Presentation from the 3rd Joint Meeting of the Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI) Networks, organised by the European Centre of Disease Prevention and Control - Stockholm, 11-13 February 2015
1) France has the highest per capita healthcare expenditures in Europe for cancer, estimated at €14 billion annually, resulting in an estimated €17 billion loss to GDP each year from cancer.
2) While drug costs account for about 20% of total cancer costs, they are rising faster than total costs. Imaging costs are also rising rapidly in the US. There is potential to better manage complications as outpatients to reduce hospitalization costs.
3) New models are needed to make drug development and use more cost-effective, such as value-based pricing where drug price reflects quality-adjusted life year benefit, smaller and more targeted clinical trials, and more efficient healthcare systems and drug development processes.
Multi-Indication Pricing: Pros, Cons and Applicability to the UKKerry Sheppard
This document discusses multi-indication pricing (MIP), where medicines are priced differently for separate indications. The document examines the pros and cons of MIP compared to uniform pricing across all indications. It also explores international examples of MIP and whether MIP could be implemented in the UK using the Systemic Anti-cancer Therapy dataset to track drug usage by indication. While MIP may allow prices to better reflect clinical value and increase access, ensuring accurate tracking of drug usage by indication presents challenges for implementation in the UK healthcare system.
The way forward for greater manchester academic health science network ahsnPM Society
The document discusses the relationship between the Manchester Academic Health Science Centre (MAHSC) and the Greater Manchester Academic Health Science Network (GM-AHSN). It outlines that MAHSC members host many of the key assets that support GM-AHSN's business plan and that GM-AHSN's domains will deliver implementation of NICE guidelines and technologies. It also describes MAHSC and GM-AHSN's areas of expertise, including systems biology, discovery assets, implementation science, and access to a large population. Finally, it discusses opportunities and challenges for partnership working with industry through case studies.
The economics and future financial outlook for the medical device industry. Presented by Martin Gold at Credit Suisse MedTech Day on March 24, 2009. Focus is on orthopedics and cardiovascular.
ROADMAP is a public-private partnership formed under the Innovative Medicines Initiative to develop efficient uses of real world evidence for the benefit of Alzheimer's disease patients and caregivers. It brings together European academic institutions and dementia experts to integrate diverse healthcare data across systems. ROADMAP aims to provide a foundation for an integrated European data environment and framework for using real world evidence to address outcomes in Alzheimer's disease. The initial two year phase will define outcomes measures, identify appropriate data sources, and provide recommendations for disease modeling to regulators and other stakeholders.
Session 2 a discussion of mary o'mahony paper in session 2a 25 augustIARIW 2014
This study measures output and productivity growth in the healthcare sectors of Germany, Hungary, Spain and the UK between 2004-2009. It finds that three of the four countries achieved similar productivity growth through different means: Germany saw significant output growth with no increase in labor, the UK had very high output growth but also high labor growth, while Hungary had low output growth accompanied by a significant reduction in labor. Spain significantly lagged the others in productivity growth, with relatively high labor growth. The paper represents a major empirical analysis that overcame challenges in measuring non-hospital outputs and quality adjustments over time and between countries.
This document discusses multi-indication pricing (MIP), an innovative pricing scheme where medicines can be priced differently for different approved indications. MIP aims to set prices that better reflect the value of a drug across its indications. The document outlines MIP frameworks, reviews international examples, and discusses challenges to implementing MIP in the UK healthcare system. Key challenges include whether the NHS can handle variable net prices by indication and monitor usage data. International experience shows MIP being used with different brands of the same drug or through sub-national pricing schemes. MIP warrants further exploration but requires collaboration across stakeholders and consideration of data and pricing model options.
Presentation from the 3rd Joint Meeting of the Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI) Networks, organised by the European Centre of Disease Prevention and Control - Stockholm, 11-13 February 2015
1) France has the highest per capita healthcare expenditures in Europe for cancer, estimated at €14 billion annually, resulting in an estimated €17 billion loss to GDP each year from cancer.
2) While drug costs account for about 20% of total cancer costs, they are rising faster than total costs. Imaging costs are also rising rapidly in the US. There is potential to better manage complications as outpatients to reduce hospitalization costs.
3) New models are needed to make drug development and use more cost-effective, such as value-based pricing where drug price reflects quality-adjusted life year benefit, smaller and more targeted clinical trials, and more efficient healthcare systems and drug development processes.
Multi-Indication Pricing: Pros, Cons and Applicability to the UKKerry Sheppard
This document discusses multi-indication pricing (MIP), where medicines are priced differently for separate indications. The document examines the pros and cons of MIP compared to uniform pricing across all indications. It also explores international examples of MIP and whether MIP could be implemented in the UK using the Systemic Anti-cancer Therapy dataset to track drug usage by indication. While MIP may allow prices to better reflect clinical value and increase access, ensuring accurate tracking of drug usage by indication presents challenges for implementation in the UK healthcare system.
