lowest barrier which is responsible for fusion enhancement at energies below the barrier. There are several orders of magnitude could be considered due to the tunneling through the barrier. The barrier height could be deduced from the measured cross section data for different energies, as well as using many empirical forms for incomplete and complete fusion of two massive nuclei. Firstly, we present a formula for barrier height (ODEFF) and check, over wide ranges of interacting pairs the percentage agreement with those calculated or measured values for all pairs within ZP ZT ≤ 3000. Secondly, the more recently measured excitation functions are studied using four models of nuclear forces, indicating that most of them can be used for wide energy range while the others failed to do so .We refer this notice to the theory deducing the model . For this, the 14 undertaken pairs recover the range18 ≤ ZP ZT ≤ 1320
Dynamic light scattering can be used to measure the diffusion of small particles undergoing Brownian motion. An experiment is described that uses a laser, sample cell containing diffusing particles, lenses, photodetector, and photon correlator. The photodetector records the scattered light as pulses, which are clustered for moving particles due to the Doppler effect. The photon correlator measures the intensity correlation function over time to determine the decay time of fluctuations, which relates to particle size and diffusion coefficient according to equations presented. Dynamic light scattering is a powerful technique for studying phenomena involving fluctuations at the microscopic scale.
Life Expectancy Estimate with Bivariate Weibull Distribution using Archimedea...CSCJournals
Archimedean copulas are used to construct bivariate Weibull distributions. Co-movement structures of variables are analyzed through the copulas, where the tail dependence between the variables is explored with more flexibility. Based on the distance between the copula distribution and its empirical version, a copula that may best fit data is selected. With extra computing costs, the adequacy of the copula chosen is then assessed. When multiple myeloma data are considered, it is found that relationship between survival time of a patient and the hemoglobin level is well described by the Clayton copula. The bivariate Weibull distribution constructed by the copula is used to estimate value at risk from which we investigate the anticipated longest life expectancy of a patient with the disease over the treatment period.
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Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
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তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
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বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
Mottin panasenko-2011-journal plos-one_0014350
1. Multiscale Modeling of Light Absorption in Tissues:
Limitations of Classical Homogenization Approach
Stephane Mottin1*, Grigory Panasenko2*, S. Sivaji Ganesh3
1 CNRS, University of Lyon, University of Saint-Etienne, UMR5516, Saint-Etienne, France, 2 University of Lyon, University of Saint-Etienne, LAMUSE, Saint-Etienne, France,
3 IIT Bombay, Powai, Mumbai, India
Abstract
In biophotonics, the light absorption in a tissue is usually modeled by the Helmholtz equation with two constant
parameters, the scattering coefficient and the absorption coefficient. This classic approximation of ‘‘haemoglobin diluted
everywhere’’ (constant absorption coefficient) corresponds to the classical homogenization approach. The paper discusses
the limitations of this approach. The scattering coefficient is supposed to be constant (equal to one) while the absorption
coefficient is equal to zero everywhere except for a periodic set of thin parallel strips simulating the blood vessels, where it
is a large parameter v: The problem contains two other parameters which are small: E , the ratio of the distance between the
axes of vessels to the characteristic macroscopic size, and d, the ratio of the thickness of thin vessels and the period. We
construct asymptotic expansion in two cases: E ?0, v??, d?0,vd??, E 2 vd?0: and E ?0, v??, d?0,E 2 vd2 ??, and
prove that in the first case the classical homogenization (averaging) of the differential equation is true while in the second
case it is wrong. This result may be applied in the biomedical optics, for instance, in the modeling of the skin and cosmetics.
Citation: Mottin S, Panasenko G, Ganesh SS (2010) Multiscale Modeling of Light Absorption in Tissues: Limitations of Classical Homogenization Approach. PLoS
ONE 5(12): e14350. doi:10.1371/journal.pone.0014350
Editor: Giuseppe Chirico, University of Milano-Bicocca, Italy
Received December 2, 2009; Accepted October 4, 2010; Published December 31, 2010
Copyright: ß 2010 Mottin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: The results were supported by the Program Emergence of the Region Rhone-Alpes. The theoretical part was supported by the CNRS postdoctoral grant
and by the grant of the Russian Federal Agency on Research and Innovations Contract No 02.740.11.5091 ‘‘Multiscale Models in Physics, Biology and Technologies:
Asymptotic and Numerical Analysis’’. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
* E-mail: mottin@univ-st-etienne.fr (SM); grigory.panasenko@univ-st-etienne.fr (GP)
Introduction This distance is also used in 3D simulation of tumor growth and
angiogenesis [2]. Assume at the first approximation that the tissue
Physical background of the problem is a nearly periodic structure. Moreover, consider the two-
In the present paper we consider the Helmholtz equation with dimensional idealization of this periodic structure that is, the
rapidly oscillating large potential with a periodic support having a periodic set of the parallel strait narrow identic vessels separated
small measure of its intersection with a period. This absorption by the homogeneous tissue. Let L be the macroscopic character-
coefficient q of the potential (more precisely, it is the ratio between istic size and let E L be the distance between two neighboring
the absorption coefficient and the diffusion coefficient) depends on vessels (strips). It means that the parameter E stands here for the
three small parameters: E is a standard homogenization parameter ratio of the distance between two neighboring vessels and the
that is the ratio of the period of the potential and the characteristic characteristic macroscopic size L. It is assumed throughout that
macroscopic size; d is the ratio between the measure of the this ratio is a small parameter. Indeed, if the characteristic
intersection of the support of q and the period; v{1 is a small macroscopic size (L) is equal to 10 mm (it is a typical value of the
parameter standing for the inverse of the ratio of the maximal diffuse optical tomography [3]) and the distance between the
value of the coefficient q and the diffusion coefficient multiplied by vessels is equal to 0.18 mm, then E ~0:018. The second parameter
the square of the characteristic macroscopic size of the problem of the model is the ratio of the thickness of the vessels and the
(we will consider the case when q takes only two values: v and 0). distance between neighboring vessels denoted d. This d as well is
The Helmholtz equation supposed to be a small parameter. Thus, in the discussed above
structure we have d~15=180~0:08333 . . .. In the spectral
x window 500 nm–700 nm, the oxyhaemoglobin extinction coeffi-
1
{D uE ,d,v zq uE ,d,v ~f : ð1Þ cient shows a wide dynamic from 275 (mole/L){1 cm{1 at
E
690 nm (the lowest) and 55 500 (mole/L){1 cm{1 at 575 nm [4].
