Construction technology I Topcon machine control I Alaa AbouEleninAlaa AbouElenin
https://www.youtube.com/watch?v=3Khchk678os
construction technology and automation leading change in the construction industry BIM technology 3D machine control systems 2D machine control systems laser leveling and grading mobile mapping 3D scanning drone technology GPS systems Total stations Topcon Leica Trimble Komatsu Caterpillar Volvo Vogele Wirtgen Doosan Hyundai Gomaco Power curbers Ammann Sitech Topcon mmGPS 3DMC smoothride paving grading dozer excavator grader paver ICE institute of civil engineers Dubai Middle East UAE Saudi Arabia Egypt Qatar Oman Bahrain Kuwait Jordan Bentley Autodesk Alaa AbouElenin 3D systems 3D technology Geospatial GIS systems CORS station reference stations geopositioning
https://www.youtube.com/watch?v=3Khchk678os
Construction technology I Topcon machine control I Alaa AbouEleninAlaa AbouElenin
https://www.youtube.com/watch?v=3Khchk678os
construction technology and automation leading change in the construction industry BIM technology 3D machine control systems 2D machine control systems laser leveling and grading mobile mapping 3D scanning drone technology GPS systems Total stations Topcon Leica Trimble Komatsu Caterpillar Volvo Vogele Wirtgen Doosan Hyundai Gomaco Power curbers Ammann Sitech Topcon mmGPS 3DMC smoothride paving grading dozer excavator grader paver ICE institute of civil engineers Dubai Middle East UAE Saudi Arabia Egypt Qatar Oman Bahrain Kuwait Jordan Bentley Autodesk Alaa AbouElenin 3D systems 3D technology Geospatial GIS systems CORS station reference stations geopositioning
https://www.youtube.com/watch?v=3Khchk678os
Business Ecosystems in the Factory of the FutureStefan Ferber
Die Internet der Dinge-Technologie birgt auch für die Industrie ein enormes Potenzial. Durch die Vernetzung von Maschinen, Werkstücken, Systemen und Marktteilnehmer entlang der Wertschöpfungskette können in Zukunft Fertigungsprozesse völlig neu organisiert werden. Durch diese Veränderungen entstehen sowohl für bestehende als auch für neue Marktteilnehmer spannende Möglichkeiten für neue Geschäftsmodelle und Kooperationen.
In seinem Vortrag zeigt Dr. Stefan Ferber am Beispiel von Instandhaltung und Logistik, wie sich das Business für Unternehmen verändert und wie der Produktionsstandort Deutschland von diesen Veränderungen profitiert.
This is a description of the IBM Industrie 4.0 Zone @ CeBIT 2015, comprised of 10 live demonstration points with real scenarios created for and with our clients and partners.
Join the IBM Industrie 4.0 Core Tech Team on your journey through the zone!
Michele Nati - Digital Catapult viewpoint on Industrie 4.0 - Digital Technolo...MicheleNati
Presentation showing Digital Catapult interest and fit in Industrie 4.0 movement. Digital Technologies for Manufacturing Innovation: Embracing Industry 4.0 - Nottingham, November 30th
An introduction to Industrie 4.0(Internet of Things), and its Potential impact on Supply Chain. Industrie 4.0, touted as the Game changer and a seed for next industrial revolution. Funded by German Bundes Ministerium fur Education & Technologie.
MongoDB IoT CITY Tour EINDHOVEN: Bosch & Tech Mahindra: Industrial Internet, ...MongoDB
All of these concepts are promising to transform the current industrial landscape by leveraging the IoT. In this presentation, Bosch, TechMahindra and MongoDB will present a concrete example that goes from concept to implementation. Learn how advanced hand-held tightening tools, user ID cards, wireless indoor localisation technology, M2M asset management and big data can be combined to form a powerful track and trace solution for advanced manufacturing requirements.
Industrie 4.0, digitalization, standards and norms, Smart Factory, disruptive business models, ENGINEERING 2050, components of a Smart Factory, Industrie 4.0 for small and medium–sized companies, Internet of Things, Cloud Security, from Big Data to Smart Data, IT security for industrial processes
MongoDB IoT City Tour STUTTGART: Industrial Internet, Industry 4.0, Smart Fac...MongoDB
Presented by, Dirk Slama, Business Development Director at Bosch SI
Industrial Internet, Smart Factory, Industry 4.0 – all of these concepts are promising to transform the current industrial landscape by leveraging the IoT. In this presentation, Bosch, TechMahindra and MongoDB will present a concrete example that goes from concept to implementation. Learn how advanced handheld tightening tools, user ID cards, wireless indoor localisation technology, M2M asset management and big data can be combined to form a powerful track and trace solution for advanced manufacturing requirements.