The way forward for greater manchester academic health science network ahsnPM Society
The document discusses the relationship between the Manchester Academic Health Science Centre (MAHSC) and the Greater Manchester Academic Health Science Network (GM-AHSN). It outlines that MAHSC members host many of the key assets that support GM-AHSN's business plan and that GM-AHSN's domains will deliver implementation of NICE guidelines and technologies. It also describes MAHSC and GM-AHSN's areas of expertise, including systems biology, discovery assets, implementation science, and access to a large population. Finally, it discusses opportunities and challenges for partnership working with industry through case studies.
The economics and future financial outlook for the medical device industry. Presented by Martin Gold at Credit Suisse MedTech Day on March 24, 2009. Focus is on orthopedics and cardiovascular.
ROADMAP is a public-private partnership formed under the Innovative Medicines Initiative to develop efficient uses of real world evidence for the benefit of Alzheimer's disease patients and caregivers. It brings together European academic institutions and dementia experts to integrate diverse healthcare data across systems. ROADMAP aims to provide a foundation for an integrated European data environment and framework for using real world evidence to address outcomes in Alzheimer's disease. The initial two year phase will define outcomes measures, identify appropriate data sources, and provide recommendations for disease modeling to regulators and other stakeholders.
Session 2 a discussion of mary o'mahony paper in session 2a 25 augustIARIW 2014
This study measures output and productivity growth in the healthcare sectors of Germany, Hungary, Spain and the UK between 2004-2009. It finds that three of the four countries achieved similar productivity growth through different means: Germany saw significant output growth with no increase in labor, the UK had very high output growth but also high labor growth, while Hungary had low output growth accompanied by a significant reduction in labor. Spain significantly lagged the others in productivity growth, with relatively high labor growth. The paper represents a major empirical analysis that overcame challenges in measuring non-hospital outputs and quality adjustments over time and between countries.
This document discusses multi-indication pricing (MIP), an innovative pricing scheme where medicines can be priced differently for different approved indications. MIP aims to set prices that better reflect the value of a drug across its indications. The document outlines MIP frameworks, reviews international examples, and discusses challenges to implementing MIP in the UK healthcare system. Key challenges include whether the NHS can handle variable net prices by indication and monitor usage data. International experience shows MIP being used with different brands of the same drug or through sub-national pricing schemes. MIP warrants further exploration but requires collaboration across stakeholders and consideration of data and pricing model options.
Country level cost saving with hospital inventory system.Mustafa Said YILDIZ
Turkey implemented a Health Transformation Program in 2003 that achieved major reforms through centralized coordination. As part of this, the Ministry of Health mandated an integrated health IT system connecting over 800 hospitals to manage inventories. This addressed high stock levels caused by outdated rules, and unneeded stocks from ineffective estimates. Hospitals were required to limit stock to a 3-month supply level. The IT system allowed hospitals to see if others had exceeded or unneeded supplies, facilitating transfers and saving over $378 billion from 2009-2013 on inventory costs. This country-level cost savings was achieved without compromising quality or access to healthcare services.
160929 roche presentation molecule to businessSMBBV
This document discusses challenges around the affordability of oncology drugs in the Netherlands and potential solutions. It notes that spending on expensive oncology drugs has increased 15% in recent years. To maintain affordability and accessibility, the Netherlands uses measures like rational pharmacotherapy guidelines and price negotiations. However, these may not be appropriate for new personalized medicines and combination therapies. The document argues that personalized reimbursement models based on a drug's actual value and outcomes for patients are needed to optimize value and deal with future treatment approaches. Collaboration between stakeholders is important to sustain affordability while ensuring access to innovative therapies.
This document summarizes a presentation given at an ISPOR conference on multi-indication pricing. It discusses the challenges of setting one price for a drug across multiple indications when the value may differ based on the indication. It provides examples showing large price differences between indications for the same drugs in different countries. Stakeholders generally support prices reflecting relative value but have concerns about implementation. UK workshop participants felt more collaboration would be needed between stakeholders if the UK pursued multi-indication pricing schemes.
Intro to informatics pharmacist by Linus LayLinus Lay
Presented by Linus Lay, Pharm.D. Candidate from the University of Rhode Island Class of 2022.
This presentation was in-service to RxInsider, a B2B multimedia publishing and technology company for the "business of pharmacy." Pharmacy Informatics is a rising field in the specialties of pharmacy. This presentation provides a brief background on the responsibilities of an informatics pharmacist, short history of the specialty curriculum, and the current education for the field of informatics for student pharmacists.
View MyCred Portfolio: https://mycred.com/p/2929377185
View Youtube Video: https://youtu.be/WTi2ldztl2I
Marketing Strategy for a medical device companysaurabhmalani
This is a marketing strategy for a leading medical device company for a new product launch. This presentation won the Babson Marketing Case Competition - 2012 with prize money of $5000. 16 schools across the globe were competing in this competition.