is considered below as a model of the light absorption in tissues In order to quantify the maximum variation we compare arterial
under hypothesis that this absorption takes place only in the set of blood (90 percent saturated) with pure water at 690 nm and
parallel thin blood vessels (where q~v=0) and this absorption is 575 nm then the ratio of the absorption coefficient is respectively
ignored outside of these vessels. 300 and 400000. At 700 nm the absorption of tissue (without
The linear dimensions of the vessels are much smaller than the blood) is about ten times less than that of the pure water [5]. In the
linear dimensions of the body as a whole. Typically the distance visible window the maximum of this ratio can be more than
between two neighboring large micro-vessels (of about 15 mm in 10000. That is why in the idealized model we consider the case
the diameter) is around 180 mm in primate cerebral cortex [1]. when the absorption coefficient is equal to zero out of vessels. As
PLoS ONE | www.plosone.org 1 December 2010 | Volume 5 | Issue 12 | e14350
2. Modeling of Light Absorption
we have mentioned above the light absorption process is described
here by the Helmholtz equation (1), where q is just non-
ðBÞ E ?0, v??, d?0,E 2 vd2 ??:
dimensionalized absorption coefficient, equal to zero out of vessels
and equal to the great (dimensionless) parameter v within the
vessels. Let us remind that the physical sense of this great It means that the ‘‘diluting’’ of vessels in multiscale modeling of
parameter is the ratio of the absorption and diffusion effects, more light absorption of tissues may be applied only in justified cases, in
exactly, the ratio of the absorption coefficient and the diffusion particular, in case A. In fact, the situations when the coefficients of
coefficient multiplied (i.e. the ratio is multiplied) by the square of equations depend on two or more small parameters and it leads to
the characteristic macroscopic size L. Let the haemoglobin a fail of classical homogenization are not too surprising now: first
concentration be 150 g/liter. Then in order to convert the molar results of this type could be found in [15–17]. For some cases the
extinction coefficient E to the absorption coefficient (in mm{1 ), non-classical asymptotic expansions were constructed. However,
one has to multiply it by 0.00054. At the wavelength 575 nm for to our knowledge, such examples have not been constructed for
the scattering coefficient close to 2.5 mm{1 , v is about 23000. rapidly oscillating large potentials with narrow support. The
Then E 2 vd~0:62 and E 2 vd2 ~0:05: In the case of penetrating present paper tries to contribute in this important case of
vessels with the average diameter close to 65 mm, at the same biophysical applications.
wavelength, E 2 vd2 ~1. Then the case when E 2 vd2 is greater than In order to simplify technical details of the analysis we consider
one can be found in a spectral window below 600 nm and for the boundary value problem for the Helmholtz equation set in a
vessels of large diameter. In neurophotonics, the highly vascular- layer f0vx1 v1,x2 [Rg with the Dirichlet conditions on the
ized pie-matter correspond to the maximal values of E 2 vd2 . The boundary of the layer; we assume that the right-hand sides of the
highly vascularized tumors could be also a special case when equation and of the boundary condition do not depend on x2 . In
E 2 vd2 is very high. this case we may seek a solution independent of x2 as well. The
Models of this ‘‘composite medium’’ are widely considered in Helmholtz equation takes the following form:
biophysics. Let us give a short review of these results. The partial
differential equation (PDE) diffusion with absorption is one of the x
most important in life science, and in particular, in tissue optics {u00,d,v zq
E uE ,d,v ~f (x), ð3Þ
E
[6]. The researchers are interested in two types of results:
where x stands for x1 , E is a small positive parameter, such that,
a) when the optical properties are unknown, and they want to 1=E is an integer.
