This document discusses how technology is enabling major changes in healthcare and opportunities for patient engagement. It notes that a university medical center with over 11,000 employees and 1,000 beds aims to significantly impact healthcare. Technologies like 3D printing, sensors, and mobile apps are discussed as enabling new models of remote and do-it-yourself healthcare. The role of patients is shifting from passive recipients of care to active partners in their health. New alliances between organizations will be needed to support innovations that put patients first and reimburse for health outcomes rather than services.