Slides from a presentation Adrian gave on the subject of indication-based pricing at the 2018 ISPOR Europe conference in Barcelona, Spain on November 12th.
UpToDate is an evidence-based clinical decision support resource covering over 24 medical specialties and over 10,500 clinical topics. It has over 425,000 references from over 460 medical journals. It is authored by over 6,300 physicians, editors, and peer reviewers and has over 30,000 graphics. UpToDate has over 1.1 million users worldwide across more than 32,000 institutional sites and provides over 26 million topic views per month. Surveys find that 92-99% of clinicians who subscribe are satisfied with UpToDate and find that it helps improve patient care and saves them time.
This document summarizes work by the MIT Center for Biomedical Innovation on analyzing the cell and gene therapy pipeline. It estimates that there will be approximately 80-100 new gene and cell therapy product approvals in the United States by 2031, treating around 410,000-550,000 patients. The majority of these therapies will be for oncology (cancer) patients. It also provides estimates of total reimbursement for these new therapies in 2031 of $20-30 billion, with $15-21 billion for oncology treatments. Near term therapies discussed include already approved CAR-T cancer therapies and gene therapies for rare diseases like spinal muscular atrophy.
Using information to deliver world-class care at lower cost. CernerFundació TicSalut
III Edició "The British Experience in Technologies for Health". Hospital de Sant Pau, Barcelona. 9 de novembre de 2011. Esdeveniment organitzat per la Fundació TICSalut i el Departament de Comerç i Inversions del Consolat General Britànic a Barcelona, UK Trade & Investment, per posar en contacte oportunitats i coneixements entre el Regne Unit i Catalunya.
Americans pay significantly more for prescription drugs than people in other Western nations. In 2000, Americans paid 60% more on average for brand name drugs compared to seven other Western nations. By 2003, Americans paid 81% more on average. For many patented drugs in 2003, Americans paid 58-118% more than people in Switzerland, Britain, Germany, Canada, Sweden, France, and Italy. High drug costs in the US are driven by the pharmaceutical industry spending billions on marketing to doctors, creating influence over prescribing decisions and loyalty to brand name drugs. Marketing accounts for 30% of drug costs while research and development accounts for only 10-15%. Expensive new drugs are heavily marketed, including for off-label uses, driving up overall
Opportunity costs and local health servicespending decisions: A qualitative ...Kerry Sheppard
This document summarizes a qualitative study of how local health boards in Wales fund new healthcare technologies approved by regulatory agencies. Semi-structured interviews found that boards generally plan for such costs in advance using contingency funds. Efficiency savings from reducing unnecessary spending, not service displacements, were the most common way of funding new treatments. The opportunity cost is not wholly felt through displaced NHS services but also falls on increased efficiency efforts and other public spending areas. The study challenges the assumption that healthcare budgets are fixed and that approving new treatments necessarily displaces existing services.
Why RWE Matters to Payers: Incorporating RWE in Health Economic Analysis to M...Office of Health Economics
1. Real world data (RWD) collected outside clinical trials reflects outcomes in the real world. Real world evidence (RWE) generated from RWD can help understand effectiveness, maximize value for payers, and manage uncertainty given evolving research and development.
2. Managed entry agreements (MEAs) are used to formally incorporate RWD to manage product entry addressing uncertainty while maximizing payer value through performance-linked reimbursement or coverage with evidence development.
3. Challenges to the use of RWE include implementation burdens, governance of data collection and analysis, and methodological issues in dealing with less controlled real world data.
EuroBioForum 2013 - Day 2 | Rachael RitchieEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# REGIONAL PERSPECTIVES #
Genome British Colombia, Canada:
Regional Perspectives on Personalized Medicine in British Columbia, Canada
Dr Rachael Ritchie
Director Business Development Genome British Colombia
=======================================
http://www.eurobioforum.eu
The EU Directive on cross-border healthcare aims to increase transparency in healthcare across EU countries. It will initially involve publishing information for all hospitals and hospital services, and then expand to include outpatient services. This will form an EU-wide standard for healthcare quality, guidelines, price lists, and other consumer information. Each member state must create easy-to-use websites providing this information by the end of 2013. The goal is to drive competition for better quality and value in healthcare through transparency and increased patient involvement in healthcare choices.
EuroBioForum 2013 - Day 1 | Pierre MeulienEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Canada:
Genomics and personalised health in Canada
Dr Pierre Meulien, President and CEO at Genome Canada
=======================================
http://www.eurobioforum.eu
The document discusses the future of the generics industry and global spending on medicines. It notes that global spending on medicines will grow nearly $1.2 trillion by 2016, with generics contributing a greater share. Developed markets will see slower growth due to patent expiries and cost containment actions. Pharmerging markets' spending share will increase due to population and economic growth driving higher medicine use. Generics can help reduce costs and maintain access to affordable medicines in the short and long term by increasing efficiency and freeing up funds for new therapies. A long term strategy of expanding generic use can generate ongoing savings while maintaining patient access.