Meetup #3 - Cyber-physical view of the Internet of EverythingFrancesco Rago
The Internet of Everything (IoE) is built on the connections among people, processes, data, and internet of things. However, it is not about these four dimensions in isolation. Each amplifies the capabilities of the other three. It is in the intersection of all of these elements that the true power of Internet of Everything is realized.
We will examine the Cyber-physical view to explore Specification, Hybrid and Heterogeneous Models, Conceptual frameworks, Multiform Time, and much more.
The convergence of integrated software, efficient hardware and modern networking infrastructure has created a new technology environment. Industry 4.0 sits at the convergence of these technologies and enables many industries that we actively track. Catalyst Investors’ history in software and TMT is quite relevant to Industry 4.0. We are excited to meet and partner with growth stage companies that are built as Industry 4.0 solutions from the ground up, as well as existing service businesses that can adopt Industry 4.0 technologies as an evolution.
The workshop "Platforms for connected Factories of the Future" took place on 5 and 6 of October 2015 in Brussels. Main objective on the first workshop day was to give an overview on existing activities in industries and research regarding platforms for the manufacturing area.
Industry 4.0, Demystifying key Industry 4, Industry 4 training courseBryan Len
Industry 4.0, This has developed in light of the fact that progresses in sensor technology and network modules have permitted greater hardware to be estimated, checked and followed among locales, and organized from a focal, remote area.
What is Industry 4.0 ?
Industry 4.0 is in some cases clarified as the combination of digitalization with conventional mechanical procedures. This outcomes in wise worth chains and item lifecycles that start with advancement, experience fabricating, gathering, item conveyance and upkeep, and end with reusing.
Industry 4 and IoT ( Internet Of Things ) :
Lately, Industry 4.0 has come to be related with the Internet of Things (IoT). Industry 4.0 alludes to the following stage in modern innovation, with mechanical technology, PCs and hardware getting associated with the Internet of Things, and improved by AI calculations.
Advantages from IoT-implanted Industry 4.0, include:
More extravagant and all the more convenient examination
Digitizing and comprehending data
Improving consumer loyalty
Improving item quality
Lift productivity and profitability
Continuous experiences that lead to better, quicker choices
Industry 4.0 Training Course by Tonex :
Industry 4.0 Training course covers key ideas of future savvy manufacturing plants, the digital physical frameworks and physical procedures inside these industrial facilities and the virtualization methods and shrewd dynamic capacities which would bolster directors in driving these activities.
Industry 4.0 Course Modules :
Demystifying, Making Industry 4.0 concept easier to you
Driving Industry 4.0
Administration Industry 4.0 Capabilities
Key Industry 4.0 Technologies
Adjusting Industry 4.0 and Strategies
The Automation Pyramid and New Business Models in Industry 4.0
Industry 4.0 and Technologies
Discretionary Workshop
Industry 4, Demystifying key Industry 4, Industry 4 training course. Request more information.
Visit tonex.com for Industry 4 course and workshop detail.
https://www.tonex.com/training-courses/industry-4-0-training-industries-4-0-crash-course/
Digital technologies will play crucial roles in enhancing societies and economies. As the pandemic continues to push the world to do physical distancing, digital transformations are happening across multiple industries. Here's how intelligent connectivity transforms the journey of digital society and pushes the Industry 4.0 agenda.
Business Ecosystems in the Factory of the FutureStefan Ferber
Die Internet der Dinge-Technologie birgt auch für die Industrie ein enormes Potenzial. Durch die Vernetzung von Maschinen, Werkstücken, Systemen und Marktteilnehmer entlang der Wertschöpfungskette können in Zukunft Fertigungsprozesse völlig neu organisiert werden. Durch diese Veränderungen entstehen sowohl für bestehende als auch für neue Marktteilnehmer spannende Möglichkeiten für neue Geschäftsmodelle und Kooperationen.
In seinem Vortrag zeigt Dr. Stefan Ferber am Beispiel von Instandhaltung und Logistik, wie sich das Business für Unternehmen verändert und wie der Produktionsstandort Deutschland von diesen Veränderungen profitiert.
This is a description of the IBM Industrie 4.0 Zone @ CeBIT 2015, comprised of 10 live demonstration points with real scenarios created for and with our clients and partners.
Join the IBM Industrie 4.0 Core Tech Team on your journey through the zone!
Michele Nati - Digital Catapult viewpoint on Industrie 4.0 - Digital Technolo...MicheleNati
Presentation showing Digital Catapult interest and fit in Industrie 4.0 movement. Digital Technologies for Manufacturing Innovation: Embracing Industry 4.0 - Nottingham, November 30th
An introduction to Industrie 4.0(Internet of Things), and its Potential impact on Supply Chain. Industrie 4.0, touted as the Game changer and a seed for next industrial revolution. Funded by German Bundes Ministerium fur Education & Technologie.