find them using observed measurements, it is the harder well- We consider a boundary condition corresponding to a constant
known inverse problem. solution in the case of the constant absorption coefficient q~v
b) when the optical properties are known, then they can use and of a constant right-hand side f ~1. Then uE ,d,v ~1=v. So,
many strategies to calculate various quantities of interest these boundary conditions are:
(reflectance, transmission, fluence). This is often referred to as
the forward problem. 1
uE ,d,v (0)~uE ,d,v (1)~ ð4Þ
But in all these approaches, the community of research in v
biophotonics uses the volumetric averaging of the absorption
coefficient. This problem is crucial in the domain of in vivo diffuse Similar problems were addressed by many authors [18–22];
optical tomography [3,7], and is always present in in vivo optical however the potentials considered in these works are typically E {1
neuromethods [8]. or E {2 . In this work, there are three parameters and we study all
There are as well some experimental papers on the problem of relevant asymptotic regimes. We follow the ideas and methods of
averaging of blood absorption of light in tissue but without the [15–17,23,24] in the sense that we construct asymptotic expan-
homogenization theory [9–14]. sions for uE and analyze all the important asymptotic regimes of
Our goal in the present paper is to show that the classical the parameters E , v, d.
homogenization (averaging) approach to the solution of Mention that the Helmholtz equation (1) (or (3)) is not a perfect
equation (1) leading to the approximation model for the light absorption process: it is not more than an
approximation of a more adequate model based on the radiation
transfer equation [25]. Indeed, one can introduce the average
{D u0 zvqw u0 ~f : ð2Þ
(over all directions v) for the diffused radiation intensity I(x,v) :
where vqw is often approximated to the volumic mean value of ð
q, has some limitations. Indeed, we will show that it is right for 1
u(x)~ I(x,v)dv:
some combination of magnitudes of parameters E ,d,v: it can be 4p
proved that uE ,d,v ?u0 but it is inapplicable for some other
combinations. In this paper we do not construct the expansions for
all possible combinations; we only prove the classical homogeni- In the case of the described above plane geometry the diffusion
zation result in the case approximation of the radiation transfer has a form [25]
ðAÞ E ?0, v??, d?0,vd??, E 2 vd?0, d 1 du
{ z[(x1 )u(x1 )
À Ác dx1 3([(x1 )zs(x1 )) dx1
and there exists cw0,such that, v E 2 vd ~Oð1Þ,
~[(x1 )g(x1 )zs(x1 )f (x1 ), x1 [(0,L),
and we show that the homogeneous model (2) is inapplicable in the where [(x1 ) and s(x1 ) are the coefficients corresponding to the
case light absorption and dispersion respectively, g is the blood heat
PLoS ONE | www.plosone.org 2 December 2010 | Volume 5 | Issue 12 | e14350
3. Modeling of Light Absorption
radiation intensity and f is the external radiation intensity, L is the
1 x
thickness of the irradiated skin strip, is the dimension factor. LE uE ,d,v :{u00,d,v zq
E uE ,d,v ~f (x) in V, ð6Þ
3 E
Introducing the new variable corresponding to the relative optical
depth of the radiation process
1
Ð x1 uE ,d,v (0)~uE ,d,v (1)~ on LV: ð7Þ
[(y)zs(y)dy v
X ~X (x1 )~ Ð0L ,
0 [(y)zs(y)dy Note that we have the following a priori estimate for solution of
equation (6) with boundary condition (7) replaced by the
we get for U(X ) (here U(X (x1 ))~u(x1 )): homogeneous one
[A2 [A2 uE ,d,v (0)~uE ,d,v (1)~0:
{U 00 (X )z U(X )~ (g{f )zA2 f , X [(0,1),
[zs [zs
Ð 2 Proposition 0.1. There exists a constant C independent of small
L
where A2 ~3 0 ([(y)zs(y)dy , and functions [,s,g,f depend parameters such that
on x1 (X ), solution of equation
kuE ,d,v kH 1 (V) ƒC k f kL2 (V) :
Ð x1 0
[(y)zs(y)dy
Ð0L ~X : Here C may be taken equal to 1=2. A well-known imbedding
0 [(y)zs(y)dy
theorem gives:
Corollary 0.1. There exists a constant C independent of small
Making the change of unknown function parameters such that
U ~A{2 (U{gzf ) kuE ,d,v kL? (V) ƒC k f kL2 (V) :
we get finally equation (3): Applying equation, we get:
