UCLA CTSI KL2
Translational Science Award
     Mitchell Wong, MD PhD
      Director, KL2 Program
Award Overview
• Career development support for junior faculty
  within the UCLA CTSI Consortium

• Interdisciplinary, translational science (basic,
  clinical and HSR)

• Similar in structure to K08/K23 award
Support
• Annual award, renewable for up to 3-years
• Support
  – $75k salary plus benefits
  – $25k research support
  – $4k for tuition or coursework
  – $2k for travel
  – $1500 for statistical support in addition to in-kind
    support from DOM Stats
Eligibility
• Doctoral level research degree or professional degree
  (with advanced research training)
• Faculty level title as of July 1, 2013 at a UCLA CTSI
  Institution
• Commit 75% of effort to translational research and
  aims of the KL2 (50% minimum for some specialties
  like surgery)
• U.S. Citizen or non-citizen national, permanent U.S.
  resident
Eligibility (Prior/Pending Grants)
• May have had a small grant (R03, R21)
• May have had prior K12 funding (total K funding cannot
  exceed 5 years)
• Cannot have:
   – Prior or current PI of a NIH R01 or equivalent grant (direct
     costs>$100k per year)
   – Prior or current PI of a K08/K23 award
   – Prior or current PI of a VA Career Development or R01
     Equivalent grant
   – PI of a pending K award application, pending R award in
     similar area
   – Current co-investigator funding on an R01/Project grant
Future Funding for KL2
• KL2 Awardees may apply for K08/K23 or VA CDAs
   – Must relinquish KL2 if awardee receives NIH/VA CDA
   – Total CDA funding (KL2 + individual CDA) cannot exceed 5
     years.

• KL2 Awardees may apply for R01, Program grants
   – Must maintain 75% effort on KL2 in year 1
   – May decrease to 50% effort in last 2 years of K support
Selection Criteria
1. Proposed research- Quality, innovation, significance,
   feasibility, promise for future funding, relevance to
   interdisciplinary, translational research
2. Candidate- Training, productivity, promise
3. Mentor- Track record in mentorship and research,
   commitment to candidate
4. Educational Plan- Well described and planned, fit with
   research plan, provides candidate with new skill set
5. (Environment)- Commitment from institution,
   department/division, availability of support and
   resources to conduct research and educational plan
Application Components
• Letter of intent- Name, mentor, title, biosketch, specific aims
  (to help KL2 selection committee identify appropriate
  reviewers)
• Application (6 pages)- Research, Education and Career Plan
• Mentor’s Letter (2 pages)
• Institutional Letter (2 pages) from department chair or division
  chief
• Letters of support (2 max)
• Candidate’s CV and other support page
• Mentor’s Biosketch
• Budget and budget justification
• References
• Data and Safety Monitoring Plan (when applicable)
• Appendices allowable (e.g. letter of support for use of
  equipment or data)
Timeline
•   Letter of intent deadline February 4, 2013
•   Application deadline February 25, 2013
•   Awardees will be notified in late April 2013
•   Grant start date July 1, 2013
•   Research funds will not be released until IRB
    approval received
Common Pitfalls
• Inadequate education plan that does not tie in
  to research plan
• Lack of clear commitment from
  division/department
• Not in a faculty position by 7/1/2013
Common Questions
• Is start date flexible? No
• Can postdoctoral fellows apply? Yes, if they have a faculty appointment
  no later than 7/1/2013
• Does the mentor need to be at a UCLA CTSI Institution? No, but distance
  mentoring is difficult so if the primary mentor is not local, that may raise
  concern.
• Does the project have to involve direct patient contact? No.
• Ok to have a VA CDA? No.
• Can an applicant have a J1 Visa? No.
• I don’t have my junior faculty appointment yet? Need an appointment by
  7/1/2013. If in process, have the chief or chair indicate in their letter the
  commitment to your faculty appointment by 7/1/2013.

