This document summarizes an experimental study on replacing natural river sand and coarse aggregate with manufactured sand (M-sand) and ground granulated blast furnace slag (GGBS) aggregate in concrete. M25 grade concrete was produced with 0-50% replacement of river sand by M-sand and 0-30% replacement of coarse aggregate by GGBS aggregate. Compressive and flexural strengths were tested at 7, 14, and 28 days of curing. Results showed that replacing river sand by 75% M-sand and coarse aggregate by 20% GGBS aggregate produced concrete with optimal strength. This replacement improved bonding between particles in the concrete due to the irregular shapes and sizes of M-sand and GGBS