Corollary 0.2. There exists a constant C independent of small
parameters such that
{U 00 zqU ~f ,
X [(0,1)
00
u
A2 [ E ,d,v L? (V) ƒC(1zv) k f kL? (V) :
with q~ :
[zs
The choice of the boundary conditions (4) is not too important
Returning now to equation (6) with non-homogeneous bound-
for our analysis: the asymptotic approach developed below can be
ary condition (7) we can present the solution as a sum of the
applied in the case of other conditions, for instance,
solution of equation (6) with homogeneous boundary condition
and the solution of the homogeneous equation (6) with non-
1 homogeneous boundary condition (7). Applying the maximum
uE ,d,v (0)~uE ,d,v (1)~ ,
vd principle argument, we get:
corresponding to a constant solution for equation (3) with q Proposition 0.2. There exists a constant C independent of small
replaced by its volumic mean vqw, or parameters such that solution of problem (6)-(7) satisfies:
1
uE ,d,v (0)~uE ,d,v (1)~0, kuE ,d,v kL? (V) ƒC k f kL2 (V) z :
v
or the periodicity conditions (mention that the diffusion approx-
imation of the radiation transfer may loose its precision near the Remark 0.1. If boundary condition (7) is replaced by another
boundary). one:
Mathematical statement of the problem uE ,d,v (0)~A, uE ,d,v (1)~B
Consider interval V~½0,1Š and let 0vdv1=2: Let q(:) be a 1-
periodic function defined on the basic period ½0,1Š by with some numbers A and B then the estimate of Proposition 0.2
takes form:
8
d d
v if y[(0, )|(1{ ,1) kuE ,d,v kL? (V) ƒC (k f kL2 (V) zjAjzjBj):
q(y) :~ 2 2 ð5Þ
:
0 otherwise:
Let us mention one more useful inequality for functions v of
Let f be smooth enough (this assertion will be formulated more C 2 ð½0,l ŠÞ :
precisely later). We are interested in studying the asymptotic
behaviour as E ?0, v??, and d?0 of uE ,d,v solving the following 2
boundary value problem: kv0 kL? ð½0,l ŠÞ ƒ kvkL? ð½0,l ŠÞ zl kv00 kL? ð½0,l ŠÞ ð8Þ
l
PLoS ONE | www.plosone.org 3 December 2010 | Volume 5 | Issue 12 | e14350
4. Modeling of Light Absorption
Ðx
Proof: For any x,x0 [½0,lŠ, v0 (x){v0 (x0 )~ x0 v00 (t)dt: Choose x0
such that jv0 (x0 )j~ minx[½0,lŠ jv0 (x)j: We get: d 2 Nlp p
dNl{1
(j1 )z2 (j)zNl{2 (j){q(j) Nlp{2 (j)~hp
p
l ð15Þ
dj2 dj
0 0 00
jv (x)jƒjv (x0 )jzl max jv j:
x[½0,lŠ
are chosen to be of average zero for all p and l such that,
If v0 (x0 )~0, then the estimate is proved. If v0 (x0 )=0, then the sign (p,l)=(0,0); N0 is chosen equal to 1. We get: N0 ~1, Nl0 ~0,
0 0
of v0 is constant on the whole interval Ð ½0,lŠ; consider the case v0 w0: 1 2
Nl ~0 for all l, N0 is a 1-periodic solution of equation
l
Then v is increasing and v(1)~v(0)z 0 v0 (t)dt§v(0)zlv0 (x0 ), and
so,
d 2 N0 2
2
(j1 )~q(j){SqT,
dj
0vv0 (x0 )ƒ(v(1){v(0))=lƒ(2=l)kvkL? ð½0,l ŠÞ
and we get (8). In the same way we consider the opposite case when
v0 v0: SqT~vd:
Methods We solve the family of equations (15) by determining for each
Asymptotic expansion in the case fixed p§0 the solutions Nlp for all l[N. Due to the form of the
equation (15) the behavior of Nl2m and Nl2mz1 will be similar.
E ?0,v??,d?0,vd??,E 2 vd?0
With this background, we now state the principal result
Consider the K-th level approximation uK of uE given by an
E concerning the 1-periodic functions Nlp .
ansatz from [15]:
Lemma 0.1. Let vdw1. For each p§0 (of the form p~2m or
X p~2mz1) and l[N,
uK (x)~
E E lzp Nlp (j)Dl vE (x) x , ð9Þ
0ƒl,pƒKz1:0ƒlzpƒKz1 j~ 1. Functions Nlp are piecewise polynomials on ½0, 1Š with respect to the
E '
d d
partition 0, ,1{ ,1 .
dl 2 2
where Nlp (:) are 1-periodic functions, Dl ~ , and vE is a smooth
dxl 2. There exists a constant Cm
independent of the small parameters such that,
function which will be sought in a form
for jaj~0,1, Da Nlp ? ƒCl,m (vd)m , Dj ~d=dj, and
j
L ½0 1Š
hp ƒCl,m (vd)m .
l
X
Kz1
vE (x)~ E r vr (x) : ð10Þ Proof. The proof is by induction on m.
r~0 0
Step (i). Let m~0. That is, p~0,1. We get: N0 ~1,
Substituting the expression for uK from (9) in (6) we obtain hp ~SNl{2 (j)T~dl,2 dp,0 , Nlp satisfy equations (15) with the last
l
p
E
two terms equal to zero; so Nl0 ~0, for all lw0, Nl1 ~0 for all l§0
and the assertion of lemma for m~0 is evident.
