This document discusses the history of prostate cancer screening and the role of PSA testing. It notes that in the pre-screening era, 30-35% of men were diagnosed with bone metastases and 45-50% with nodal disease. PSA testing led to more early-stage diagnoses and declining metastatic disease and mortality rates. However, PSA testing rates have declined in recent years in some countries, which could lead to more advanced cases being detected if screening is not continued in a targeted way to avoid overtesting. The optimal path forward is debated.