This document discusses the challenges of value-based pricing for pharmaceuticals and proposes multi-indication pricing as a solution. It notes that a single price across all indications can restrict access for some patients and discourage development of new indications. Multi-indication pricing, where the price varies based on the value for each indication or patient subgroup, could increase access for more patients while still reflecting value. However, it adds complexity. The document explores options for implementing multi-indication pricing such as blended pricing or differential rebates and argues that this approach is needed as most drugs now have multiple indications.
Biomarkers: Discovery Techniques and Applications - A Global Market Overview ...MarketResearch.com
This document provides a summary of a market research report on biomarkers. It discusses biomarker discovery techniques like bioimaging, bioinformatics, and omics technologies. It also analyzes biomarker markets by therapeutic areas like cardiology, neurology, and oncology. The global biomarkers market was estimated to be $47 billion in 2013, with the US as the leading market. The market is projected to grow to $63.2 billion by 2020 with a compound annual growth rate of 18.8%. The 350-page report provides market data, profiles major companies, and lists biomarkers research organizations.
Atelier 2 : Essais cliniques internationaux quels sont les facteurs clés de s...EuroHealthNet
This document summarizes information about Merck & Co., a large pharmaceutical company, and RPS, a clinical research organization. It discusses Merck's revenues, R&D investments, therapeutic areas, and a merger in 2009. It then provides details about RPS's history, operations in 45 countries, and growth. The remainder discusses changes in pharmaceutical R&D and outsourcing strategies, differences in conducting global versus local clinical trials, and key factors for successful international monitoring.
Merck & Co., Inc. at UBS Global Healthcare ConferenceDeepa K
Merck provided an overview of its business and outlook for 2015. Key points include:
1) Merck reported Q1 2015 global sales of $9.4 billion, with pharmaceutical sales up 5% and animal health up 13%.
2) Merck is focused on four key growth platforms: diabetes, vaccines, hospital acute care, and oncology.
3) Merck has several new product launches underway or planned for 2015 in these core areas, including KEYTRUDA, BELSOMRA, GARDASIL9, and ZERBAXA.
4) Merck's pipeline includes late-stage programs in areas with large unmet needs like hepatitis C, atherosclerosis,
The document discusses opportunities and challenges for personalized medicines and sickle cell disease treatments. It provides an overview of current limited treatment options for sickle cell disease and highlights several new treatment options currently under development or approval, including Novartis' crizanlizumab, Global Blood Therapeutics' voxelotor, and gene therapies. It notes obstacles to access like high drug costs, long review processes, Canada's drug pricing system, and the small market size. The presentation calls on stakeholders to work together to improve access and education.
Country level cost saving with hospital inventory system.Mustafa Said YILDIZ
Turkey implemented a Health Transformation Program in 2003 that achieved major reforms through centralized coordination. As part of this, the Ministry of Health mandated an integrated health IT system connecting over 800 hospitals to manage inventories. This addressed high stock levels caused by outdated rules, and unneeded stocks from ineffective estimates. Hospitals were required to limit stock to a 3-month supply level. The IT system allowed hospitals to see if others had exceeded or unneeded supplies, facilitating transfers and saving over $378 billion from 2009-2013 on inventory costs. This country-level cost savings was achieved without compromising quality or access to healthcare services.
160929 roche presentation molecule to businessSMBBV
This document discusses challenges around the affordability of oncology drugs in the Netherlands and potential solutions. It notes that spending on expensive oncology drugs has increased 15% in recent years. To maintain affordability and accessibility, the Netherlands uses measures like rational pharmacotherapy guidelines and price negotiations. However, these may not be appropriate for new personalized medicines and combination therapies. The document argues that personalized reimbursement models based on a drug's actual value and outcomes for patients are needed to optimize value and deal with future treatment approaches. Collaboration between stakeholders is important to sustain affordability while ensuring access to innovative therapies.
This document summarizes a presentation given at an ISPOR conference on multi-indication pricing. It discusses the challenges of setting one price for a drug across multiple indications when the value may differ based on the indication. It provides examples showing large price differences between indications for the same drugs in different countries. Stakeholders generally support prices reflecting relative value but have concerns about implementation. UK workshop participants felt more collaboration would be needed between stakeholders if the UK pursued multi-indication pricing schemes.
Intro to informatics pharmacist by Linus LayLinus Lay
Presented by Linus Lay, Pharm.D. Candidate from the University of Rhode Island Class of 2022.
This presentation was in-service to RxInsider, a B2B multimedia publishing and technology company for the "business of pharmacy." Pharmacy Informatics is a rising field in the specialties of pharmacy. This presentation provides a brief background on the responsibilities of an informatics pharmacist, short history of the specialty curriculum, and the current education for the field of informatics for student pharmacists.
View MyCred Portfolio: https://mycred.com/p/2929377185
View Youtube Video: https://youtu.be/WTi2ldztl2I
Marketing Strategy for a medical device companysaurabhmalani
This is a marketing strategy for a leading medical device company for a new product launch. This presentation won the Babson Marketing Case Competition - 2012 with prize money of $5000. 16 schools across the globe were competing in this competition.