x X
K z1
Step (ii). Let m§1 and let all Nlp , Dj Nlp and hp with
{D2 uK zq uK ~{ E lzp{2 Hlp Dl vE (x)zBE ,K ð11Þ l
E
E E
lzp~0
1 pƒ2mz1 be bounded by cl,m (vd)½p=2Š , where ½aŠ stands for the
integer part of a, and cl,m is a constant independent of the small
where parameters. Consider equation (15) for p~2mz2. For l~0 it
takes form
d 2 Nlp p
dNl{1
Hlp ~ 2
(j1 )z2 (j)zNl{2 (j){q(j) Nlp{2 (j)
p
ð12Þ 2mz2
d 2 N0
dj dj 2m 2m
(j1 )~q(j)N0 {Sq(j)N0 T,
dj2
and BE ,K is given by
1
( with the piecewise polynomial right hand side; moreover, the
X p
dNl{1
BE ,K ~E K { (j)zNl{2 (j){q(j)Nlp{2 (j) Dl vE (x){
2 p primitive (with vanishing mean value) of this right hand side is also
1
pzl~Kz2
dj bounded by the same order. That is why, integrating this equation
) ð13Þ
ð13Þ twice and keeping every time the vanishing mean for the primitive,
X
p p{2
{ l
E Nl{2 (j){q(j)Nl (j) D vE (x) : we prove the assertion of lemma for l~0. In the same way we
2mz3
pzl~Kz3 prove it for N0 .
Now we apply again (15), express D2 Nlp from this equation and
j
In writing expressions (11), (12) we followed the convention that
Nlp ~0 if at least one of the two indices p or l, is negative. prove by induction on l that all h2mz2 , h2mz3 , the right hand sides
l l
We choose Hlp (j) being a constant such that the equation (12) and so, finally, Nl2mz2 and Nl2mz3 are bounded by Cl,mz1 (vd)mz1 .
has a solution, i.e. The lemma is proved.
Substituting the expression for uK from (9) in (7) we obtain
E
hp ~SNl{2 (j){q(j) Nlp{2 (j)T,
l
p
ð14Þ
1 X 1
ð1 uK (0){ ~ E lzp Nlp (0)Dl vE (0){ , ð16Þ
E
where S.T~ .dj: Also, periodic solutions Nlp of equation v 0ƒl,pƒKz1:0ƒlzpƒKz1 v
0
PLoS ONE | www.plosone.org 4 December 2010 | Volume 5 | Issue 12 | e14350
5. Modeling of Light Absorption
X
1 1 1 1 X p
r
uK (1){
E ~ E lzp Nlp Dl vE (1){ ; vr (0)~ dr,0 z Nl (0)Dl vr{l{p (0), ð25Þ
v 0ƒl,pƒKz1:0ƒlzpƒKz1 E v v lzp~1
and applying the 1{periodicity of functions Nlp and the divisibility
of 1 by E we get: 1 X p
r
vr (1)~ dr,0 z Nl (0)Dl vr{l{p (1), ð26Þ
v lzp~1
1 X 1
uK (1){
E ~ E lzp Nlp (0)Dl vE (1){ :ð17Þ
v 0ƒl,pƒKz1:0ƒlzpƒKz1 v Here SqT~dv is supposed to be greater than 1. These equations
have a form
Substituting the expression for vE (10) in (11),(16),(17), we get:
{D2 vr (x)zSqTvr (x)~fr , x[(0,1), vr (0)~ar ,vr (1)~br ,
x
{D2 uK zq( ) uK
E where ar ,br are some real numbers and fr is a smooth function. In
E E
ð18Þ the same way as in the first section we prove that
X
K z1
~{ E lzpzr{2 hp Dl vr (x)zBE ,K zBE ,K
l 1 2
lzpzr~0 kvr kL? (V) ƒC (kfr kL? (V) zjar jzjbr j),
and
00
v ? ƒC(1zvd) (kfr k ? zjar jzjbr j),
r L (V) L (V)
1
uK (0){
E
v ð19Þ and so,
X 1
~ E lzpzr
Nlp (0)Dl vr (0){ E ,K
zB3 , 0
v v 0
r L? (V) ƒC1 (vd) (kfr kL? (V) zjar jzjbr j),v
0ƒl,p,rƒKz1:0ƒlzpzrƒKz1
where the constants C and C1 are independent of small
1 parameters.
uK (1){
E
v ð20Þ Applying the induction on m, we get:
X 1
~ E lzpzr
Nlp (0)Dl vr (1){ E ,K
zB4 : 2m
0ƒl,p,rƒKz1:0ƒlzpzrƒKz1
v D vr ? ƒCm (vd)m (kfr k ? zjar jzjbr j)
L (v) L (v)
X
m{1
z (vd)m{j{1 D2j fr L? (v) ,
Here
j~1
X
BE ,K ~
2 E lzpzr{2 hp Dl vr (x)
l ð21Þ where the constants Cm are independent of small parameters.
