molecular hydrogen is a very simple yet never yet commercialized regenerative medicine agent. My patent seeks to create the economic infrastructure to support a broad range of applications based upon a solid base of evidence for efficacy as an anti-aging tool.

1. Molecular Hydrogen
“An idea and pharmaceutical whose time
has come” a food and nutraceutical ….

2. Molecular Hydrogen
“An idea whose time has come”
History
Historical applications:
-Dirigible-until the Hindenberg Incident
-Hydrogenation of oil-until vascular incidents
-Inert and non toxic-useless in biomedical
-Industrial gas for welding, petroleum refining,
and industrial chemical engineering
-No historical medical uses prior to 1976

3. Molecular Hydrogen
“An idea whose time has come”
The paradigm shifts
First hint of useful bio-activity:

4. Molecular Hydrogen
“An idea whose time has come”
Early roadblocks
-Fyfe and Dole publish in AAAS “Science”
-University sees hyperbaric hydrogen as insurance
liability ,“a bomb”, and orders apparatus to be
deconstructed.
-No interest by medical or private industry to put
molecular hydrogen into any product pipeline
-Inertness of molecular hydrogen questioned

5. Molecular Hydrogen
“An idea whose time has come”
Safety to humans established
-Molecular hydrogen finds application in diving gas
mixtures
-Still considered inert and biomedically useless
-Safe long term use established….GRAS

6. Molecular Hydrogen
“An idea whose time has come”
hyperbaric H2 physiological effects

7. Molecular Hydrogen
“An idea whose time has come”
hyperbaric H2- 3 decades after seminal
paper

8. Molecular Hydrogen
“An idea whose time has come”
Hydrogen water
-Spas market special spring waters as therapeutic
-H2 levels at homeopathic levels of 4-6 ppm
-Easily dismissed as a mineral water with an added
placebo effect
-Investigation begins to separate fact from fancy

9. Molecular Hydrogen
“An idea whose time has come”
Fringe medicine publishes data

10. Molecular Hydrogen
“An idea whose time has come”
Explosion of interest begins

11. Fig.?1 Illustration of the generation and scavenging systems of reactive oxygen species (ROS) in mitochondria. Superoxide
radical anions (<ce:glyph name="rad"/> O<ce:inf loc="post"> 2</ce:inf> <ce:sup loc="post"> ?</ce:sup> ) are generated by the...
Shigeo Ohta
Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of
mitochondrial diseases
Biochimica et Biophysica Acta (BBA) - General Subjects Volume 1820, Issue 5 2012 586 - 594
http://dx.doi.org/10.1016/j.bbagen.2011.05.006

39. Molecular Hydrogen
“An idea whose time has come”
Future directions
-Hydrogen water at 4-6ppm has benefits
-Lactulose produces H2 in gut but benefits are
skewed by poor bioavailability and
catabolism by other microflora
-Inhaled H2 poses explosion hazards to
dwellings, requires contracts and specialized
equipment

40. Molecular Hydrogen
“An idea whose time has come”
Future directions
-What if there were a simple way to increase
bioavailabilty with no need for dispensing
equipment or hazards of explosive gases?
-What if the delivery mode was marketable as
food or food supplement that would slowly
diffuse molecular hydrogen into body fluids,
lungs and tissues of all descriptions?

41. Molecular Hydrogen
“An idea whose time has come”
Future directions
INVENTOR :
JOHNSON , MORRIS, F. , whose complete address is of
SW34-01-16-W2, BOX 10, BEAUBIER , SASKATCHEWAN , CELL PHONE 701-240-9411, email
lifespan.pharma.inc@gmail.com CANADA
Method to use a stable foam composed of bubbles of various food/ supplement/ cosmetic/
pharmaceutical substances to increase the bio-availability of otherwise inert molecular hydrogen
gas for medically useful health maintenance , health promotion, anti-aging and generalized disease
process interference purposes in biological living systems in a manner which manages regulatory
and insurance risks and impediments to mass commercialization.

42. Molecular Hydrogen
“An idea whose time has come”
Future directions

43. Molecular Hydrogen
“An idea whose time has come”
Future directions

44. Molecular Hydrogen
“An idea whose time has come”
Future directions
-With the protection of a pending patent would
a modest amount of capital launch products
and be easily scaleable with contract
manufacturing and find distribution
channels?
-Would capital partner invest to expand the IP
package to include beverages and
cosmeceuticals and nutraceuticals?

45. Molecular Hydrogen
“An idea whose time has come”
Future directions
-Proposed manufacturing at Food Centre and POS
pilot plant in Saskatoon , Saskatchewan
-Business offices in Saskatoon and Lake Alma ,
Saskatchewan
-Equity and royalty swap for risk capital.
Morris Johnson, SW34-01-16W2, Box 10
Beaubier, Sk., Canada, 701-240-9411
Lifespan.pharma.inc@gmail.com