Slides from a presentation Adrian gave on the subject of indication-based pricing at the 2018 ISPOR Europe conference in Barcelona, Spain on November 12th.
UpToDate is an evidence-based clinical decision support resource covering over 24 medical specialties and over 10,500 clinical topics. It has over 425,000 references from over 460 medical journals. It is authored by over 6,300 physicians, editors, and peer reviewers and has over 30,000 graphics. UpToDate has over 1.1 million users worldwide across more than 32,000 institutional sites and provides over 26 million topic views per month. Surveys find that 92-99% of clinicians who subscribe are satisfied with UpToDate and find that it helps improve patient care and saves them time.
This document summarizes work by the MIT Center for Biomedical Innovation on analyzing the cell and gene therapy pipeline. It estimates that there will be approximately 80-100 new gene and cell therapy product approvals in the United States by 2031, treating around 410,000-550,000 patients. The majority of these therapies will be for oncology (cancer) patients. It also provides estimates of total reimbursement for these new therapies in 2031 of $20-30 billion, with $15-21 billion for oncology treatments. Near term therapies discussed include already approved CAR-T cancer therapies and gene therapies for rare diseases like spinal muscular atrophy.
Using information to deliver world-class care at lower cost. CernerFundació TicSalut
III Edició "The British Experience in Technologies for Health". Hospital de Sant Pau, Barcelona. 9 de novembre de 2011. Esdeveniment organitzat per la Fundació TICSalut i el Departament de Comerç i Inversions del Consolat General Britànic a Barcelona, UK Trade & Investment, per posar en contacte oportunitats i coneixements entre el Regne Unit i Catalunya.
Americans pay significantly more for prescription drugs than people in other Western nations. In 2000, Americans paid 60% more on average for brand name drugs compared to seven other Western nations. By 2003, Americans paid 81% more on average. For many patented drugs in 2003, Americans paid 58-118% more than people in Switzerland, Britain, Germany, Canada, Sweden, France, and Italy. High drug costs in the US are driven by the pharmaceutical industry spending billions on marketing to doctors, creating influence over prescribing decisions and loyalty to brand name drugs. Marketing accounts for 30% of drug costs while research and development accounts for only 10-15%. Expensive new drugs are heavily marketed, including for off-label uses, driving up overall
Opportunity costs and local health servicespending decisions: A qualitative ...Kerry Sheppard
This document summarizes a qualitative study of how local health boards in Wales fund new healthcare technologies approved by regulatory agencies. Semi-structured interviews found that boards generally plan for such costs in advance using contingency funds. Efficiency savings from reducing unnecessary spending, not service displacements, were the most common way of funding new treatments. The opportunity cost is not wholly felt through displaced NHS services but also falls on increased efficiency efforts and other public spending areas. The study challenges the assumption that healthcare budgets are fixed and that approving new treatments necessarily displaces existing services.
Why RWE Matters to Payers: Incorporating RWE in Health Economic Analysis to M...Office of Health Economics
1. Real world data (RWD) collected outside clinical trials reflects outcomes in the real world. Real world evidence (RWE) generated from RWD can help understand effectiveness, maximize value for payers, and manage uncertainty given evolving research and development.
2. Managed entry agreements (MEAs) are used to formally incorporate RWD to manage product entry addressing uncertainty while maximizing payer value through performance-linked reimbursement or coverage with evidence development.
3. Challenges to the use of RWE include implementation burdens, governance of data collection and analysis, and methodological issues in dealing with less controlled real world data.
EuroBioForum 2013 - Day 2 | Rachael RitchieEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# REGIONAL PERSPECTIVES #
Genome British Colombia, Canada:
Regional Perspectives on Personalized Medicine in British Columbia, Canada
Dr Rachael Ritchie
Director Business Development Genome British Colombia
=======================================
http://www.eurobioforum.eu
The EU Directive on cross-border healthcare aims to increase transparency in healthcare across EU countries. It will initially involve publishing information for all hospitals and hospital services, and then expand to include outpatient services. This will form an EU-wide standard for healthcare quality, guidelines, price lists, and other consumer information. Each member state must create easy-to-use websites providing this information by the end of 2013. The goal is to drive competition for better quality and value in healthcare through transparency and increased patient involvement in healthcare choices.
EuroBioForum 2013 - Day 1 | Pierre MeulienEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Canada:
Genomics and personalised health in Canada
Dr Pierre Meulien, President and CEO at Genome Canada
=======================================
http://www.eurobioforum.eu
The document discusses the future of the generics industry and global spending on medicines. It notes that global spending on medicines will grow nearly $1.2 trillion by 2016, with generics contributing a greater share. Developed markets will see slower growth due to patent expiries and cost containment actions. Pharmerging markets' spending share will increase due to population and economic growth driving higher medicine use. Generics can help reduce costs and maintain access to affordable medicines in the short and long term by increasing efficiency and freeing up funds for new therapies. A long term strategy of expanding generic use can generate ongoing savings while maintaining patient access.