0ƒl,p,rƒKz1:Kz2ƒlzpzrƒ2Kz2 Applying now (8), we get: for mw0
2m{1
X D vr L? (v) ƒCm’ (vd)m (kfr kL? (v) zjar jzjbr j)
BE ,K ~
3 E lzpzr
Nlp (0)Dl vr (0), ð22Þ
0ƒl,p,rƒKz1:Kz2ƒlzpzrƒ2Kz2 X
m{1
z (vd)m{j{1 D2j fr L? (v) ,
and j~1
X and so,
BE ,K ~
4 E lzpzr Nlp (0)Dl vr (1): ð23Þ
0ƒl,p,rƒKz1:Kz2ƒlzpzrƒ2Kz2 l
D vr ? ƒCl (vd)½(lz1)=2Š kfr k ? zjar jzjbr j)
L (v) L (v)
Define now functions vr from boundary value problems: ½(lz1)=2Š{1
X
z (vd)½(lz1)=2Š{j{1 D2j fr L? (v) :
j~1
{D2 vr (x)zSqTvr (x)
X
rz2 ð24Þ
~f dr,0 z hp Dl vr{l{pz2 (x), x[(0,1) Remark 0.2. Functions vr depend on small parameters but
l
lzp~3 their asymptotic expansion can be constructed by classical
boundary layer technique (see [23]). For instance, if
and f [C 2K1 (½0,1Š), then v0 has a form:
PLoS ONE | www.plosone.org 5 December 2010 | Volume 5 | Issue 12 | e14350
6. Modeling of Light Absorption
The expansion of vr has a similar form of a linear combination
1 1 pffiffiffiffi
ffi with bounded coefficients of functions
{x vd
v0 (x)~ f (x)z ðd{f (0)Þe
vd vd
1 pffiffiffiffi
ffi vrg (x)~
z ðd{f (1)Þe(x{1) vd zO(1 (vd)2 )~
vd 2K1 {1
X pffiffiffiffiffiffi pffiffiffiffiffiffi
1
1 1 pffiffiffiffiffi U0r,j ({x vd)zU1r,j (x{1) vd zur,j (x) zRr (x),
~ f (x)z ðd{f (0)Þe{x vd j~0 (vd)(jz2{r)=2
vd vd
1 pffiffiffiffi
ffi where ur,j satisfy equations (functions with the negative indices are
z ðd{f (1)Þe(x{1) vd z
vd equal to zero)
X 1
K1 {1 pffiffiffiffi
ffi pffiffiffiffi
ffi
z D2j f (x){D2j f (0)e{x vd {D2j f (1)e(x{1) vd
jz1 ur,j (x)~Fr,j{2 (x){D2 ur,j{2 (x),
j~1 (vd)
À Á
zR0 (x), R0 (x)~O 1 (vd)K1 : and exponentially decaying at infinity functions U0r,j satisfy
equations
{D2 U0r,j zU0r,j ~F0r,j{2 (j), j[(0,?),
Moreover, if f [C 2K1 zK2 (½0,1Š), then R0 is K2 times differentia- j
ble and satisfies the estimate (see the above a priori estimate for vr ):
and boundary conditions
l .
D R0 ? ~O 1 (vd)K1 {(lz1)=2 , lƒK2 :
L (½0,1Š) U0r,j (0)~{ur,j (1),
exponentially decaying at infinity functions U1r,j satisfy equations
In the same way we construct by induction the expansions of
functions vr , rƒKz1. Assume that K1 §2K, K2 §Kz1.
{D2 U1r,j zU1r,j ~F1r,j{2 (j), j[({?,0),
j
Consider the right hand side fr having the form of a linear
.
combination with some bounded coefficients hp (vd)½p=2Š of
l and boundary conditions
functions g having a form:
U1r,j (0)~{ur,j (0)
g(x)~
2K1 {1
X 1 pffiffiffiffiffiffi pffiffiffiffiffiffi and of the exponents
~
F0r,j {x vd zF1r,j (x{1) vd zFr,j (x) zRr (x)
(j{r)=2
j~0 (vd)
2K1 {1 pffiffiffiffi
ffi
X 1
where F0r,j ,F1r,j ,Fr,j are 2K1 zK2 {r times differentiable functions (jz2{r)=2
ar,j e{xvd
,
j~0 (vd)
independent of small parameters vd and E , such that, there exist
constants c1 ,c2 independent of small parameters satisfying for any
real j inequalities 2K1 {1
X 1 pffiffiffiffi
ffi
l b e(x{1)
(jz2{r)=2 r,j
vd
:
D F0r,j (j)ƒc1 e{c2 jjj ,Dl F0r,j (j)ƒc1 e{c2 jjj , lƒK2 {l, j~0 (vd)
j j
Here
Fr,j are K1 zK2 {r times differentiable on ½0,1Š,
l .
. D Rr ? ~O 1 (vd)K1 {(rzlz1)=2 , lƒK2 {r:
l L (½0,1Š)
D Rr ?
