Mobile personal sensing (MPS) uses mobile technologies like smartphones to continuously and unobtrusively collect health data from individuals in their real-world contexts. This allows for innovative approaches to monitoring health behaviors and delivering evidence-based health programs (EBP) on a much larger scale than traditional methods. MPS integrates data on individuals' behaviors, locations, social interactions, and biology to power just-in-time interventions and support for conditions like HIV, diabetes, and other diseases. Open platforms for MPS could help standardize functions across diseases and programs, allowing customized solutions while avoiding redundant development efforts.