Mona Lisa is one of the most famous paintings in the world, created by Leonardo da Vinci between 1503 and 1506. The subject's mysterious smile and expression have intrigued millions and been the topic of much discussion and speculation over the years. The painting is considered a masterpiece due to da Vinci's remarkable ability to depict the figure and landscape with subtle shading and detail. Mona Lisa herself is thought to be the wife of a wealthy merchant from Florence.