~ ~O 1 (vd)K1 {(rzlz1)=2 , lƒK2 {l:
L (½0,1Š)
Applying the induction on r, the explicit expressions for the
The right hand sides of the boundary conditions as well have a right hand sides of the problems (24),(25),(26) for vr and the
.
similar form: they are some linear combinations with bounded estimates of Lemma 0.1 we prove that there exist constants Cl,r
coefficients Nlp (0) (vd)½p=2Š of constants s and t having a form: independent of small parameters, such that,
l
2K1 {1
X D vr ƒCl,r (vd)(lzr)=2{1 : ð27Þ
1 L? (v)
s~ a ,
(jz2{r)=2 r,j
j~0 (vd)
This estimate and Lemma 0.1 are crucial for evaluation of the
discrepancies B1 ,B2 ,B3 and B4 :
2K1 {1
X 1
t~ br,j ,
j~0 (vd)(jz2{r)=2 EBE ,K EL? (v) ƒCK v(E 2 vd)K=2 (vd){1=2 , a~1,2,
a
ð28Þ
E ,K
where ar,j ,br,j are independent of small parameters. Bb ƒCK (E 2 vd)(Kz1)=2 (vd){1 , a~3,4:
PLoS ONE | www.plosone.org 6 December 2010 | Volume 5 | Issue 12 | e14350
7. Modeling of Light Absorption
Now, applying the a priori estimate of the Remark after previous section. In particular, the solution of the problem is
Proposition 0.2 we get the estimate different from the behavior of the solution v0 of the homogenized
equation. For the sake of simplicity consider the right hand side
f (x)~1. Consider an auxiliary function g defined on the interval
uE ,d,v {uK ~O v(E 2 vd)K=2 (vd){1 :
E L? (½0,1Š) ½{1,1Š as a function from C 2 (½{1,1Š) independent of small
parameters such that it equals to zero on the interval ½{1=3,1=3Š
Assume that there exists a positive real c such that, v(E 2 vd)c is and it equals to one on ½{1,{2=3Š|½2=3,1Š. Let us keep the same
bounded by a constant independent of small parameters. Then the notation g for the 2-periodic extension of this function on R.
last bound yields: Consider an approximation for uE ,d,v having a form:
8 !
uE ,d,v {uK ? 2 K=2{c
(vd){1 : 1 d Ed 1 Ed Ed
E L (½0,1Š) ~O (E vd) {
x{ x{E z zCz if x[ ,E {
2
2 2 v 2 2
E d pffiffiffi !
x{ v 2x 1 Ed
Taking K1 w2czK, we get: u(x)~ Ce 2 g z if x[ 0, ð29Þ
Ed v 2
E d pffiffiffi !
K
{xzE { v 2(x{E ) 1 Ed
uE ,d,v {uE 1 ~O (E 2 vd)K1 =2{c ~O (E 2 vd)K=2 (vd){1 : Ce
: 2 g z if x[ E { ,E
L? (½0,1Š) Ed v 2
pffiffiffiffi
where C~E (1{d)=(2 v) and extend it E {periodically to ½0,1Š.
On the other hand, (27) and Lemma 0.1 give: By a simple calculation we find that u satisfies the boundary
conditions exactly and the equation with a discrepancy of order
pffiffiffiffi pffiffiffi v pffiffiffi
K1 (E d){1 ve{E d v=6 , i.e. pffiffiffiffi e{E d v=6 . Assume that there exists
uE {uK{1
E ~O (E 2 vd)K=2 (vd){1 :
L? (½0,1Š) vE d pffiffiffiffi
a positive real c suchffiffiffithat, v~Oð(E vd)c Þ. Then for any positive
pffiffiffiffi {E d v=6
p
K, (E d){1 ve ~O(v{K ).
So, from the triangle inequality we get
So, the discrepancy of the equation is O(v{K ): Applying now
Corollary 1.1, we get an error estimate in L? {norm of the same
uE ,d,v {uK{1 ~O (E 2 vd)K=2 (vd){1 : order:
E L? (½0,1Š)
Theorem 0.1. Assume that there exists a positive real c such that, ku{uE ,d,v kL? (½0,1Š) ~O(v{K ):
v(E 2 vd)c is bounded by a constant independent of small parameters. Let f
belong to C 3(2czKz1) (½0,1Š). Then there exists a constant C independent of
small parameters such that Mention that for Kw1 the right hand side of this bound is
much smaller than the values of approximation u(x), and so the
relative error of the approximation of the exact solution uE ,d,v by u
uE ,d,v {uK{1 ? ~C(E 2 vd)K=2 (vd){1 :
E L (½0,1Š) is small.
Results and Discussion
Consider now the very first term of the expansion v0 and K~0
we get: The main observations on the asymptotic analysis
Corollary 0.3. There exists a constant C independent of small We record some observations in the following remark.
parameters such that Remark 0.4. Let us compare the asymptotic behavior of
solution for f ~1 in the cases
kuE ,d,v {v0 kL? (V) ƒC E 2 :
(A) E ?0, v??, d?0,vd??, E 2 vd?0
Mention that the error of order E 2 is much smaller than v0 that and
1
is of order , and so the relative error of the approximation of the (B) E ?0, v??, d?0,E 2 vd2 ??:
vd
exact solution uE ,d,v by v0 is small.
