This document discusses best practices for deploying mission critical workloads on AWS. It defines mission critical workloads as those that must be secure, available, and resilient. It provides examples of customers like Capital One and News UK successfully running critical applications on AWS infrastructure. The document outlines the security, reliability, performance and scale benefits AWS provides including availability zones, encryption options, and services like CloudTrail and VPC. It argues AWS allows customers to securely run a wide variety of critical applications at a lower cost than traditional data centers.