This document discusses the challenges of value-based pricing for pharmaceuticals and proposes multi-indication pricing as a solution. It notes that a single price across all indications can restrict access for some patients and discourage development of new indications. Multi-indication pricing, where the price varies based on the value for each indication or patient subgroup, could increase access for more patients while still reflecting value. However, it adds complexity. The document explores options for implementing multi-indication pricing such as blended pricing or differential rebates and argues that this approach is needed as most drugs now have multiple indications.
Biomarkers: Discovery Techniques and Applications - A Global Market Overview ...MarketResearch.com
This document provides a summary of a market research report on biomarkers. It discusses biomarker discovery techniques like bioimaging, bioinformatics, and omics technologies. It also analyzes biomarker markets by therapeutic areas like cardiology, neurology, and oncology. The global biomarkers market was estimated to be $47 billion in 2013, with the US as the leading market. The market is projected to grow to $63.2 billion by 2020 with a compound annual growth rate of 18.8%. The 350-page report provides market data, profiles major companies, and lists biomarkers research organizations.
Atelier 2 : Essais cliniques internationaux quels sont les facteurs clés de s...EuroHealthNet
This document summarizes information about Merck & Co., a large pharmaceutical company, and RPS, a clinical research organization. It discusses Merck's revenues, R&D investments, therapeutic areas, and a merger in 2009. It then provides details about RPS's history, operations in 45 countries, and growth. The remainder discusses changes in pharmaceutical R&D and outsourcing strategies, differences in conducting global versus local clinical trials, and key factors for successful international monitoring.
Merck & Co., Inc. at UBS Global Healthcare ConferenceDeepa K
Merck provided an overview of its business and outlook for 2015. Key points include:
1) Merck reported Q1 2015 global sales of $9.4 billion, with pharmaceutical sales up 5% and animal health up 13%.
2) Merck is focused on four key growth platforms: diabetes, vaccines, hospital acute care, and oncology.
3) Merck has several new product launches underway or planned for 2015 in these core areas, including KEYTRUDA, BELSOMRA, GARDASIL9, and ZERBAXA.
4) Merck's pipeline includes late-stage programs in areas with large unmet needs like hepatitis C, atherosclerosis,
The document discusses opportunities and challenges for personalized medicines and sickle cell disease treatments. It provides an overview of current limited treatment options for sickle cell disease and highlights several new treatment options currently under development or approval, including Novartis' crizanlizumab, Global Blood Therapeutics' voxelotor, and gene therapies. It notes obstacles to access like high drug costs, long review processes, Canada's drug pricing system, and the small market size. The presentation calls on stakeholders to work together to improve access and education.
Obama care a new opportunity in us healthcare - finproBusiness Finland
The document summarizes opportunities in the US healthcare market, particularly resulting from healthcare reform under the Affordable Care Act (ObamaCare). It notes that the US market is the largest globally and is growing. ObamaCare aims to expand insurance coverage and reduce costs. This is driving demand for new technologies, services, and business models focused on prevention, home care, and integrating wellness. The document outlines market sizes and growth rates for key sectors like pharmaceuticals, medical devices, and digital health. It promotes a Finpro program to help Finnish healthcare companies explore opportunities in major US industry clusters.
Existing healthcare systems face challenges in providing accurate, evidence-based, and sustainable care as populations age. There is a need to better utilize existing healthcare data and expertise to help people live healthier lives. IBM Watson Health aims to address this need by combining healthcare data and systems with cognitive computing to enhance care delivery, clinical decision making, research, and population health management.
Health Valley Event Presentatie Rob ten HoedtHealth Valley
1. Rob ten Hoedt, President of Medtronic Europe, gave a presentation on the medical technology industry and Medtronic's role in innovation in Europe.
2. Key trends in European healthcare include aging populations, rising costs, and a focus on prevention and chronic disease management outside hospitals.
3. Medtronic is developing innovative solutions like implantable devices, biologics, and wireless technologies to treat conditions like heart disease, diabetes, and neurological disorders.
1. Graham Love discusses the development of personalized medicine in Ireland from the perspective of the Health Research Board.
2. While some personalized cancer care exists, moving towards personalized medicine research requires large-scale sequencing efforts and clinical trials to validate biomarkers and treatments.
3. For personalized medicine to become a true revolution, there needs to be greater efforts to educate decision-makers and the general public about what personalized medicine is and its potential benefits.
- The document discusses building a digital health ecosystem in Africa using mobile technology to transform healthcare delivery. It describes how patient monitoring solutions using digital devices can generate savings for hospitals by reducing readmissions for chronic diseases.
- The medopad platform is presented as an integrated digital health solution that can enable real-time patient monitoring, care coordination between patients and providers, and clinical research across different diseases like cardiology, oncology and diabetes.
