1. James Watson and Francis Crick discovered the double helical structure of DNA in 1953. 2. Barbara McClintock discovered mobile genetic elements in maize plants in 1965, which helped establish the concept of jumping genes. 3. Genetic diseases like sickle cell anemia, thalassemia, albinism and Huntington's chorea are caused by defects in genes and result in characteristic symptoms. Protein models help understand protein structure and function.