Mechanical Behavior In Living Cells Consistent With The Tensegrity Model By Simpson

Mechanical Behavior in Living Cells Consistent with the Tensegrity Model Ning Wang et al. PNAS 2001; 98:7765-7770 Presented by: David L. Simpson ARTNews- February 1981

Outline ,[object Object],[object Object],[object Object],[object Object],[object Object]

Current Models of Cell Mechanics ,[object Object],[object Object],[object Object],[object Object]

Tensegrity Model ,[object Object],[object Object],[object Object]

Intent of Selected Paper ,[object Object],[object Object],[object Object],[object Object]

Motivation for Study ,[object Object],[object Object]

Oscillatory Magnetic Twisting Cytometry ,[object Object],[object Object],[object Object],[object Object],J. Appl. Physiol. Vol. 89, Issue 4, 1619-1632, October 2000

Traction Force Microscopy ,[object Object],[object Object]

MLC Phosphorylation and Intracellular Calcium ,[object Object],[object Object],Fig 3. PNAS 2001; 98:7765-7770

Internal Cell Deformation Depends on Molecular Connectivity Closed circles: RGD Beads Open circle: AcLDL Beads Fig 1. PNAS 2001; 98:7765-7770

Microtubules Bear Compression in Living Cells Fig 2. PNAS 2001; 98:7765-7770

Microtubules Bear Compression in Living Cells Prestress is transferred to external adhesions which increases traction. Fig 5. PNAS 2001; 98:7765-7770

Quantitative Measurements Support the Tensegrity Model Prestress as a function of histamine and colchicine concentration Shear Modulus as a function of histamine concentration Shear modulus as a function of prestress. Notice the linear relationship over specified range Fig 4. PNAS 2001; 98:7765-7770

An a priori Prediction ,[object Object],[object Object]

Strengths and Limitations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Let’s Discuss ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],Let’s Discuss AND I’M SPENT…THANKS FOR YOUR ATTENTION

Mechanical Behavior In Living Cells Consistent With The Tensegrity Model By Simpson

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Mechanical Behavior In Living Cells Consistent With The Tensegrity Model By Simpson