MongoDB IoT CITY Tour EINDHOVEN: Bosch & Tech Mahindra: Industrial Internet, ...MongoDB
All of these concepts are promising to transform the current industrial landscape by leveraging the IoT. In this presentation, Bosch, TechMahindra and MongoDB will present a concrete example that goes from concept to implementation. Learn how advanced hand-held tightening tools, user ID cards, wireless indoor localisation technology, M2M asset management and big data can be combined to form a powerful track and trace solution for advanced manufacturing requirements.
Industrie 4.0, digitalization, standards and norms, Smart Factory, disruptive business models, ENGINEERING 2050, components of a Smart Factory, Industrie 4.0 for small and medium–sized companies, Internet of Things, Cloud Security, from Big Data to Smart Data, IT security for industrial processes
MongoDB IoT City Tour STUTTGART: Industrial Internet, Industry 4.0, Smart Fac...MongoDB
Presented by, Dirk Slama, Business Development Director at Bosch SI
Industrial Internet, Smart Factory, Industry 4.0 – all of these concepts are promising to transform the current industrial landscape by leveraging the IoT. In this presentation, Bosch, TechMahindra and MongoDB will present a concrete example that goes from concept to implementation. Learn how advanced handheld tightening tools, user ID cards, wireless indoor localisation technology, M2M asset management and big data can be combined to form a powerful track and trace solution for advanced manufacturing requirements.
Meetup #3 - Cyber-physical view of the Internet of EverythingFrancesco Rago
The Internet of Everything (IoE) is built on the connections among people, processes, data, and internet of things. However, it is not about these four dimensions in isolation. Each amplifies the capabilities of the other three. It is in the intersection of all of these elements that the true power of Internet of Everything is realized.
We will examine the Cyber-physical view to explore Specification, Hybrid and Heterogeneous Models, Conceptual frameworks, Multiform Time, and much more.
The convergence of integrated software, efficient hardware and modern networking infrastructure has created a new technology environment. Industry 4.0 sits at the convergence of these technologies and enables many industries that we actively track. Catalyst Investors’ history in software and TMT is quite relevant to Industry 4.0. We are excited to meet and partner with growth stage companies that are built as Industry 4.0 solutions from the ground up, as well as existing service businesses that can adopt Industry 4.0 technologies as an evolution.
The workshop "Platforms for connected Factories of the Future" took place on 5 and 6 of October 2015 in Brussels. Main objective on the first workshop day was to give an overview on existing activities in industries and research regarding platforms for the manufacturing area.
Industry 4.0, Demystifying key Industry 4, Industry 4 training courseBryan Len
Industry 4.0, This has developed in light of the fact that progresses in sensor technology and network modules have permitted greater hardware to be estimated, checked and followed among locales, and organized from a focal, remote area.
What is Industry 4.0 ?
Industry 4.0 is in some cases clarified as the combination of digitalization with conventional mechanical procedures. This outcomes in wise worth chains and item lifecycles that start with advancement, experience fabricating, gathering, item conveyance and upkeep, and end with reusing.
Industry 4 and IoT ( Internet Of Things ) :
Lately, Industry 4.0 has come to be related with the Internet of Things (IoT). Industry 4.0 alludes to the following stage in modern innovation, with mechanical technology, PCs and hardware getting associated with the Internet of Things, and improved by AI calculations.
Advantages from IoT-implanted Industry 4.0, include:
More extravagant and all the more convenient examination
Digitizing and comprehending data
Improving consumer loyalty
Improving item quality
Lift productivity and profitability
Continuous experiences that lead to better, quicker choices
Industry 4.0 Training Course by Tonex :
Industry 4.0 Training course covers key ideas of future savvy manufacturing plants, the digital physical frameworks and physical procedures inside these industrial facilities and the virtualization methods and shrewd dynamic capacities which would bolster directors in driving these activities.
Industry 4.0 Course Modules :
Demystifying, Making Industry 4.0 concept easier to you
Driving Industry 4.0
Administration Industry 4.0 Capabilities
Key Industry 4.0 Technologies
Adjusting Industry 4.0 and Strategies
The Automation Pyramid and New Business Models in Industry 4.0
Industry 4.0 and Technologies
Discretionary Workshop
Industry 4, Demystifying key Industry 4, Industry 4 training course. Request more information.
Visit tonex.com for Industry 4 course and workshop detail.
https://www.tonex.com/training-courses/industry-4-0-training-industries-4-0-crash-course/
Digital technologies will play crucial roles in enhancing societies and economies. As the pandemic continues to push the world to do physical distancing, digital transformations are happening across multiple industries. Here's how intelligent connectivity transforms the journey of digital society and pushes the Industry 4.0 agenda.
In today’s fast-paced world it is not straightforward to quickly evaluate the potential of innovative technologies and to learn the necessary skills to implement and integrate them into existing landscapes. Jan and Dries show you how they use the AD&I Incubator to help them with both of these tasks.