- Examples of pilot programs using medopad in cancer and cardiology care demonstrate improved outcomes and cost savings. The platform aims to connect the global healthcare community to enhance care in developing countries.
The document discusses factors contributing to rising health care expenditures in the United States. It identifies increased demand from chronic disease and an aging population, new medical technologies, high pharmaceutical costs, and administrative inefficiencies compared to other countries as key drivers. While the uninsured account for some costs, evidence shows their emergency department utilization has not increased and is not a primary cause of overcrowding. Overall rising medical costs are challenging to curb due to demand for new, often expensive treatments and an inability to control utilization.
Peter L. Slavin, M.D., 2015 Leadership in Academic Medicine Lectureuabsom
Peter L. Slavin, M.D., president of Massachusetts General Hospital, presented “The Future of Academic Medicine” on Thursday, Aug. 6 as the featured speaker for the 2015 Leadership in Academic Medicine Lecture, sponsored by UAB Medicine.
Globalization Of Clinical Trials 2010 Josep M. Badenasjosepmariabadenas
Globalization of clinical trials can help bring drugs to market more quickly. While the majority of research and development spending still occurs in developed countries like the US and Western Europe, emerging markets are playing a larger role in global drug development. Countries like India and China provide opportunities for cost-effective clinical trials due to their large patient populations and improving healthcare infrastructures and regulations. However, conducting trials globally also presents challenges around cultural and medical practice differences that need to be addressed.
The NHS’ vision for medicines optimisation - the role for pharma in driving ...PM Society
The document discusses the challenges facing the NHS, including an aging population and rising costs of medicines. It notes that 30-50% of medicines are not taken as intended, leading to poor patient outcomes and increased healthcare spending. The NHS envisions a strategy of "medicines optimisation" to improve adherence, safety, and value. This will require engaging patients, health professionals, companies, and using health technology to optimize the use and management of medicines across care settings.
IV Congresso Internacional CBA2017
17 a 19 de setembro de 2017
Medicina Digital e as Novas Fronteiras: da Assistência à Pesquisa
Roberto Botelho MD, PhD
Connectacare
Modern medical technology can contribute to achieving a sustainable healthcare system through value-based innovation. The medical technology industry in Europe is large, employing many people and investing heavily in research and development. However, aging populations are increasing healthcare costs and straining budgets. The industry recognizes it needs new business models focused on improving health outcomes and reducing costs to better support sustainable healthcare systems into the future. Value-based innovation that addresses both patient and system needs can help systems adapt to challenges through greater efficiency and productivity.
How to Use Data to Improve Patient Safety: Part 2Health Catalyst
Stan and Valere will discuss how using an automated trigger tool for all-cause harm reviews will provide timely, real-time patient safety data useful to drive down harm rates with earlier interventions. Additional benefits of this approach include having a more accurate and robust source of data for identifying harm trends to then be able to integrate the findings into existing quality improvement processes for further quality improvement efforts.
Attendees will learn how to:
Understand the importance of dedicating resources to impact downstream costs
Identify their key sources of Patient Safety data
Integrate Patient Safety data in to existing Quality Improvement Processes
Learn and improve from real-time safety analytics combined with a Culture of Safety
EuroBioForum 2013 - Day 2 | Mark PoznanskyEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# REGIONAL PERSPECTIVES #
Ontario Genomics Institute, Canada:
Innovative Research, Innovative Translation
Dr Mark Poznansky
President and CEO Ontario Genomics Institute
=======================================
http://www.eurobioforum.eu
Pich Deck for Pepper Bio, for TechCruch's Pitch Deck Teardown seriesHajeJanKamps
This document discusses the limitations of current approaches to drug discovery and development and introduces Pepper's transomics platform as a solution. Specifically:
- Traditional drug R&D focuses on static, limited, and unlinked data that misses causal relationships and the full complexity of biology.
- Pepper's platform incorporates multi-omics data across genomics, transcriptomics, proteomics, and phosphoproteomics to capture a more functional and global understanding of disease biology.
- This transomics approach exceeds other methods in target identification and aims to address key questions in drug development around identifying the right target and developing the right drug for patients.
Consumerism, Innovation and Best Practices to Thrive in the Future of HealthJustin Barnes
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Consumer Driven Health – IHPME Research Day
Looks to the Future of Health Care
The trend towards consumer driven health, whether it be mobile apps, wearable devices, or easy access to electronic health records, is changing the landscape of our health care system and the way we think about care.