Mitchell Wong, MD, PhD “UCLA CTSI KL2 Award”

  • 1.
    UCLA CTSI KL2 TranslationalScience Award Mitchell Wong, MD PhD Director, KL2 Program
  • 2.
    Award Overview • Careerdevelopment support for junior faculty within the UCLA CTSI Consortium • Interdisciplinary, translational science (basic, clinical and HSR) • Similar in structure to K08/K23 award
  • 3.
    Support • Annual award,renewable for up to 3-years • Support – $75k salary plus benefits – $25k research support – $4k for tuition or coursework – $2k for travel – $1500 for statistical support in addition to in-kind support from DOM Stats
  • 4.
    Eligibility • Doctoral levelresearch degree or professional degree (with advanced research training) • Faculty level title as of July 1, 2013 at a UCLA CTSI Institution • Commit 75% of effort to translational research and aims of the KL2 (50% minimum for some specialties like surgery) • U.S. Citizen or non-citizen national, permanent U.S. resident
  • 5.
    Eligibility (Prior/Pending Grants) •May have had a small grant (R03, R21) • May have had prior K12 funding (total K funding cannot exceed 5 years) • Cannot have: – Prior or current PI of a NIH R01 or equivalent grant (direct costs>$100k per year) – Prior or current PI of a K08/K23 award – Prior or current PI of a VA Career Development or R01 Equivalent grant – PI of a pending K award application, pending R award in similar area – Current co-investigator funding on an R01/Project grant
  • 6.
    Future Funding forKL2 • KL2 Awardees may apply for K08/K23 or VA CDAs – Must relinquish KL2 if awardee receives NIH/VA CDA – Total CDA funding (KL2 + individual CDA) cannot exceed 5 years. • KL2 Awardees may apply for R01, Program grants – Must maintain 75% effort on KL2 in year 1 – May decrease to 50% effort in last 2 years of K support
  • 7.
    Selection Criteria 1. Proposedresearch- Quality, innovation, significance, feasibility, promise for future funding, relevance to interdisciplinary, translational research 2. Candidate- Training, productivity, promise 3. Mentor- Track record in mentorship and research, commitment to candidate 4. Educational Plan- Well described and planned, fit with research plan, provides candidate with new skill set 5. (Environment)- Commitment from institution, department/division, availability of support and resources to conduct research and educational plan
  • 8.
    Application Components • Letterof intent- Name, mentor, title, biosketch, specific aims (to help KL2 selection committee identify appropriate reviewers) • Application (6 pages)- Research, Education and Career Plan • Mentor’s Letter (2 pages) • Institutional Letter (2 pages) from department chair or division chief • Letters of support (2 max) • Candidate’s CV and other support page • Mentor’s Biosketch • Budget and budget justification • References • Data and Safety Monitoring Plan (when applicable) • Appendices allowable (e.g. letter of support for use of equipment or data)
  • 9.
    Timeline • Letter of intent deadline February 4, 2013 • Application deadline February 25, 2013 • Awardees will be notified in late April 2013 • Grant start date July 1, 2013 • Research funds will not be released until IRB approval received
  • 10.
    Common Pitfalls • Inadequateeducation plan that does not tie in to research plan • Lack of clear commitment from division/department • Not in a faculty position by 7/1/2013
  • 11.
    Common Questions • Isstart date flexible? No • Can postdoctoral fellows apply? Yes, if they have a faculty appointment no later than 7/1/2013 • Does the mentor need to be at a UCLA CTSI Institution? No, but distance mentoring is difficult so if the primary mentor is not local, that may raise concern. • Does the project have to involve direct patient contact? No. • Ok to have a VA CDA? No. • Can an applicant have a J1 Visa? No. • I don’t have my junior faculty appointment yet? Need an appointment by 7/1/2013. If in process, have the chief or chair indicate in their letter the commitment to your faculty appointment by 7/1/2013.