Artificial Intelligence and IoT @ BoschPavlin Dobrev
Presentation about Bosch vision of Artificial Intelligence #AI http://bosch-ai.com and Internet of Things #IoT http://iot.bosch.com at Software University (softuni.bg) event
CEIPI summer school on IP in Europe 2018 - Presentation IP Strategies in EuropeMIPLM
Prof. Alexander J. Wurzer gave a presentation on IP Strategy in Europe along with industry insights into European best practice cases for IP strategy across different sectors, technologies, and business models.
Lessons learned after one year of open source activities in the Internet of Things
We at Bosch believe that the technology that comes with the “Internet of Things” (IoT) has genuine potential to deliver value, meaning, insight and fun in order to tackle major challenges of the 21st century in several domains like mobility, energy, home & building, cities and manufacturing. In our vision of the future, each of our electronic products is connected to the internet. This connectivity will allow for disruptive business models and new services. Developing the business ecosystem around IoT targeting different stakeholders in the IoT value chain from silicon vendors to system integrators is a major task for Bosch. Typical examples are:
* Strategic Alliances: Industrial Internet Consortium (IIC) addressing partner companies and potential customers of IoT projects though showcasing IoT use-cases in real world test beds. Bosch was the initiator of first public IIC test bed.
* Business Consortia: Hubject (Electromobility) and mozaiq (Smart Home) in order to break though in immature markets. Bosch is amongst the co-founding companies.
* System Integrators: Partnership with TechM, Infosys, and TCS to scale out internationally.
* Standardization: OSGi Alliance membership with ProSyst – now belonging to Bosch – a longstanding member of the OSGi board, also driving the IoT activities. OSGi is Bosch strategic IoT technology.
* Open Source: Building on open technology like Eclipse, Apache, CloudFoundry, Linux and bringing IoT key elements to the commons via Eclipse IoT.
This talk will highlight how Bosch tries to align the above activities developing the IoT market using the example of OSGi. Particularly, the lessons learned after one year of active open source contribution to the Eclipse IoT community will be discussed: from topics regarding product liability, change of software business model, impact on agile development and team dynamics we at Bosch believe that other companies from old industry probably face similar impediments. They are part of the very different approaches and world views found in embedded system development as compared to Internet & IT software development.
Besides learning new tricks and all the challenges, we at Bosch are committed to an open platform approach as we believe that “nobody can do I(o)T alone”.
MongoDB IoT City Tour LONDON: Industrial Internet, Industry 4.0, Smart Factor...MongoDB
Presented by, Deepak Maheshwari, Tech Mahindra
Industrial Internet, Smart Factory, Industry 4.0 – all of these concepts are promising to transform the current industrial landscape by leveraging the IoT. In this presentation, Bosch, TechMahindra and MongoDB will present a concrete example that goes from concept to implementation. Learn how advanced handheld tightening tools, user ID cards, wireless indoor localisation technology, M2M asset management and big data can be combined to form a powerful track and trace solution for advanced manufacturing requirements.
Accenture Industrial Equipment: The Race to Reinventaccenture
The digital universe is expanding and for Industrial Equipment companies, creating value with digital isn’t just a simple game of mixing and matching digital technologies. Companies also need to reinvent their operating models, production and value chains, becoming what we call Industry X.0 businesses.
A chamada Indústria 4.0 é uma das fronteiras da mudança tecnológica no mundo. A Alemanha é um dos países mais dinâmicos nesse processo. A própria expressão "Indústria 4.0" foi cunhada naquele país, onde ela representa, mais do que palavras, uma estratégia nacional. Para abordar os desafios que a Indústria 4.0 coloca para a Alemanha e também para o Brasil, a Fundação FHC recebe o chefe global de tecnologia e inovação da Siemens, Norbert Luetke-Entrup.
NORBERT LÜTKE-ENTRUP
Mestre e PhD em Física pela Universidade de Bonn (Alemanha) e pela Université Pierre et Marie Curie (Paris), é chefe do Departamento de Tecnologia Corporativa e Gestão da Inovação do Grupo Siemens. Atuou como consultor, líder de projeto e vice-presidente na sede da Siemens Management Consulting (SMC) em Munique, entre 2000 a 2008, e como vice-presidente administrativo do escritório da empresa em Pequim (China).
Similar to MIPLM research project - Protection of Digital Business Models by Digital Patents (20)
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx
MIPLM research project - Protection of Digital Business Models by Digital Patents
1. PROTECTION OF DIGITAL BUSINESS
MODELS BY DIGITAL PATENTS
Decomposition and characterization of digital business models and
applicability for patent protection on different structural elements
Dr. Frederik Golks
Corporate Intellectual Property
20/09/2018 CEIPI Strasbourg
