Modern Disease Trends in Correlation to Glyphosate Application: a 20-Year Perspective in Graphs

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This document contains graphs that show correlations between the rise in use of glyphosate herbicide on various crops like wheat, corn, and soy, and the rise in various diseases between 1990 and 2010. The graphs show correlations between glyphosate use and increased celiac disease diagnosis, autism rates in children, thyroid cancer rates, acute kidney injuries, renal disease deaths, and Parkinson's disease deaths. The document suggests these correlations provide evidence that glyphosate may be linked to the rise of these modern diseases.

Health & Medicine

Modern Disease Trends in Correlation to Glyphosate
Application: a 20-Year Perspective in Graphs

Sources: The Journal of Interdisciplinary Toxicology: (Review Paper) Glyphosate, pathways to modern diseases II: Celiac sprue
and gluten intolerance / Nancy Swanson - http://www.examiner.com/slideshow/gmos-glyphosate-and-neurological-
disorders#slide=2

Celiac Diagnosis
Hospital discharge diagnosis of celiac disease compared
to glyphosate used on wheat from 1990 to 2010.
Source: The Journal of Interdisciplinary Toxicology

Glyphosate Link to Celiac Disease
Illustration of the myriad ways in which glyphosate can be linked to celiac
disease or its associated pathologies.
Source: The Journal of Interdisciplinary Toxicology

Glyphosate Link to Celiac Disease
… Continued
Source: The Journal of Interdisciplinary Toxicology
Illustration of the myriad ways in which glyphosate can be linked to celiac
disease or its associated pathologies.

Glyphosate and Autism
Number of children (6-21 years) with autism plotted against
glyphosate use on corn & soy from 1990 to 2010.
Image Sourced From: Nancy Swanson - http://www.examiner.com/slideshow/
gmos-glyphosate-and-neurological-disorders#slide=2

Deaths Due to Intestinal Infection
Deaths due to intestinal infection compared to glyphosate
applied to wheat (per 1,000 pounds) from 1990 to 2010.
Source: The Journal of Interdisciplinary Toxicology

Thyroid Cancer Rate
Thyroid cancer incidence rate compared to glyphosate
applied to U.S. corn & soy crops – along with percent of
genetically engineered (GMO) corn & soy planted – from
1975 to 2009.
Source: The Journal of Interdisciplinary Toxicology

Acute Kidney Injury
Number of hospitalizations for acute kidney injury
compared to glyphosate applied to corn & soy
from 1990 to 2010.
Source: The Journal of Interdisciplinary Toxicology

Renal Disease Deaths
End stage renal (kidney) disease deaths compared to
percent of genetically engineered (GMO) corn & soy
planted – along with glyphosate applied to corn & soy –
from 1985 to 2010.
Source: The Journal of Interdisciplinary Toxicology

Parkinson’s Disease Deaths
Deaths from Parkinson's disease compared to glyphosate
used on corn & soy – along with the amount of genetically
engineered (GMO) corn & soy planted – from 1979 to 2010.
Source: The Journal of Interdisciplinary Toxicology

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The document presents graphs that correlate the increasing use of glyphosate herbicide with various modern disease trends over the past 20-30 years. It shows correlations between glyphosate used on wheat and the rise of celiac disease diagnoses. It also graphs correlations between glyphosate used on corn and soy with rises in autism, thyroid cancer, kidney injuries, kidney disease deaths, and Parkinson's disease deaths. The sources are from a review paper in The Journal of Interdisciplinary Toxicology and an examiner slideshow on glyphosate and neurological disorders.

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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities. In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions. Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved. Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.

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Cell Therapy Expansion and Challenges in Autoimmune Disease

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Modern Disease Trends in Correlation to Glyphosate Application: a 20-Year Perspective in Graphs

1. Modern Disease Trends in Correlation to Glyphosate Application: a 20-Year Perspective in Graphs Sources: The Journal of Interdisciplinary Toxicology: (Review Paper) Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance / Nancy Swanson - http://www.examiner.com/slideshow/gmos-glyphosate-and-neurological- disorders#slide=2

2. Celiac Diagnosis Hospital discharge diagnosis of celiac disease compared to glyphosate used on wheat from 1990 to 2010. Source: The Journal of Interdisciplinary Toxicology

3. Glyphosate Link to Celiac Disease Illustration of the myriad ways in which glyphosate can be linked to celiac disease or its associated pathologies. Source: The Journal of Interdisciplinary Toxicology

4. Glyphosate Link to Celiac Disease … Continued Source: The Journal of Interdisciplinary Toxicology Illustration of the myriad ways in which glyphosate can be linked to celiac disease or its associated pathologies.

5. Glyphosate and Autism Number of children (6-21 years) with autism plotted against glyphosate use on corn & soy from 1990 to 2010. Image Sourced From: Nancy Swanson - http://www.examiner.com/slideshow/ gmos-glyphosate-and-neurological-disorders#slide=2

6. Deaths Due to Intestinal Infection Deaths due to intestinal infection compared to glyphosate applied to wheat (per 1,000 pounds) from 1990 to 2010. Source: The Journal of Interdisciplinary Toxicology

7. Thyroid Cancer Rate Thyroid cancer incidence rate compared to glyphosate applied to U.S. corn & soy crops – along with percent of genetically engineered (GMO) corn & soy planted – from 1975 to 2009. Source: The Journal of Interdisciplinary Toxicology

8. Acute Kidney Injury Number of hospitalizations for acute kidney injury compared to glyphosate applied to corn & soy from 1990 to 2010. Source: The Journal of Interdisciplinary Toxicology

9. Renal Disease Deaths End stage renal (kidney) disease deaths compared to percent of genetically engineered (GMO) corn & soy planted – along with glyphosate applied to corn & soy – from 1985 to 2010. Source: The Journal of Interdisciplinary Toxicology

10. Parkinson’s Disease Deaths Deaths from Parkinson's disease compared to glyphosate used on corn & soy – along with the amount of genetically engineered (GMO) corn & soy planted – from 1979 to 2010. Source: The Journal of Interdisciplinary Toxicology

11. Do you suspect that you or a loved one is suffering with digestive issues like gluten sensitivity or celiac? Our Nutrition Director, Erica Kasuli, MS, RD, CDN, is available for consultations both in-person and over the phone. Her expertise and culinary creativity will help guide you and your family toward optimal brain and body function using the healing powers of food. Ÿ Find us online: www.amenclinics.com Ÿ Or call us at: 1-888-564-2700

Modern Disease Trends in Correlation to Glyphosate Application: a 20-Year Perspective in Graphs

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