This document discusses liquid oral dosage forms, also known as extemporaneous preparations. Liquid oral dosage forms are used for short term treatment of acute conditions lasting 3-7 days. They contain vehicles like water, medicaments for the targeted condition, and other components like preservatives, flavoring agents, and coloring agents. Common vehicles include aromatic waters which also act as flavoring agents. Medicaments are selected based on the condition being treated such as cough suppressants, anti-diarrheal drugs, or expectorants. Chemical stabilizers like ascorbic acid and preservatives like benzoic acid are also included. Specific examples of liquid oral dosage forms provided are for conditions like cough, diarrhea, and rheumatism

1. PRESENTED BY:
L.GOPI B.PHARM
AADHI BHAGAWAN COLLEGE OF
PHARMACY
RANTHAM
GUIDED BY:
K.SHYAMALA M.PHARM.,
ASST PROF OF DEPARTMENT OF
PHARMACEUTICS
AADHI BHAGAWAN COLLEGE OF
PHARMACY
RANTHAM

2. Definition
 Liquid dosage form taken through oral
route.
 Use upto 3-7 days
 Fresh products formulated &
dispenced.
◦ Volume:
 60ml
 120ml
 240ml

3. Short term product:
 To treat acute condition such as:
◦ Cough
◦ Diarrhoea
◦ Constipation
◦ Rheumatism
◦ In-digestion

4. COMPONENTS:
 Vehicles
 Medicaments
 Chemical stabilizer
 Preservative
 Colouring agent
 Flavouring agent

5. VEHICLE:
 Water
 Aromatic water(flavouring agent)
◦ Example:
 Peppermint water
 Cinnamon water
 Camphor water
 Chloroform water

6. MEDICAMENTS:
 Cough supresent drug
 Anti diarrhial drug
 Compound gential infusion(use: a bitter
that stimulate the appitate)
 Orange peal infusion(use:bitter &
carminative)
 Senega infusion (use:expectorant)

7. CHEMICAL STABILIZER:
Antioxidant or chemical
stability
◦ Ascorbic acid
◦ Sodium meta bi sulphite

8. PRESERVATIVE:
 Benzoic acid (0.1%w/v)
 Chloroform (0.25%v/v)

9. COLOURING AGENT:
 No need of colouring agent (maximum
they are coloured)
 If needed FDA approved colouring
agent are used.

10. FLAVOURING AGENT:
 Syrup or glycerol (sweetning agent for
childrens preparation).
 Liquorice liquid extract (to mark the saline
taste of ammonium salt & alkali iodide in cough
mixture).
 Lemon sprit (to cover the taste of alkaline
citrates).
 Orange syrup
 Aromatic water
◦ Ex:
 anise water(use:carminative & flavouring agent)

11. Specific Example:
 Ammonium chloride & morphine
mixture
 Ferric ammonium citrate
 Compound gentain infusion
 Sodium salicylate mixture