Remark 0.3. Here we have considered the case when vd
stands for a large parameter tending to the infinity. The case when In the case (A), the leading term is equal to the solution v0 of
vd is a positive finite constant may be considered by a classical the homogenized equation (2), that is the constant 1=(vd) plus
technique [15] and the estimate of Corollary 0.3 becomes two exponents rapidly decaying from the boundary: their
contribution can be neglected at the distance of order of
.pffiffiffiffiffiffi
kuE ,d,v {v0 kL? (V) ƒC E 2 : O (1 vd)ln(vd) vv1. In the case (B) the approximate
solution is completely different: it is E {periodic piecewise
quadratic function of order E 2 except for the small intervals
where the potential is large. That is why the homogeneous model
Asymptotic analysis: case E ?0, v??, d?0, E 2 vd2 ?? (2) is inapplicable in this case.
Here we will construct an example where the behavior of the Thus, the homogenized model (2) may be applied only in the
solution is completely different from the behavior described in the case E ?0, v??, d?0,vd??, E 2 vd?0, when it is justified
PLoS ONE | www.plosone.org 7 December 2010 | Volume 5 | Issue 12 | e14350
8. Modeling of Light Absorption
theoretically. The homogenized model may be inapplicable in the while the solution of equation (6) with boundary condition (7)
case if E 2 vd is not small. rapidly oscillates (see (29)).
This theoretical argument is confirmed by some physical reasons
On the effective absorption coefficient, the volumetric and by experimental observations. Many authors [10,12,14,29] show
mean and the total absorption coefficient that the assumption of a homogeneous distribution of blood in the
Biological tissues are highly heterogeneous media at the tissue may strongly overestimate the total blood absorption when
microscopic scale. For years, the patterns of the mammalian absorption is high and/or the vessels have sufficient diameter. For
cortex micro-angioarchitecture have attracted the interest of many large vessels less of light reaches the center of the vessel, and the
research groups [1,26–28]. At different scales the blood vessels absorbers in the center of a vessel contribute less and less to the total
have very different physical characteristics. Moreover the attenuation of the light. However, the total blood absorption is an
absorption coefficient is great in the vessels and small out of the important qualitative characteristic of the absorption process and so it
vessels in UV and visible parts of the spectrum. At the end they should be calculated with a great precision. Let us apply the above
induce multiscale complex photon propagation and absorption. asymptotic analysis provided for equation (6) with boundary condition
On the other hand the experimental data are obtained mainly at (7) and calculate the total blood absorption in cases A and B. Let us
the macroscopic scale, and so one of the main questions is how to define the total absorption coefficient m as a ratio of the integrals
make a passage from the micro-scale to the macro-scale. The main
mathematical tool of such passage from one scale to another (the Ð1
up-scaling) is the homogenization theory, see [15,19,23,24] and 0 q(x=E )uE ,d,v (x)dx
m~ Ð1 :
0 uE ,d,v (x)dx
the references there. Normally, the microscopic description of the
heterogeneous medium can be replaced by an equation with
constant coefficients. This equation is called the homogenized
equation and the constant coefficients are effective coefficients. For the particular case of a constant coefficient q we get
This homogeneous approximation for the heterogeneous medium evidently m~q. In the case A substituting the leading term of an
is justified if the solutions of both models are close in some norms. asymptotic expansion we get that the asymptotic behavior of m is
In some cases a heterogeneous medium cannot be approximated given by an approximate formula mvqw, i.e. it is close to the
by a homogeneous one [16,17,23,24]. Then the notion of an volumetric mean of q that is, vd. In the case B the value of this
effective coefficient cannot be introduced in the above sense. total absorption coefficient m is much less than the volumetric
In particular, in the present paper we prove that if product mean (that was observed in the discussed above experiments): the
E 2 vd is small then the homogenized model (2) is justified and the direct computations for the ffiffiffiapproximation (29) show that
pffiffiffiffi p ffi
effective absorption coefficient is equal to the volumetric mean mvqw=(0:5E vd) with E vdww1:
value vqw of function q. The smallness of the value of this The authors of papers [10,12,14,29] characterize the fall of the
product E 2 vd means that the relative error of the approximation total absorption coefficient by the correction factor Cd ~m=vqw
of the heterogeneous medium by the homogeneous one is of order and discuss the situations when this factor is different from 1. In
of this product. The effective absorption coefficient is an important our asymptotic analysis we see that in the case A Cd 1 but in the
quantity because the detailed knowledge of the tissue macroscopic case B Cd vv1.
optical properties is essential for an optimization of optical We hope that our result will help to analyze the link between the
methods i.e. for modeling the color of skin, of port-wine stains total absorption coefficient m and other parameters which may be
and for tumor detection; it helps to adapt an appropriate applied in optical tomography [3,7].
photodynamic therapy, in particular, some laser treatment.
On the other hand the present paper shows the limitations of
Acknowledgments
the homogenized models for the absorption problems. Indeed, if
product E 2 vd2 is not small then the homogenized model (2) as well The authors are grateful to Andrey Amosov for fruitful discussions.
as other homogenized models (with other possible constant values
of the effective absorption coefficient) do not approximate the Author Contributions
initial microscale model, because the solution of problem (2) does
Analyzed the data: SM GP SG. Wrote the paper: SM GP SG.
not oscillate for any choice of the effective absorption coefficient,
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