Little's Law establishes the relationship between concurrency C, throughput T, and response time R, where C = T * R. Amdahl's Law states that parallelizing work can provide speedup, but there is a limit to speedup based on the portion of work that remains serialized. For databases and disk performance, throughput is affected by coordination between nodes completing units of work, as concurrency is decremented during entry and exit, represented by a kappa factor of less than 95%.