Overview of the Health B2B2C Ecosystem; Use Social Media as a Market Focus Tool; Measure Your Performance; American Health Insurance Reality; Lack of Doctor Relationship; PR is the New Primary Care Facilitator; For Health Marketers – End-users Matter; Innovation drives healthcare advances; Ways to Improve Health and Make Money; Medicine Is a Team Sport; Big Data- Allowing Individual Patients to Leverage The Many; Some Examples of What Works- Equashield, EarlySense, MD Anderson, LifePoint; 3D Systems; American Association for Cancer Research,
EANM patient information on thyroid cancerMarika Porrey
Judith Taylor and Beate Bartès discussed best practices for developing thyroid cancer patient information materials. They described 3 key aspects: 1) Clinicians and patients collaborating on guidelines and matching patient leaflets to ensure information is evidence-based and understandable, like the British Thyroid Association did. 2) European groups developing guidelines and patient leaflets together, like the European Society of Endocrinology. 3) The Thyroid Cancer Alliance creating materials for advanced disease treatments through a patient-clinician workshop. Reliable patient information is endorsed, regularly updated, and connects patients to support groups.
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1. The Future of
Medical Publishing
Dr Maria Kouimtzi
Editorial Director Pharmacy & Informatics
Global Clinical Solutions
Wiley-Blackwell
2. The business
• comprised of significant commercial players, world-
leading university presses and a large group of not-for-
profit learned society publishers
• ex-UK turnover of around £1bn per annum, of which
80% will derive from subscriptions overseas
• UK is a world hub, alongside the US, the Netherlands
and Germany
3. The business
• publishing 1.7m peer-reviewed articles/ year in > 20,000
journals
• 40% of activity derives from the US (JAMA, NEJM), 25%
of activity from the UK (Nature, The Lancet, BMJ)
• no. of published articles grown consistently for many
years by around 4% pa
• journal submissions growing by 5-10% pa on average
5. • 2000-2005: sales of print books went into decline
• Picture is mixed, varies according to market
• UK: R&D budgets ring-fenced
• Germany: impressive 10% increase in R&D budget
• China: above inflation increase in R&D budget
• US: Obama’s pledge to double NIH budget over next
decade, extra $3 bn for NSF in stimulus package
6. Future trends
• How in how the content is delivered:
OA, Handhelds
• Changes in the type of content:
CDS products, ‘clever’ content, CPD
7. Open Access
• Gold: author/funder/ institution pays a fee to the
publisher to make the peer-reviewed published article
available on open access immediately on publication
• Green: sponsorship with public or charitable funds. A
version of their article is accessible in an open
repository, which could be managed on a subject basis
(e.g. UKPMC) or on an institutional basis (e.g. the
University of Southampton)
8. Handhelds
• 59% of all adults in the US are now mobile internet
users
• 175,000 US physicians using an Apple device
• >250,000 apps for iPhone
• 30,000 apps for Android OS
• 6,000 apps claim to be delivering health, medical,
and fitness functionalities
• <30% are aimed to health professionals
14. Are journal articles read?
Work field Articles read
(per year)
Time spent
(hours)
Time per
article (min)
Medicine ~322 118 22
Chemists ~276 198 43
Life scientists ~239 104 26
Physicists ~204 153 45
Soc
Sci/Psych
~191 121 38
Engineers ~72 97 81
Source: Tenopir C (2004) User Behavior Across International and Disciplinary Boundaries.
Proceedings of the American Society for Information Science and Technology. Volume 41,
Issue 1, pages 20–30, 2004.
15.
16. Presenting symptom Dx: Tests
Dx: Diagnosis is
made
Dx: investigations
Dx: consider differential diagnoses
Dx: History
Tx: First line (medical?)
Tx: First line (medical?)
Co-morbidities
Renal / hepatic
impairment?
Interactions?
Side affects acceptable?
Tx: 2nd line (medical?)
Tx: failure
Tx: success
Ongoing: monitor condition, need for
ongoing treatment (side-effects?)
Clinical pathway:
decisions, decisions...
17. Presenting symptom Dx: Tests
Dx: Diagnosis is
made
Dx: investigations
Dx: consider differential diagnoses
Dx: History
Tx: First line (medical?)
Tx: First line (medical?)
Co-morbidities
Renal / hepatic
impairment?
Interactions?
Side affects acceptable?
Tx: 2nd line (medical?)
Tx: failure
Tx: success
Ongoing: monitor condition, need for
ongoing treatment (side-effects?)
Clinical pathway: with
CDS support
21. CDS: why?
•Staying up to date with drug information
•Identifying therapeutic conflicts
•Managing large volumes of medical and patient
data often in different systems
•Reducing medical error and improving safety
•Improving productivity and assisting with coding
compliance and reimbursement
22. CDS: the market
• approximately 10% of the medical publishing business relates
directly to clinical solutions
• 2 two key players in this market at present:
• Reed Elsevier: 20% market share, First Consult responsible
for 21% (€ 21 million) of Reed’s health revenues
• Wolters Kluwer: 15% share, UpToDate responsible for 20% of
Wolters’ health revenues (€ 15 million)
• CDS divisions within Reed and Wolters have shown the
largest actual and predicted growth rates of around 6 – 8% pa
• 10-12% predicted growth pa for overall business
28. CPD
•4-6% growth
•compulsory CME in many
countries
•electronic solutions, tailored for
students faculties, health
institutions, educational institutions